SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_009122468.1 NCBI__GCF_900129655.1:WP_009122468.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

P52697 6-phosphogluconolactonase; 6-P-gluconolactonase; Pgl; EC 3.1.1.31 from Escherichia coli (strain K12) (see paper)
35% identity, 67% coverage: 101:351/372 of query aligns to 70:313/331 of P52697

query
sites
P52697
G
 
G
N
 
A
L
 
L
R
 
T
L
 
F
L
 
A
N
 
A
S
 
E
E
 
S
R
 
A
T
 
L
P
 
P
G
 
G
A
 
S
A
 
-
P
 
P
C
 
T
Y
 
H
V
 
I
S
 
S
T
 
T
N
 
D
-
 
H
-
 
Q
G
 
G
K
 
Q
E
 
F
V
 
V
L
 
F
T
 
V
A
 
G
N
 
S
Y
 
Y
S
 
N
G
 
A
G
 
G
N
 
N
M
 
V
S
 
S
V
 
V
F
 
T
R
 
R
L
 
L
R
 
-
K
 
E
D
 
D
G
 
G
T
 
L
L
 
P
S
 
V
P
 
G
A
 
V
E
 
V
A
 
D
L
 
V
F
 
V
K
 
E
G
 
G
T
 
L
A
 
D
N
 
G
G
 
-
P
 
-
D
 
-
T
 
-
I
 
-
R
 
-
Q
 
-
I
 
-
V
 
-
P
 
-
H
 
-
I
 
C
H
 
H
C
 
S
A
 
A
L
 
N
F
 
I
S
 
S
P
 
P
D
 
D
G
 
N
K
 
R
Y
 
T
I
 
L
F
 
W
A
 
V
T
 
P
D
 
A
F
 
L
S
 
K
A
 
Q
D
 
D
R
 
R
I
 
I
L
 
C
R
 
L
F
 
F
T
 
T
L
 
V
S
 
S
S
 
D
E
 
D
G
 
G
N
 
H
-
 
L
I
 
V
S
 
A
R
 
Q
L
 
D
P
 
P
G
 
A
E
 
E
A
 
V
T
 
T
D
 
T
I
 
V
T
 
E
P
 
-
D
 
G
S
 
A
G
 
G
P
 
P
R
 
R
H
 
H
L
 
M
T
 
V
F
 
F
S
 
H
P
 
P
N
 
N
G
 
E
K
 
Q
F
 
Y
A
 
A
Y
 
Y
L
 
C
I
 
V
N
 
N
E
 
E
L
 
L
S
 
N
G
 
S
K
 
S
V
 
V
I
 
D
A
 
V
F
 
W
G
 
E
Y
 
L
T
 
K
D
 
D
-
 
P
-
 
H
G
 
G
K
 
N
L
 
I
E
 
E
Q
 
C
I
 
V
Q
 
Q
S
 
T
I
 
L
-
 
D
-
 
M
-
 
M
A
 
P
A
 
E
D
 
N
S
 
F
L
 
S
Q
 
D
A
 
T
R
 
R
G
 
W
S
 
A
A
 
A
D
 
D
I
 
I
H
 
H
L
 
I
S
 
T
P
 
P
D
 
D
G
 
G
K
 
R
F
 
H
L
 
L
Y
 
Y
A
 
A
S
 
C
N
 
D
R
 
R
L
 
T
E
 
-
G
 
A
D
 
S
G
 
L
I
 
I
A
 
T
I
 
V
F
 
F
T
 
S
V
 
V
D
 
S
T
 
E
V
 
D
N
 
G
G
 
S
T
 
V
L
 
L
T
 
S
R
 
K
A
 
E
G
 
G
Y
 
F
Q
 
Q
P
 
P
T
 
T
G
 
E
I
 
T
H
 
Q
P
 
P
R
 
R
H
 
G
F
 
F
N
 
N
I
 
V
T
 
D
P
 
H
N
 
S
G
 
G
K
|
K
Y
 
Y
L
 
L
L
 
I
A
 
A
A
 
A
C
 
G
R
 
Q
D
 
K
S
 
S
N
 
H
V
 
H
I
 
I
Q
 
S
V
 
V
Y
 
Y
E
 
E
R
 
I
D
 
V
T
 
G
E
 
E
N
 
Q
G
 
G
L
 
L
L
 
L
K
 
H
D
 
E

Q72U69 Antigen Lp49; Leptospiral 49 kilodalton protein; Lp49 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) (see paper)
27% identity, 45% coverage: 175:343/372 of query aligns to 283:454/456 of Q72U69

query
sites
Q72U69
L
 
L
F
 
L
S
 
S
P
 
K
D
 
D
G
 
G
K
 
K
Y
 
E
I
 
L
F
 
Y
A
 
I
T
 
A
D
 
Q
F
 
F
S
 
S
A
 
A
D
 
S
-
 
N
-
 
Q
-
 
E
-
 
S
-
 
G
-
 
G
-
 
G
R
 
R
I
 
L
L
 
G
R
 
I
F
 
Y
T
 
S
L
 
M
S
 
D
S
 
K
E
 
E
G
 
K
N
 
L
I
 
I
S
 
D
R
 
T
L
 
-
P
 
-
G
 
-
E
 
-
A
 
-
T
 
-
D
 
-
I
 
I
T
 
G
P
 
P
D
 
P
S
 
G
G
 
N
P
 
K
R
 
R
H
 
H
L
 
I
T
 
V
F
 
S
S
 
G
P
 
N
N
 
T
G
 
E
K
 
N
F
 
K
A
 
I
Y
 
Y
L
 
V
I
 
S
N
 
D
E
 
M
L
x
C
S
x
C
G
 
S
K
 
K
V
 
I
I
 
E
A
 
V
F
 
Y
G
 
D
Y
 
L
T
 
K
D
 
E
G
 
K
K
 
K
L
 
V
E
 
Q
Q
 
K
I
 
-
Q
 
-
S
 
S
I
 
I
A
 
P
A
 
V
D
 
-
S
 
-
L
 
-
Q
 
-
A
 
F
R
 
D
G
 
K
S
 
P
A
 
N
D
 
T
I
 
I
H
 
A
L
 
L
S
 
S
P
 
P
D
 
D
G
 
G
K
 
K
F
 
Y
L
 
L
Y
 
Y
A
 
V
S
 
S
N
 
C
R
 
R
-
 
G
-
 
P
-
 
N
-
 
H
-
 
P
L
 
T
E
 
E
G
 
G
-
 
Y
-
 
L
-
 
K
D
 
K
G
 
G
I
 
L
A
 
V
-
 
L
-
 
G
-
 
K
I
 
V
F
 
Y
T
 
V
V
 
I
D
 
D
T
 
T
V
 
T
N
 
T
G
 
D
T
 
T
L
 
V
T
 
K
-
 
E
-
 
F
-
 
W
R
 
E
A
 
A
G
 
G
Y
 
N
Q
 
Q
P
 
P
T
 
T
G
 
G
I
 
L
H
 
-
P
 
-
R
 
-
H
 
-
F
 
-
N
 
D
I
 
V
T
 
S
P
 
P
N
 
D
G
 
N
K
 
R
Y
 
Y
L
 
L
L
 
V
A
 
I
A
 
S
C
 
D
R
 
F
D
 
L
S
 
D
N
 
H
V
 
Q
I
 
I
Q
 
R
V
 
V
Y
 
Y
E
 
R
R
 
R
D
 
D

Query Sequence

>WP_009122468.1 NCBI__GCF_900129655.1:WP_009122468.1
MKLLYCMLGLSMAACTPQKTVNSGEDELSMLIGTYTDGTSKGIYSFRFNQKTGTATPLGS
VELSNPSYLTPSEDGKFIYAVSEMNDSTAAVNALAFDKQTGNLRLLNSERTPGAAPCYVS
TNGKEVLTANYSGGNMSVFRLRKDGTLSPAEALFKGTANGPDTIRQIVPHIHCALFSPDG
KYIFATDFSADRILRFTLSSEGNISRLPGEATDITPDSGPRHLTFSPNGKFAYLINELSG
KVIAFGYTDGKLEQIQSIAADSLQARGSADIHLSPDGKFLYASNRLEGDGIAIFTVDTVN
GTLTRAGYQPTGIHPRHFNITPNGKYLLAACRDSNVIQVYERDTENGLLKDTQQDILIDK
PVCVQFIPPFHN

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory