SitesBLAST

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
26% identity, 84% coverage: 6:170/197 of query aligns to 2:194/234 of Q7WTT9

query
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Q7WTT9

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C12 (= C16) binding [4Fe-4S] cluster
C15 (= C19) binding [4Fe-4S] cluster
C18 (= C22) binding [4Fe-4S] cluster
C22 (= C26) binding [4Fe-4S] cluster
C57 (= C59) binding [4Fe-4S] cluster
C60 (= C62) binding [4Fe-4S] cluster
C65 (= C67) binding [4Fe-4S] cluster
C69 (= C71) binding [4Fe-4S] cluster
C89 (= C91) binding [4Fe-4S] cluster
C92 (= C94) binding [4Fe-4S] cluster
C95 (= C97) binding [4Fe-4S] cluster
C99 (= C101) binding [4Fe-4S] cluster
C164 (vs. gap) binding [4Fe-4S] cluster
C167 (vs. gap) binding [4Fe-4S] cluster
C179 (= C155) binding [4Fe-4S] cluster
C183 (= C159) binding [4Fe-4S] cluster

6f0kB Alternative complex iii (see paper)
27% identity, 87% coverage: 12:183/197 of query aligns to 729:931/961 of 6f0kB

query
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6f0kB

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binding fe3-s4 cluster: C803 (= C71), V805 (= V73), M818 (≠ H86), C823 (= C91), I824 (= I92), G825 (= G93), C829 (= C97), M869 (= M120)
binding heme c: N821 (≠ D89), R822 (≠ K90), R884 (≠ E138), N887 (≠ K141)
binding iron/sulfur cluster: C733 (= C16), T734 (≠ I17), G735 (≠ E18), C736 (= C19), N737 (≠ F20), A738 (≠ G21), C739 (= C22), C743 (= C26), W765 (vs. gap), I768 (vs. gap), C791 (= C59), M792 (= M60), H793 (= H61), C794 (= C62), P798 (= P66), C799 (= C67), N816 (≠ V84), C833 (= C101), C872 (= C123), Y874 (≠ M125), C875 (= C126), A901 (vs. gap), C902 (= C155), C906 (= C159)

Sites not aligning to the query:

binding heme c: 719

7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
29% identity, 92% coverage: 12:192/197 of query aligns to 8:174/174 of 7qv7A

query
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7qv7A

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binding iron/sulfur cluster: C12 (= C16), L13 (≠ I17), G14 (≠ E18), C15 (= C19), Y16 (≠ F20), C18 (= C22), C22 (= C26), H26 (= H30), L37 (≠ V42), C51 (= C59), R52 (≠ M60), C54 (= C62), C59 (= C67), C63 (= C71), C82 (= C91), I83 (= I92), G84 (= G93), C85 (= C94), C88 (= C97), C92 (= C101), I97 (≠ P106), F99 (= F108), C125 (= C123), L127 (≠ M125), C128 (= C126), A136 (≠ M154), C137 (= C155), C141 (= C159)

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
27% identity, 95% coverage: 5:192/197 of query aligns to 28:218/294 of P0AAJ3

query
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P0AAJ3

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C39 (= C16) binding [4Fe-4S] cluster
C42 (= C19) binding [4Fe-4S] cluster
C45 (= C22) binding [4Fe-4S] cluster
C49 (= C26) binding [4Fe-4S] cluster
C100 (= C59) binding [4Fe-4S] cluster
C103 (= C62) binding [4Fe-4S] cluster
C108 (= C67) binding [4Fe-4S] cluster
C112 (= C71) binding [4Fe-4S] cluster
C133 (= C91) binding [4Fe-4S] cluster
C136 (= C94) binding [4Fe-4S] cluster
C139 (= C97) binding [4Fe-4S] cluster
C143 (= C101) binding [4Fe-4S] cluster
C160 (= C123) binding [4Fe-4S] cluster
C163 (= C126) binding [4Fe-4S] cluster
C175 (= C155) binding [4Fe-4S] cluster
C179 (= C159) binding [4Fe-4S] cluster

1kqfB Formate dehydrogenase n from e. Coli (see paper)
27% identity, 95% coverage: 5:192/197 of query aligns to 27:217/289 of 1kqfB

query
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1kqfB

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G

binding protoporphyrin ix containing fe: Y137 (= Y96)
binding iron/sulfur cluster: K31 (≠ F9), C38 (= C16), I39 (= I17), G40 (≠ E18), C41 (= C19), K42 (≠ F20), C44 (= C22), C48 (= C26), N52 (≠ H30), T77 (≠ K40), M79 (≠ V42), C99 (= C59), M100 (= M60), H101 (= H61), C102 (= C62), P105 (≠ A65), C107 (= C67), C111 (= C71), P112 (= P72), I117 (≠ Y77), V125 (= V84), C132 (= C91), I133 (= I92), G134 (= G93), C135 (= C94), G136 (= G95), Y137 (= Y96), C138 (= C97), C142 (= C101), I146 (≠ A105), P147 (= P106), V156 (≠ M120), K158 (= K122), C159 (= C123), L161 (≠ M125), C162 (= C126), P172 (= P153), C174 (= C155), C178 (= C159), P179 (≠ S160), I183 (≠ L164)

Sites not aligning to the query:

binding protoporphyrin ix containing fe: 252

6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
25% identity, 85% coverage: 2:168/197 of query aligns to 678:884/929 of 6lodB

query
sites
6lodB

Y

Y

N

N

Y

G

A

Y

R

K

M

W

K

G

F

M

Y

S

C

I

D

D

T

L

E

N

R

V

C
|
C

I
x
N

E
x
S

C
|
C

F
x
N

G
x
A

C
|
C

V

V

I

V

A

A

C
|
C

D

Q

E

S

A

E

H
x
N

E

N

L

I

P

P

L

V

G

-

I

V

A

G

R

K

R

D

K

E

V

V

-

W

-

L

-

G

-

R

-

E

-

M

-

H

-
x
W

V

I

T

R

L
x
I

N

D

D

Q

G

Y

I

Y

E

V

G

G

K

D

E

E

-

H

-

T

-

P

-

N

-

V

F

Y

S

N

V

M

S

V

V

M

A
x
L

C
|
C

M
x
Q

H
x
Q

C
|
C

T

E

D

H

A

A

P
|
P

C
|
C

E

E

Q

I

V
|
V

C
|
C

P
|
P

V

V

D

A

C

A

F

T

Y

V

I

H

R

D

E

A

D

E

G

G

I

L

V
x
N

L

N

H

M

D

V

K

Y

D
x
N

K
x
R

C
|
C

I
x
V

G
|
G

C
x
T

G

K

Y

Y

C
|
C

L

S

Y

N

A

N

C
|
C

P

P

F
x
Y

G

K

A
x
V

P
x
R

Q

R

F

F

-

N

-

F

-

L

-

Q

-

Y

-

Q

-

D

-

V

-

P

-

Y

-

R

-

S

P

P

K

I

D

D

G

A

A

S

-

T

-

E

-

N

-

D

-

S

-

I

-

P

-

V

-

L

-

K

-

M

-

R

-

N

-

P

-

D

-

V

-

T

F

V

G

R

I

A

R

R

G

G

V

V

M
|
M

D

E

K
|
K

C
|
C

T

T

M
x
F

C
|
C

A

V

G

Q

G

R

P

I

E

N

P

E

T

A

F

-

S
x
R

I
|
I

E

Q

E

A

R
|
R

E

T

K

E

Y

-

G

-

Q

N

N

R

R

R

I

I

A

A

E

D

G

G

K

E

V

I

-

M

P
x
T

M

A

C
|
C

A

Q

T

V

C
|
C

S

P

T

T

N

Q

A

A

L
x
I

L

V

V

F

G

G

D

D

binding fe3-s4 cluster: V758 (= V70), C759 (= C71), P760 (= P72), C779 (= C91), V780 (≠ I92), G781 (= G93), T782 (≠ C94), C785 (= C97), M838 (= M120)
binding heme c: N777 (≠ D89), R778 (≠ K90), R852 (≠ S135), I853 (= I136), R856 (= R139)
binding iron/sulfur cluster: C692 (= C16), N693 (≠ I17), S694 (≠ E18), C695 (= C19), N696 (≠ F20), A697 (≠ G21), C698 (= C22), C702 (= C26), N706 (≠ H30), W724 (vs. gap), I727 (≠ L44), L746 (≠ A58), C747 (= C59), Q748 (≠ M60), Q749 (≠ H61), C750 (= C62), P754 (= P66), C755 (= C67), N772 (≠ V84), C789 (= C101), Y791 (≠ F103), V793 (≠ A105), R794 (≠ P106), K840 (= K122), C841 (= C123), F843 (≠ M125), C844 (= C126), T869 (≠ P153), C871 (= C155), C875 (= C159), I880 (≠ L164)

8k9fB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 2.9 angstrom (see paper)
25% identity, 87% coverage: 16:187/197 of query aligns to 719:926/951 of 8k9fB

query
sites
8k9fB

C
|
C

I

I

E
x
G

C
|
C

F
x
N

G

A

C
|
C

V

V

I

V

A

A

C
|
C

D

Q

E

A

A

E

H
x
N

E

N

L

I

P

A

L

V

G

-

I

V

A

G

R

K

R

D

K

Q

V

V

-

S

-

R

-

G

-

R

-

E

-

M

-

H

-
x
W

V
x
I

T

R

L

I

N

D

D

R

G

Y

I

F

E

A

G

G

K

E

E

D

-

L

-

D

-

N

-

P

-

S

-

I

F

Y

S

M

V

M

S
x
P

V

V

A

N

C
|
C

M
|
M

H
x
Q

C
|
C

T

E

D

K

A

A

P

P

C
|
C

E

E

Q

V

V

V

C
|
C

P
|
P

V

V

D

A

C

A

F

T

Y

V

I

H

R

D

E

Y

D

E

G

G

I

L

V
x
N

L

N

H
x
M

D

V

K

Y

D
x
N

K
x
R

C
|
C

I

V

G
|
G

C
x
T

G
x
K

Y
|
Y

C
|
C

L

S

Y

N

A

N

C
|
C

P

P

F
x
Y

G

K

A
x
V

P

R

Q

R

-

F

-

N

-

F

-

L

-

Q

-

Y

-

S

-

D

-

T

-

E

-

T

-

F

-

K

-

L

-

A

F

F

P

N

K

P

D

D

G

V

A

T

F

V

G

R

I

I

R

R

G

G

V

V

M

M

D

E

K

K

C
|
C

T

T

M
x
Y

C
|
C

A

V

G

Q

G

R

P

I

E

S

P

G

T

A

F
x
R

S

I

I

A

E

A

E
x
K

R

R

E

A

-

A

-

V

K

Q

Y

A

G

G

Q

Q

N

S

R

S

-

Y

-

V

I

I

A

S

E

D

G

G

K

A

V

I

P

Q

M
x
T

-

A

C
|
C

A

E

A

Q

T

A

C
|
C

S
x
P

T
|
T

N

G

A

A

L

I

L

V

V

F

G

G

D

D

A

I

-

N

E

D

S

S

V

N

S

S

K

R

I

V

Y

A

R

K

E

W

R

K

V

A

A

E

A

G

R

H

G

N

K

Y

G

G

V

L

binding fe3-s4 cluster: C787 (= C71), P788 (= P72), M802 (≠ H86), C807 (= C91), G809 (= G93), T810 (≠ C94), K811 (≠ G95), Y812 (= Y96), C813 (= C97)
binding heme c: N805 (≠ D89), R806 (≠ K90), R867 (≠ F134), K871 (≠ E138)
binding iron/sulfur cluster: C719 (= C16), G721 (≠ E18), C722 (= C19), N723 (≠ F20), C725 (= C22), C729 (= C26), N733 (≠ H30), W751 (vs. gap), I752 (≠ V42), P772 (≠ S56), C775 (= C59), M776 (= M60), Q777 (≠ H61), C778 (= C62), C783 (= C67), N800 (≠ V84), C817 (= C101), Y819 (≠ F103), V821 (≠ A105), C856 (= C123), Y858 (≠ M125), C859 (= C126), T891 (≠ M154), C893 (= C155), C897 (= C159), P898 (≠ S160), T899 (= T161)

Sites not aligning to the query:

8k9eB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 3.3 angstrom (see paper)
25% identity, 87% coverage: 16:187/197 of query aligns to 719:926/951 of 8k9eB

query
sites
8k9eB

C
|
C

I
|
I

E
x
G

C
|
C

F
x
N

G

A

C
|
C

V

V

I

V

A

A

C
|
C

D

Q

E

A

A

E

H
x
N

E

N

L

I

P

A

L

V

G

-

I

V

A

G

R

K

R

D

K

Q

V

V

-

S

-

R

-

G

-

R

-

E

-

M

-

H

-

W

V

I

T

R

L
x
I

N

D

D

R

G

Y

I

F

E

A

G

G

K

E

E

D

-

L

-

D

-

N

-

P

-

S

-

I

F

Y

S

M

V

M

S

P

V

V

A

N

C
|
C

M
|
M

H

Q

C
|
C

T

E

D

K

A

A

P
|
P

C
|
C

E

E

Q

V

V

V

C
|
C

P

P

V

V

D

A

C

A

F

T

Y

V

I

H

R

D

E

Y

D

E

G

G

I

L

V
x
N

L

N

H
x
M

D

V

K

Y

D
x
N

K

R

C
|
C

I
x
V

G
|
G

C
x
T

G
x
K

Y
|
Y

C
|
C

L

S

Y

N

A

N

C
|
C

P

P

F
x
Y

G

K

A
x
V

P
x
R

Q

R

-

F

-

N

-

F

-

L

-

Q

-

Y

-

S

-

D

-

T

-

E

-

T

-

F

-

K

-

L

-

A

F

F

P

N

K

P

D

D

G

V

A

T

F

V

G

R

I

I

R

R

G

G

V

V

M
|
M

D

E

K

K

C
|
C

T

T

M
x
Y

C
|
C

A

V

G

Q

G

R

P

I

E

S

P

G

T

A

F
x
R

S

I

I

A

E

A

E
x
K

R

R

E

A

-

A

-

V

K

Q

Y

A

G

G

Q

Q

N

S

R

S

-

Y

-

V

I

I

A

S

E

D

G

G

K

A

V

I

P

Q

M
x
T

-

A

C
|
C

A

E

A

Q

T

A

C
|
C

S

P

T
|
T

N

G

A

A

L

I

L

V

V

F

G

G

D

D

A

I

-

N

E

D

S

S

V

N

S

S

K

R

I

V

Y

A

R

K

E

W

R

K

V

A

A

E

A

G

R

H

G

N

K

Y

G

G

V

L

binding fe3-s4 cluster: C787 (= C71), M802 (≠ H86), C807 (= C91), V808 (≠ I92), G809 (= G93), T810 (≠ C94), K811 (≠ G95), Y812 (= Y96), C813 (= C97), M853 (= M120)
binding heme c: N805 (≠ D89), R867 (≠ F134), K871 (≠ E138)
binding iron/sulfur cluster: C719 (= C16), I720 (= I17), G721 (≠ E18), C722 (= C19), N723 (≠ F20), C725 (= C22), C729 (= C26), N733 (≠ H30), I754 (≠ L44), C775 (= C59), M776 (= M60), C778 (= C62), P782 (= P66), C783 (= C67), N800 (≠ V84), C817 (= C101), Y819 (≠ F103), V821 (≠ A105), R822 (≠ P106), C856 (= C123), Y858 (≠ M125), C859 (= C126), T891 (≠ M154), C893 (= C155), C897 (= C159), T899 (= T161)

Sites not aligning to the query:

binding heme c: 3

8c0zC Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
32% identity, 62% coverage: 8:130/197 of query aligns to 4:120/158 of 8c0zC

query
sites
8c0zC

K

S

F

L

Y

H

C

I

D

D

T

P

E

A

R

K

C
|
C

I
x
T

E

G

C
|
C

F

L

G

Q

C
|
C

V

E

I

M

A

A

C
|
C

D

S

E

Y

A

E

H

H

E

T

L

G

P

V

L

I

G

N

I

P

A

S

R

K

R

S

K

R

V

I

V

K

T

V

L

F

N

S

D

F

G

E

I

H

E

E

G

G

K

R

E

K

F

-

S

-

V

V

S

P

V

Y

A

T

C
|
C

M

T

H

Q

C
|
C

T

T

D

E

A

A

P

W

C
|
C

E

L

Q

H

V

S

C
|
C

P

P

V

V

D

D

C

-

F

-

Y

A

I
|
I

R

R

E

L

D

D

-

L

-

T

G

G

I

A

V

K

L

M

H

V

D

F

K

E

D

D

K

T

C
|
C

I

V

G

G

C
|
C

G

K

Y

V

C
|
C

L

T

Y

I

A

A

C
|
C

P

P

F

F

G

G

A
x
T

P

I

Q

N

F

Y

P

N

K

Q

D

D

G

-

A

-

F

-

G

-

I

-

R

T

G

G

V

K

M

V

D

Q

K
|
K

C
|
C

T

D

M

L

C
|
C

A

E

G

G

G

D

P

P

binding iron/sulfur cluster: C12 (= C16), T13 (≠ I17), C15 (= C19), C18 (= C22), C22 (= C26), C53 (= C59), C56 (= C62), C61 (= C67), C65 (= C71), I70 (= I78), C86 (= C91), C89 (= C94), C92 (= C97), C96 (= C101), T100 (≠ A105), K112 (= K122), C113 (= C123), C116 (= C126)

Sites not aligning to the query:

binding iron/sulfur cluster: 122, 126, 128

7z0sB Structure of the escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase h) (see paper)
40% identity, 49% coverage: 12:108/197 of query aligns to 8:99/170 of 7z0sB

query
sites
7z0sB

D

D

T

S

E

T

R

L

C
|
C

I
|
I

E
x
G

C
|
C

F
x
H

G
x
T

C
|
C

V

E

I

A

A

A

C
|
C

D

S

E

E

A

T

H
|
H

-

R

E

Q

L

H

P

G

L

L

G

Q

I

S

A

M

R

P

R
|
R

K
x
L

V

R

V

V

T

M

L

L

N

N

D

E

G

K

I

E

E

S

G

A

K
x
P

E

Q

F
x
L

S

-

V

-

S

-

V

-

A

-

C
|
C

M
x
H

H
|
H

C
|
C

T

E

D

D

A

A

P

P

C
|
C

E

A

Q

V

V

V

C
|
C

P
|
P

V

V

D

N

C

A

F
x
I

Y

T

I

-

R

R

E

V

D

D

G

G

I

A

V
|
V

L

Q

H
x
L

D

N

K

E

D

S

K

L

C
|
C

I
x
V

G

S

C
|
C

G
x
K

Y

L

C
|
C

L

G

Y

I

A

A

C
|
C

P

P

F

F

G

G

A

A

P
x
I

Q

E

F

F

binding iron/sulfur cluster: C12 (= C16), I13 (= I17), G14 (≠ E18), C15 (= C19), H16 (≠ F20), T17 (≠ G21), C18 (= C22), C22 (= C26), H26 (= H30), R36 (= R39), L37 (≠ K40), P48 (≠ K51), L50 (≠ F53), C51 (= C59), H52 (≠ M60), H53 (= H61), C54 (= C62), C59 (= C67), C63 (= C71), P64 (= P72), I68 (≠ F76), V75 (= V84), L77 (≠ H86), C82 (= C91), V83 (≠ I92), C85 (= C94), K86 (≠ G95), C88 (= C97), C92 (= C101), I97 (≠ P106)

Sites not aligning to the query:

binding iron/sulfur cluster: 140, 142, 143, 144, 145, 146, 153, 155, 159, 160, 161, 164

7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
33% identity, 61% coverage: 12:132/197 of query aligns to 10:148/183 of 7qv7B

query
sites
7qv7B

D

N

T

P

E

A

R

K

C
|
C

I

I

E
x
G

C
|
C

F
x
K

G
x
A

C
|
C

V

E

I

V

A

A

C
|
C

D

F

E

A

A

V

H
|
H

E

N

-

R

-

N

-

H

-

V

-

G

L

A

P

T

L

V

G

G

I

T

A

V

R

S

R

I

K

P

V

V

V

I

T

P

L
x
R

N

L

D

H

G

L

I

I

E

K

G

T

K

E

E

H

F

G

S

T

V

M

S

P

V

I

A

Q

C
|
C

M
x
R

H
|
H

C
|
C

T

E

D

D

A
|
A

P

P

C
|
C

E

A

Q

N

V

V

C
|
C

P

T

V

V

D

G

C
x
A

F
x
I

Y

K

I

-

R

R

E

E

D

G

G

N

I

A

V

I

L

V

H

V

D

D

K

E

D

K

K

L

C
|
C

I
|
I

G

G

C
|
C

G

K

Y

S

C
|
C

L

L

Y

L

A

A

C
|
C

P

P

F

F

G

G

A

A

-
x
I

-

E

-

L

P

P

Q

Q

F

Y

P

-

K

E

D

D

G

G

-

R

-

E

A

V

F

F

G

Q

I

I

-

N

-

L

-

K

-

L

-

V

-

Q

-

E

-

P

R

R

G

I

V

I

M

A

D

Y

K

K

C
|
C

T

D

M
x
L

C
|
C

A

N

G

D

G

L

P

G

E

E

P
|
P

binding iron/sulfur cluster: C14 (= C16), G16 (≠ E18), C17 (= C19), K18 (≠ F20), A19 (≠ G21), C20 (= C22), C24 (= C26), H28 (= H30), R48 (≠ L44), C63 (= C59), R64 (≠ M60), H65 (= H61), C66 (= C62), A69 (= A65), C71 (= C67), C75 (= C71), A79 (≠ C75), I80 (≠ F76), C94 (= C91), I95 (= I92), C97 (= C94), C100 (= C97), C104 (= C101), I109 (vs. gap), C139 (= C123), L141 (≠ M125), C142 (= C126), P148 (= P132)

Sites not aligning to the query:

binding iron/sulfur cluster: 150, 154, 155, 159

6x6uB Wor5 from pyrococcus furiosus, taurine-bound (see paper)
30% identity, 64% coverage: 6:131/197 of query aligns to 2:120/167 of 6x6uB

query
sites
6x6uB

R

R

M

I

K

W

F

I

Y

L

C

I

D

T

T

P

E
x
D

R

K

C
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C

I
x
S

E

G

C
|
C

F
x
R

G

L

C
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C

V

E

I

V

A

T

C
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C

D

S

E

L

A

E

H
|
H

E

E

-

G

-

I

L

I

P

W

L

P

G

E

I

A

A

S

R
|
R

R
x
I

K

R

V
|
V

V

F

T

E

L

L

N

F

D

P

G

G

I

I

E

-

G

-

K

-

E

-

F

-

S

N

V

V

S

P

V

H

A

T

C
|
C

M
x
V

H

Q

C
|
C

T

P

D

D

A

Y

P
|
P

C
|
C

E

V

Q

N

V

A

C
|
C

P
|
P

V

T

D

N

C

A

F
x
L

Y

S

I

V

R

D

E

E

D

K

-

T

G

G

I

A

V

V

L

V

H

V

D

N

K

E

D

E

K

K

C
|
C

I
|
I

G
x
T

C
|
C

G
|
G

Y

A

C
|
C

L

V

Y

L

A

A

C
|
C

P

P

F

G

G

K

A

V

P
|
P

Q

R

F

I

P

P

K

A

D

G

G

-

A

-

F

-

G

-

I

-

R

K

G

G

V

S

M

V

D

V

K

I

C
|
C

T
x
D

M
x
L

C
|
C

A

G

G

G

G

N

P
|
P

E

K

binding phosphate ion: D10 (≠ E14)
binding iron/sulfur cluster: C12 (= C16), S13 (≠ I17), C15 (= C19), R16 (≠ F20), C18 (= C22), C22 (= C26), H26 (= H30), R36 (= R38), I37 (≠ R39), V39 (= V41), C52 (= C59), V53 (≠ M60), C55 (= C62), P59 (= P66), C60 (= C67), C64 (= C71), P65 (= P72), L69 (≠ F76), C85 (= C91), I86 (= I92), T87 (≠ G93), C88 (= C94), G89 (= G95), C91 (= C97), C95 (= C101), P100 (= P106), C112 (= C123), D113 (≠ T124), L114 (≠ M125), C115 (= C126), P119 (= P130)

Sites not aligning to the query:

binding phosphate ion: 128, 130, 161, 162
binding iron/sulfur cluster: 121, 125, 130, 133

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
32% identity, 63% coverage: 53:177/197 of query aligns to 127:231/329 of 5ch7B

query
sites
5ch7B

F

F

S

Y

V

L

S
x
P

V

R

A

M

C
|
C

M
x
N

H

H

C
|
C

T

T

D

K

A
x
P

P

A

C
|
C

E

L

Q

E

V

A

C
|
C

P

P

V

N

D

E

C

A

F
x
I

Y

Y

I

K

R

R

E

E

-

Q

D

D

G

G

I

I

V

V

L

V

H

I

D

H

K

Q

D

D

K

K

C
|
C

I
x
K

G
|
G

C
x
A

G
x
Q

Y
x
A

C
|
C

L

V

Y

Q

A

S

C
|
C

P

P

F

Y

G

A

A

K

P

P

Q

Y

F

F

P

-

K

-

D

-

G

-

A

-

F

-

G

-

I

-

R

N

G

P

V

L

M

T

D

N

K

K

C
x
A

T

N

M

K

C
|
C

A

I

G
|
G

G

-

P

-

E

-

P

-

T
x
C

F

F

S

P

I

-

E

-

R

-

E

-

K

-

Y

-

G

-

Q

-

N

-

R

R

I

I

A

E

E

Q

G

G

K

V

V

A

P

P

M

A

C
|
C

A

V

A

A

T

Q

C
|
C

S
x
V

T
x
G

N

R

A

A

L

M

L

H

V

V

G

G

D

F

A

V

E

D

S

D

V

V

-

N

S

S

K

S

I

V

Y

Y

R

K

binding fe3-s4 cluster: C145 (= C71), I150 (≠ F76), C166 (= C91), K167 (≠ I92), G168 (= G93), A169 (≠ C94), Q170 (≠ G95), A171 (≠ Y96), C172 (= C97), A190 (≠ C123)
binding iron/sulfur cluster: P130 (≠ S56), C133 (= C59), N134 (≠ M60), C136 (= C62), P139 (≠ A65), C141 (= C67), C176 (= C101), C193 (= C126), G195 (= G128), C196 (≠ T133), C208 (= C155), C212 (= C159), V213 (≠ S160), G214 (≠ T161)

Sites not aligning to the query:

binding iron/sulfur cluster: 17, 18, 19, 20, 21, 23, 27, 31, 43, 45

6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
25% identity, 58% coverage: 12:126/197 of query aligns to 689:868/948 of 6btmB

query
sites
6btmB

D

D

T

L

E

N

R

A

C

C

I

T

E

G

C

C

F

G

G

A

C

C

V

V

I

I

A

A

C

C

D

H

E

A

A

E

H

N

E

N

L

V

P

P

L

V

G

-

I

V

A

G

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K

R

A

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N

R

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D

-

M

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H

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R

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Y

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S

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E

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S

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E

-

R

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K

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E

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G

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I

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A

G

G

K

L

E

S

F

S

S

S

V

L

S

S

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T

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F

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N

-

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M

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E

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K

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P

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G

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D

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N

-

P

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Q

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F

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Q

-

P

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C
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C

M
x
Q

H

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|
C

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N

D

H

A

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C

E

E

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C

P

P

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A

C

A

F

T

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S

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x
N

L

H

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M

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Y

D

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|
C

I
x
V

G

G

C
x
T

G

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Y

Y

C
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C

L

A

Y

N

A

N

C
|
C

P

P

F

Y

G

K

A

V

P
x
R

Q

R

F

F

-

N

-

W

-

F

-

L

-

Y

P

N

K

K

D

N

G

S

A

E

F

F

G

D

I

Y

-

H

-

M

-

N

-

D

-

L

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G

-

R

-

M

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V

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L

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N

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P

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D

-

V

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N

-

V

-

R

-

S

R

R

G

G

V

V

M
|
M

D

E

K

K

C

C

T

S

M

F

C

C

binding fe3-s4 cluster: C789 (= C71), C809 (= C91), V810 (≠ I92), T812 (≠ C94), C815 (= C97), M862 (= M120)
binding iron/sulfur cluster: C777 (= C59), Q778 (≠ M60), C780 (= C62), C785 (= C67), N802 (≠ V84), C819 (= C101), R824 (≠ P106)

Sites not aligning to the query:

binding (2R)-3-{[(2R)-2-(decanoylamino)-3-hydroxypropyl]sulfanyl}propane-1,2-diyl ditetradecanoate: 1, 2

4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
30% identity, 76% coverage: 12:161/197 of query aligns to 9:151/274 of 4v4cB

query
sites
4v4cB

D

D

T

V

E

A

R

K

C
|
C

I
x
Q

E
x
D

C
|
C

F
x
N

G
x
N

C
|
C

V

F

I

M

A

G

C
|
C

D

M

E

D

A

E

H

H

E

E

L

L

-

N

-

E

-

W

P

P

L

G

G

Y

I

T

A

A

R

S

R

M

K

Q

V

R

V

G

T

H

L

R

N

W

D

M

G

N

I

I

E

E

G

R

K

R

E

E

F

R

S

G

V

T

-

Y

-

P

-

R

-

N

-

D

-
x
I

-
x
N

-

Y

-

R

S

P

V

T

A

P

C
|
C

M
|
M

H
|
H

C
|
C

T

E

D

N

A

A

P

P

C
|
C

E

-

Q

V

V

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C

K

P

G

V

N

D

G

C

A

F

V

Y

Y

I

Q

R

R

E

E

D

D

G

G

I

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V

L

L

H

I

D

D

K

P

D

E

K

K

C

A

I

K

G

G

C

K

G

K

Y

E

C

L

L

L

Y

D

A

T

C
|
C

P

P

F

Y

G

G

A
x
V

P

M

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Y

F

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P

N

K

E

D

E

G

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A

-

F

-

G

-

I

-

R

E

G

N

V

V

M

A

D

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K

K

C
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C

T

T

M
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M

C
|
C

A

A

G

-

P

-

E

-

P

-

T

-

F

-

S

H

I

L

E

L

E

D

R

D

E

E

K

S

Y

W

G

A

Q

P

N

-

R

-

I

-

A

-

E

-

G

-

K

K

V

M

P
|
P

M

R

C
|
C

A

A

A

H

T

N

C
|
C

S

G

T
x
S

binding calcium ion: I61 (vs. gap), N62 (vs. gap)
binding iron/sulfur cluster: C13 (= C16), Q14 (≠ I17), D15 (≠ E18), C16 (= C19), N17 (≠ F20), N18 (≠ G21), C19 (= C22), C23 (= C26), C68 (= C59), M69 (= M60), H70 (= H61), C71 (= C62), C76 (= C67), V92 (= V84), C109 (= C101), V113 (≠ A105), C126 (= C123), M128 (= M125), C129 (= C126), P143 (= P153), C145 (= C155), C149 (= C159), S151 (≠ T161)

Sites not aligning to the query:

binding iron/sulfur cluster: 153, 154

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
37% identity, 38% coverage: 53:126/197 of query aligns to 130:199/337 of 2ivfB

query
sites
2ivfB

F

F

S

Y

V

L

S

A

V

R

A
x
M

C
|
C

M
x
N

H
|
H

C
|
C

T

T

D

N

A
x
P

P

A

C
|
C

E

L

Q

A

V

A

C
|
C

P

P

V
x
T

D

G

C

A

F
x
I

Y

Y

I

K

R

R

E

E

D

D

-

N

G

G

I

I

V
|
V

L

L

H

V

D

D

K

Q

D

E

K

R

C
|
C

I
x
K

G
|
G

C
x
H

G
x
R

Y
x
H

C
|
C

L

V

Y

E

A

A

C
|
C

P

P

F

Y

G

K

A
|
A

P
x
I

Q

Y

F

F

P

N

K

P

D

-

G

-

A

-

F

-

G

-

I

V

R

S

G

Q

V

T

M
x
S

D

E

K
|
K

C
|
C

T
x
I

M
x
L

C
|
C

binding fe3-s4 cluster: C148 (= C71), T150 (≠ V73), I153 (≠ F76), C169 (= C91), K170 (≠ I92), G171 (= G93), H172 (≠ C94), R173 (≠ G95), H174 (≠ Y96), C175 (= C97), S193 (≠ M120)
binding protoporphyrin ix containing fe: T150 (≠ V73), K170 (≠ I92), H172 (≠ C94)
binding iron/sulfur cluster: M135 (≠ A58), C136 (= C59), N137 (≠ M60), H138 (= H61), C139 (= C62), P142 (≠ A65), C144 (= C67), V162 (= V84), C179 (= C101), A183 (= A105), I184 (≠ P106), K195 (= K122), C196 (= C123), I197 (≠ T124), L198 (≠ M125), C199 (= C126)

Sites not aligning to the query:

binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41, 209, 211, 215, 219, 220

Query Sequence

>WP_007473593.1 NCBI__GCF_000170735.1:WP_007473593.1
MYNYARMKFYCDTERCIECFGCVIACDEAHELPLGIARRKVVTLNDGIEGKEFSVSVACM
HCTDAPCEQVCPVDCFYIREDGIVLHDKDKCIGCGYCLYACPFGAPQFPKDGAFGIRGVM
DKCTMCAGGPEPTFSIEEREKYGQNRIAEGKVPMCAATCSTNALLVGDAESVSKIYRERV
AARGKGVQTPYGWKEAY

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory