SitesBLAST
Comparing WP_005817128.1 NCBI__GCF_000021925.1:WP_005817128.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
40% identity, 94% coverage: 29:460/462 of query aligns to 33:465/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P70), G75 (= G72), S76 (= S73), G77 (≠ A74), T78 (= T75), G79 (≠ N76), L80 (= L77), A83 (≠ G80), C84 (≠ T81), P137 (= P134), G138 (= G135), E139 (≠ T136), A142 (= A140), T143 (= T141), G146 (= G144), N147 (≠ S145), S149 (= S147), T150 (≠ E148), A152 (≠ S150), G153 (= G151), E203 (= E201), G204 (= G202), I209 (= I207), E422 (= E417), H423 (= H418)
- binding fe (iii) ion: H377 (= H373), H384 (= H380), E422 (= E417)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
35% identity, 98% coverage: 4:456/462 of query aligns to 2:453/459 of P9WIT1
- K354 (≠ H352) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R324), H369 (= H373), H376 (= H380), H414 (= H418)
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W322 (≠ L328), E413 (= E417), H414 (= H418), N450 (= N454)
- binding manganese (ii) ion: H369 (= H373), H376 (= H380), E413 (= E417)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ A33), P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W323 (≠ L328), E414 (= E417), H415 (= H418), N451 (= N454)
- binding manganese (ii) ion: H370 (= H373), H377 (= H380), E414 (= E417)
- binding pyruvic acid: R319 (= R324), H370 (= H373), H377 (= H380), H415 (= H418)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ L77), R317 (= R324), W321 (≠ L328), H368 (= H373), H375 (= H380), H413 (= H418)
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W321 (≠ L328), Y322 (≠ P329), E412 (= E417), H413 (= H418), N449 (= N454)
- binding manganese (ii) ion: H368 (= H373), H375 (= H380), E412 (= E417)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), H369 (= H373), E413 (= E417), N450 (= N454)
- binding deaminohydroxyvaline: R319 (= R324), H414 (= H418)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W322 (≠ L328), E413 (= E417), H414 (= H418), N450 (= N454)
- binding lactic acid: R318 (= R324), H369 (= H373), H376 (= H380), H414 (= H418)
- binding manganese (ii) ion: H369 (= H373), H376 (= H380), E413 (= E417)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R324), W322 (≠ L328), H369 (= H373), H376 (= H380), H414 (= H418)
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W322 (≠ L328), E413 (= E417), N450 (= N454)
- binding manganese (ii) ion: H369 (= H373), H376 (= H380), E413 (= E417)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ A33), P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W322 (≠ L328), E413 (= E417), H414 (= H418), N450 (= N454)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R324), H369 (= H373), H376 (= H380), H414 (= H418)
- binding manganese (ii) ion: H369 (= H373), H376 (= H380), E413 (= E417)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), Y324 (≠ P329), H370 (= H373), E414 (= E417), N451 (= N454)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R324), W323 (≠ L328), H415 (= H418)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R324), W323 (≠ L328), H370 (= H373), H415 (= H418)
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), H370 (= H373), E414 (= E417), N451 (= N454)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R324), W323 (≠ L328), H415 (= H418)
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), Y324 (≠ P329), H370 (= H373), E414 (= E417), N451 (= N454)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), H370 (= H373), E414 (= E417), N451 (= N454)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R324), W323 (≠ L328), H415 (= H418)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), H370 (= H373), E414 (= E417), N451 (= N454)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R324), H415 (= H418)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), Y324 (≠ P329), H370 (= H373), E414 (= E417), N451 (= N454)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ L77), R319 (= R324), W323 (≠ L328), H415 (= H418)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R324), W322 (≠ L328), H369 (= H373), H376 (= H380), H413 (= H418)
- binding flavin-adenine dinucleotide: E32 (≠ A33), P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), W322 (≠ L328), E412 (= E417), H413 (= H418), N449 (= N454)
- binding manganese (ii) ion: H369 (= H373), H376 (= H380), E412 (= E417)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
30% identity, 99% coverage: 2:459/462 of query aligns to 1:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R324), W322 (≠ L328), S336 (≠ L340), H369 (= H373), H376 (= H380), H413 (= H418)
- binding flavin-adenine dinucleotide: P68 (= P70), G70 (= G72), T71 (≠ S73), G72 (≠ A74), T73 (= T75), G74 (≠ N76), G78 (= G80), V79 (≠ T81), L90 (≠ M92), P132 (= P134), G133 (= G135), A134 (≠ T136), G140 (= G144), M141 (≠ S145), A143 (≠ S147), T144 (≠ E148), A146 (≠ S150), S147 (≠ G151), E200 (= E201), G201 (= G202), I206 (= I207), E412 (= E417), N449 (= N454)
- binding manganese (ii) ion: H369 (= H373), H376 (= H380), E412 (= E417)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
29% identity, 99% coverage: 2:459/462 of query aligns to 2:465/465 of 3pm9A
- active site: A149 (≠ S150), L159 (≠ V160)
- binding flavin-adenine dinucleotide: P69 (= P70), Q70 (≠ R71), G71 (= G72), G72 (≠ S73), N73 (≠ A74), T74 (= T75), G75 (≠ N76), L76 (= L77), G79 (= G80), Q80 (≠ T81), L91 (≠ M92), L133 (≠ P134), G134 (= G135), A135 (≠ T136), C139 (≠ A140), T140 (= T141), G142 (= G143), G143 (= G144), S146 (= S147), T147 (≠ E148), A149 (≠ S150), G150 (= G151), E200 (= E201), G201 (= G202), I205 (= I206), I206 (= I207), E423 (= E417)
P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 99% coverage: 1:459/462 of query aligns to 26:496/496 of P39976
Sites not aligning to the query:
- 17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
27% identity, 95% coverage: 19:457/462 of query aligns to 25:462/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R325), T337 (≠ P329), K348 (≠ L340), Y379 (≠ F371), H381 (= H373), H388 (= H380), H423 (= H418)
- binding flavin-adenine dinucleotide: W39 (≠ A33), P75 (= P70), Q76 (≠ R71), G77 (= G72), G78 (≠ S73), N79 (≠ A74), T80 (= T75), G81 (≠ N76), M82 (≠ L77), G85 (= G80), S86 (≠ T81), L139 (≠ P134), G140 (= G135), A141 (≠ T136), C145 (≠ A140), G149 (= G144), N150 (≠ S145), A152 (≠ S147), T153 (≠ E148), G157 (= G152), G207 (= G202), I212 (= I207), E422 (= E417), N459 (= N454)
- binding zinc ion: H381 (= H373), H388 (= H380), E422 (= E417)
Query Sequence
>WP_005817128.1 NCBI__GCF_000021925.1:WP_005817128.1
MLKAEALNELIQVLGKENVVTEHEELLSYSYDATAAMPHQTPDVFVTPKTTEQVSEVMKI
ATKYDLPVYPRGSATNLSGGTIPIEKGIVMSMLHMNQIIEVDAENLTATVQPGVIIQDLN
DAALEHGLFYPPDPGTVKTATMGGSVSESSGGLRGLKYGVTKHYVMGMKLVRANGDIIKW
GGKTVKNVTGYDLTALFTGAEGTLGIITEIIVKLNPVPEARKALLGVFDDIDKAGNAIAA
IIRNKVIPATLEIMDNITIRTVENFTHAGLPVDAEAILLCEVDGYKEAVEREAALVEKIL
KEQGAVEINVAKTDEERDKIWLARRNALPALAQRRPTTVLEDATVPRSKIPHMIKAIRQI
AEKYDLLIGTFGHAGDGNLHPTILTDENNKEEMERVDKAVEEIFQVAVSLGGTLSGEHGI
GMAKAKFLPLEFGEAGVKLLKDIKEACDPDYRINPGKMVRRD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory