SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_007155382.1 NCBI__GCF_000170835.1:WP_007155382.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
42% identity, 95% coverage: 24:495/497 of query aligns to 18:488/491 of 5gtlA

query
sites
5gtlA

Q

K

M

M

T

F

I

I

N

N

G

G

K

E

F

F

V

V

K

S

G

A

Q

I

S

G

G

G

K

K

T

T

Y

F

T

E

T

T

I

Y

N

N

P

P

S

A

T

T

D

E

Q

D

P

V

L

L

A

A

D

V

V

V

P

C

F

E

A

A

T

Q

A

E

E

E

D

D

V

I

K

D

S

A

A

A

V

V

A

K

S

A

A

A

K

R

A

S

A

A

F

F

P

E

G

S

-

G

-

P

W

W

K

A

K

E

L

M

H

T

V

T

D

A

E

E

R

R

G

A

K

H

M

L

L

I

K

Y

A

K

L

L

S

A

R

D

A

L

V

I

R

E

E

E

R

H

A

R

E

E

M

E

F

L

G

A

M

Q

L

L

D

E

A

A

L

L

D

D

C

N

G

G

N

K

P

P

Y

Y

Q

Q

-

V

A

A

M

L

V

D

D

D

D

D

A

I

N

S

K

A

G

T

A

V

G

E

L

N

L

Y

E

R

H

Y

F

Y

S

A

N

G

L

W

G

T

M

T

E

K

L

I

K

I

G

G

Q

Q

T

T

V

I

P

P

T

I

P

S

G

K

G

D

G

Y

L

L

N

N

Y

Y

T

T

R

R

L

H

E

E

P

P

F

V

G

G

V

V

V

V

A

G

R

Q

I
|
I

L

I

P
|
P

F

W

N
|
N

H

F

P

P

I

L

S

V

F

M

A

S

V

S

G

W

K

K

I

M

A

G

S

A

A

A

L

L

I

A

A

T

G

G

N

C

T

T

V

I

V

V

M

L

K
|
K

I

P

A
|
A

D
x
E

Q
|
Q

T

T

P

P

L

L

S

S

A

L

L

L

L

Y

F

A

G

A

K

K

L

L

I

F

Q

K

E

E

H

A

-

G

L

F

P

P

P

N

G

G

V

V

V

V

N

N

V

F

I

V

T

P

G

G

D

F

G
|
G

A

P

T

E

T

A

G
|
G

A

A

S

A

L

I

V

V

S

N

H

H

P

H

D

D

I

I

H

D

R

K

I

V

A

A

F

F

T

T

G
|
G

S
|
S

V

T

A

V

T
|
T

G

G

N

K

L

Y

I

I

S

M

Q

R

Q

Q

A

S

G

A

-

E

-

M

I

I

A

K

V

H

L

V

S

T

L

L

E
|
E

L
|
L

G

G

G

G

K

K

N

S

P

P

L

N

I

I

I

I

Y

L

P

E

D

D

V

A

D

D

V

L

Q

E

K

E

V

A

A

I

D

N

A

G

A

A

V

F

A

Q

G

G

M

I

N

M

F

Y

T

-

R

-

S

N

Q

H

G

G

Q

Q

S

N

C
|
C

G

S

S

A

N

G

S

S

R

R

V

V

F

F

V

V

H

H

R

R

D

K

L

H

H

Y

D

E

E

T

F

V

V

V

S

D

E

A

V

L

V

V

K

K

R

M

V

A

E

N

K

N

I

V

K

K

V

L

G

G

H

A

A

G

D

M

A

E

D

K

D

E

T

T

E

E

M

M

G

G

P

P

V

L

V

V

T

S

R

K

Q

K

H

Q

Y

Q

D

E

R

R

V

V

M

L

H

N

Y

Y

I

I

D

E

S

Q

A

G

K

K

S

K

E

E

G

G

A

A

K

T

L

V

M

A

T

A

G

G

G

G

G

E

H

R

A

A

K

-

G

-

E

-

D

-

L

L

A

E

D

K

G

G

Y

Y

F

F

I

V

E

K

P

P

T

T

V

V

F

F

D

T

E

D

V

V

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

K

E

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

M

V

S

V

I

V

L

L

V

P

W

F

D

D

D

S

E

T

A

E

S

E

M

V

M

I

E

E

Q

R

V

A

N

N

G

N

V

S

E

S

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

W

T

T

N

Q

D

N

I

I

S

K

T

T

A

G

L

H

R

Q

V

V

G

A

D

N

D

K

I

L

E

K

A

A

G

G

Y

T

V

V

W

W

I

I

N

N

G

D

H

Y

G

N

G

L

K

E

R

N

F

-

K

A

G

A

A

A

P

P

F

F

G

G

G

G

V

Y

K

K

N

Q

S

S

G

G

I

I

G

G

R

R

E
|
E

H

L

D

G

T

S

S

Y

E

A

I

L

R

D

S

N

F

Y

T

T

Q

E

E

V

K

K

N

S

I

V

N

W

V

V

active site: N165 (= N168), K188 (= K191), E263 (= E263), C297 (= C299), E394 (= E400), E471 (= E478)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I164), P163 (= P166), K188 (= K191), A190 (= A193), E191 (≠ D194), Q192 (= Q195), G221 (= G223), G225 (= G227), G241 (= G243), S242 (= S244), T245 (= T247), L264 (= L264), C297 (= C299), E394 (= E400), F396 (= F402)

5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
42% identity, 95% coverage: 24:495/497 of query aligns to 18:488/491 of 5gtkA

query
sites
5gtkA

Q

K

M

M

T

F

I

I

N

N

G

G

K

E

F

F

V

V

K

S

G

A

Q

I

S

G

G

G

K

K

T

T

Y

F

T

E

T

T

I

Y

N

N

P

P

S

A

T

T

D

E

Q

D

P

V

L

L

A

A

D

V

V

V

P

C

F

E

A

A

T

Q

A

E

E

E

D

D

V

I

K

D

S

A

A

A

V

V

A

K

S

A

A

A

K

R

A

S

A

A

F

F

P

E

G

S

-

G

-

P

W

W

K

A

K

E

L

M

H

T

V

T

D

A

E

E

R

R

G

A

K

H

M

L

L

I

K

Y

A

K

L

L

S

A

R

D

A

L

V

I

R

E

E

E

R

H

A

R

E

E

M

E

F

L

G

A

M

Q

L

L

D

E

A

A

L

L

D

D

C

N

G

G

N

K

P

P

Y

Y

Q

Q

-

V

A

A

M

L

V

D

D

D

D

D

A

I

N

S

K

A

G

T

A

V

G

E

L

N

L

Y

E

R

H

Y

F

Y

S

A

N

G

L

W

G

T

M

T

E

K

L

I

K

I

G

G

Q

Q

T

T

V

I

P

P

T

I

P

S

G

K

G

D

G

Y

L

L

N

N

Y

Y

T

T

R

R

L

H

E

E

P

P

F

V

G

G

V

V

V

V

A

G

R

Q

I
|
I

L
x
I

P
|
P

F
x
W

N
|
N

H

F

P

P

I

L

S

V

F

M

A

S

V

S

G

W

K

K

I

M

A

G

S

A

A

A

L

L

I

A

A

T

G

G

N

C

T

T

V

I

V

V

M

L

K
|
K

I

P

A

A

D
x
E

Q

Q

T

T

P

P

L

L

S

S

A

L

L

L

L

Y

F

A

G

A

K

K

L

L

I

F

Q

K

E

E

H

A

-

G

L

F

P

P

P

N

G

G

V

V

V

V

N

N

V

F

I

V

T

P

G

G

D

F

G
|
G

A

P

T

E

T

A

G
|
G

A
|
A

S

A

L

I

V

V

S

N

H

H

P

H

D

D

I

I

H

D

R

K

I

V

A

A

F
|
F

T

T

G
|
G

S
|
S

V

T

A

V

T
|
T

G

G

N

K

L
x
Y

I

I

S

M

Q

R

Q

Q

A

S

G

A

-

E

-

M

I

I

A

K

V

H

L

V

S

T

L

L

E
|
E

L
|
L

G

G

G

G

K

K

N

S

P

P

L

N

I

I

I

I

Y

L

P

E

D

D

V

A

D

D

V

L

Q

E

K

E

V

A

A

I

D

N

A

G

A

A

V

F

A

Q

G

G

M

I

N

M

F

Y

T

-

R

-

S

N

Q

H

G

G

Q

Q

S

N

C
|
C

G

S

S

A

N

G

S

S

R

R

V

V

F

F

V

V

H

H

R

R

D

K

L

H

H

Y

D

E

E

T

F

V

V

V

S

D

E

A

V

L

V

V

K

K

R

M

V

A

E

N

K

N

I

V

K

K

V

L

G

G

H

A

A

G

D

M

A

E

D

K

D

E

T

T

E

E

M

M

G

G

P

P

V

L

V

V

T

S

R

K

Q

K

H
x
Q

Y

Q

D

E

R
|
R

V

V

M

L

H

N

Y

Y

I

I

D

E

S

Q

A

G

K

K

S

K

E

E

G

G

A

A

K

T

L

V

M

A

T

A

G

G

G

G

G

E

H

R

A

A

K

-

G

-

E

-

D

-

L

L

A

E

D

K

G

G

Y

Y

F

F

I

V

E

K

P

P

T

T

V

V

F

F

D

T

E

D

V

V

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

K

E

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

M

V

S

V

I

V

L

L

V

P

W

F

D

D

D

S

E

T

A

E

S

E

M

V

M

I

E

E

Q

R

V

A

N

N

G

N

V

S

E

S

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

W

T

T

N

Q

D

N

I

I

S

K

T

T

A

G

L

H

R

Q

V

V

G

A

D

N

D

K

I

L

E

K

A

A

G

G

Y

T

V

V

W

W

I

I

N

N

G

D

H

Y

G

N

G

L

K

E

R

N

F

-

K

A

G

A

A

A

P

P

F

F

G

G

G

G

V

Y

K

K

N

Q

S

S

G

G

I

I

G

G

R

R

E
|
E

H

L

D

G

T

S

S

Y

E

A

I

L

R

D

S

N

F

Y

T

T

Q

E

E

V

K

K

N

S

I

V

N

W

V

V

active site: N165 (= N168), K188 (= K191), E263 (= E263), C297 (= C299), E394 (= E400), E471 (= E478)
binding nicotinamide-adenine-dinucleotide: I161 (= I164), I162 (≠ L165), P163 (= P166), W164 (≠ F167), K188 (= K191), E191 (≠ D194), G221 (= G223), G225 (= G227), A226 (= A228), F239 (= F241), G241 (= G243), S242 (= S244), T245 (= T247), Y248 (≠ L250), L264 (= L264), C297 (= C299), Q344 (≠ H346), R347 (= R349), E394 (= E400), F396 (= F402)

8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
44% identity, 95% coverage: 24:495/497 of query aligns to 15:488/497 of 8skfA

query
sites
8skfA

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T
|
T

I
|
I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D
|
D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I
|
I

L
x
G

P
x
A

F
x
W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K
|
K

I

P

A

S

D
x
E

Q
x
V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G
|
G

A

A

T

E

T

T

G
|
G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F

F

T
|
T

G
|
G

S
x
G

V

V

A

A

T
x
S

G

G

N

K

L
x
K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E
|
E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C
|
C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H

H

Y

R

D

Q

R

N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E

E

I

I

F
|
F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding calcium ion: T33 (= T42), I34 (= I43), D100 (= D109), V187 (≠ Q195)
binding nicotinamide-adenine-dinucleotide: I156 (= I164), G157 (≠ L165), A158 (≠ P166), W159 (≠ F167), K183 (= K191), E186 (≠ D194), G216 (= G223), G220 (= G227), T235 (= T242), G236 (= G243), G237 (≠ S244), S240 (≠ T247), K243 (≠ L250), E259 (= E263), C293 (= C299), F396 (= F402)

8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8vr1A

query
sites
8vr1A

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I

I

L

G

P

A

F
x
W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K

K

I

P

A

S

D

E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G

G

A

A

T

E

T

T

G

G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F

F

T

T

G
|
G

S
x
G

V

V

A
|
A

T
x
S

G

G

N

K

L

K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C

C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H

H

Y

R

D

Q

R

N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding cytidine-5'-triphosphate: W150 (≠ F167), G227 (= G243), G228 (≠ S244), A230 (= A246), S231 (≠ T247), E385 (= E400), F387 (= F402)

8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8vr0A

query
sites
8vr0A

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I

I

L

G

P

A

F
x
W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K

K

I

P

A

S

D

E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G

G

A

A

T

E

T

T

G

G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F

F

T

T

G
|
G

S
x
G

V

V

A

A

T

S

G

G

N

K

L

K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C

C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H
|
H

Y

R

D

Q

R

N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding guanosine-5'-monophosphate: W150 (≠ F167), G227 (= G243), G228 (≠ S244), H331 (= H346), E385 (= E400), F387 (= F402)

8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8vqzA

query
sites
8vqzA

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I

I

L

G

P

A

F
x
W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K

K

I

P

A

S

D

E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G

G

A

A

T

E

T

T

G

G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F

F

T

T

G
|
G

S
x
G

V

V

A

A

T

S

G

G

N

K

L

K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C

C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H
|
H

Y

R

D

Q

R
x
N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E
|
E

I

I

F
|
F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding cytidine-5'-monophosphate: W150 (≠ F167), G227 (= G243), G228 (≠ S244), H331 (= H346), N334 (≠ R349), E385 (= E400), F387 (= F402)

8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8vqwC

query
sites
8vqwC

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I
|
I

L

G

P

A

F
x
W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K
|
K

I

P

A
x
S

D
x
E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G
|
G

A

A

T

E

T

T

G
|
G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F
|
F

T

T

G
|
G

S
x
G

V

V

A

A

T
x
S

G

G

N

K

L

K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C

C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H
|
H

Y

R

D

Q

R

N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E

E

I

I

F
|
F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding coenzyme a: I147 (= I164), W150 (≠ F167), K174 (= K191), S176 (≠ A193), E177 (≠ D194), G207 (= G223), G211 (= G227), F225 (= F241), G227 (= G243), G228 (≠ S244), S231 (≠ T247), H331 (= H346), F387 (= F402)

8vj3A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (fad bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8vj3A

query
sites
8vj3A

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I
|
I

L
x
G

P

A

F
x
W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K
|
K

I

P

A
x
S

D
x
E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G
|
G

A

A

T

E

T

T

G
|
G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F
|
F

T

T

G

G

S

G

V

V

A

A

T
x
S

G

G

N

K

L

K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C

C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H

H

Y

R

D

Q

R

N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E

E

I

I

F

F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding flavin-adenine dinucleotide: I147 (= I164), G148 (≠ L165), W150 (≠ F167), K174 (= K191), S176 (≠ A193), E177 (≠ D194), G207 (= G223), G211 (= G227), F225 (= F241), S231 (≠ T247)

8uzoA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (adp bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8uzoA

query
sites
8uzoA

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I
|
I

L
x
G

P

A

F

W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K
|
K

I

P

A

S

D

E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G
|
G

A

A

T

E

T

T

G
|
G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F
|
F

T

T

G
|
G

S
x
G

V

V

A

A

T
x
S

G

G

N

K

L

K

I
x
V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L

V

A

A

A

D

D

A

I

A

A

V

M

A

M

G

A

M

-

N

N

F

F

T

Y

R

-

S

S

Q

S

G

G

Q

Q

S

V

C

C

G

T

S

N

N

G

S

T

R

R

V

V

F

F

V

V

H

P

R

A

D

K

L

F

H

K

D

A

E

E

F

F

V

E

S

H

E

K

V

I

V

L

K

E

R

R

V

V

E

G

K

R

I

I

K

R

V

A

G

G

H

D

A

L

D

F

A

A

D

D

D

D

T

T

E

N

M

F

G

G

P

P

V

L

V

V

T

S

R

F

Q

P

H

H

Y

R

D

Q

R

N

V

V

M

L

H

R

Y

Y

I

I

D

E

S

S

A

G

K

K

S

S

E

E

G

G

A

A

K

R

L

L

M

L

T

C

G

G

G

G

G

D

H

V

A

L

K

K

G

G

E

E

D

G

L

F

A

D

D

N

G

G

Y

A

F

W

I

V

E

A

P

P

T

T

V

V

F

F

D

T

E

D

V

C

T

T

H

D

D

D

M

M

T

T

I

I

A

V

R

R

E

E

E

E

I

I

F

F

G

G

P

P

V

V

M

M

S

S

I

I

L

L

V

S

W

Y

D

D

D

D

E

E

A

A

S

E

M

V

M

I

E

R

Q

R

V

A

N

N

G

A

V

T

E

E

Y

Y

G

G

L

L

C

A

A

A

N

G

V

V

W

V

T

T

N

P

D

D

I

L

S

N

T

R

A

A

L

H

R

R

V

I

G

I

D

H

D

Q

I

L

E

E

A

A

G

G

Y

I

V

C

W

W

I

I

N

N

G

S

H

W

G

G

G

E

K

S

R

P

F

A

K

E

G

-

A

M

P

P

F

V

G

G

G

G

V

Y

K

K

N

H

S

S

G

G

I

I

G

G

R

R

E

E

H

N

D

G

T

V

S

M

E

T

I

L

R

Q

S

S

F

Y

T

T

Q

Q

E

V

K

K

N

S

I

I

N

Q

V

V

binding adenosine-5'-diphosphate: I147 (= I164), G148 (≠ L165), K174 (= K191), G207 (= G223), G211 (= G227), F225 (= F241), G227 (= G243), G228 (≠ S244), S231 (≠ T247), V235 (≠ I251)

8uznA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (amp bound)
44% identity, 95% coverage: 24:495/497 of query aligns to 6:479/488 of 8uznA

query
sites
8uznA

Q

Q

M

L

T

Y

I

I

N

H

G

G

K

K

F

F

V

V

K

A

G

A

Q

T

S

S

G

G

K

K

T

T

Y

F

T

E

T

T

I

I

N

N

P

P

S

A

T

T

D

G

Q

E

P

V

L

L

A

A

D

T

V

V

P

Q

F

A

A

A

T

G

A

R

E

E

D

D

V

V

K

D

S

R

A

A

V

V

A

K

S

S

A

A

K

Q

A

Q

A

G

F

Q

P

K

G

V

W

W

K

A

K

A

L

M

H

S

V

A

D

M

E

A

R

R

G

S

K

R

M

I

L

L

K

R

A

K

L

A

S

V

R

D

A

I

V

L

R

R

E

E

R

R

A

N

E

D

M

E

F

L

G

A

M

R

L

L

D

E

A

T

L

L

D

D

C

T

G

G

N

K

P

P

Y

L

-

S

Q

E

A

T

M

A

V

A

D

V

D

D

A

I

N

V

K

T

G

G

A

A

G

D

L

V

L

L

E

E

H

Y

F

Y

S

A

N

G

L

L

G

I

M

P

E

A

L

L

K

E

G

G

Q

S

T

Q

V

I

P

P

T

L

P

R

G

D

G

S

G

S

L

F

N

V

Y

Y

T

T

R

R

L

R

E

E

P

P

F

L

G

G

V

V

V

V

A

A

R

G

I
|
I

L
x
G

P

A

F

W

N

N

H

Y

P

P

I

I

S

Q

F

I

A

A

V

L

G

W

K

K

I

S

A

A

S

P

A

A

L

L

I

A

A

A

G

G

N

N

T

A

V

M

V

I

M

F

K
|
K

I

P

A
x
S

D
x
E

Q

V

T

T

P

P

L

L

S

T

A

A

L

L

L

K

F

L

G

A

K

E

L

I

I

Y

Q

R

E

E

H

A

-

G

L

L

P

P

P

D

G

G

V

V

V

F

N

N

V

V

I

L

T

P

G

G

D

I

G
|
G

A

A

T

E

T

T

G
|
G

A

Q

S

Y

L

L

V

T

S

E

H

H

P

P

D

D

I

I

H

A

R

K

I

I

A

S

F
|
F

T

T

G

G

S
x
G

V

V

A

A

T
x
S

G

G

N

K

L
x
K

I

V

-

M

-

A

-

N

S

S

Q

A

Q

A

A

S

G

S

I

L

A

K

V

E

L

V

S

T

L

M

E

E

L

L

G

G

G

G

K

K

N

S

P

P

L

L

I

I

I

I

Y

A

P

E

D

D

V

A

D

N

V

L

Q

D

K

L