SitesBLAST
Comparing WP_007475074.1 NCBI__GCF_000170735.1:WP_007475074.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 18 hits to proteins with known functional sites (download)
5c4iC Structure of an oxalate oxidoreductase (see paper)
40% identity, 96% coverage: 1:303/317 of query aligns to 2:297/312 of 5c4iC
- active site: N143 (= N145)
- binding magnesium ion: D110 (= D112), N138 (= N140), S140 (≠ N142)
- binding iron/sulfur cluster: C24 (= C24), C27 (= C27), P29 (≠ H29), C52 (= C52), A142 (= A144), C225 (= C226), P226 (≠ T227), K227 (≠ T228)
- binding thiamine diphosphate: T50 (= T50), G51 (= G51), C52 (= C52), I74 (≠ F74), G109 (= G111), D110 (= D112), G111 (= G113), Y136 (≠ L138), N138 (= N140), S140 (≠ N142), Y141 (= Y143), A142 (= A144), N143 (= N145), T144 (= T146)
5exeC Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-tpp adduct (see paper)
40% identity, 96% coverage: 1:303/317 of query aligns to 2:297/314 of 5exeC
- active site: N143 (= N145)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-carboxy-4-methyl-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: T50 (= T50), G51 (= G51), C52 (= C52), I74 (≠ F74), G109 (= G111), D110 (= D112), G111 (= G113), Y136 (≠ L138), N138 (= N140), S140 (≠ N142), Y141 (= Y143), A142 (= A144), N143 (= N145), T144 (= T146)
- binding magnesium ion: D110 (= D112), D130 (= D132), N138 (= N140), S140 (≠ N142), L211 (= L212), Q213 (≠ T214)
- binding iron/sulfur cluster: C24 (= C24), C27 (= C27), P29 (≠ H29), C52 (= C52), C225 (= C226), P226 (≠ T227), K227 (≠ T228)
5exdF Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
40% identity, 96% coverage: 1:303/317 of query aligns to 2:297/310 of 5exdF
- active site: N143 (= N145)
- binding magnesium ion: D110 (= D112), N138 (= N140), S140 (≠ N142)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-[1,1,2-tris(oxidanyl)-2-oxidanylidene-ethyl]-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: T50 (= T50), G51 (= G51), C52 (= C52), I74 (≠ F74), D110 (= D112), G111 (= G113), Y136 (≠ L138), N138 (= N140), S140 (≠ N142), Y141 (= Y143), A142 (= A144), N143 (= N145), T144 (= T146)
- binding iron/sulfur cluster: C24 (= C24), C27 (= C27), P29 (≠ H29), C52 (= C52), A142 (= A144), C225 (= C226), K227 (≠ T228)
7plmA Cryoem reconstruction of pyruvate ferredoxin oxidoreductase (pfor) in anaerobic conditions (see paper)
31% identity, 66% coverage: 109:316/317 of query aligns to 927:1131/1177 of 7plmA
- binding calcium ion: D950 (= D132), N952 (≠ L134), F1026 (≠ V215), G1028 (= G216)
- binding magnesium ion: D930 (= D112), T958 (≠ N140), V960 (≠ N142), S962 (≠ A144)
- binding iron/sulfur cluster: S962 (≠ A144), C1038 (= C226), I1039 (≠ T227)
- binding thiamine diphosphate: G929 (= G111), D930 (= D112), G931 (= G113), V960 (≠ N142), Y961 (= Y143), S962 (≠ A144), N963 (= N145), T964 (= T146)
Sites not aligning to the query:
- binding iron/sulfur cluster: 458, 657, 659, 664, 665, 666, 667, 668, 670, 674, 675, 679, 708, 715, 716, 717, 718, 719, 721, 725, 726, 731, 732, 781, 782, 785, 787, 810
- binding thiamine diphosphate: 27, 28, 29, 63, 787, 808, 809, 810, 839
P94692 Pyruvate:ferredoxin oxidoreductase; PFOR; POR; Pyruvate synthase; EC 1.2.7.1 from Desulfocurvibacter africanus (Desulfovibrio africanus) (see 3 papers)
33% identity, 56% coverage: 109:286/317 of query aligns to 960:1137/1232 of P94692
- GDGW 962:965 (≠ GDGG 111:114) binding thiamine diphosphate
- D963 (= D112) binding Mg(2+)
- D983 (= D132) binding Ca(2+)
- N985 (≠ L134) binding Ca(2+)
- T991 (≠ N140) binding Mg(2+)
- TEVYSN 991:996 (≠ NENYAN 140:145) binding thiamine diphosphate
- V993 (≠ N142) binding Mg(2+)
- A1056 (≠ L212) binding Ca(2+)
- F1059 (≠ V215) binding Ca(2+)
- G1061 (= G216) binding Ca(2+)
- S1063 (≠ T218) binding Ca(2+)
- C1071 (= C226) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 31 binding pyruvate
- 64 binding thiamine diphosphate
- 114 binding pyruvate
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 695 binding [4Fe-4S] cluster
- 699 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 751 binding [4Fe-4S] cluster
- 755 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 815 binding [4Fe-4S] cluster
- 817 binding thiamine diphosphate
- 840 binding [4Fe-4S] cluster; binding thiamine diphosphate
2c3uA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus, oxygen inhibited form (see paper)
33% identity, 56% coverage: 109:286/317 of query aligns to 959:1136/1231 of 2c3uA
- active site: N995 (= N145)
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: G961 (= G111), D962 (= D112), G963 (= G113), W964 (≠ G114), V992 (≠ N142), Y993 (= Y143), S994 (≠ A144), N995 (= N145), T996 (= T146)
- binding calcium ion: D982 (= D132), N984 (≠ L134), A1055 (≠ L212), E1056 (= E213), F1058 (≠ V215), G1060 (= G216), S1062 (≠ T218)
- binding magnesium ion: D962 (= D112), T990 (≠ N140), V992 (≠ N142)
- binding pyruvic acid: N995 (= N145)
- binding iron/sulfur cluster: C1070 (= C226), I1071 (≠ T227)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: 28, 29, 63, 87, 816, 837, 839, 868, 869
- binding pyruvic acid: 30, 113, 122
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 811, 814, 816, 839
2c3pA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
33% identity, 56% coverage: 109:286/317 of query aligns to 959:1136/1231 of 2c3pA
- active site: N995 (= N145)
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: G961 (= G111), D962 (= D112), G963 (= G113), V992 (≠ N142), Y993 (= Y143), S994 (≠ A144), N995 (= N145), T996 (= T146)
- binding calcium ion: D982 (= D132), V983 (≠ F133), N984 (≠ L134), A1055 (≠ L212), E1056 (= E213), F1058 (≠ V215), G1060 (= G216), S1062 (≠ T218)
- binding magnesium ion: D962 (= D112), T990 (≠ N140), V992 (≠ N142)
- binding iron/sulfur cluster: S994 (≠ A144), C1070 (= C226), I1071 (≠ T227)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: 28, 29, 30, 63, 87, 113, 816, 837, 838, 839, 868, 869
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839
2c3oA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
33% identity, 56% coverage: 109:286/317 of query aligns to 959:1136/1231 of 2c3oA
- active site: N995 (= N145)
- binding calcium ion: D982 (= D132), N984 (≠ L134), E1056 (= E213), F1058 (≠ V215), G1060 (= G216)
- binding magnesium ion: D962 (= D112), T990 (≠ N140), V992 (≠ N142)
- binding pyruvic acid: T996 (= T146)
- binding iron/sulfur cluster: C1070 (= C226), I1071 (≠ T227)
- binding thiamine diphosphate: G961 (= G111), D962 (= D112), G963 (= G113), V992 (≠ N142), Y993 (= Y143), S994 (≠ A144), N995 (= N145), T996 (= T146)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding pyruvic acid: 30, 113
- binding iron/sulfur cluster: 458, 681, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 746, 747, 748, 749, 750, 754, 760, 761, 810, 811, 814, 816, 839
- binding thiamine diphosphate: 28, 29, 63, 87, 816, 837, 838, 839, 868
1kekA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase (see paper)
33% identity, 56% coverage: 109:286/317 of query aligns to 959:1136/1231 of 1kekA
- active site: N995 (= N145)
- binding calcium ion: D982 (= D132), N984 (≠ L134), A1055 (≠ L212), E1056 (= E213), F1058 (≠ V215), S1062 (≠ T218)
- binding 2-acetyl-thiamine diphosphate: G961 (= G111), D962 (= D112), G963 (= G113), V992 (≠ N142), Y993 (= Y143), S994 (≠ A144), N995 (= N145), T996 (= T146)
- binding magnesium ion: D962 (= D112), T990 (≠ N140), V992 (≠ N142)
- binding iron/sulfur cluster: C1070 (= C226), I1071 (≠ T227)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 2-acetyl-thiamine diphosphate: 29, 63, 87, 113, 816, 837, 838, 839, 868
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 703, 737, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839
1b0pA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
33% identity, 56% coverage: 109:286/317 of query aligns to 959:1136/1231 of 1b0pA
- active site: N995 (= N145)
- binding calcium ion: D982 (= D132), N984 (≠ L134), A1055 (≠ L212), E1056 (= E213), F1058 (≠ V215), G1060 (= G216)
- binding magnesium ion: D962 (= D112), T990 (≠ N140), V992 (≠ N142)
- binding iron/sulfur cluster: S994 (≠ A144), C1070 (= C226), I1071 (≠ T227)
- binding thiamine diphosphate: G961 (= G111), D962 (= D112), G963 (= G113), V992 (≠ N142), Y993 (= Y143), S994 (≠ A144), N995 (= N145), T996 (= T146)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 737, 744, 745, 747, 748, 750, 754, 755, 760, 811, 814, 816, 839
- binding thiamine diphosphate: 28, 29, 63, 816, 837, 838, 839, 868
Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
24% identity, 92% coverage: 24:315/317 of query aligns to 809:1156/1171 of Q2RMD6
- C809 (= C24) binding [4Fe-4S] cluster
- C812 (= C27) binding [4Fe-4S] cluster
- E814 (≠ H29) binding thiamine diphosphate
- C837 (= C52) binding [4Fe-4S] cluster; binding thiamine diphosphate
- D967 (= D112) binding Mg(2+)
- DGW 967:969 (≠ DGG 112:114) binding thiamine diphosphate
- T995 (≠ N140) binding Mg(2+)
- TEVYSN 995:1000 (≠ NENYAN 140:145) binding thiamine diphosphate
- V997 (≠ N142) binding Mg(2+)
- C1075 (= C226) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 424:428 binding CoA
- 456 binding CoA
- 556 binding CoA
- 598 binding CoA
- 686 binding [4Fe-4S] cluster
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 696 binding [4Fe-4S] cluster
- 742 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 752 binding [4Fe-4S] cluster
6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound (see paper)
24% identity, 92% coverage: 24:315/317 of query aligns to 808:1155/1169 of 6ciqA
- active site: N999 (= N145)
- binding coenzyme a: N999 (= N145)
- binding magnesium ion: D966 (= D112), T994 (≠ N140), V996 (≠ N142)
- binding iron/sulfur cluster: C808 (= C24), C811 (= C27), E813 (≠ H29), C836 (= C52), S998 (≠ A144), C1074 (= C226), I1075 (≠ T227)
- binding thiamine diphosphate: E813 (≠ H29), G835 (= G51), C836 (= C52), F865 (= F74), G965 (= G111), D966 (= D112), G967 (= G113), V996 (≠ N142), Y997 (= Y143), S998 (≠ A144), N999 (= N145), T1000 (= T146)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding coenzyme a: 28, 423, 424, 427, 428, 553, 586
- binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 696, 700, 734, 741, 742, 743, 744, 745, 747, 751, 757, 807
- binding thiamine diphosphate: 26, 27, 61, 85
6cinB Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
24% identity, 92% coverage: 24:315/317 of query aligns to 808:1155/1169 of 6cinB
- active site: N999 (= N145)
- binding magnesium ion: D966 (= D112), T994 (≠ N140), V996 (≠ N142)
- binding iron/sulfur cluster: C808 (= C24), C811 (= C27), E813 (≠ H29), C836 (= C52), S998 (≠ A144), C1074 (= C226), I1075 (≠ T227)
- binding thiamine diphosphate: T834 (= T50), G835 (= G51), C836 (= C52), F865 (= F74), G965 (= G111), D966 (= D112), G967 (= G113), V996 (≠ N142), Y997 (= Y143), S998 (≠ A144), N999 (= N145), T1000 (= T146)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding iron/sulfur cluster: 455, 678, 685, 686, 687, 688, 689, 691, 695, 700, 741, 742, 743, 744, 745, 746, 747, 751, 752, 757, 758, 807
- binding thiamine diphosphate: 26, 27, 61
6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound (see paper)
33% identity, 50% coverage: 94:253/317 of query aligns to 942:1100/1165 of 6cipA
Sites not aligning to the query:
- active site: 28, 61, 111
- binding 2-acetyl-thiamine diphosphate: 27, 61, 85, 111, 813, 834, 835, 836, 865
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836
6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound (see paper)
33% identity, 50% coverage: 94:253/317 of query aligns to 942:1100/1164 of 6cioA
- active site: N999 (= N145)
- binding magnesium ion: D966 (= D112), T994 (≠ N140), V996 (≠ N142)
- binding iron/sulfur cluster: C1074 (= C226), I1075 (≠ T227)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: G965 (= G111), D966 (= D112), G967 (= G113), V996 (≠ N142), Y997 (= Y143), S998 (≠ A144), N999 (= N145), T1000 (= T146)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: 26, 27, 28, 61, 85, 111, 813, 834, 835, 836, 865
6n2oD 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
27% identity, 79% coverage: 24:272/317 of query aligns to 25:251/291 of 6n2oD
- binding magnesium ion: D101 (= D112), N129 (= N140), I131 (≠ N142)
- binding succinyl-coenzyme a: I57 (vs. gap), R62 (≠ I59), L134 (≠ N145), K136 (≠ G147)
- binding iron/sulfur cluster: C25 (= C24), C28 (= C27), C59 (= C56), C208 (= C226), T210 (= T228), F211 (= F232)
- binding thiamine diphosphate: I57 (vs. gap), G58 (vs. gap), C59 (= C56), S60 (= S57), H76 (≠ F74), G102 (= G113), D103 (≠ G114), N129 (= N140), I131 (≠ N142), G133 (≠ A144), L134 (≠ N145), T135 (= T146)
Sites not aligning to the query:
6n2oB 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
27% identity, 79% coverage: 24:272/317 of query aligns to 25:251/291 of 6n2oB
- binding 2-oxoglutaric acid: R62 (≠ I59), L134 (≠ N145)
- binding coenzyme a: K136 (≠ G147), Y150 (≠ S161)
- binding magnesium ion: D101 (= D112), N129 (= N140), I131 (≠ N142)
- binding iron/sulfur cluster: C25 (= C24), C28 (= C27), C59 (= C56), C208 (= C226), T210 (= T228), F211 (= F232)
- binding thiamine diphosphate: I57 (vs. gap), G58 (vs. gap), C59 (= C56), S60 (= S57), H76 (≠ F74), G102 (= G113), D103 (≠ G114), N129 (= N140), I131 (≠ N142), Y132 (= Y143), G133 (≠ A144), L134 (≠ N145), T135 (= T146)
Sites not aligning to the query:
6n2nB Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus (see paper)
27% identity, 79% coverage: 24:272/317 of query aligns to 25:251/291 of 6n2nB
- binding magnesium ion: D101 (= D112), N129 (= N140), I131 (≠ N142)
- binding iron/sulfur cluster: C25 (= C24), C28 (= C27), H30 (= H29), C59 (= C56), C208 (= C226), T210 (= T228), F211 (= F232)
- binding thiamine diphosphate: I57 (vs. gap), G58 (vs. gap), C59 (= C56), S60 (= S57), H76 (≠ F74), G100 (= G111), D101 (= D112), G102 (= G113), D103 (≠ G114), N129 (= N140), I131 (≠ N142), Y132 (= Y143), G133 (≠ A144), L134 (≠ N145), T135 (= T146)
Sites not aligning to the query:
Query Sequence
>WP_007475074.1 NCBI__GCF_000170735.1:WP_007475074.1
MKKITNLKEFACTPDRFQGGHRLCPGCAHSMIVREVVNATDDDLVISTATGCLEVCSAIY
PYTSWDVSWIHIGFENAGAAIAGAEAMHSALSRKGKLFNDDRKVKFVAFGGDGGTYDIGF
QSLSGAVERGHDFLYVCLDNENYANTGGQRSSATPLGAHTSTTPRGRVSYGEKQKKKDLT
MIMAAHGCPYVATAIPSTKHWKDLAQKAAKALETVGPTFINALSPCTTEWKFKPEETTEI
SDLAVETCAFPLYEIEDGYKLRITYRPKDKLPIEEYLSRQGRFSHLFKPENKWIIKEWQK
QVDEYWDYLQRREEAGV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory