Comparing WP_005456121.1 NCBI__GCF_000244975.1:WP_005456121.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
46% identity, 97% coverage: 4:324/330 of query aligns to 4:328/330 of 6cfoB
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
46% identity, 97% coverage: 4:324/330 of query aligns to 5:329/331 of 6cerD
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
46% identity, 97% coverage: 4:324/330 of query aligns to 33:357/359 of P11177
Sites not aligning to the query:
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
44% identity, 92% coverage: 8:312/330 of query aligns to 7:310/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
44% identity, 92% coverage: 8:312/330 of query aligns to 7:310/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
44% identity, 92% coverage: 8:312/330 of query aligns to 7:310/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
44% identity, 92% coverage: 8:312/330 of query aligns to 7:310/324 of 1w85B
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
39% identity, 96% coverage: 8:324/330 of query aligns to 9:336/338 of 1qs0B
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
43% identity, 92% coverage: 1:303/330 of query aligns to 1:303/324 of Q5SLR3
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
43% identity, 90% coverage: 8:303/330 of query aligns to 7:302/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
43% identity, 90% coverage: 8:303/330 of query aligns to 7:302/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
43% identity, 90% coverage: 8:303/330 of query aligns to 7:302/323 of 1umbD
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
34% identity, 95% coverage: 8:320/330 of query aligns to 9:320/326 of 1dtwB
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
34% identity, 95% coverage: 8:320/330 of query aligns to 12:323/329 of 2j9fD
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
35% identity, 89% coverage: 8:301/330 of query aligns to 75:369/392 of P21953
6yakDDD C-terminal component of the split chain transketolase (see paper)
31% identity, 84% coverage: 4:279/330 of query aligns to 3:264/311 of 6yakDDD
8a45F Structural analysis of 1-deoxy-d-xylulose 5-phosphate synthase from pseudomonas aeruginosa with 2-acetyl thiamine diphosphate (see paper)
28% identity, 78% coverage: 51:309/330 of query aligns to 315:556/573 of 8a45F
Sites not aligning to the query:
8a5kA Structural analysis of 1-deoxy-d-xylulose 5-phosphate synthase from pseudomonas aeruginosa and klebsiella pneumoniae reveals conformational changes upon cofactor binding (see paper)
28% identity, 78% coverage: 51:309/330 of query aligns to 304:545/562 of 8a5kA
Sites not aligning to the query:
8a4dA 1-deoxy-d-xylulose 5-phosphate synthase from pseudomonas aeruginosa with a thiamine analog inhibitor (see paper)
28% identity, 78% coverage: 51:309/330 of query aligns to 304:545/564 of 8a4dA
Sites not aligning to the query:
8oghA Truncated 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from mycobacterium tuberculosis with butylacetylphosphonate (bap) bound
30% identity, 75% coverage: 45:292/330 of query aligns to 270:509/549 of 8oghA
Sites not aligning to the query:
>WP_005456121.1 NCBI__GCF_000244975.1:WP_005456121.1
MPVISYREALRNTLREELRRDDDVLLIGEEIGVFGGSYKITSGLLEEFGEKRVRDTPIAE
EGFVGAAVGAAMLGLRPIVEIMTINFSLLALDQIVNHAAKIYGMFGGQTSVPMVIRTPGG
GGQQLGATHSQNIELYYAFVPGLKVVAPSTPADARALLLAAVRDDDPVLFLENLALYNTK
GEVPDDLGPAEIGRAAVVREGTDITIVGYSRMAAVAVEVADRLRDESGVSAEVIDLRSLR
PLDRETLVASARRTGCVVVAEDDWLTYGVGAEIAASISDGAFDHLDAPVRRVAAAEVPLP
YAKPLETAALPSAESLHTAVLETLAAIGRR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory