SitesBLAST
Comparing WP_008498617.1 NCBI__GCF_000342445.1:WP_008498617.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9RW55 Proline dehydrogenase; PRODH; DrPRODH; Proline oxidase; EC 1.5.5.2 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
42% identity, 92% coverage: 22:300/302 of query aligns to 26:308/310 of Q9RW55
- G63 (= G62) mutation to A: 140-fold decrease in catalytic efficiency for proline.
- E64 (= E63) mutation to A: 27-fold decrease in catalytic efficiency for proline.
- K98 (= K97) binding substrate
- M136 (= M132) binding FAD
- Q166 (= Q160) binding FAD
- RMVKGA 187:192 (≠ RLVKGA 179:184) binding FAD
- TH 229:230 (= TH 221:222) binding FAD
- RR 291:292 (= RR 283:284) binding substrate
- RIAE 292:295 (≠ RLAE 284:287) binding FAD
4h6qA Structure of oxidized deinococcus radiodurans proline dehydrogenase complexed with l-tetrahydrofuroic acid (see paper)
43% identity, 89% coverage: 22:289/302 of query aligns to 10:281/281 of 4h6qA
- binding flavin-adenine dinucleotide: D119 (= D131), M120 (= M132), Q150 (= Q160), R171 (= R179), V173 (= V181), K174 (= K182), G175 (= G183), A176 (= A184), A212 (= A220), T213 (= T221), H214 (= H222), M240 (= M248), L241 (= L249), I244 (≠ F252), R276 (= R284), E279 (= E287), P281 (= P289)
- binding tetrahydrofuran-2-carboxylic acid: K82 (= K97), Y262 (= Y270), R275 (= R283), R276 (= R284)
4h6rA Structure of reduced deinococcus radiodurans proline dehydrogenase (see paper)
43% identity, 89% coverage: 22:289/302 of query aligns to 1:272/272 of 4h6rA
- binding dihydroflavine-adenine dinucleotide: D110 (= D131), M111 (= M132), V139 (= V158), Q141 (= Q160), R162 (= R179), V164 (= V181), K165 (= K182), G166 (= G183), A167 (= A184), A203 (= A220), T204 (= T221), H205 (= H222), Q230 (= Q247), L232 (= L249), I235 (≠ F252), Y253 (= Y270), R267 (= R284), E270 (= E287), P272 (= P289)
Q72IB8 Proline dehydrogenase; PRODH; Proline oxidase; TtPRODH; EC 1.5.5.2 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
43% identity, 86% coverage: 32:291/302 of query aligns to 34:296/307 of Q72IB8
2g37B Structure of thermus thermophilus l-proline dehydrogenase (see paper)
43% identity, 85% coverage: 32:289/302 of query aligns to 40:300/300 of 2g37B
- binding flavin-adenine dinucleotide: D139 (= D131), M140 (= M132), V167 (= V158), R190 (= R179), V192 (= V181), K193 (= K182), G194 (= G183), A195 (= A184), A231 (= A220), T232 (= T221), H233 (= H222), D234 (= D223), L260 (= L249), V263 (≠ F252), Y281 (= Y270)
5m42A Structure of thermus thermophilus l-proline dehydrogenase lacking alpha helices a, b and c (see paper)
43% identity, 77% coverage: 43:274/302 of query aligns to 8:242/242 of 5m42A
- binding flavin mononucleotide: D96 (= D131), M97 (= M132), V124 (= V158), Q126 (= Q160), R147 (= R179), V149 (= V181), K150 (= K182), G151 (= G183), A152 (= A184), A188 (= A220), T189 (= T221), H190 (= H222), L217 (= L249)
7na0A Structure of geobacter sulfurreducens proline utilization a (puta) variant a206w (see paper)
26% identity, 89% coverage: 30:298/302 of query aligns to 98:418/981 of 7na0A
- binding flavin-adenine dinucleotide: D226 (= D131), M227 (= M132), V256 (= V158), Q258 (= Q160), R285 (= R179), V287 (= V181), K288 (= K182), G289 (= G183), A290 (= A184), Y291 (= Y185), W292 (≠ K186), W309 (vs. gap), T310 (vs. gap), I311 (vs. gap), K312 (= K196), S315 (≠ V199), A338 (≠ H222), S339 (≠ D223), H340 (= H224), N341 (≠ H225), L367 (= L249), Y388 (= Y270), E407 (= E287), S413 (≠ N293), F414 (≠ L294)
4nmdA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca reduced with dithionite (see paper)
26% identity, 89% coverage: 30:298/302 of query aligns to 98:418/979 of 4nmdA
- binding dihydroflavine-adenine dinucleotide: D226 (= D131), M227 (= M132), V256 (= V158), Q258 (= Q160), R285 (= R179), V287 (= V181), K288 (= K182), G289 (= G183), A290 (= A184), W292 (≠ K186), W309 (vs. gap), T310 (vs. gap), I311 (vs. gap), K312 (= K196), S315 (≠ V199), A338 (≠ H222), S339 (≠ D223), H340 (= H224), N341 (≠ H225), Q365 (= Q247), V366 (≠ M248), L367 (= L249), Y388 (= Y270), F414 (≠ L294)
Sites not aligning to the query:
4nmfB Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine and complexed with menadione bisulfite (see paper)
26% identity, 89% coverage: 30:298/302 of query aligns to 97:417/979 of 4nmfB
- binding (2R)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K184 (vs. gap), Y290 (= Y185), Y387 (= Y270), Y399 (= Y280), R402 (= R283), R403 (= R284)
- binding (2S)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K184 (vs. gap), L366 (= L249), Y399 (= Y280), R402 (= R283)
- binding N-propargylglycine-modified flavin adenine dinucleotide: K184 (vs. gap), D225 (= D131), M226 (= M132), V255 (= V158), Q257 (= Q160), R284 (= R179), V286 (= V181), K287 (= K182), G288 (= G183), A289 (= A184), W291 (≠ K186), W308 (vs. gap), T309 (vs. gap), I310 (vs. gap), K311 (= K196), S314 (≠ V199), A337 (≠ H222), S338 (≠ D223), H339 (= H224), N340 (≠ H225), Q364 (= Q247), L366 (= L249), Y387 (= Y270), E406 (= E287), E411 (≠ I292), S412 (≠ N293), F413 (≠ L294)
Sites not aligning to the query:
4nmaA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca in complex with l-tetrahydro-2-furoic acid (see paper)
26% identity, 89% coverage: 30:298/302 of query aligns to 98:418/977 of 4nmaA
- binding flavin-adenine dinucleotide: D226 (= D131), M227 (= M132), Q258 (= Q160), R285 (= R179), V287 (= V181), K288 (= K182), G289 (= G183), A290 (= A184), Y291 (= Y185), W292 (≠ K186), W309 (vs. gap), T310 (vs. gap), I311 (vs. gap), K312 (= K196), S315 (≠ V199), A338 (≠ H222), S339 (≠ D223), H340 (= H224), N341 (≠ H225), Q365 (= Q247), L367 (= L249), E407 (= E287), S413 (≠ N293), F414 (≠ L294)
- binding tetrahydrofuran-2-carboxylic acid: K185 (vs. gap), Y388 (= Y270), Y400 (= Y280), R403 (= R283), R404 (= R284)
Sites not aligning to the query:
4nmfA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine and complexed with menadione bisulfite (see paper)
26% identity, 89% coverage: 30:298/302 of query aligns to 94:414/973 of 4nmfA
- binding (2R)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K181 (vs. gap), Y287 (= Y185), Y384 (= Y270), Y396 (= Y280), R399 (= R283), R400 (= R284)
- binding N-propargylglycine-modified flavin adenine dinucleotide: K181 (vs. gap), D222 (= D131), M223 (= M132), V252 (= V158), Q254 (= Q160), R281 (= R179), V283 (= V181), K284 (= K182), G285 (= G183), A286 (= A184), W288 (≠ K186), W305 (vs. gap), T306 (vs. gap), I307 (vs. gap), K308 (= K196), S311 (≠ V199), A334 (≠ H222), S335 (≠ D223), H336 (= H224), N337 (≠ H225), Q361 (= Q247), V362 (≠ M248), L363 (= L249), Y384 (= Y270), E403 (= E287), E408 (≠ I292), F410 (≠ L294)
Sites not aligning to the query:
5ur2B Crystal structure of proline utilization a (puta) from bdellovibrio bacteriovorus inactivated by n-propargylglycine (see paper)
28% identity, 87% coverage: 28:291/302 of query aligns to 87:402/959 of 5ur2B
- binding N-propargylglycine-modified flavin adenine dinucleotide: K174 (≠ H93), D215 (= D131), M216 (= M132), Q249 (= Q160), V278 (= V181), K279 (= K182), G280 (= G183), A281 (= A184), W283 (≠ K186), Y300 (≠ F193), T301 (≠ Q194), N302 (≠ E195), K303 (= K196), S306 (≠ V199), A329 (= A220), S330 (≠ T221), H331 (= H222), N332 (≠ D223), Q356 (= Q247), M357 (= M248), L358 (= L249), Y379 (= Y270), E398 (= E287)
Sites not aligning to the query:
4nmcA Crystal structure of oxidized proline utilization a (puta) from geobacter sulfurreducens pca complexed with zwittergent 3-12 (see paper)
27% identity, 86% coverage: 30:289/302 of query aligns to 87:397/941 of 4nmcA
- binding flavin-adenine dinucleotide: D215 (= D131), M216 (= M132), V245 (= V158), Q247 (= Q160), R274 (= R179), V276 (= V181), K277 (= K182), G278 (= G183), A279 (= A184), W281 (≠ K186), W298 (vs. gap), T299 (vs. gap), I300 (vs. gap), K301 (= K196), S304 (≠ V199), A327 (≠ H222), S328 (≠ D223), H329 (= H224), N330 (≠ H225), L356 (= L249), Y377 (= Y270)
Sites not aligning to the query:
4nmeA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine (see paper)
26% identity, 89% coverage: 30:298/302 of query aligns to 96:413/972 of 4nmeA
- binding N-propargylglycine-modified flavin adenine dinucleotide: K183 (vs. gap), D224 (= D131), M225 (= M132), V254 (= V158), Q256 (= Q160), R283 (= R179), V285 (= V181), K286 (= K182), G287 (= G183), A288 (= A184), W290 (≠ K186), W307 (vs. gap), T308 (vs. gap), I309 (vs. gap), K310 (= K196), S313 (≠ V199), A336 (≠ H222), S337 (≠ D223), H338 (= H224), N339 (≠ H225), Q363 (= Q247), L365 (= L249), Y383 (= Y270), E402 (= E287), F409 (≠ L294)
Sites not aligning to the query:
7sqnA Structure of the e. Coli puta proline dehydrogenase domain (residues 86-630) complexed with (2s)-oxetane-2-carboxylic acid (see paper)
27% identity, 94% coverage: 14:297/302 of query aligns to 133:462/503 of 7sqnA