SitesBLAST
Comparing WP_007692672.1 NCBI__GCF_000336675.1:WP_007692672.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3eheA Crystal structure of udp-glucose 4 epimerase (gale-1) from archaeoglobus fulgidus
43% identity, 97% coverage: 8:308/309 of query aligns to 2:288/290 of 3eheA
- active site: T111 (≠ S118), S112 (= S119), T113 (= T120), Y135 (= Y142), K139 (= K146)
- binding nicotinamide-adenine-dinucleotide: G6 (= G12), G9 (= G15), F10 (≠ L16), I11 (≠ V17), D29 (= D35), N30 (≠ D36), L31 (≠ C37), S32 (= S38), S33 (≠ K39), G34 (= G40), D49 (= D55), L50 (≠ M56), I68 (≠ F76), A69 (= A77), A70 (= A78), T109 (= T116), Y135 (= Y142), K139 (= K146), F162 (= F169), A163 (= A170), N164 (= N171), V165 (≠ I172)
3aw9A Structure of udp-galactose 4-epimerase mutant
43% identity, 98% coverage: 7:308/309 of query aligns to 2:304/304 of 3aw9A
- active site: A105 (≠ T116), S107 (= S118), S108 (= S119), T109 (= T120), Y131 (= Y142), K135 (= K146), L166 (≠ Q177), G169 (≠ N180)
- binding galactose-uridine-5'-diphosphate: P69 (≠ T80), V71 (≠ T82), S107 (= S118), Y131 (= Y142), N160 (= N171), H168 (≠ G179), V170 (= V181), D173 (= D184), L188 (= L199), Q193 (= Q204), K195 (= K206), Y197 (= Y208), V234 (= V242), W263 (= W268), D266 (= D271)
- binding nicotinamide-adenine-dinucleotide: G7 (= G12), G10 (= G15), F11 (≠ L16), I12 (≠ V17), D31 (= D35), I32 (≠ D36), R46 (≠ T57), D47 (≠ S58), L48 (≠ E59), F65 (= F76), A66 (= A77), A67 (= A78), E82 (= E93), A105 (≠ T116), S106 (= S117), Y131 (= Y142), K135 (= K146), Y158 (≠ F169), N160 (= N171), V161 (≠ I172), H168 (≠ G179)
4zrnA Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
32% identity, 94% coverage: 8:298/309 of query aligns to 3:298/309 of 4zrnA
- active site: T117 (≠ S118), G119 (vs. gap), A120 (≠ T120), Y143 (= Y142), K147 (= K146), Y181 (vs. gap), G185 (≠ N180)
- binding nicotinamide-adenine-dinucleotide: G7 (= G12), G10 (= G15), F11 (≠ L16), I12 (≠ V17), D31 (= D35), N32 (≠ D36), S34 (= S38), S35 (≠ K39), G36 (= G40), S51 (≠ D55), I52 (≠ M56), L73 (≠ F76), A74 (= A77), A75 (= A78), T92 (≠ E93), S115 (≠ T116), S116 (= S117), Y143 (= Y142), K147 (= K146), Y170 (≠ F169), V173 (≠ I172)
- binding uridine-5'-diphosphate-glucose: T117 (≠ S118), G119 (vs. gap), A120 (≠ T120), Y143 (= Y142), N172 (= N171), G185 (≠ N180), V186 (= V181), H201 (≠ E197), F203 (≠ L199), Y208 (≠ Q204), R210 (≠ K206), V244 (= V242), R267 (≠ D265), D270 (= D271)
6dntA Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
28% identity, 99% coverage: 3:308/309 of query aligns to 1:310/310 of 6dntA
- active site: S120 (= S118), S121 (= S119), A122 (≠ T120), Y144 (= Y142), K148 (= K146), A187 (vs. gap)
- binding (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid: A80 (≠ T80), S120 (= S118), S121 (= S119), Y144 (= Y142), F172 (≠ A170), N173 (= N171), A187 (vs. gap), V188 (= V181), K191 (≠ D184), V203 (≠ E197), I204 (= I198), Y205 (≠ L199), Q210 (= Q204), R212 (≠ K206), I246 (≠ V242), R269 (= R266), D272 (= D271)
- binding nicotinamide-adenine-dinucleotide: G10 (= G12), G13 (= G15), F14 (≠ L16), I15 (≠ V17), D33 (= D35), N34 (≠ D36), L35 (≠ C37), S36 (= S38), S37 (≠ K39), G38 (= G40), D57 (= D55), L58 (≠ M56), L76 (≠ F76), A77 (= A77), A78 (= A78), A80 (≠ T80), S118 (≠ T116), S119 (= S117), Y144 (= Y142), K148 (= K146), Y171 (≠ F169), V174 (≠ I172)
- binding zinc ion: E209 (≠ R203), H275 (≠ K274)
Q9LPG6 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2; NDP-rhamnose synthase; Protein MUCILAGE-MODIFIED 4; Protein RHAMNOSE BIOSYNTHESIS 2; Rhamnose biosynthetic enzyme 2; AtRHM2; UDP-L-rhamnose synthase MUM4; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
31% identity, 95% coverage: 6:299/309 of query aligns to 9:316/667 of Q9LPG6
- G18 (= G15) mutation to A: Abolishes dehydratase activity.
- K36 (≠ E30) mutation to A: Reduces dehydratase activity.
- D96 (= D81) mutation to N: In mum4-1; no extruded mucilage and seed coat defects. Abolishes dehydratase activity.
- K165 (= K146) mutation to A: Abolishes dehydratase activity.
- G193 (= G174) mutation to R: In mum4-2; no extruded mucilage and seed coat defects. Abolishes dehydratase activity.
Sites not aligning to the query:
- 392 G→A: No effect on dehydratase activity.
- 413 K→A: No effect on dehydratase activity.
- 518 K→A: No effect on dehydratase activity.
Q9SYM5 Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1; Protein REPRESSOR OF LRX1 1; Rhamnose biosynthetic enzyme 1; AtRHM1; EC 4.2.1.76; EC 1.1.1.-; EC 5.1.3.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
31% identity, 96% coverage: 4:299/309 of query aligns to 5:314/669 of Q9SYM5
- R283 (≠ G267) mutation to K: In rol1-2; Abolishes dehydratase activity in vitro (PubMed:16766693). Induces aberrant accumulation of flavonols leading to alterations in plant growth and cell shape formation (PubMed:18567791, PubMed:18757557).
2p5uA Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
33% identity, 94% coverage: 7:298/309 of query aligns to 2:301/311 of 2p5uA
- active site: T117 (≠ S118), G119 (vs. gap), A120 (≠ T120), Y143 (= Y142), K147 (= K146), H181 (vs. gap), G185 (≠ N180)
- binding nicotinamide-adenine-dinucleotide: G10 (= G15), F11 (≠ L16), I12 (≠ V17), D31 (= D35), N32 (≠ D36), L33 (≠ C37), A34 (≠ S38), T35 (≠ K39), G36 (= G40), D51 (= D55), L52 (≠ M56), Q73 (≠ F76), A74 (= A77), A75 (= A78), A77 (≠ T80), S116 (= S117), Y143 (= Y142), K147 (= K146), V173 (≠ I172)
6bwlA X-ray structure of pal from bacillus thuringiensis (see paper)
28% identity, 95% coverage: 7:299/309 of query aligns to 2:304/313 of 6bwlA
- active site: T122 (≠ S118), C123 (≠ S119), M124 (≠ T120), Y147 (= Y142), K151 (= K146)
- binding nicotinamide-adenine-dinucleotide: G7 (= G12), G10 (= G15), F11 (≠ L16), I12 (≠ V17), D31 (= D35), N32 (≠ D36), L33 (≠ C37), N35 (≠ K39), S36 (≠ G40), D57 (= D55), I58 (≠ M56), L79 (≠ F76), A80 (= A77), A81 (= A78), I83 (≠ T80), M120 (≠ T116), K151 (= K146), N176 (= N171), T177 (≠ I172)
- binding uridine-5'-diphosphate: N176 (= N171), G189 (≠ N180), V190 (= V181), N205 (≠ E197), I206 (= I198), Y207 (≠ L199), Q212 (= Q204), R214 (≠ K206), I250 (≠ V242), E275 (≠ D271)
8vr2B Crystal structure of the pcryo_0617 oxidoreductase/decarboxylase from psychrobacter cryohalolentis k5 in the presence of NAD and udp
26% identity, 97% coverage: 1:301/309 of query aligns to 3:308/321 of 8vr2B
- binding nicotinamide-adenine-dinucleotide: G14 (= G12), G17 (= G15), F18 (≠ L16), I19 (≠ V17), D37 (= D35), N38 (≠ D36), E40 (≠ S38), R41 (≠ K39), N61 (≠ D55), V62 (≠ M56), A81 (≠ F76), A82 (= A77), A83 (= A78), F124 (≠ T116), K154 (= K146), P177 (≠ F169), N179 (= N171)
- binding uridine-5'-diphosphate: R147 (≠ I139), G189 (≠ V181), A190 (≠ V182), M194 (≠ I186), Y205 (≠ E197), I206 (= I198), F207 (≠ L199), R214 (≠ K206), I251 (≠ V242)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac (see paper)
30% identity, 78% coverage: 6:245/309 of query aligns to 1:250/307 of 6wjaA
- active site: A118 (≠ S118), A119 (≠ S119), A120 (≠ T120), F143 (≠ Y142), K147 (= K146)
- binding nicotinamide-adenine-dinucleotide: G7 (= G12), G10 (= G15), F11 (≠ L16), I12 (≠ V17), D31 (= D35), D32 (= D36), S34 (= S38), T35 (≠ K39), G36 (= G40), A55 (≠ T57), L74 (≠ F76), A75 (= A77), A76 (= A78), S93 (≠ E93), F143 (≠ Y142), K147 (= K146), F170 (= F169), F171 (≠ A170), I173 (= I172)
- binding uridine-diphosphate-n-acetylgalactosamine: V80 (≠ T82), A120 (≠ T120), N172 (= N171), G186 (≠ N180), V187 (= V181), F191 (= F185), T202 (≠ E197), F204 (≠ L199), R211 (≠ K206), L247 (≠ V242)
Sites not aligning to the query:
6wj9B Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
30% identity, 78% coverage: 6:245/309 of query aligns to 2:251/308 of 6wj9B
- active site: A119 (≠ S118), A120 (≠ S119), A121 (≠ T120), F144 (≠ Y142), K148 (= K146)
- binding nicotinamide-adenine-dinucleotide: G8 (= G12), G11 (= G15), F12 (≠ L16), I13 (≠ V17), D32 (= D35), D33 (= D36), S35 (= S38), T36 (≠ K39), G37 (= G40), D55 (≠ M56), A56 (≠ T57), L75 (≠ F76), A76 (= A77), A77 (= A78), S94 (≠ E93), A117 (≠ T116), A119 (≠ S118), F144 (≠ Y142), K148 (= K146), F171 (= F169), F172 (≠ A170), I174 (= I172)
- binding uridine-diphosphate-n-acetylglucosamine: V81 (≠ T82), N173 (= N171), G187 (≠ N180), V188 (= V181), F192 (= F185), T203 (≠ E197), L204 (≠ I198), F205 (≠ L199), R212 (≠ K206), L248 (≠ V242)
Sites not aligning to the query:
2c20A Crystal structure of udp-glucose 4-epimerase
28% identity, 78% coverage: 8:249/309 of query aligns to 3:266/329 of 2c20A
- active site: T117 (≠ S118), A118 (≠ S119), A119 (≠ T120), Y141 (= Y142), K145 (= K146), H184 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: G7 (= G12), G10 (= G15), Y11 (≠ L16), I12 (≠ V17), D31 (= D35), N32 (≠ D36), Q34 (≠ S38), T35 (≠ K39), G36 (= G40), D51 (= D55), L52 (≠ M56), F73 (= F76), A74 (= A77), A75 (= A78), N92 (≠ E93), Y141 (= Y142), K145 (= K146), Y168 (≠ F169), F169 (≠ A170), V171 (≠ I172), H184 (vs. gap)
- binding zinc ion: E182 (vs. gap), H184 (vs. gap), E187 (vs. gap), H189 (≠ N180)
2b69A Crystal structure of human udp-glucoronic acid decarboxylase
29% identity, 98% coverage: 6:308/309 of query aligns to 2:308/312 of 2b69A
- active site: T115 (≠ S118), S116 (= S119), E117 (≠ T120), Y144 (= Y142), K148 (= K146), R185 (≠ N180)
- binding nicotinamide-adenine-dinucleotide: G8 (= G12), G11 (= G15), F12 (≠ L16), V13 (= V17), D32 (= D35), N33 (≠ D36), T36 (≠ K39), G37 (= G40), D57 (= D61), V58 (= V62), L72 (≠ F76), A73 (= A77), S74 (≠ A78), A76 (≠ Y79), T91 (≠ E93), T115 (≠ S118), Y144 (= Y142), K148 (= K146), I171 (≠ F169), N173 (= N171), R185 (≠ N180)
- binding uridine-5'-diphosphate: P61 (≠ A65), L62 (≠ I66), Y63 (≠ T67), P78 (≠ D81), N98 (= N100), G101 (≠ E103), L102 (≠ R104), K104 (≠ D106), R105 (≠ E107), Y158 (= Y156), N173 (= N171), R185 (≠ N180), V186 (= V181), N189 (≠ D184), T201 (≠ E197), Y203 (≠ L199), Q208 (= Q204), R210 (≠ K206), I244 (≠ V242), D270 (≠ V272)
Q8NBZ7 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1; EC 4.1.1.35 from Homo sapiens (Human) (see 4 papers)
29% identity, 98% coverage: 6:308/309 of query aligns to 89:395/420 of Q8NBZ7