SitesBLAST

2xb9A Structure of helicobacter pylori type ii dehydroquinase in complex with inhibitor compound (2r)-2-(4-methoxybenzyl)-3-dehydroquinic acid (see paper)
52% identity, 98% coverage: 1:155/158 of query aligns to 1:157/158 of 2xb9A

query
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2xb9A

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active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N76 (= N74), A79 (= A77), E100 (= E98), H102 (= H100), R109 (= R107)
binding (1r,2r,4s,5r)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid: N10 (= N10), Y22 (= Y22), N76 (= N74), A79 (= A77), H82 (= H80), H102 (= H100), L103 (= L101), T104 (≠ S102), R113 (= R111)

1j2yA Crystal structure of the type ii 3-dehydroquinase (see paper)
52% identity, 98% coverage: 1:155/158 of query aligns to 1:157/158 of 1j2yA

query
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1j2yA

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active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N76 (= N74), A79 (= A77), E100 (= E98), H102 (= H100), R109 (= R107)
binding 1,3,4-trihydroxy-5-oxo-cyclohexanecarboxylic acid: Y22 (= Y22), N76 (= N74), G78 (≠ A76), H82 (= H80), H102 (= H100), L103 (= L101), T104 (≠ S102), R113 (= R111)

Q48255 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
52% identity, 97% coverage: 1:154/158 of query aligns to 1:156/167 of Q48255

query
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Q48255

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N76 (= N74) binding substrate
H82 (= H80) binding substrate
D89 (= D87) binding substrate
R113 (= R111) binding substrate

2xd9A Structure of helicobacter pylori type ii dehydroquinase in complex with inhibitor compound (4r,6r,7s)-4,6,7-trihydroxy-2-((e)-prop-1- enyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid (see paper)
52% identity, 96% coverage: 1:151/158 of query aligns to 1:153/153 of 2xd9A

query
sites
2xd9A

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active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N76 (= N74), A79 (= A77), E100 (= E98), H102 (= H100), R109 (= R107)
binding (4r,6r,7s)-4,6,7-trihydroxy-2-[(1e)-prop-1-en-1-yl]-4,5,6,7-tetrahydro-1-benzothiophene-4-carboxylic acid: N10 (= N10), L14 (= L14), Y22 (= Y22), N76 (= N74), G78 (≠ A76), A79 (= A77), H82 (= H80), H102 (= H100), L103 (= L101), T104 (≠ S102), R113 (= R111)

2wksA Structure of helicobacter pylori type ii dehydroquinase with a new carbasugar-thiophene inhibitor. (see paper)
52% identity, 96% coverage: 1:151/158 of query aligns to 1:153/153 of 2wksA

query
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2wksA

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active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N76 (= N74), A79 (= A77), E100 (= E98), H102 (= H100), R109 (= R107)
binding (1R,4S,5R)-1,4,5-trihydroxy-3-[(5-methyl-1-benzothiophen-2-yl)methoxy]cyclohex-2-ene-1-carboxylic acid: L11 (= L11), Y22 (= Y22), N76 (= N74), G78 (≠ A76), A79 (= A77), H82 (= H80), H102 (= H100), L103 (= L101), T104 (≠ S102), R113 (= R111)

2xdaA Structure of helicobacter pylori type ii dehydroquinase in complex with inhibitor compound (4r,6r,7s)-2-(2-cyclopropyl)ethyl-4,6,7- trihydroxy-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid (see paper)
53% identity, 93% coverage: 1:147/158 of query aligns to 1:149/150 of 2xdaA

query
sites
2xdaA

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active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N76 (= N74), A79 (= A77), E100 (= E98), H102 (= H100), R109 (= R107)
binding (4r,6r,7s)-2-(2-cyclopropylethyl)-4,6,7-trihydroxy-4,5,6,7-tetrahydro-1-benzothiophene-4-carboxylic acid: N10 (= N10), L11 (= L11), M13 (= M13), Y22 (= Y22), N76 (= N74), A79 (= A77), H82 (= H80), H102 (= H100), L103 (= L101), T104 (≠ S102), R113 (= R111)

2c57A H.Pylori type ii dehydroquinase in complex with fa1 (see paper)
51% identity, 98% coverage: 1:155/158 of query aligns to 14:163/164 of 2c57A

query
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2c57A

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E

Q

A

Q

Q

Q

K

N

N

active site: P22 (= P9), N23 (= N10), N82 (= N74), A85 (= A77), E106 (= E98), H108 (= H100), R115 (= R107)
binding 2,3 -anhydro-quinic acid: N82 (= N74), G84 (≠ A76), A85 (= A77), H88 (= H80), H108 (= H100), L109 (= L101), T110 (≠ S102), R119 (= R111)

5ydbA Crystal structure of the complex of type ii dehydroquinate dehydratase from acinetobacter baumannii with dehydroquinic acid at 1.76 angstrom resolution
51% identity, 85% coverage: 3:136/158 of query aligns to 3:136/145 of 5ydbA

query
sites
5ydbA

I

I

K

L

V

V

I

I

H

H

G

G

P
|
P

N
|
N

L

L

N

N

M

L

L

L

G

G

I

K

R
|
R

E

E

V

P

N

E

I

V

Y
|
Y

G

G

P

H

M

L

K

T

L

L

E

D

D

N

I

I

N

N

K

R

N

Q

M

L

E

I

V

A

V

Q

A

A

K

E

Q

Q

N

A

G

S

F

I

E

T

I

L

E

D

F

T

Y

F

Q

Q

S

S

N

N

H

W

E

E

G

G

D

A

I

I

V

V

D

D

A

R

I

I

Q

H

E

Q

S

A

I

Q

N

T

E

E

K

G

V

V

D

K

G

L

I

I

N
|
N

P

P

A
|
A

F

L

T

T

H
|
H

T

T

S

S

I

V

A

A

I

L

R

R

D

D

A

A

I

L

K

L

A

G

V

V

N

A

L

I

P

P

T

F

V

I

E
|
E

V

V

H
|
H

L
|
L

S
|
S

N

N

I

V

A

H

A

A

R
|
R

E

E

D

A

F

F

R
|
R

K

H

S

S

L

Y

I

L

S

S

D

D

I

K

V

A

A

I

G

G

T

V

I

I

T

C

G

G

F

L

G

G

P

A

F

K

S

G

Y

Y

H

S

L

F

G

A

L

L

active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N74 (= N74), A77 (= A77), E98 (= E98), H100 (= H100), R107 (= R107)
binding 1,3,4-trihydroxy-5-oxo-cyclohexanecarboxylic acid: N74 (= N74), A76 (= A76), A77 (= A77), H80 (= H80), H100 (= H100), L101 (= L101), S102 (= S102), R111 (= R111)

5b6pB Structure of the dodecameric type-ii dehydrogenate dehydratase from acinetobacter baumannii at 2.00 a resolution (see paper)
51% identity, 85% coverage: 3:136/158 of query aligns to 3:136/145 of 5b6pB

query
sites
5b6pB

I

I

K

L

V

V

I

I

H

H

G

G

P
|
P

N
|
N

L

L

N

N

M

L

L

L

G

G

I

K

R
|
R

E

E

V

P

N

E

I

V

Y
|
Y

G

G

P

H

M

L

K

T

L

L

E

D

D

N

I

I

N

N

K

R

N

Q

M

L

E

I

V

A

V

Q

A

A

K

E

Q

Q

N

A

G

S

F

I

E

T

I

L

E

D

F

T

Y

F

Q

Q

S

S

N

N

H

W

E

E

G

G

D

A

I

I

V

V

D

D

A

R

I

I

Q

H

E

Q

S

A

I

Q

N

T

E

E

K

G

V

V

D

K

G

L

I

I

N
|
N

P

P

A

A

A
|
A

F

L

T

T

H

H

T

T

S

S

I

V

A

A

I

L

R

R

D

D

A

A

I

L

K

L

A

G

V

V

N

A

L

I

P

P

T

F

V

I

E
|
E

V

V

H
|
H

L
|
L

S
|
S

N

N

I

V

A

H

A

A

R
|
R

E

E

D

A

F

F

R

R

K

H

S

S

L

Y

I

L

S

S

D

D

I

K

V

A

A

I

G

G

T

V

I

I

T

C

G

G

F

L

G

G

P

A

F

K

S

G

Y

Y

H

S

L

F

G

A

L

L

active site: P9 (= P9), N10 (= N10), R17 (= R17), Y22 (= Y22), N74 (= N74), A77 (= A77), E98 (= E98), H100 (= H100), R107 (= R107)
binding sulfate ion: N74 (= N74), H100 (= H100), L101 (= L101), S102 (= S102)

6hsaA The crystal structure of type ii dehydroquinase from butyrivibrio crossotus dsm 2876
50% identity, 84% coverage: 1:132/158 of query aligns to 4:136/145 of 6hsaA

query
sites
6hsaA

M

M

K

K

I

I

K

L

V

V

I

I

H

N

G

G

P
|
P

N
|
N

L

L

N

N

M

F

L

L

G

G

I

I

R
|
R

E

E

V

K

N

N

I

I

Y
|
Y

G

G

P

N

M

E

K

N

L

Y

E

E

D

Y

I

L

N

V

K

N

N

M

M

I

E

N

V

E

V

Y

A

C

K

K

Q

S

N

K

G

N

F

I

E

E

I

V

E

E

F

C

Y

Y

Q

Q

S

S

N

N

H

H

E

E

G

G

D

A

I

I

V

I

D

D

A

K

I

I

Q

Q

E

E

S

A

I

Y

N

F

E

N

K

G

V

T

D

D

G

G

I

I

I

V

I

I

N
|
N

P

P

A

G

A
|
A

F

Y

T

T

H

H

T

Y

S

S

I

Y

A

A

I

I

R

R

D

D

A

A

I

L

K

A

A

S

V

V

N

S

-

H

L

I

P

K

T

K

V

I

E
|
E

V

V

H
|
H

L

I

S

S

N

N

I

V

A
x
N

A

E

R
|
R

E

E

D

E

F

F

R

R

K

H

K

I

S

S

L

V

I

T

S

E

D

P

I

V

V

C

A

N

G

G

T
x
Q

I

I

T

V

G

G

F

Q

G

G

P

L

F

K

S

G

Y

Y

active site: P12 (= P9), N13 (= N10), R20 (= R17), Y25 (= Y22), N77 (= N74), A80 (= A77), E102 (= E98), H104 (= H100), R111 (= R107)
binding serine: N109 (≠ A105), Q127 (≠ T123)

6hs9A The crystal structure of type ii dehydroquinase from butyrivibrio crossotus dsm 2876
50% identity, 84% coverage: 1:132/158 of query aligns to 4:136/145 of 6hs9A

query
sites
6hs9A

M

M

K

K

I

I

K

L

V

V

I

I

H

N

G

G

P
|
P

N
|
N

L

L

N

N

M

F

L

L

G

G

I

I

R
|
R

E

E

V

K

N

N

I

I

Y
|
Y

G

G

P

N

M

E

K

N

L

Y

E

E

D

Y

I

L

N

V

K

N

N

M

M

I

E

N

V

E

V

Y

A

C

K

K

Q

S

N

K

G

N

F

I

E

E

I

V

E

E

F

C

Y

Y

Q

Q

S

S

N

N

H

H

E

E

G

G

D

A

I

I

V

I

D

D

A

K

I

I

Q

Q

E

E

S

A

I

Y

N

F

E

N

K

G

V

T

D

D

G

G

I

I

I

V

I

I

N
|
N

P

P

A
x
G

A
|
A

F

Y

T

T

H
|
H

T

Y

S

S

I

Y

A

A

I

I

R

R

D

D

A

A

I

L

K

A

A

S

V

V

N

S

-

H

L

I

P

K

T

K

V

I

E
|
E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

V

A

N

A

E

R
|
R

E

E

D

E

F

F

R
|
R

K

H

K

I

S

S

L

V

I

T

S

E

D

P

I

V

V

C

A

N

G

G

T

Q

I

I

T

V

G

G

F

Q

G

G

P

L

F

K

S

G

Y

Y

active site: P12 (= P9), N13 (= N10), R20 (= R17), Y25 (= Y22), N77 (= N74), A80 (= A77), E102 (= E98), H104 (= H100), R111 (= R107)
binding (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid: R20 (= R17), Y25 (= Y22), G79 (≠ A76), A80 (= A77), H83 (= H80), I105 (≠ L101), S106 (= S102), R115 (= R111)

8idrC Crystal structure of apo-form of dehydroquinate dehydratase from corynebacterium glutamicum (see paper)
46% identity, 94% coverage: 2:150/158 of query aligns to 3:146/147 of 8idrC

query
sites
8idrC

K

K

I

I

K

L

V

L

I

L

H

N

G

G

P

P

N

N

L

L

N

N

M

M

L

L

G

G

I

K

R

R

E

E

V

P

N

D

I

I

Y

Y

G

G

P

H

M

D

K

T

L

L

E

E

D

D

I

V

N

V

K

A

N

L

M

A

E

T

V

A

V

E

A

A

K

A

Q

K

N

H

G

G

F

L

E

E

I

V

E

E

F

A

Y

L

Q

Q

S

S

N

N

H

H

E

E

G

G

D

E

I

L

V

I

D

D

A

A

I

L

Q

H

E

N

S

A

I

R

N

G

E

T

K

H

V

I

D

-

G

G

I

C

I

V

I

I

N
|
N

P

P

A
x
G

A

G

F

L

T

T

H

H

T

T

S

S

I

V

A

A

I

L

R

L

D

D

A

A

I

V

K

K

A

A

V

S

N

E

L

L

P

P

T

T

V

V

E

E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

P

A

H

A

A

R

R

E

E

D

E

F

F

R

R

K

H

S

S

L

Y

I

I

S

S

D

L

I

A

V

A

A

V

G

S

T

V

I

I

T

A

G

G

F

A

G

G

P

I

F

Q

S

G

Y

Y

H

R

L

F

G

A

L

-

A

-

M

-

M

V

Q

D

I

I

L

L

N

A

E

N

I

L

K

K

M

K

L

L

K

E

binding citrate anion: N74 (= N74), G76 (≠ A76), H100 (= H100), I101 (≠ L101), S102 (= S102)

8iduA Crystal structure of substrate bound-form dehydroquinate dehydratase from corynebacterium glutamicum (see paper)
48% identity, 83% coverage: 2:132/158 of query aligns to 3:132/145 of 8iduA

query
sites
8iduA

K

K

I

I

K

L

V

L

I

L

H

N

G

G

P

P

N

N

L

L

N

N

M

M

L

L

G

G

I

K

R

A

E

E

V

P

N

D

I

I

Y
|
Y

G

G

P

H

M

D

K

T

L

L

E

E

D

D

I

V

N

V

K

A

N

L

M

A

E

T

V

A

V

E

A

A

K

A

Q

K

N

H

G

G

F

L

E

E

I

V

E

E

F

A

Y

L

Q

Q

S

S

N

N

H

H

E

E

G

G

D

E

I

L

V

I

D

D

A

A

I

L

Q

H

E

N

S

A

I

R

N

G

E

T

K

H

V

I

D

-

G

G

I

C

I

V

I

I

N
|
N

P

P

A
x
G

F

L

T

T

H
|
H

T

T

S

S

I

V

A

A

I

L

R

L

D

D

A

A

I

V

K

K

A

A

V

S

N

E

L

L

P

P

T

T

V

V

E

E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

P

A

H

A

A

R

R

E

E

D

E

F

F

R
|
R

K

H

S

S

L

Y

I

I

S

S

D

L

I

A

V

A

A

V

G

S

T

V

I

I

T

A

G

G

F

A

G

G

P

I

F

Q

S

G

Y

Y

binding 1,3,4-trihydroxy-5-oxo-cyclohexanecarboxylic acid: Y23 (= Y22), N74 (= N74), G76 (≠ A76), G77 (≠ A77), H80 (= H80), H100 (= H100), I101 (≠ L101), S102 (= S102), R111 (= R111)

2cjfA Type ii dehydroquinase inhibitor complex (see paper)
46% identity, 85% coverage: 3:136/158 of query aligns to 8:141/149 of 2cjfA

query
sites
2cjfA

I

I

K

M

V

I

I

L

H

N

G

G

P

P

N
|
N

L
|
L

N

N

M
x
L

L
|
L

G

G

I

Q

R
|
R

E

Q

V

P

N

E

I

I

Y
|
Y

G

G

P

S

M

D

K

T

L

L

E

A

D

D

I

V

N

E

K

A

N

L

M

C

E

V

V

K

V

A

A

A

K

A

Q

A

N

H

G

G

F

G

E

T

I

V

E

D

F

F

Y

R

Q

Q

S

S

N

N

H

H

E

E

G

G

D

E

I

L

V

V

D

D

A

W

I

I

Q

H

E

E

S

A

-

R

I

L

N

N

E

H

K

C

V

-

D

-

G

G

I

I

I

V

I

I

N
|
N

P

P

A
|
A

F

Y

T

S

H
|
H

T

T

S

S

I

V

A

A

I

I

R

L

D

D

A

A

I

L

K

N

A

T

V

C

N

D

-

G

L

L

P

P

T

V

V

V

E

E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

I

A

H

A

Q

R

R

E

E

D

P

F

F

R
|
R

K

H

S

S

L

Y

I

V

S

S

D

Q

I

R

V

A

A

D

G

G

T

V

I

V

T

A

G

G

F

C

G

G

P

V

F

Q

S

G

Y

Y

H

V

L

F

G

G

L

V

binding (1s,4s,5s)-1,4,5-trihydroxy-3-[3-(phenylthio)phenyl]cyclohex-2-ene-1-carboxylic acid: N15 (= N10), L16 (= L11), L18 (≠ M13), L19 (= L14), R22 (= R17), Y27 (= Y22), N78 (= N74), A80 (= A76), A81 (= A77), H84 (= H80), H105 (= H100), I106 (≠ L101), S107 (= S102), R116 (= R111)

2bt4A Type ii dehydroquinase inhibitor complex (see paper)
46% identity, 85% coverage: 3:136/158 of query aligns to 8:141/149 of 2bt4A

query
sites
2bt4A

I

I

K

M

V

I

I

L

H

N

G

G

P

P

N
|
N

L

L

N

N

M
x
L

L

L

G

G

I

Q

R
|
R

E

Q

V

P

N

E

I

I

Y
|
Y

G

G

P

S

M

D

K

T

L

L

E

A

D

D

I

V

N

E

K

A

N

L

M

C

E

V

V

K

V

A

A

A

K

A

Q

A

N

H

G

G

F

G

E

T

I

V

E

D

F

F

Y

R

Q

Q

S

S

N

N

H

H

E

E

G

G

D

E

I

L

V

V

D

D

A

W

I

I

Q

H

E

E

S

A

-

R

I

L

N

N

E

H

K

C

V

-

D

-

G

G

I

I

I

V

I

I

N
|
N

P

P

A
|
A

F

Y

T

S

H
|
H

T

T

S

S

I

V

A

A

I

I

R

L

D

D

A

A

I

L

K

N

A

T

V

C

N

D

-

G

L

L

P

P

T

V

V

V

E

E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

I

A

H

A

Q

R

R

E

E

D

P

F

F

R
|
R

K

H

S

S

L

Y

I

V

S

S

D

Q

I

R

V

A

A

D

G

G

T

V

I

V

T

A

G

G

F

C

G

G

P

V

F

Q

S

G

Y

Y

H

V

L

F

G

G

L

V

binding (1s,3r,4r,5s)-1,3,4-trihydroxy-5-(3-phenoxypropyl)cyclohexanecarboxylic acid: N15 (= N10), L18 (≠ M13), R22 (= R17), Y27 (= Y22), N78 (= N74), A80 (= A76), A81 (= A77), H84 (= H80), H105 (= H100), I106 (≠ L101), S107 (= S102), R116 (= R111)

1gu1A Crystal structure of type ii dehydroquinase from streptomyces coelicolor complexed with 2,3-anhydro-quinic acid (see paper)
46% identity, 85% coverage: 3:136/158 of query aligns to 8:141/149 of 1gu1A

query
sites
1gu1A

I

I

K

M

V

I

I

L

H

N

G

G

P
|
P

N
|
N

L
|
L

N

N

M

L

L
|
L

G

G

I

Q

R
|
R

E

Q

V

P

N

E

I

I

Y
|
Y

G

G

P

S

M

D

K

T

L

L

E

A

D

D

I

V

N

E

K

A

N

L

M

C

E

V

V

K

V

A

A

A

K

A

Q

A

N

H

G

G

F

G

E

T

I

V

E

D

F

F

Y

R

Q

Q

S

S

N

N

H

H

E

E

G

G

D

E

I

L

V

V

D

D

A

W

I

I

Q

H

E

E

S

A

-

R

I

L

N

N

E

H

K

C

V

-

D

-

G

G

I

I

I

V

I

I

N
|
N

P

P

A
|
A

F

Y

T

S

H
|
H

T

T

S

S

I

V

A

A

I

I

R

L

D

D

A

A

I

L

K

N

A

T

V

C

N

D

-

G

L

L

P

P

T

V

V

V

E
|
E

V

V

H
|
H

L
x
I

S
|
S

N

N

I

I

A

H

A

Q

R
|
R

E

E

D

P

F

F

R
|
R

K

H

S

S

L

Y

I

V

S

S

D

Q

I

R

V

A

A

D

G

G

T

V

I

V

T

A

G

G

F

C

G

G

P

V

F

Q

S

G

Y

Y

H

V

L

F

G

G

L

V

active site: P14 (= P9), N15 (= N10), R22 (= R17), Y27 (= Y22), N78 (= N74), A81 (= A77), E103 (= E98), H105 (= H100), R112 (= R107)
binding 2,3 -anhydro-quinic acid: Y27 (= Y22), N78 (= N74), A80 (= A76), A81 (= A77), H84 (= H80), H105 (= H100), I106 (≠ L101), S107 (= S102), R116 (= R111)
binding glycerol: N15 (= N10), L16 (= L11), L19 (= L14), Y27 (= Y22)

P15474 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
46% identity, 85% coverage: 3:136/158 of query aligns to 10:143/157 of P15474

query
sites
P15474

I

I

K

M

V

I

I

L

H

N

G

G

P

P

N

N

L

L

N

N

M

L

L

L

G

G

I

Q

R
|
R

E

Q

V

P

N

E

I

I

Y

Y

G

G

P

S

M

D

K

T

L

L

E

A

D

D

I

V

N

E

K

A

N

L

M

C

E

V

V

K

V

A

A

A

K

A

Q

A

N

H

G

G

F

G

E

T

I

V

E

D

F

F

Y

R

Q

Q

S

S

N

N

H

H

E

E

G

G

D

E

I

L

V

V

D

D

A

W

I

I

Q

H

E

E

S

A

-

R

I

L

N

N

E

H

K

C

V

-

D

-

G

G

I

I

I

V

I

I

N

N

P

P

A

A

F

Y

T

S

H

H

T

T

S

S

I

V

A

A

I

I

R

L

D

D

A

A

I

L

K

N

A

T

V

C

N

D

-

G

L

L

P

P

T

V

V

V

E

E

V

V

H

H

L

I

S

S

N

N

I

I

A

H

A

Q

R

R

E

E

D

P

F

F

R

R

K

H

S

S

L

Y

I

V

S

S

D

Q

I

R

V

A

A

D

G

G

T

V

I

V

T

A

G

G

F

C

G

G

P

V

F

Q

S

G

Y

Y

H

V

L

F

G

G

L

V

R24 (= R17) mutation to A: Reduces kcat 30000-fold. Reduces KM for 3-dehydroquinate 6-fold.; mutation to K: Reduces kcat 2700-fold. Reduces KM for 3-dehydroquinate 4-fold.; mutation to Q: Reduces kcat 3100-fold. Reduces KM for 3-dehydroquinate 8-fold.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

Query Sequence

>WP_007473935.1 NCBI__GCF_000170735.1:WP_007473935.1
MKIKVIHGPNLNMLGIREVNIYGPMKLEDINKNMEVVAKQNGFEIEFYQSNHEGDIVDAI
QESINEKVDGIIINPAAFTHTSIAIRDAIKAVNLPTVEVHLSNIAAREDFRKKSLISDIV
AGTITGFGPFSYHLGLLAMMQILNEIKMLKEQQQNQGN

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory