SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_007707081.1 NCBI__GCF_001277175.1:WP_007707081.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
35% identity, 99% coverage: 1:217/219 of query aligns to 1:215/215 of 4ymtC

query
sites
4ymtC
M
 
M
E
 
T
F
 
V
D
 
D
W
 
F
S
 
L
V
 
S
I
 
M
W
 
V
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K
A
 
Y
I
 
T
P
 
P
I
 
L
L
 
F
L
 
I
D
 
S
G
 
G
A
 
L
K
 
I
M
 
M
T
 
T
L
 
L
W
 
K
I
 
L
S
 
T
I
 
F
L
 
L
G
 
A
L
 
V
A
 
T
G
 
I
G
 
G
I
 
V
V
 
L
I
 
M
G
 
G
L
 
L
L
 
F
A
 
I
G
 
A
L
 
L
A
 
M
R
 
K
S
 
M
Y
 
S
G
 
S
G
 
I
W
 
K
I
 
P
S
 
I
N
 
K
H
 
L
I
 
V
A
 
A
L
 
S
V
 
S
F
 
Y
I
 
I
E
 
E
V
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
|
P
I
x
L
V
 
L
V
 
V
Q
 
Q
V
 
L
M
 
L
Y
 
L
I
 
I
Y
 
Y
F
 
N
A
 
G
L
 
L
P
 
-
M
 
M
A
 
Q
F
 
F
P
 
-
D
 
G
I
 
M
R
 
N
I
 
I
D
 
P
T
 
A
F
 
F
T
 
T
A
 
A
A
 
G
V
 
V
I
 
S
T
 
A
I
 
L
M
 
A
I
 
I
N
|
N
S
 
S
G
 
S
A
 
A
Y
|
Y
I
 
V
A
 
A
E
 
E
I
 
I
T
 
I
R
 
R
G
 
A
S
 
G
V
 
I
L
 
Q
S
 
A
I
 
V
H
 
D
K
 
P
G
 
G
F
 
Q
S
 
N
E
 
E
A
 
A
G
 
A
L
 
R
A
 
S
L
 
L
G
 
G
L
 
M
S
 
T
R
 
H
R
 
A
E
 
M
T
 
A
I
 
M
R
 
R
H
 
Y
V
 
V
I
 
I
M
 
I
P
 
P
L
 
Q
A
 
A
L
 
I
R
 
K
R
 
N
M
 
I
L
 
L
P
 
P
A
 
A
L
 
L
G
 
G
N
 
N
Q
x
E
L
 
F
I
 
I
I
 
V
S
x
M
I
 
L
K
|
K
D
x
E
T
 
S
S
 
A
L
 
I
F
 
V
I
 
S
V
 
V
I
 
I
G
 
G
A
 
F
A
 
A
E
 
D
L
 
L
T
 
T
R
 
R
S
 
Q
G
 
A
Q
 
D
E
 
I
I
 
I
I
 
Q
A
 
S
G
 
V
N
 
T
F
 
Y
R
 
R
A
 
Y
L
 
F
E
 
E
I
 
P
W
 
Y
T
 
I
A
 
I
V
 
I
G
 
A
V
 
A
I
 
I
Y
 
Y
L
 
F
I
 
V
I
 
M
T
 
T
Q
 
L
V
 
T
L
 
F
N
 
S
I
 
K
V
 
L
L
 
L
R
 
S
I
 
L
L
 
F
E
 
E
R
 
R
R
 
R
M
 
L
K
 
R

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
36% identity, 99% coverage: 1:216/219 of query aligns to 1:214/214 of 4ymwC

query
sites
4ymwC
M
 
M
E
 
T
F
 
V
D
 
D
W
 
F
S
 
L
V
 
S
I
 
M
W
 
V
P
 
K
A
 
Y
I
 
T
P
 
P
I
 
L
L
 
F
L
 
I
D
 
S
G
 
G
A
 
L
K
 
I
M
 
M
T
 
T
L
 
L
W
 
K
I
 
L
S
 
T
I
 
F
L
 
L
G
 
A
L
 
V
A
 
T
G
 
I
G
 
G
I
 
V
V
 
L
I
 
M
G
 
G
L
 
L
L
 
F
A
 
I
G
 
A
L
 
L
A
 
M
R
 
K
S
 
M
Y
 
S
G
 
S
G
 
I
W
 
K
I
 
P
S
 
I
N
 
K
H
 
L
I
 
V
A
 
A
L
 
S
V
 
S
F
 
Y
I
 
I
E
 
E
V
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
 
P
I
 
L
V
 
L
V
 
V
Q
 
Q
V
 
L
M
 
L
Y
 
L
I
 
I
Y
 
Y
F
 
N
A
 
G
L
 
L
P
 
-
M
 
M
A
 
Q
F
 
F
P
 
-
D
 
G
I
 
M
R
 
N
I
 
I
D
 
P
T
 
A
F
 
F
T
 
T
A
 
A
A
 
G
V
 
V
I
 
S
T
 
A
I
 
L
M
 
A
I
 
I
N
|
N
S
 
S
G
 
S
A
 
A
Y
|
Y
I
 
V
A
 
A
E
 
E
I
 
I
T
 
I
R
 
R
G
 
A
S
 
G
V
 
I
L
 
Q
S
 
A
I
 
V
H
 
D
K
 
P
G
 
G
F
 
Q
S
 
N
E
 
E
A
 
A
G
 
A
L
 
R
A
 
S
L
 
L
G
 
G
L
 
M
S
 
T
R
 
H
R
 
A
E
 
M
T
 
A
I
 
M
R
 
R
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Y
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V
I
 
I
M
 
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L
 
Q
A
 
A
L
 
I
R
 
K
R
 
N
M
 
I
L
 
L
P
 
P
A
 
A
L
 
L
G
 
G
N
 
N
Q
x
E
L
 
F
I
 
I
I
 
V
S
 
M
I
 
L
K
 
K
D
x
E
T
 
S
S
 
A
L
 
I
F
 
V
I
 
S
V
 
V
I
 
I
G
 
G
A
 
F
A
 
A
E
 
D
L
 
L
T
 
T
R
 
R
S
 
Q
G
 
A
Q
 
D
E
 
I
I
 
I
I
 
Q
A
 
S
G
 
V
N
 
T
F
 
Y
R
 
R
A
 
Y
L
 
F
E
 
E
I
 
P
W
 
Y
T
 
I
A
 
I
V
 
I
G
 
A
V
 
A
I
 
I
Y
 
Y
L
 
F
I
 
V
I
 
M
T
 
T
Q
 
L
V
 
T
L
 
F
N
 
S
I
 
K
V
 
L
L
 
L
R
 
S
I
 
L
L
 
F
E
 
E
R
 
R
R
 
R
M
 
L

Query Sequence

>WP_007707081.1 NCBI__GCF_001277175.1:WP_007707081.1
MEFDWSVIWPAIPILLDGAKMTLWISILGLAGGIVIGLLAGLARSYGGWISNHIALVFIE
VIRGTPIVVQVMYIYFALPMAFPDIRIDTFTAAVITIMINSGAYIAEITRGSVLSIHKGF
SEAGLALGLSRRETIRHVIMPLALRRMLPALGNQLIISIKDTSLFIVIGAAELTRSGQEI
IAGNFRALEIWTAVGVIYLIITQVLNIVLRILERRMKIL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory