SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_008345541.1 NCBI__GCF_000691145.1:WP_008345541.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 8 hits to proteins with known functional sites (download)

Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Homo sapiens (Human) (see paper)
23% identity, 90% coverage: 5:118/127 of query aligns to 47:165/176 of Q96PE7

query
sites
Q96PE7
R
 
R
L
 
L
D
 
N
H
|
H
T
 
V
G
 
A
I
 
I
M
 
A
V
 
V
T
 
P
N
 
D
I
 
L
D
 
E
Q
 
K
S
 
A
I
 
A
D
 
A
F
 
F
Y
 
Y
E
 
K
K
 
N
V
 
I
V
 
L
G
 
G
M
 
A
K
 
Q
L
 
V
K
 
S
D
 
E
R
 
A
I
 
V
T
 
P
H
 
L
T
 
P
N
 
E
G
 
H
V
 
G
I
 
V
E
 
S
L
 
V
A
 
V
F
 
F
L
 
V
G
 
N
F
 
L
K
 
G
D
 
N
E
 
-
A
 
-
E
 
-
T
 
T
E
 
K
I
 
M
E
 
E
L
 
L
I
 
L
Q
 
H
G
 
P
Y
 
L
S
 
G
S
x
R
D
 
D
L
 
S
P
 
P
-
 
I
-
 
A
-
 
G
-
 
F
-
 
L
-
 
Q
-
 
K
-
 
N
S
 
K
E
 
A
G
 
G
K
 
G
V
 
M
H
 
H
H
|
H
L
 
I
A
 
C
F
 
I
T
 
E
T
 
V
D
 
D
N
 
N
I
 
I
H
 
N
A
 
A
E
 
A
F
 
V
N
 
M
R
 
D
I
 
L
Q
 
K
K
 
K
L
 
K
Q
 
K
I
 
I
E
 
R
L
 
S
I
 
L
D
 
S
E
 
E
E
 
E
I
 
V
T
 
K
T
 
I
L
 
G
P
 
A
N
 
H
G
 
G
Y
 
K
C
 
P
Y
 
V
F
 
I
F
 
F
F
 
L
R
 
H
G
 
P
P
 
K
D
 
D

Sites not aligning to the query:

4mttA Ni- and zn-bound gloa2 at low resolution (see paper)
25% identity, 98% coverage: 4:127/127 of query aligns to 1:126/128 of 4mttA

query
sites
4mttA
L
 
M
R
 
R
L
 
I
D
 
L
H
|
H
T
 
S
G
 
M
I
 
L
M
 
R
V
 
V
T
 
A
N
 
D
I
 
L
D
 
E
Q
 
A
S
 
A
I
 
L
D
 
E
F
 
F
Y
 
Y
E
 
T
K
 
R
V
 
A
V
 
L
G
 
D
M
 
M
K
 
R
L
 
L
K
 
L
D
 
R
R
 
R
I
 
R
T
 
D
H
 
Y
T
 
P
N
 
E
G
 
G
V
 
R
I
 
F
E
 
T
L
 
L
A
 
A
F
 
F
L
 
V
G
 
G
F
 
Y
K
 
Q
D
 
D
E
 
E
-
 
R
A
 
A
E
 
A
T
 
A
E
 
A
I
 
L
E
|
E
L
 
L
I
 
T
Q
 
H
G
 
N
Y
 
W
S
 
D
S
 
R
D
 
D
L
 
G
P
 
Y
S
 
T
E
 
Q
G
 
G
K
 
D
V
 
G
H
 
Y
-
 
G
H
|
H
L
 
L
A
 
A
F
 
I
T
 
E
T
 
V
D
 
E
N
 
D
I
 
A
H
 
A
A
 
V
E
 
T
F
 
C
N
 
A
R
 
R
I
 
A
Q
 
R
K
 
A
L
 
L
Q
 
G
I
 
Y
E
 
R
L
 
V
I
 
T
D
 
R
E
 
E
E
 
A
I
 
G
T
 
L
T
 
M
L
 
Q
P
 
H
N
 
G
G
 
R
Y
 
S
C
 
V
Y
 
I
F
 
A
F
 
F
F
 
L
R
 
E
G
 
D
P
 
P
D
 
D
Q
 
G
E
 
Y
W
 
K
I
 
V
E
|
E
F
 
L
F
 
I
Q
 
Q
R
 
K

1fa6A Crystal structure of the co(ii)-bound glyoxalase i of escherichia coli (see paper)
30% identity, 97% coverage: 4:126/127 of query aligns to 1:125/128 of 1fa6A

query
sites
1fa6A
L
 
M
R
 
R
L
 
L
D
 
L
H
|
H
T
 
T
G
 
M
I
 
L
M
 
R
V
 
V
T
 
G
N
 
D
I
 
L
D
 
Q
Q
 
R
S
 
S
I
 
I
D
 
D
F
 
F
Y
 
Y
E
 
T
K
 
K
V
 
V
V
 
L
G
 
G
M
 
M
K
 
K
L
 
L
K
 
L
D
 
R
R
 
T
I
 
S
T
 
E
H
 
N
T
 
P
N
 
E
G
 
Y
V
 
K
I
 
Y
E
 
S
L
 
L
A
 
A
F
 
F
L
 
V
G
 
G
F
 
Y
K
 
G
D
 
P
E
 
E
A
 
T
E
 
E
T
 
E
E
 
A
-
 
V
I
 
I
E
|
E
L
 
L
I
 
T
Q
 
Y
G
 
N
Y
 
W
S
 
G
S
 
V
D
 
D
L
 
K
P
 
Y
S
 
E
E
 
L
G
 
G
K
 
T
V
 
A
H
 
Y
-
 
G
H
|
H
L
 
I
A
 
A
F
 
L
T
 
S
T
 
V
D
 
D
N
 
N
I
 
A
H
 
A
A
 
E
E
 
A
F
 
C
N
 
E
R
 
K
I
 
I
Q
 
R
K
 
Q
L
 
N
Q
 
G
I
 
G
E
 
N
L
 
V
I
 
T
D
 
R
E
 
E
E
 
A
I
 
G
T
 
P
T
 
V
L
 
K
P
 
G
N
 
G
G
 
T
Y
 
T
C
 
V
Y
 
I
F
 
A
F
 
F
F
 
V
R
 
E
G
 
D
P
 
P
D
 
D
Q
 
G
E
 
Y
W
 
K
I
 
I
E
|
E
F
 
L
F
 
I
Q
 
E

1fa5A Crystal structure of the zn(ii)-bound glyoxalase i of escherichia coli (see paper)
30% identity, 97% coverage: 4:126/127 of query aligns to 1:125/128 of 1fa5A

query
sites
1fa5A
L
 
M
R
 
R
L
 
L
D
 
L
H
|
H
T
 
T
G
 
M
I
 
L
M
 
R
V
 
V
T
 
G
N
 
D
I
 
L
D
 
Q
Q
 
R
S
 
S
I
 
I
D
 
D
F
 
F
Y
 
Y
E
 
T
K
 
K
V
 
V
V
 
L
G
 
G
M
 
M
K
 
K
L
 
L
K
 
L
D
 
R
R
 
T
I
 
S
T
 
E
H
 
N
T
 
P
N
 
E
G
 
Y
V
 
K
I
 
Y
E
 
S
L
 
L
A
 
A
F
 
F
L
 
V
G
 
G
F
 
Y
K
 
G
D
 
P
E
 
E
A
 
T
E
 
E
T
 
E
E
 
A
-
 
V
I
 
I
E
|
E
L
 
L
I
 
T
Q
 
Y
G
 
N
Y
 
W
S
 
G
S
 
V
D
 
D
L
 
K
P
 
Y
S
 
E
E
 
L
G
 
G
K
 
T
V
 
A
H
 
Y
-
 
G
H
|
H
L
 
I
A
 
A
F
 
L
T
 
S
T
 
V
D
 
D
N
 
N
I
 
A
H
 
A
A
 
E
E
 
A
F
 
C
N
 
E
R
 
K
I
 
I
Q
 
R
K
 
Q
L
 
N
Q
 
G
I
 
G
E
 
N
L
 
V
I
 
T
D
 
R
E
 
E
E
 
A
I
 
G
T
 
P
T
 
V
L
 
K
P
 
G
N
 
G
G
 
T
Y
 
T
C
 
V
Y
 
I
F
 
A
F
 
F
F
 
V
R
 
E
G
 
D
P
 
P
D
 
D
Q
 
G
E
 
Y
W
 
K
I
 
I
E
|
E
F
 
L
F
 
I
Q
 
E

P0AC81 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Escherichia coli (strain K12) (see paper)
30% identity, 97% coverage: 4:126/127 of query aligns to 1:125/135 of P0AC81

query
sites
P0AC81
L
 
M
R
 
R
L
 
L
D
 
L
H
|
H
T
 
T
G
 
M
I
 
L
M
 
R
V
 
V
T
 
G
N
 
D
I
 
L
D
 
Q
Q
 
R
S
 
S
I
 
I
D
 
D
F
 
F
Y
 
Y
E
 
T
K
 
K
V
 
V
V
 
L
G
 
G
M
 
M
K
 
K
L
 
L
K
 
L
D
 
R
R
 
T
I
 
S
T
 
E
H
 
N
T
 
P
N
 
E
G
 
Y
V
 
K
I
 
Y
E
 
S
L
 
L
A
 
A
F
 
F
L
 
V
G
 
G
F
 
Y
K
 
G
D
 
P
E
 
E
A
 
T
E
 
E
T
 
E
E
 
A
-
 
V
I
 
I
E
|
E
L
 
L
I
 
T
Q
 
Y
G
 
N
Y
 
W
S
 
G
S
 
V
D
 
D
L
 
K
P
 
Y
S
 
E
E
 
L
G
 
G
K
 
T
V
 
A
H
 
Y
-
 
G
H
|
H
L
 
I
A
 
A
F
 
L
T
 
S
T
 
V
D
 
D
N
 
N
I
 
A
H
 
A
A
 
E
E
 
A
F
 
C
N
 
E
R
 
K
I
 
I
Q
 
R
K
 
Q
L
 
N
Q
 
G
I
 
G
E
 
N
L
 
V
I
 
T
D
 
R
E
 
E
E
 
A
I
 
G
T
 
P
T
 
V
L
 
K
P
 
G
N
 
G
G
 
T
Y
 
T
C
 
V
Y
 
I
F
 
A
F
 
F
F
 
V
R
 
E
G
 
D
P
 
P
D
 
D
Q
 
G
E
 
Y
W
 
K
I
 
I
E
|
E
F
 
L
F
 
I
Q
 
E

3oa4A Crystal structure of hypothetical protein bh1468 from bacillus halodurans c-125
26% identity, 87% coverage: 5:114/127 of query aligns to 4:117/138 of 3oa4A

query
sites
3oa4A
R
 
K
L
 
L
D
 
D
H
|
H
T
 
I
G
 
G
I
 
I
M
 
A
V
 
V
T
 
T
N
 
S
I
 
I
D
 
K
Q
 
D
S
 
V
I
 
L
D
 
P
F
 
F
Y
 
Y
E
 
V
K
 
G
V
 
S
V
 
L
G
 
K
M
 
L
K
 
K
L
 
L
K
 
L
D
 
G
R
 
M
I
 
E
T
 
D
H
 
L
T
 
P
N
 
S
G
 
Q
V
 
G
I
 
V
E
 
K
L
x
I
A
 
A
F
 
F
L
 
L
G
 
-
F
 
-
K
 
-
D
 
E
E
 
I
A
 
G
E
 
E
T
 
S
E
 
K
I
 
I
E
|
E
L
 
L
I
 
L
Q
 
E
G
 
P
Y
 
L
S
 
S
S
 
E
D
 
E
L
 
S
P
 
P
-
 
I
-
 
A
-
 
K
-
 
F
-
 
I
-
 
Q
-
 
K
-
 
R
S
 
G
E
 
E
G
 
G
K
 
-
V
 
I
H
 
H
H
|
H
L
 
I
A
 
A
F
 
I
T
 
G
T
 
V
D
 
K
N
 
S
I
 
I
H
 
E
A
 
E
E
 
R
F
 
I
N
 
Q
R
 
E
I
 
V
Q
 
K
K
 
E
L
 
N
Q
 
G
I
 
V
E
 
Q
L
 
M
I
 
I
D
 
N
E
 
D
E
 
E
I
 
P
T
 
V
T
 
P
L
 
G
P
 
A
N
 
R
G
 
G
Y
 
A
C
 
Q
Y
 
V
F
 
A
F
 
F
F
 
L

Sites not aligning to the query:

6qh4C Crystal structure of human methylmalonyl-coa epimerase (mcee) p.Arg143cys variant
23% identity, 72% coverage: 5:95/127 of query aligns to 11:106/138 of 6qh4C

query
sites
6qh4C
R
 
R
L
 
L
D
 
N
H
|
H
T
 
V
G
 
A
I
 
I
M
 
A
V
 
V
T
 
P
N
 
D
I
 
L
D
 
E
Q
 
K
S
 
A
I
 
A
D
 
A
F
 
F
Y
 
Y
E
 
K
K
 
N
V
 
I
V
 
L
G
 
G
M
 
A
K
 
Q
L
 
V
K
 
S
D
 
E
R
 
A
I
 
V
T
 
P
H
 
L
T
 
P
N
 
E
G
 
H
V
 
G
I
 
V
E
 
S
L
x
V
A
 
V
F
 
F
L
 
V
G
 
N
F
 
L
K
 
G
D
 
N
E
 
-
A
 
-
E
 
-
T
 
T
E
 
K
I
 
M
E
|
E
L
 
L
I
 
L
Q
 
H
G
 
P
Y
 
L
S
 
G
S
 
L
D
 
D
L
 
S
P
 
P
-
 
I
-
 
A
-
 
G
-
 
F
-
 
L
-
 
Q
-
 
K
-
 
N
S
 
K
E
 
A
G
 
G
K
 
G
V
 
M
H
 
H
H
|
H
L
 
I
A
 
C
F
 
I
T
 
E
T
 
V
D
 
D
N
 
N
I
 
I
H
 
N
A
 
A
E
 
A
F
 
V
N
 
M
R
 
D
I
 
L
Q
 
K
K
 
K
L
 
K
Q
 
K
I
 
I

Sites not aligning to the query:

Q948T6 Lactoylglutathione lyase; Aldoketomutase; Allergen Glb33; Glyoxalase I; Glx I; Glyoxylase I 11; OsGLYI-11; OsGLYI11; Ketone-aldehyde mutase; Methylglyoxalase; PP33; S-D-lactoylglutathione methylglyoxal lyase; Allergen Ory s Glyoxalase I; EC 4.4.1.5 from Oryza sativa subsp. japonica (Rice) (see paper)
30% identity, 69% coverage: 11:97/127 of query aligns to 161:249/291 of Q948T6

query
sites
Q948T6
I
 
L
M
 
R
V
 
V
T
 
G
N
 
D
I
 
L
D
 
D
Q
 
R
S
 
S
I
 
I
D
 
K
F
 
F
Y
 
Y
E
 
E
K
 
K
V
 
A
V
 
L
G
 
G
M
 
M
K
 
K
L
 
L
K
 
L
D
 
R
R
 
K
I
 
K
T
 
D
H
 
V
T
 
P
N
 
D
G
 
Y
V
 
K
I
 
Y
E
 
T
L
 
I
A
 
A
F
 
M
L
 
L
G
 
G
F
 
Y
K
 
A
D
 
D
E
 
E
A
 
D
E
 
K
T
 
T
E
 
T
-
 
V
I
 
I
E
|
E
L
 
L
I
 
T
Q
 
Y
G
 
N
Y
 
Y
S
 
G
S
 
V
D
 
T
L
 
E
P
 
Y
S
 
T
E
 
K
G
 
G
K
 
N
V
 
A
H
 
Y
-
 
A
H
 
Q
L
 
V
A
 
A
F
 
I
T
 
G
T
 
T
D
 
E
N
 
D
I
 
V
H
 
Y
A
 
K
E
 
S
F
 
A
N
 
E
R
 
A
I
 
V
Q
 
E
K
 
L
L
 
V
Q
 
T
I
 
K
E
 
E
L
 
L

Sites not aligning to the query:

Query Sequence

>WP_008345541.1 NCBI__GCF_000691145.1:WP_008345541.1
MTTLRLDHTGIMVTNIDQSIDFYEKVVGMKLKDRITHTNGVIELAFLGFKDEAETEIELI
QGYSSDLPSEGKVHHLAFTTDNIHAEFNRIQKLQIELIDEEITTLPNGYCYFFFRGPDQE
WIEFFQR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory