SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_008538998.1 NCBI__GCF_000245775.1:WP_008538998.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

P69797 PTS system mannose-specific EIIAB component; EIIAB-Man; EIII-Man; EC 2.7.1.191 from Escherichia coli (strain K12) (see 4 papers)
65% identity, 99% coverage: 1:157/158 of query aligns to 162:318/323 of P69797

query
sites
P69797
M
 
M
K
 
V
I
 
I
V
 
G
L
 
L
A
 
A
R
 
R
I
 
I
D
 
D
D
 
D
R
 
R
L
 
L
I
 
I
H
|
H
G
 
G
Q
 
Q
V
 
V
A
 
A
T
 
T
V
 
R
W
 
W
A
 
T
K
 
K
V
 
E
T
 
T
G
 
N
C
 
V
E
 
S
R
 
R
I
 
I
I
 
I
V
 
V
C
 
V
D
 
S
D
 
D
D
 
E
V
 
V
A
 
A
S
 
A
D
 
D
T
 
T
I
 
V
R
 
R
A
 
K
T
 
T
L
 
L
L
 
L
K
 
T
Q
 
Q
V
 
V
A
 
A
P
 
P
P
 
P
G
 
G
I
 
V
K
 
T
S
 
A
S
x
H
V
 
V
V
 
V
S
 
D
V
 
V
D
 
A
K
 
K
A
 
M
I
 
I
R
 
R
V
 
V
Y
 
Y
N
 
N
N
 
N
P
 
P
K
|
K
Y
 
Y
E
 
A
N
 
G
D
 
E
K
 
R
C
 
V
L
 
M
L
 
L
L
 
L
F
 
F
T
 
T
N
 
N
P
 
P
T
 
T
S
 
D
V
 
V
L
 
E
R
 
R
M
 
L
V
 
V
E
 
E
G
 
G
G
 
G
V
 
V
D
 
K
I
 
I
K
 
T
S
 
S
V
 
V
N
 
N
V
 
V
G
 
G
G
 
G
M
 
M
S
 
A
F
 
F
K
 
R
E
 
Q
G
 
G
K
 
K
R
 
T
Q
 
Q
I
 
V
T
 
N
N
 
N
A
 
A
V
 
V
S
 
S
V
 
V
D
 
D
D
 
E
K
 
K
D
 
D
V
 
I
E
 
E
S
 
A
F
 
F
K
 
K
K
 
K
L
 
L
S
 
N
E
 
A
K
 
R
G
 
G
I
 
I
E
 
E
I
 
L
E
 
E
F
 
V
R
 
R
K
 
K
V
 
V
D
 
S
T
 
T
D
 
D
K
 
P
R
 
K
V
 
L
N
 
K
L
 
M
M
 
M
E
 
D
I
 
L
I
 
I

Sites not aligning to the query:

P26380 PTS system fructose-specific EIIB component; EIIB-Fru; Fructose-specific phosphotransferase enzyme IIB component; lev-PTS; p18; EC 2.7.1.202 from Bacillus subtilis (strain 168) (see paper)
47% identity, 100% coverage: 1:158/158 of query aligns to 2:159/163 of P26380

query
sites
P26380
M
 
M
K
 
N
I
 
I
V
 
V
L
 
L
A
 
A
R
 
R
I
 
I
D
 
D
D
 
D
R
 
R
L
 
F
I
 
I
H
|
H
G
 
G
Q
 
Q
V
 
I
A
 
L
T
 
T
V
 
R
W
 
W
A
 
I
K
 
K
V
 
V
T
 
H
G
 
A
C
 
A
E
 
D
R
 
R
I
 
I
I
 
I
V
 
V
C
 
V
D
 
S
D
 
D
D
 
D
V
 
I
A
 
A
S
 
Q
D
 
D
T
 
E
I
 
M
R
 
R
A
 
K
T
 
T
L
 
L
L
 
I
K
 
L
Q
 
S
V
 
V
A
 
A
P
 
P
P
 
S
G
 
N
I
 
V
K
 
K
S
 
A
S
 
S
V
 
A
V
 
V
S
 
S
V
 
V
D
 
S
K
 
K
A
 
M
I
 
A
R
 
K
V
 
A
Y
 
F
N
 
H
N
 
S
P
 
P
K
 
R
Y
 
Y
E
 
E
N
 
G
D
 
V
K
 
T
C
 
A
L
 
M
L
 
L
L
 
L
F
 
F
T
 
E
N
 
N
P
 
P
T
 
S
S
 
D
V
 
I
L
 
V
R
 
S
M
 
L
V
 
I
E
 
E
G
 
A
G
 
G
V
 
V
D
 
P
I
 
I
K
 
K
S
 
T
V
 
V
N
 
N
V
 
V
G
 
G
G
 
G
M
 
M
S
 
R
F
 
F
K
 
E
E
 
N
G
 
H
K
 
R
R
 
R
Q
 
Q
I
 
I
T
 
T
N
 
K
A
 
S
V
 
V
S
 
S
V
 
V
D
 
T
D
 
E
K
 
Q
D
 
D
V
 
I
E
 
K
S
 
A
F
 
F
K
 
E
K
 
T
L
 
L
S
 
S
E
 
D
K
 
K
G
 
G
I
 
V
E
 
K
I
 
L
E
 
E
F
 
L
R
 
R
K
 
Q
V
 
L
D
 
P
T
 
S
D
 
D
K
 
A
R
 
S
V
 
E
N
 
D
L
 
F
M
 
V
E
 
Q
I
 
I
I
 
L
K
 
R

Query Sequence

>WP_008538998.1 NCBI__GCF_000245775.1:WP_008538998.1
MKIVLARIDDRLIHGQVATVWAKVTGCERIIVCDDDVASDTIRATLLKQVAPPGIKSSVV
SVDKAIRVYNNPKYENDKCLLLFTNPTSVLRMVEGGVDIKSVNVGGMSFKEGKRQITNAV
SVDDKDVESFKKLSEKGIEIEFRKVDTDKRVNLMEIIK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory