SitesBLAST
Comparing WP_009543467.1 NCBI__GCF_000017845.1:WP_009543467.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 9:575/582 of 3ea4A
- active site: Y32 (= Y40), G34 (= G42), G35 (= G43), A36 (= A44), S37 (≠ I45), E58 (= E69), T81 (= T92), F120 (= F131), Q121 (= Q132), E122 (= E133), K170 (= K181), M265 (= M278), V292 (= V305), V399 (= V412), G425 (= G437), M427 (= M439), D452 (= D464), N479 (= N491), H481 (≠ W493), L482 (≠ Q494), M484 (= M496), V485 (= V497), W488 (= W500), H557 (≠ R563)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D303), R291 (= R304), W488 (= W500), S567 (≠ P573)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R171), G221 (= G232), G222 (= G233), G223 (= G234), T245 (= T258), L246 (= L259), M247 (= M260), L263 (= L276), G264 (= G277), M265 (= M278), H266 (= H279), G285 (= G298), R287 (= R300), D289 (= D302), R291 (= R304), D309 (= D322), I310 (= I323), G327 (= G340), D328 (= D341), V329 (= V342), M404 (= M417), G422 (≠ A434)
- binding magnesium ion: D452 (= D464), N479 (= N491), H481 (≠ W493)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V412), G400 (= G413), Q401 (= Q414), H402 (= H415), M427 (= M439), G451 (= G463), D452 (= D464), G453 (≠ A465), S454 (= S466), N479 (= N491), H481 (≠ W493), L482 (≠ Q494), G483 (= G495), M484 (= M496), V485 (= V497)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 9:575/582 of 3e9yA
- active site: Y32 (= Y40), G34 (= G42), G35 (= G43), A36 (= A44), S37 (≠ I45), E58 (= E69), T81 (= T92), F120 (= F131), Q121 (= Q132), E122 (= E133), K170 (= K181), M265 (= M278), V292 (= V305), V399 (= V412), G425 (= G437), M427 (= M439), D452 (= D464), N479 (= N491), H481 (≠ W493), L482 (≠ Q494), M484 (= M496), V485 (= V497), W488 (= W500), H557 (≠ R563)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D303), R291 (= R304), W488 (= W500), S567 (≠ P573)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R171), G221 (= G232), G222 (= G233), G223 (= G234), T245 (= T258), L246 (= L259), M247 (= M260), L263 (= L276), G285 (= G298), R287 (= R300), D289 (= D302), R291 (= R304), D309 (= D322), I310 (= I323), G327 (= G340), D328 (= D341), V329 (= V342), M404 (= M417), G422 (≠ A434)
- binding magnesium ion: D452 (= D464), N479 (= N491), H481 (≠ W493)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V412), G400 (= G413), Q401 (= Q414), H402 (= H415), M427 (= M439), G451 (= G463), G453 (≠ A465), S454 (= S466), N479 (= N491), H481 (≠ W493), L482 (≠ Q494), G483 (= G495), M484 (= M496), V485 (= V497)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
45% identity, 91% coverage: 17:581/619 of query aligns to 95:661/670 of P17597
- A122 (= A44) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L46) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E69) binding
- S186 (= S111) binding
- P197 (≠ G122) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ A124) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q132) binding
- K220 (= K145) binding
- R246 (= R171) binding ; binding
- K256 (= K181) binding
- G308 (= G233) binding
- TL 331:332 (= TL 258:259) binding
- C340 (≠ E267) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 276:279) binding
- GVRFD 371:375 (≠ GARFD 298:302) binding
- DR 376:377 (= DR 303:304) binding
- DI 395:396 (= DI 322:323) binding
- DV 414:415 (= DV 341:342) binding
- QH 487:488 (= QH 414:415) binding
- GG 508:509 (≠ AG 434:435) binding
- GAM 511:513 (≠ GTM 437:439) binding
- D538 (= D464) binding
- DGS 538:540 (≠ DAS 464:466) binding
- N565 (= N491) binding
- NQHLGM 565:570 (≠ NGWQGM 491:496) binding
- H567 (≠ W493) binding
- W574 (= W500) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ P573) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M278), R292 (= R304), W489 (= W500), S568 (≠ P573)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G437), M428 (= M439), G452 (= G463), D453 (= D464), G454 (≠ A465), S455 (= S466), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), M263 (= M275), L264 (= L276), M266 (= M278), H267 (= H279), G286 (= G298), R288 (= R300), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434)
- binding magnesium ion: A37 (= A44), T82 (= T92), S83 (= S93), Q122 (= Q132), Y381 (≠ E394), D453 (= D464), M458 (= M469), Q461 (= Q472), N480 (= N491), H482 (≠ W493), K533 (≠ H538)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/583 of 5k3sA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R304), M485 (= M496), W489 (= W500), G569 (= G574)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), M266 (= M278), G286 (= G298), R288 (= R300), D290 (= D302), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G437), M428 (= M439), D453 (= D464), G454 (≠ A465), S455 (= S466), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/585 of 5k2oA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M278), R292 (= R304), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), G286 (= G298), R288 (= R300), D290 (= D302), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), Q404 (= Q416), M405 (= M417), G423 (≠ A434)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), M428 (= M439), D453 (= D464), G454 (≠ A465), S455 (= S466), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G437), M428 (= M439), G452 (= G463), D453 (= D464), G454 (≠ A465), S455 (= S466), M458 (= M469), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), R292 (= R304), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434)
- binding magnesium ion: F370 (≠ A383), D453 (= D464), M458 (= M469), Q461 (= Q472), N480 (= N491), H482 (≠ W493), K533 (≠ H538)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M278), R292 (= R304), M485 (= M496), W489 (= W500), S568 (≠ P573)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 5wj1A
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), M263 (= M275), L264 (= L276), G286 (= G298), R288 (= R300), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M278), D291 (= D303), R292 (= R304), M485 (= M496), W489 (= W500), S568 (≠ P573)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), M428 (= M439), D453 (= D464), G454 (≠ A465), S455 (= S466), M458 (= M469), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 5k6tA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H279), R292 (= R304), M485 (= M496), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), G286 (= G298), R288 (= R300), D290 (= D302), R292 (= R304), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), Q404 (= Q416), M405 (= M417), G423 (≠ A434)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G437), M428 (= M439), G452 (= G463), G454 (≠ A465), S455 (= S466), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 5k6rA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R304), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), M266 (= M278), G286 (= G298), R288 (= R300), R292 (= R304), V293 (= V305), D310 (= D322), I311 (= I323), G328 (= G340), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G437), M428 (= M439), D453 (= D464), G454 (≠ A465), S455 (= S466), M458 (= M469), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 1z8nA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K145), R161 (= R171), Y191 (= Y203), R194 (≠ T206), D291 (= D303), R292 (= R304), D312 (= D324), W489 (= W500), G569 (= G574)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), G265 (= G277), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), R292 (= R304), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491)
- binding thiamine diphosphate: V400 (= V412), G401 (= G413), Q402 (= Q414), H403 (= H415), G426 (= G437), M428 (= M439), G452 (= G463), G454 (≠ A465), S455 (= S466), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), G484 (= G495), M485 (= M496), V486 (= V497)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 1yi1A
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D303), R292 (= R304), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), M263 (= M275), L264 (= L276), G265 (= G277), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 1yi0A
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D303), R292 (= R304), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), G265 (= G277), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), R292 (= R304), V293 (= V305), D310 (= D322), I311 (= I323), G328 (= G340), D329 (= D341), V330 (= V342), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 1yhzA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D303), R292 (= R304), M485 (= M496), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), Q404 (= Q416), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 1yhyA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D303), R292 (= R304), V486 (= V497), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G222 (= G232), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), G265 (= G277), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), Q404 (= Q416), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
45% identity, 91% coverage: 17:581/619 of query aligns to 10:576/582 of 1ybhA
- active site: Y33 (= Y40), G35 (= G42), G36 (= G43), A37 (= A44), S38 (≠ I45), E59 (= E69), T82 (= T92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (= K181), M266 (= M278), V293 (= V305), V400 (= V412), G426 (= G437), M428 (= M439), D453 (= D464), N480 (= N491), H482 (≠ W493), L483 (≠ Q494), M485 (= M496), V486 (= V497), W489 (= W500), H558 (≠ R563)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M278), D291 (= D303), R292 (= R304), M485 (= M496), W489 (= W500), S568 (≠ P573)
- binding flavin-adenine dinucleotide: R161 (= R171), G223 (= G233), G224 (= G234), T246 (= T258), L247 (= L259), M248 (= M260), L264 (= L276), M266 (= M278), H267 (= H279), G286 (= G298), V287 (≠ A299), R288 (= R300), D290 (= D302), V293 (= V305), D310 (= D322), I311 (= I323), D329 (= D341), V330 (= V342), Q404 (= Q416), M405 (= M417), G423 (≠ A434), G424 (= G435)
- binding magnesium ion: D453 (= D464), N480 (= N491), H482 (≠ W493)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
45% identity, 92% coverage: 19:589/619 of query aligns to 91:663/664 of P09114
- P191 (≠ G122) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W500) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
44% identity, 92% coverage: 19:589/619 of query aligns to 94:666/667 of P09342
- C161 (= C89) modified: Disulfide link with 307
- P194 (≠ G122) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ A237) modified: Disulfide link with 161
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 93% coverage: 20:595/619 of query aligns to 9:587/596 of 1t9cA
- active site: Y29 (= Y40), G31 (= G42), G32 (= G43), A33 (= A44), I34 (= I45), E55 (= E69), T78 (= T92), F117 (= F131), Q118 (= Q132), E119 (= E133), K167 (= K181), R227 (≠ A242), M263 (= M278), V290 (= V305), V406 (= V412), L431 (= L436), G432 (= G437), M434 (= M439), D459 (= D464), N486 (= N491), E488 (≠ W493), Q489 (= Q494), M491 (= M496), V492 (= V497), W495 (= W500), L517 (= L524), G522 (= G529), L523 (≠ V530), K556 (≠ R563)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G43), V107 (= V121), P108 (≠ G122), F117 (= F131), K167 (= K181), D288 (= D303), R289 (= R304), W495 (= W500)
- binding flavin-adenine dinucleotide: R157 (= R171), G216 (= G232), A217 (≠ G233), G218 (= G234), N221 (≠ A237), T243 (= T258), L244 (= L259), Q245 (≠ M260), L261 (= L276), M263 (= M278), H264 (= H279), G283 (= G298), A284 (= A299), R285 (= R300), D287 (= D302), R289 (= R304), V290 (= V305), E316 (≠ D322), V317 (≠ I323), N321 (≠ E327), G334 (= G340), D335 (= D341), A336 (≠ V342), M411 (= M417), G429 (≠ A434), G430 (= G435)
- binding magnesium ion: D459 (= D464), N486 (= N491), E488 (≠ W493)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 93% coverage: 20:595/619 of query aligns to 10:588/597 of 1t9aA
- active site: Y30 (= Y40), G32 (= G42), G33 (= G43), A34 (= A44), I35 (= I45), E56 (= E69), T79 (= T92), F118 (= F131), Q119 (= Q132), E120 (= E133), K168 (= K181), R228 (≠ A242), M264 (= M278), V291 (= V305), V407 (= V412), L432 (= L436), G433 (= G437), M435 (= M439), D460 (= D464), N487 (= N491), E489 (≠ W493), Q490 (= Q494), M492 (= M496), V493 (= V497), W496 (= W500), L518 (= L524), G523 (= G529), L524 (≠ V530), K557 (≠ R563)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G43), V108 (= V121), P109 (≠ G122), F118 (= F131), K168 (= K181), M264 (= M278), D289 (= D303), R290 (= R304), M492 (= M496), V493 (= V497), W496 (= W500)
- binding flavin-adenine dinucleotide: R158 (= R171), G217 (= G232), A218 (≠ G233), G219 (= G234), N222 (≠ A237), T244 (= T258), L245 (= L259), Q246 (≠ M260), L262 (= L276), M264 (= M278), H265 (= H279), G284 (= G298), A285 (= A299), R286 (= R300), D288 (= D302), R290 (= R304), V291 (= V305), E317 (≠ D322), V318 (≠ I323), N322 (≠ E327), G335 (= G340), D336 (= D341), A337 (≠ V342), Q411 (= Q416), M412 (= M417), G430 (≠ A434), G431 (= G435)
- binding magnesium ion: D460 (= D464), N487 (= N491), E489 (≠ W493)
- binding propyl trihydrogen diphosphate: V407 (= V412), G408 (= G413), Q409 (= Q414), H410 (= H415), M435 (= M439), G459 (= G463), D460 (= D464), A461 (= A465), S462 (= S466), N487 (= N491), E489 (≠ W493), Q490 (= Q494), G491 (= G495), M492 (= M496)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G437), M435 (= M439), M465 (= M469)
Query Sequence
>WP_009543467.1 NCBI__GCF_000017845.1:WP_009543467.1
MVSSIAKITSPLAETPQRRTGAYALIDSLVRHGVKHIFGYPGGAILPIYDELYRAEARGD
IQHFLVRHEQGASHAADGYARATGKVGVCFGTSGPGATNLVTGIATAHLDSIPMVVVTGQ
VGRAAIGSDAFQETDIFGITLPIVKHSYVVRHAEDMAKIVAEAFHIASTGRPGPVLIDVP
KDVGLEECDYIPVEPGQVKLPGYRPTVKGNPRQINAALSLIETSERPLLYVGGGAIAANA
HAQVQELAERFQIPVTTTLMGIGSFDEHHPLSVGMLGMHGTAYANFAVSECDLLIAVGAR
FDDRVTGKLDEFASRARVIHIDIDPAEVGKNRLPEVPIVGDVRQVLEQLLQRSREIDVPL
DAEKTTPWLNRINRWREQYPLVAPHYDHRISPQEVIVEVGRQAPHAYYTTDVGQHQMWAA
QFLNNGPRRWISSAGLGTMGYGMPAAMGVKVALPEEEVICISGDASFQMNLQELATLAQY
NIAAKTVIINNGWQGMVRQWQQTFYGERYSSSNMQTGMPDFELLAKAFGVKGITVTEHSQ
LAGAVAEMLAHDGPVLMDVHVKRDENCYPMVAPGKSNAQMIGLPELKSSELMTELIRCTY
CGTDNPVTNKFCPECGTKI
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory