SitesBLAST
Comparing WP_005455827.1 NCBI__GCF_000244975.1:WP_005455827.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WPQ3 Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit; EC 6.3.4.14 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 97% coverage: 1:644/664 of query aligns to 1:650/654 of P9WPQ3
- K322 (≠ A310) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8j78I Human 3-methylcrotonyl-coa carboxylase in bccp-h2 state
38% identity, 96% coverage: 2:636/664 of query aligns to 4:638/651 of 8j78I
8rthA Trypanosoma brucei 3-methylcrotonyl-coa carboxylase (see paper)
42% identity, 95% coverage: 2:634/664 of query aligns to 2:651/666 of 8rthA
7ybuA Human propionyl-coenzyme a carboxylase
39% identity, 96% coverage: 4:643/664 of query aligns to 7:666/670 of 7ybuA
P05165 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Homo sapiens (Human) (see 6 papers)
39% identity, 96% coverage: 4:643/664 of query aligns to 65:724/728 of P05165
- A75 (= A14) to P: in PA-1; dbSNP:rs794727479
- R77 (= R16) to W: in PA-1; loss of function; dbSNP:rs141371306
- A138 (= A77) to T: in PA-1; loss of function; dbSNP:rs202247814
- I164 (≠ V103) to T: in PA-1; loss of function; dbSNP:rs202247815
- G197 (≠ P136) to E: in PA-1
- M229 (= M159) to K: in PA-1; dbSNP:rs375628794
- Q297 (= Q227) to R: in PA-1
- D368 (= D297) to G: in PA-1
- M373 (≠ Q302) to K: in PA-1; unstable protein; loss of function; dbSNP:rs121964958
- G379 (= G308) to V: in PA-1; dbSNP:rs794727087
- C398 (≠ A325) to R: in PA-1
- R399 (= R326) to Q: in PA-1; dbSNP:rs1301904623
- P423 (≠ E354) to L: in PA-1; dbSNP:rs1443858896
- L532 (≠ V459) natural variant: Missing (in PA-1)
- V551 (= V476) to F: in dbSNP:rs61749895
- W559 (= W484) to L: in PA-1; dbSNP:rs118169528
- G631 (= G559) to R: in PA-1; loss of function; dbSNP:rs796052018
- G668 (= G587) to R: in PA-1; loss of biotinylation; dbSNP:rs771438170
- K694 (= K613) modified: N6-biotinyllysine; by HLCS
- C712 (≠ V631) natural variant: Missing (in PA-1; loss of biotinylation)
Sites not aligning to the query:
- 1:52 modified: transit peptide, Mitochondrion
8sgxX Leishmania tarentolae propionyl-coa carboxylase (alpha-4-beta-6) (see paper)
38% identity, 96% coverage: 5:643/664 of query aligns to 1:653/657 of 8sgxX
2vr1A Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p. (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:440/444 of 2vr1A
- active site: K116 (= K116), K159 (= K149), D194 (≠ S186), H207 (= H199), R233 (= R225), T272 (= T263), E274 (= E265), E286 (= E278), N288 (= N280), R290 (= R282), E294 (= E286), R336 (= R326)
- binding phosphodifluoromethylphosphonic acid-adenylate ester: K159 (= K149), R165 (= R157), M167 (= M159), Y201 (≠ F193), L202 (= L194), E274 (= E265), L276 (= L267), E286 (= E278), N288 (= N280), I435 (≠ T435)
8hz4A The tetrameric structure of biotin carboxylase from chloroflexus aurantiacus in complex with bicarbonate (see paper)
48% identity, 67% coverage: 1:443/664 of query aligns to 1:442/456 of 8hz4A
Q5LUF3 Propionyl-CoA carboxylase alpha chain; EC 6.4.1.3 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
45% identity, 66% coverage: 1:438/664 of query aligns to 1:461/681 of Q5LUF3
- F348 (≠ W336) binding biotin
Sites not aligning to the query:
- 515 W→L: No effect on holoenzyme formation.
- 599 L→A: Loss of holoenzyme formation; when associated with A-602 and A-603.
- 602 L→A: Loss of holoenzyme formation; when associated with A-602 and A-603.
- 603 M→A: No effect on holoenzyme formation. Loss of holoenzyme formation; when associated with A-602 and A-603.
- 647 modified: N6-biotinyllysine
4mv4A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2 (see paper)
43% identity, 66% coverage: 1:440/664 of query aligns to 1:439/442 of 4mv4A
- active site: K116 (= K116), K159 (= K149), D193 (≠ S186), H206 (= H199), R232 (= R225), T271 (= T263), E273 (= E265), E285 (= E278), N287 (= N280), R289 (= R282), E293 (= E286), R335 (= R326)
- binding phosphomethylphosphonic acid adenylate ester: K159 (= K149), G164 (= G154), M166 (= M159), E198 (= E191), Y200 (≠ F193), L201 (= L194), H233 (= H226), L275 (= L267), E285 (= E278)
- binding magnesium ion: E273 (= E265), E285 (= E278)
4mv3A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate (see paper)
43% identity, 66% coverage: 1:440/664 of query aligns to 1:436/439 of 4mv3A
- active site: K116 (= K116), K159 (= K149), D190 (≠ S186), H203 (= H199), R229 (= R225), T268 (= T263), E270 (= E265), E282 (= E278), N284 (= N280), R286 (= R282), E290 (= E286), R332 (= R326)
- binding phosphomethylphosphonic acid adenylate ester: K159 (= K149), M163 (= M159), E195 (= E191), Y197 (≠ F193), L198 (= L194), E270 (= E265), L272 (= L267), E282 (= E278)
- binding bicarbonate ion: R286 (= R282), Q288 (= Q284), V289 (= V285)
6oi8A Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine (see paper)
43% identity, 66% coverage: 1:440/664 of query aligns to 1:437/440 of 6oi8A
- active site: K116 (= K116), K159 (= K149), D191 (≠ S186), H204 (= H199), R230 (= R225), T269 (= T263), E271 (= E265), E283 (= E278), N285 (= N280), R287 (= R282), E291 (= E286), R333 (= R326)
- binding 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine: I157 (≠ L147), K159 (= K149), M164 (= M159), E196 (= E191), Y198 (≠ F193), L199 (= L194), H204 (= H199), Q228 (= Q223), E271 (= E265), L273 (= L267), E283 (= E278), I432 (≠ T435)
2vqdA Crystal structure of biotin carboxylase from pseudomonas aeruginosa complexed with ampcp (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/447 of 2vqdA
- active site: K116 (= K116), K159 (= K149), P196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding phosphomethylphosphonic acid adenosyl ester: K116 (= K116), I157 (≠ L147), K159 (= K149), G164 (= G154), G166 (= G156), F203 (= F193), L204 (= L194), H209 (= H199), Q233 (= Q223), H236 (= H226), L278 (= L267), E288 (= E278), I437 (≠ T435)
- binding magnesium ion: E276 (= E265), E288 (= E278)
3jziA Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazole series (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/445 of 3jziA
- active site: K116 (= K116), K159 (= K149), D196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide: K116 (= K116), K159 (= K149), A160 (= A150), G164 (= G154), G165 (= G155), M169 (= M159), Y199 (≠ F189), E201 (= E191), K202 (≠ R192), Y203 (≠ F193), H209 (= H199), Q233 (= Q223), H236 (= H226), L278 (= L267), I287 (≠ L277), E288 (= E278)
2w6oA Crystal structure of biotin carboxylase from e. Coli in complex with 4-amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/445 of 2w6oA
- active site: K116 (= K116), K159 (= K149), D196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one: K159 (= K149), K202 (≠ R192), Y203 (≠ F193), L204 (= L194), L278 (= L267), I437 (≠ T435)
2w6nA Crystal structure of biotin carboxylase from e. Coli in complex with amino-oxazole fragment series (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/445 of 2w6nA
- active site: K116 (= K116), K159 (= K149), D196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding 2-amino-n,n-bis(phenylmethyl)-1,3-oxazole-5-carboxamide: I157 (≠ L147), K159 (= K149), M169 (= M159), E201 (= E191), K202 (≠ R192), Y203 (≠ F193), L278 (= L267)
2v59A Crystal structure of biotin carboxylase from e.Coli in complex with potent inhibitor 2 (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/445 of 2v59A
- active site: K116 (= K116), K159 (= K149), D196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding 6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine: K159 (= K149), Y203 (≠ F193), L204 (= L194), H209 (= H199), Q233 (= Q223), H236 (= H226), L278 (= L267), I437 (≠ T435)
6oi9A Crystal structure of e. Coli biotin carboxylase complexed with 7-[3- (aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3- d]pyrimidin-2-amine (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/446 of 6oi9A
- active site: E276 (= E265), E288 (= E278), N290 (= N280), E296 (= E286), R338 (= R326)
- binding 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine: K159 (= K149), M169 (= M159), E201 (= E191), Y203 (≠ F193), L204 (= L194), H209 (= H199), Q233 (= Q223), H236 (= H226), E276 (= E265), L278 (= L267), E288 (= E278), I437 (≠ T435)
2w71A Crystal structure of biotin carboxylase from e. Coli in complex with the imidazole-pyrimidine inhibitor (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/446 of 2w71A
- active site: K116 (= K116), K159 (= K149), D196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine: K159 (= K149), Y203 (≠ F193), L204 (= L194), H209 (= H199), Q233 (= Q223), H236 (= H226), L278 (= L267), I437 (≠ T435)
2w70A Crystal structure of biotin carboxylase from e. Coli in complex with the amino-thiazole-pyrimidine fragment (see paper)
44% identity, 66% coverage: 1:440/664 of query aligns to 1:442/446 of 2w70A
- active site: K116 (= K116), K159 (= K149), D196 (≠ S186), H209 (= H199), R235 (= R225), T274 (= T263), E276 (= E265), E288 (= E278), N290 (= N280), R292 (= R282), E296 (= E286), R338 (= R326)
- binding 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine: I157 (≠ L147), K159 (= K149), G166 (= G156), M169 (= M159), E201 (= E191), Y203 (≠ F193), L204 (= L194), L278 (= L267)
Query Sequence
>WP_005455827.1 NCBI__GCF_000244975.1:WP_005455827.1
MITNLLVANRGEIALRIFRTCREWGVGTVAVHSDPDANALHVAAADAAVRLPGAAPADTY
LRVDAVVSAALAAGADAVHPGYGFLSENAEFARAVLDAGLVWVGPSPESIALMGSKTESK
RVVAAAGVPVLAELDPESLTEEDLPVLVKASAGGGGRGMRVVRDRAEAAEAVAAARAEAA
SAFGDSAVFCERFLERGRHIEVQVLADTHGTVWAVGERECSIQRRHQKVVEEAPSGVDEG
LRQRLFEAAREVCRVTDYVGAGTVEFLVTDDGEFFFLEMNTRLQVEHPVTECVTGLDLVA
WQLRIAEGQALQGEPPRPRGHAIEARLYAEDPRSDWRPGSGTLHRFAVRDVRAEFTVPDR
YGIRLDSGVADGTEVSVHYDPMLAKVIAWGPDRTSAARMLAGTLASARVHGPVTNRDLLV
AVLRHPDFLAGDTHTDFLTRHADRVLDAGPGEAGARLSVLAAALADAEHNRTHARVLGSL
PGGWRNVPSAPQVKTYRHDGTDRSVRYSATRTGPVLEEHPEVTVVAVTPERVLLSCDGVR
RTFHVTRHPGLVVVDSPLGSVSLAPVPRFTDPAAELAEGSLVAPMPGTVVRLAVSVGDEV
RAGQPLLWLEAMKMEHRVTAPADGVVTELAVAEGAQVEQGAVMAVVTAGEATDVGAVETT
EESA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory