SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_007691423.1 NCBI__GCF_000336675.1:WP_007691423.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1wkhA Acetylornithine aminotransferase from thermus thermophilus hb8
46% identity, 98% coverage: 5:374/378 of query aligns to 15:386/387 of 1wkhA

query
sites
1wkhA

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active site: F132 (= F122), E184 (= E174), D217 (= D207), Q220 (= Q210), K246 (= K236), T275 (= T263), R363 (= R351)
binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: Y46 (= Y36), S104 (= S94), G105 (= G95), T106 (= T96), F132 (= F122), S133 (≠ H123), E184 (= E174), E189 (= E179), D217 (= D207), I219 (≠ V209), K246 (= K236), R363 (= R351)

Sites not aligning to the query:

active site: 13

1wkgA Acetylornithine aminotransferase from thermus thermophilus hb8
46% identity, 98% coverage: 5:374/378 of query aligns to 15:386/387 of 1wkgA

query
sites
1wkgA

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active site: F132 (= F122), E184 (= E174), D217 (= D207), Q220 (= Q210), K246 (= K236), T275 (= T263), R363 (= R351)
binding n~2~-acetyl-n~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-l-ornithine: Y16 (≠ H6), Y46 (= Y36), G105 (= G95), T106 (= T96), F132 (= F122), S133 (≠ H123), R135 (= R125), E184 (= E174), D217 (= D207), I219 (≠ V209), Q220 (= Q210), K246 (= K236), G273 (≠ N261), T274 (≠ A262), T275 (= T263)

Sites not aligning to the query:

active site: 13

1vefA Acetylornithine aminotransferase from thermus thermophilus hb8
46% identity, 98% coverage: 5:374/378 of query aligns to 15:386/387 of 1vefA

query
sites
1vefA

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active site: F132 (= F122), D217 (= D207), K246 (= K236), T275 (= T263), R363 (= R351)
binding pyridoxal-5'-phosphate: G105 (= G95), T106 (= T96), F132 (= F122), S133 (≠ H123), E184 (= E174), D217 (= D207), I219 (≠ V209), K246 (= K236)

Sites not aligning to the query:

active site: 13

Q5SHH5 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
46% identity, 98% coverage: 5:374/378 of query aligns to 23:394/395 of Q5SHH5

query
sites
Q5SHH5

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I

A

L

P

P

E

P

G

E

L

L

E

N

N

R

V

V

W

F

L

P

C

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

N

N

E

E

A

A

A

A

L

L

K

K

F

F

A

A

R

R

S

A

A

H

T

T

G

G

R

R

S

K

K

K

I

F

V

V

A

A

T

A

M

M

Q

R

G

G

F

F

H

S

G

G

R

R

T

T

M

M

G

G

A

S

L

L

A

S

T

V

T

T

W

W

N

E

N

P

D

K

Y

Y

R

R

D

E

P

P

F

F

E

L

P

P

L

L

I

V

G

E

D

P

V

V

E

E

F

F

V

I

P

P

Y

Y

G

N

D

D

S

V

E

E

A

A

L

L

A

K

E

R

A

A

V

V

D

D

D

E

E

E

T

T

A

A

A

A

V

V

I

I

V

L

E

E

P

P

I

V

Q

Q

G

G

E

E

G

G

G

G

I

V

N

R

V

P

P

A

T

T

D

P

G

E

Y

F

L

L

A

R

A

A

A

A

R

R

E

E

C

I

T

T

E

Q

D

E

A

K

G

G

A

A

A

L

L

L

V

I

F

L

D

D

E

E

V

I

Q

Q

T

T

G

G

M

M

G

G

R

R

T

T

G

G

T

K

L

R

W

F

A

A

S

F

Q

E

Q

H

A

F

G

G

V

I

V

V

P

P

D

D

V

I

L

L

T

T

T

L

A

A

K
|
K

G

A

L

L

A

G

N

G

G

G

L

V

P

P

A

L

G

G

T

A

A

A

L

V

C

M

A

R

D

E

W

E

I

V

A

A

D

R

D

S

-

M

-

P

H

K

G

G

P

G

H

H

N

G

A

T

T
|
T

F

F

S

G

G

G

G

N

P

P

V

L

V

A

S

M

A

A

A

A

V

G

D

V

A

A

T

A

V

I

S

R

T

Y

L

L

V

E

E

R

E

T

E

R

V

L

P

W

S

E

N

R

A

A

G

A

A

E

V

L

G

G

E

P

Y

W

L

F

R

M

A

E

G

K

L

L

D

R

A

A

A

I

I

P

G

S

D

P

D

K

V

I

R

R

E

E

I

V

R

R

G

G

E

M

G

G

L

L

M

M

I

V

G

G

I

L

E

E

V

L

K

K

R

E

G

K

A

A

N

A

R

P

A

Y

L

I

R

A

D

R

L

L

A

E

L

K

D

E

S

H

N

R

L

V

L

L

A

A

L

L

P

Q

A

A

G

G

R

P

S

T

V

V

V

I

R

R

L

F

L

L

P

P

P

P

L

L

V

V

L

I

D

E

E

K

D

E

D

D

A

L

D

E

E

R

V

V

V

V

D

E

A

A

L

V

S

R

N

A

V

V

L

L

GT 113:114 (= GT 95:96) binding pyridoxal 5'-phosphate
K254 (= K236) modified: N6-(pyridoxal phosphate)lysine
T283 (= T263) binding pyridoxal 5'-phosphate

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
46% identity, 99% coverage: 1:374/378 of query aligns to 12:383/390 of A0QYS9

query
sites
A0QYS9

M

M

S

N

N

N

F

Y

I

-

H

-

S

G

E

T

K

P

P

P

I

L

R

S

I

L

E

V

R

S

G

G

E

E

G

G

A

A

Y

V

L

V

Y

T

D

D

T

A

D

D

G

G

T

R

E

E

Y

Y

L

L

D

D

C

L

G

L

A

G

S

G

Y

I

A

A

C

V

T

N

P

L

L

L

G

G

H

H

D

R

H

H

P

P

A

A

V

V

N

I

E

E

A

A

V

V

H

T

D

T

Q

Q

V

L

D

D

R

T

L

L

T

G

F

H

V

T

Q

S

A

N

S

L

Y

Y

P

A

V

T

D

E

A

P

R

G

D

I

R

A

A

L

F

A

D

E

A

A

L

L

A

V

A

G

A

Q

A

L

P

-

E

-

G

G

L

T

E

Q

-

A

N

R

V

V

W

F

L

F

C

C

N

N

S

S

G

G

T

T

E

E

A

A

N

N

E

E

A

V

A

A

L

F

K

K

F

I

A

T

R

R

S

-

A

L

T

T

G

G

R

K

S

T

K

K

I

I

V

V

A

A

T

A

M

E

Q

G

G

A

F

F

H

H

G

G

R

R

T

T

M

M

G

G

A

S

L

L

A

A

T

L

T

T

W

G

N

Q

N

P

D

S

Y

K

R

Q

D

A

P

P

F

F

E

E

P

P

L

L

I

P

G

G

D

N

V

V

E

M

F

H

V

V

P

P

Y

Y

G

G

D

D

S

V

E

A

A

A

L

L

A

E

E

A

A

A

V

V

D

D

D

D

E

Q

T

T

A

A

A

A

V

V

I

F

V

L

E

E

P

P

I

I

Q

M

G

G

E

E

G

G

G

G

I

V

N

V

V

V

P

P

T

P

D

A

G

G

Y

Y

L

L

A

V

A

A

A

A

R

R

E

E

C

I

T

T

E

S

D

K

A

H

G

G

A

A

A

L

L

L

V

V

F

L

D

D

E

E

V

V

Q

Q

T

T

G

G

M

V

G

G

R

R

T

T

G

G

T

A

L

F

W

F

A

A

S

H

Q

Q

Q

H

A

D

G

G

V

I

V

V

P

P

D

D

V

V

L

V

T

T

T

M

A

A

K

K

G

G

L

L

A

G

N

G

G

G

L

L

P

P

A

I

G

G

T

A

A

C

L

L

C

A

A

V

D

G

W

A

I

T

A

G

D

D

D

L

H

L

G

T

P

P

-

G

-

L

H

H

N

G

A

S

T

T

F

F

S

G

G

G

G

N

P

P

V

V

V

C

S

T

A

A

A

A

V

G

D

L

A

A

T

V

V

L

S

K

T

T

L

L

V

A

E

A

E

E

E

D

V

L

P

V

S

A

N

R

A

A

G

G

A

V

V

L

G

G

E
x
K

Y

T

L

L

R

S

A

H

G

G

L

I

D

E

A

E

A

L

I

G

G

H

D

P

D

L

V

V

R

D

E

K

I

V

R

R

G

G

E

K

G

G

L

L

M

L

I

Q

G

G

I

I

E

V

V

L

K

T

R

V

G

P

A

S

N

A

R

K

A

A

L

V

R

E

D

T

L

A

A

A

L

R

D

D

S

A

N

G

L

F

L

L

A

V

L

N

P

A

A

A

G

A

R

P

S

E

V

V

V

V

R

R

L

L

L

A

P

P

P

P

L

L

V

I

L

I

D

T

E

E

D

G

D

Q

A

I

D

E

E

A

V

F

V

I

D

T

A

A

L

L

S

P

N

A

V

V

L

L

K304 (≠ E295) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
41% identity, 98% coverage: 6:374/378 of query aligns to 73:453/457 of Q9M8M7

query
sites
Q9M8M7

H

Y

S

A

E

R

K

A

P

P

I

V

R

V

I

L

E

S

R

S

G

G

E

K

G

G

A

C

Y

K

L

L

Y

F

D

D

T

P

D

E

G

G

T

K

E

E

Y

Y

L

L

D

D

C

C

G

A

A

S

S

G

Y

I

A

A

C

V

T

N

P

A

L

L

G

G

H

H

D

G

H

D

P

P

A

D

V

W

N

L

E

R

A

A

V

V

H

T

D

E

Q

Q

V

A

D

G

R

V

L

L

T

A

F

H

V

V

Q

S

A

N

S

V

Y

Y

P

Y

V

T

D

I

A

P

R

Q

D

I

R

E

A

L

F

A

D

K

A

R

L

L

A

V

A

A

A

S

A

S

P

F

E

A

G

-

L

-

E

D

N

R

V

V

W

F

L

F

C

C

N

N

S

S

G

G

T

T

E

E

A

A

N

N

E

E

A

A

A

A

L

I

K

K

F

F

A

S

R

R

S

K

-

F

-

Q

-

R

-

F

-

T

-

H

-

P

-

E

-

D

-

K

-

E

-

V

A

A

T

T

G

G

R

-

S

-

K

-

I

F

V

I

A

A

T

F

M

T

Q

N

G

S

F

F

H

H

G

G

R

R

T

T

M

L

G

G

A

A

L

L

A

A

T

L

T

T

W

S

N

K

N

E

D

Q

Y

Y

R

R

D

T

P

P

F

F

E

E

P

P

L

I

I

M

G

P

D

G

V

V

E

T

F

F

V

L

P

E

Y

Y

G

G

D

N

S

I

E

Q

A

A

L

A

A

T

E

D

A

L

V

I

D

R

D

S

-

G

E

K

T

I

A

A

A

A

V

V

I

F

V

V

E

E

P

P

I

I

Q

Q

G

G

E

E

G

G

G

G

I

I

N

Y

V

S

P

A

T

T

D

K

G

E

Y

F

L

L

A

Q

A

S

A

L

R

R

E

S

C

A

T

C

E

D

D

A

A

A

G

G

A

S

A

L

L

L

V

V

F

F

D

D

E

E

V

V

Q

Q

T

C

G

G

M

L

G

G

R

R

T

T

G

G

T

L

L

M

W

W

A

A

S

Y

Q

E

Q

A

A

F

G

G

V

V

V

T

P

P

D

D

V

I

L

M

T

T

T

V

A

A

K

K

G

P

L

L

A

A

N

G

G

G

L

L

P

P

A

I

G

G

T

A

A

V

L

L

C

V

A

T

D

E

W

K

I

V

A

A

D

E

-

T

-

I

D

N

H

Y

G

G

P

D

H

H

N

G

A

S

T

T

F

F

S

A

G

G

G

S

P

P

V

L

V

V

S

C

A

S

A

A

V

A

D

I

A

A

T

V

V

M

S

D

T

K

L

V

V

S

E

K

E

P

E

S

V

F

P

L

S

S

N

S

A

V

G

S

A

N

V

K

G

G

E

R

Y

Y

L

F

R

R

A

D

G

L

L

L

D

V

A

K

A

K

I

L

G

G

D

G

D

N

-

S

-

H

V

V

R

K

E

E

I

V

R

R

G

G

E

E

G

G

L

L

M

I

I

I

G

G

I

V

E

E

V

L

K

D

R

V

G

P

A

A

N

S

R

-

A

S

L

L

R

V

D

D

L

A

A

C

L

R

D

D

S

S

N

G

L

L

L

L

A

I

L

L

P

T

A

A

G

G

R

K

-

G

S

N

V

V

V

V

R

R

L

I

L

V

P

P

P

P

L

L

V

V

L

I

D

S

E

E

D

E

D

E

A

I

D

E

E

R

V

A

V

V

D

E

A

I

L

M

S

S

N

Q

V

N

L

L

Sites not aligning to the query:

1:41 modified: transit peptide, Chloroplast and mitochondrion
42 modified: N-acetylvaline; in Acetylornithine aminotransferase, chloroplastic

P9WPZ7 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
45% identity, 99% coverage: 1:374/378 of query aligns to 20:393/400 of P9WPZ7

query
sites
P9WPZ7

M

M

S

N

N

N

F

Y

I

-

H

-

S

G

E

T

K

P

P

P

I

I

R

A

I

L

E

A

R

S

G

G

E

D

G

G

A

A

Y

V

L

V

Y

T

D

D

T

V

D

D

G

G

T

R

E

T

Y

Y

L

I

D

D

C

L

G

L

A

G

S

G

Y

I

A

A

C

V

T

N

P

V

L

L

G

G

H

H

D

R

H

H

P

P

A

A

V

V

N

I

E

E

A

A

V

V

H

T

D

R

Q

Q

V

M

D

S

R

T

L

L

-

G

-

H

-

T

T

S

F

N

V

L

Q

Y

A

A

S

T

Y

E

P

P

V

G

D

I

A

A

R

L

D

A

R

E

A

E

F

L

D

V

A

A

L

L

A

L

A

G

A

A

A

-

P

-

E

D

G

Q

L

R

E

T

N

R

V

V

W

F

L

F

C

C

N

N

S

S

G

G

T

A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

F

L

A

S

R

R

S

-

A

L

T

T

G

G

R

R

S

T

K

K

I

L

V

V

A

A

T

A

M

H

Q

D

G

A

F

F

H

H

G

G

R

R

T

T

M

M

G

G

A

S

L

L

A

A

T

L

T

T

W

G

N

Q

N

P

D

A

Y

K

R

Q

D

T

P

P

F

F

E

A

P

P

L

L

I

P

G

G

D

D

V

V

E

T

F

H

V

V

P

G

Y

Y

G

G

D

D

S

V

E

D

A

A

L

L

A

A

E

A

A

A

V

V

D

D

D

D

E

H

T

T

A

A

A

A

V

V

I

F

V

L

E

E

P

P

I

I

Q

M

G

G

E

E

G

S

G

G

I

V

N

V

V

V

P

P

T

P

D

A

G

G

Y

Y

L

L

A

A

A

A

A

A

R

R

E

D

C

I

T

T

E

A

D

R

A

R

G

G

A

A

A

L

L

L

V

V

F

L

D

D

E

E

V

V

Q

Q

T

T

G

G

M

M

G

G

R

R

T

T

G

G

T

A

L

F

W

F

A

A

S

H

Q

Q

Q

H

A

D

G

G

V

I

V

T

P

P

D

D

V

V

L

V

T

T

T

L

A

A

K

K

G

G

L

L

A

G

N

G

G

G

L

L

P

P

A

I

G

G

T

A

A

C

L

L

C

A

A

V

D

G

W

P

I

A

A

A

D

E

D

L

H

L

G

T

P

P

-

G

-

L

H

H

N

G

A

S

T

T

F

F

S

G

G

G

G

N

P

P

V

V

V

C

S

A

A

A

A

A

V

A

D

L

A

A

T

V

V

L

S

R

T

V

L

L

V

A

E

S

E

D

E

G

V

L

P

V

S

R

N

R

A

A

G

E

A

V

V

L

G

G

E
x
K

Y

S

L

L

R

R

A

H

G

G

L

I

D

E

A

A

A

L

I

G

G

H

D

P

D

L

V

I

R

D

E

H

I

V

R

R

G

G

E

R

G

G

L

L

M

L

I

L

G

G

I

I

E

A

V

L

K

T

R

A

G

P

A

H

N

A

R

K

A

D

L

A

R

E

D

A

L

T

A

A

L

R

D

D

S

A

N

G

L

Y

L

L

A

V

L

N

P

A

A

A

G

A

R

P

S

D

V

V

V

I

R

R

L

L

L

A

P

P

P

P

L

L

V

I

L

I

D

A

E

E

D

A

D

Q

A

L

D

D

E

G

V

F

V

V

D

A

A

A

L

L

S

P

N

A

V

I

L

L

K314 (≠ E295) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylthreonine; partial

7nncC Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal-5'-phosphate and 6-methoxyquinoline-3-carboxylic acid
45% identity, 99% coverage: 1:374/378 of query aligns to 14:387/391 of 7nncC

query
sites
7nncC

M

M

S

N

N

N

F

Y

I

-

H

-

S

G

E

T

K

P

P

P

I

I

R

A

I

L

E

A

R

S

G

G

E

D

G

G

A

A

Y

V

L

V

Y

T

D

D

T

V

D

D

G

G

T

R

E

T

Y

Y

L

I

D

D

C

L

G

L

A

G

S

G

Y

I

A

A

C

V

T

N

P

V

L

L

G

G

H

H

D

R

H

H

P

P

A

A

V

V

N

I

E

E

A

A

V

V

H

T

D

R

Q

Q

V

M

D

S

R

T

L

L

-

G

-

H

-

T

T

S

F
x
N

V
x
L

Q

Y

A

A

S

T

Y

E

P

P

V

G

D

I

A

A

R

L

D

A

R

E

A

E

F

L

D

V

A

A

L

L

A

L

A

G

A

A

A

-

P

-

E

D

G

Q

L

R

E

T

N

R

V

V

W

F

L

F

C

C

N

N

S

S

G

G

T

A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

F

L

A

S

R

R

S

-

A

L

T

T

G

G

R

R

S

T

K

K

I

L

V

V

A

A

T

A

M

H

Q

D

G

A

F
|
F

H

H

G

G

R

R

T

T

M

M

G

G

A

S

L

L

A

A

T

L

T

T

W

G

N

Q

N

P

D

A

Y

K

R

Q

D

T

P

P

F

F

E

A

P

P

L

L

I

P

G

G

D

D

V

V

E

T

F

H

V

V

P

G

Y

Y

G

G

D

D

S

V

E

D

A

A

L

L

A

A

E

A

A

A

V

V

D

D

D

D

E

H

T

T

A

A

A

A

V

V

I

F

V

L

E

E

P

P

I

I

Q

M

G

G

E

E

G

S

G

G

I

V

N

V

V

V

P

P

T

P

D

A

G

G

Y

Y

L

L

A

A

A

A

A

A

R

R

E

D

C

I

T

T

E

A

D

R

A

R

G

G

A

A

A

L

L

L

V

V

F

L

D
|
D

E

E

V

V

Q

Q

T

T

G

G

M

M

G

G

R

R

T

T

G

G

T

A

L

F

W

F

A

A

S

H

Q

Q

Q

H

A

D

G

G

V

I

V

T

P

P

D

D

V

V

L

V

T

T

T

L

A

A

K
|
K

G

G

L

L

A

G

N

G

G

G

L

L

P

P

A

I

G

G

T

A

A

C

L

L

C

A

A

V

D

G

W

P

I

A

A

A

D

E

D

L

H

L

G

T

P

P

-

G

-

L

H

H

N

G

A

S

T

T

F

F

S

G

G

G

G

N

P

P

V

V

V

C

S

A

A

A

A

A

V

A

D

L

A

A

T

V

V

L

S

R

T

V

L

L

V

A

E

S

E

D

E

G

V

L

P

V

S

R

N

R

A

A

G

E

A

V

V

L

G

G

E

K

Y

S

L

L

R

R

A

H

G

G

L

I

D

E

A

A

A

L

I

G

G

H

D

P

D

L

V

I

R

D

E

H

I

V

R

R

G

G

E

R

G

G

L

L

M

L

I

L

G

G

I

I

E

A

V

L

K

T

R

A

G

P

A

H

N

A

R

K

A

D

L

A

R

E

D

A

L

T

A

A

L

R

D

D

S

A

N

G

L

Y

L

L

A

V

L

N

P

A

A

A

G

A

R

P

S

D

V

V

V

I

R

R

L

L

L

A

P

P

P

P

L

L

V

I

L

I

D

A

E

E

D

A

D

Q

A

L

D

D

E

G

V

F

V

V

D

A

A

A

L

L

S

P

N

A

V

I

L

L

active site: F133 (= F122), D218 (= D207), K247 (= K236)
binding 6-methoxyquinoline-3-carboxylic acid: N75 (≠ F61), L76 (≠ V62)

7nn4A Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal 5'-phosphate and 3-hydroxy-2-naphthoic acid.
45% identity, 99% coverage: 1:374/378 of query aligns to 14:387/391 of 7nn4A

query
sites
7nn4A

M

M

S

N

N

N

F
x
Y

I

-

H

-

S

G

E

T

K

P

P

P

I

I

R

A

I

L

E

A

R

S

G

G

E

D

G

G

A

A

Y

V

L

V

Y

T

D

D

T

V

D

D

G

G

T

R

E

T

Y

Y

L

I

D

D

C

L

G

L

A

G

S

G

Y

I

A

A

C

V

T

N

P

V

L

L

G

G

H

H

D

R

H

H

P

P

A

A

V

V

N

I

E

E

A

A

V

V

H

T

D

R

Q

Q

V

M

D

S

R

T

L

L

-

G

-

H

-

T

T

S

F

N

V
x
L

Q

Y

A

A

S

T

Y

E

P

P

V

G

D

I

A

A

R

L

D

A

R

E

A

E

F

L

D

V

A

A

L

L

A

L

A

G

A

A

A

-

P

-

E

D

G

Q

L

R

E

T

N

R

V

V

W

F

L

F

C

C

N

N

S

S

G

G

T

A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

F

L

A

S

R

R

S

-

A

L

T

T

G

G

R

R

S

T

K

K

I

L

V

V

A

A

T

A

M

H

Q

D

G

A

F
|
F

H

H

G

G

R
|
R

T

T

M

M

G

G

A

S

L

L

A

A

T

L

T

T

W

G

N

Q

N

P

D

A

Y

K

R

Q

D

T

P

P

F

F

E

A

P

P

L

L

I

P

G

G

D

D

V

V

E

T

F

H

V

V

P

G

Y

Y

G

G

D

D

S

V

E

D

A

A

L

L

A

A

E

A

A

A

V

V

D

D

D

D

E

H

T

T

A

A

A

A

V

V

I

F

V

L

E

E

P

P

I

I

Q

M

G

G

E

E

G

S

G

G

I

V

N

V

V

V

P

P

T

P

D

A

G

G

Y

Y

L

L

A

A

A

A

A

A

R

R

E

D

C

I

T

T

E

A

D

R

A

R

G

G

A

A

A

L

L

L

V

V

F

L

D
|
D

E

E

V

V

Q

Q

T

T

G

G

M

M

G

G

R

R

T

T

G

G

T

A

L

F

W

F

A

A

S

H

Q

Q

Q

H

A

D

G

G

V

I

V

T

P

P

D

D

V

V

L

V

T

T

T

L

A

A

K
|
K

G

G

L

L

A

G

N

G

G

G

L

L

P

P

A

I

G

G

T

A

A

C

L

L

C

A

A

V

D

G

W

P

I

A

A

A

D

E

D

L

H

L

G

T

P

P

-

G

-

L

H

H

N
x
G

A

S

T

T

F

F

S

G

G

G

G

N

P

P

V

V

V

C

S

A

A

A

A

A

V

A

D

L

A

A

T

V

V

L

S

R

T

V

L

L

V

A

E

S

E

D

E

G

V

L

P

V

S

R

N

R

A

A

G

E

A

V

V

L

G

G

E

K

Y

S

L

L

R

R

A

H

G

G

L

I

D

E

A

A

A

L

I

G

G

H

D

P

D

L

V

I

R

D

E

H

I

V

R

R

G

G

E

R

G

G

L

L

M

L

I

L

G

G

I

I

E

A

V

L

K

T

R

A

G

P

A

H

N

A

R

K

A

D

L

A

R

E

D

A

L

T

A

A

L

R

D

D

S

A

N

G

L

Y

L

L

A

V

L

N

P

A

A

A

G

A

R

P

S

D

V

V

V

I

R

R

L

L

L

A

P

P

P

P

L

L

V

I

L

I

D

A

E

E

D

A

D

Q

A

L

D

D

E

G

V

F

V

V

D

A

A

A

L

L

S

P

N

A

V

I

L

L

active site: F133 (= F122), D218 (= D207), K247 (= K236)
binding 3-hydroxynaphthalene-2-carboxylic acid: Y17 (≠ F4), L76 (≠ V62), R136 (= R125), G274 (≠ N261)

8ht4B Crystal structure of acetylornithine aminotransferase complex with plp from corynebacterium glutamicum (see paper)
41% identity, 98% coverage: 6:374/378 of query aligns to 14:389/390 of 8ht4B

query
sites
8ht4B

H

Y

S

G

E

T

K

P

P

P

I

V

R

E

I

L

E

V

R

S

G

G

E

K

G

G

A

A

Y

T

L

V

Y

T

D

D

T

D

D

Q

G

G

T

N

E

V

Y

Y

L

I

D

D

C

L

G

L

A

A

S

G

Y

I

A

A

C

V

T

N

P

A

L

L

G

G

H

H

D

A

H

H

P

P

A

A

V

I

N

I

E

E

A

A

V

V

H

T

D

N

Q

Q

V

I

D

G

R

Q

L

L

T

G

F

H

V

V

Q

S

-

N

-

L

-

F

A

A

S

S

Y

R

P

P

V

V

-

V

-

E

-

V

-

A

-

E

-

E

-

L

D

I

A

K

R

R

D

F

R

S

A

L

F

D

D

D

A

A

L

T

A

L

A

A

A

A

A

Q

P

-

E

-

G

-

L

-

E

T

N

R

V

V

W

F

L

F

C

C

N

N

S
|
S

G
|
G

T
x
A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

F

I

A

A

R

R

S

-

A

L

T

T

G

G

R

R

S

S

K

R

I

I

V

L

A

A

T

A

M

V

Q

H

G

G

F
|
F

H
|
H

G

G

R

R

T

T

M

M

G

G

A

S

L

L

A

A

T

L

T

T

W

G

N

Q

N

P

D

D

Y

K

R

R

D

E

P

A

F

F

E

L

P

P

L

M

I

P

G

S

D

G

V

V

E

E

F

F

V

Y

P

P

Y

Y

G

G

D

D

S

T

E

D

A

Y

L

L

A

R

E

K

A

M

V

V

D

E

D

T

-

N

-

P

-

T

E

D

T

V

A

A

A

A

V

I

I

F

V

L

E
|
E

P

P

I

I

Q

Q

G

G

E

E

G

T

G

G

I

V

N

V

V

P

P

A

T

P

D

E

G

G

Y

F

L

L

A

K

A

A

A

V

R

R

E

E

C

L

T

C

E

D

D

E

A

Y

G

G

A

I

A

L

L

M

V

I

F

T

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

M

V

G

G

R

R

T

T

G

G

T

D

L

F

W

F

A

A

S

H

Q

Q

Q

H

A

D

G

G

V

V

V

V

P

P

D

D

V

V

L

V

T

T

T

M

A

A

K
|
K

G

G

L

L

A

G

N

G

G

G

L

L

P

P

A

I

G

G

T

A

A

C

L

L

C

A

A

T

D

G

W

R

I

A

A

A

D

E

D

L

H

M

G

T

P

P

-

G

-

K

H

H

N

G

A

T

T

T

F

F

S

G

G

G

G

N

P

P

V

V

V

A

S

C

A

A

A

A

V

A

D

K

A

A

T

V

V

L

S

S

T

-

L

V

V

V

E

D

E

D

E

A

V

F

P

C

S

A

N

E

A

V

G

A

A

R

V

K

G

G

E

E

Y

L

L

F

R

K

A

E

G

L

L

L

D

-

A

-

A

A

I

K

G

V

D

D

D

G

V

V

R

V

E

D

I

V

R

R

G

G

E

R

G

G

L

L

M

M

I

L

G

G

I

V

E

V

V

L

K

E

R

R

G

D

-

V

A

A

N

K

R

Q

A

A

L

V

R

L

D

D

L

G

A

F

L

K

D

H

S

G

N

V

L

I

L

L

A

N

L

A

P

P

A

A

G

-

R

D

S

N

V

I

V

I

R

R

L

L

L

T

P

P

P

P

L

L

V

V

L

I

D

T

E

D

D

E

D

E

A

I

D

A

E

D

V

A

V

V

D

K

A

A

L

I

S

A

N

E

V

T

L

I

binding pyridoxal-5'-phosphate: S108 (= S94), G109 (= G95), A110 (≠ T96), F135 (= F122), H136 (= H123), E190 (= E174), D223 (= D207), V225 (= V209), Q226 (= Q210), K252 (= K236)

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
37% identity, 98% coverage: 6:376/378 of query aligns to 15:392/393 of 2ordA

query
sites
2ordA

H

Y

S

S

E

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F

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P

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A

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I

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E

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G

G

A

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Y

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I

Y

Y

D

D

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E

D

K

G

G

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N

E

A

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Y

L

L

D

D

C

F

G

T

A

S

S

G

Y

I

A

A

C

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T

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P

V

L

L

G

G

H

H

D

S

H

H

P

P

A

R

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L

N

V

E

E

A

A

V

I

H

K

D

D

Q

Q

V

A

D

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L

L

T

I

F

H

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C

Q

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A

N

S

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A

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Q

D

M

R

E

A

L

F

A

D

E

A

L

L

L

A

S

A

K

A

N

A

T

P

F

E

G

G

G

L

-

E

-

N

K

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V

W

F

L

F

C

A

N

N

S

T

G
|
G

T
|
T

E

E

A

A

N

N

E

E

A

A

A

A

L

I

K

K

F

I

A

A

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S

K

A

Y

T

G

G

K

R

K

S

K

-

S

-

E

-

K

-

K

-

Y

K

R

I

I

V

L

A

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M

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|
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H

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G

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T

M

L

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G

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L

A

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A

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G

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N

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|
E

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M

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G

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V

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G

G

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G

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|
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M

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N

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A

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N

N

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|
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G

G

active site: F134 (= F122), E186 (= E174), D219 (= D207), Q222 (= Q210), K248 (= K236), T276 (= T263), R367 (= R351)
binding pyridoxal-5'-phosphate: G102 (= G95), T103 (= T96), F134 (= F122), H135 (= H123), E186 (= E174), D219 (= D207), V221 (= V209), Q222 (= Q210), K248 (= K236)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
37% identity, 98% coverage: 6:376/378 of query aligns to 7:384/385 of Q9X2A5

query
sites
Q9X2A5

H

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L

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H

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D

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Q

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A

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A

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L

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A

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F

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G

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L

-

E

-

N

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W

F

L

F

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A

N

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T

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A

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A

A

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F

I

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G

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D

D

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V

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L

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A

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K

G

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A

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-

N

A

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D

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G

G

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H

H

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T
|
T

F

F

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G

G

G

N

P

P

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L

V

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A

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A

A

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L

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Y

Y

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A

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A

M

I

K

G

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-

E

-

Y

D

D

D

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A

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D

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R

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G

G

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M

G

G

L

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M

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I

G

G

I

I

E

Q

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F

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G

E

-

V

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N

N

R

R

A

E

L

V

R

A

D

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A

C

L

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D

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N

N

K

L

L

L

L

A

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P

A

A

G

G

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N

S

N

V

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I

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R

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F

L

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I

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G

G

GT 94:95 (= GT 95:96) binding pyridoxal 5'-phosphate
T268 (= T263) binding pyridoxal 5'-phosphate

3nx3A Crystal structure of acetylornithine aminotransferase (argd) from campylobacter jejuni
34% identity, 96% coverage: 11:374/378 of query aligns to 13:385/388 of 3nx3A

query
sites
3nx3A

I

I

R

V

I

L

E

E

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G

G

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Q

G

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A

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Y

Y

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G

A

T

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E

K

Y

Y

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G

Y

I

A

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P

A

L

L

G

G

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Y

D

N

H

H

P

A

A

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F

N

N

E

A

A

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I

H

K

D

A

Q

Q

V

V

D

D

R

K

L

L

T

L

F

H

V

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Q

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A

N

S

L

Y

Y

P

Y

V

N

D

E

A

-

R

-

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N

R

I

A

A

F

A

D

A

A