SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_009543483.1 NCBI__GCF_000017845.1:WP_009543483.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 9 hits to proteins with known functional sites (download)

2f1kA Crystal structure of synechocystis arogenate dehydrogenase (see paper)
58% identity, 98% coverage: 1:278/284 of query aligns to 1:278/279 of 2f1kA

query
sites
2f1kA

M

M

K

K

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I

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x
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binding nadp nicotinamide-adenine-dinucleotide phosphate: G7 (= G7), G9 (= G9), L10 (= L10), I11 (= I11), S30 (= S30), R31 (= R31), Q32 (≠ K32), T35 (= T35), T65 (= T65), P66 (= P66), V90 (= V90), A91 (≠ G91), S92 (= S92), G116 (= G116), T117 (= T117), Q120 (= Q120), G121 (= G121)

5uyyA Crystal structure of prephenate dehydrogenase tyra from bacillus anthracis in complex with l-tyrosine (see paper)
32% identity, 90% coverage: 2:256/284 of query aligns to 11:269/373 of 5uyyA

query
sites
5uyyA

K

K

I

V

G

V

I

L

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G

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G

G

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L

I

I

G

G

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A

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N

K

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binding tyrosine: N147 (≠ A132)

Sites not aligning to the query:

binding tyrosine: 309, 310, 311, 314, 315, 329, 336, 343

6u60B Crystal structure of prephenate dehydrogenase tyra from bacillus anthracis in complex with NAD and l-tyrosine (see paper)
32% identity, 90% coverage: 2:256/284 of query aligns to 3:261/365 of 6u60B

query
sites
6u60B

K

K

I

V

G

V

I

L

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I

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G

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T

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L
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A

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H

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binding nicotinamide-adenine-dinucleotide: G10 (= G9), L11 (= L10), I12 (= I11), D32 (≠ S30), I33 (≠ R31), A67 (≠ C64), P69 (= P66), E72 (≠ L69), V94 (= V90), S96 (= S92), G128 (= G121)
binding tyrosine: K126 (≠ E119)

Sites not aligning to the query:

binding tyrosine: 301, 302, 303, 306, 307, 320, 321

3ggoA Crystal structure of prephenate dehydrogenase from a. Aeolicus with hpp and nadh (see paper)
29% identity, 95% coverage: 5:274/284 of query aligns to 10:282/285 of 3ggoA

query
sites
3ggoA

I

I

I

V

G

G

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G

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M

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binding 3-(4-hydroxy-phenyl)pyruvic acid: G217 (≠ S209), G218 (≠ S210), G219 (= G211)
binding 1,4-dihydronicotinamide adenine dinucleotide: V13 (≠ L8), G14 (= G9), F15 (≠ L10), M16 (≠ I11), D37 (≠ S30), I38 (≠ R31), S42 (≠ T35), S73 (≠ C64), S74 (≠ T65), P75 (= P66), T78 (≠ L69), Q99 (≠ V90), S101 (= S92), A125 (= A115), G131 (= G121), M233 (≠ L225)

3ggpA Crystal structure of prephenate dehydrogenase from a. Aeolicus in complex with hydroxyphenyl propionate and NAD+ (see paper)
29% identity, 95% coverage: 5:274/284 of query aligns to 10:282/286 of 3ggpA

query
sites
3ggpA

I

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E

E

P

N

-

I

L

L

W

G

S

K

N

R

F

F

V

V

G

G

G

G

H

H

P

P

M

I

A

A

G

G

T

T

A

E

E

K

Q

S

G
|
G

I

V

E

E

A

Y

A

S

Q

L

K

D

N

N

L

L

F

Y

K

E

A

G

A

K

P

K

Y

V

V

I

I

L

T

T

P

P

T

T

E

K

N

K

T

T

P

D

K

K

N

K

S

R

I

L

K

K

I

L

L

V

E

K

Q

R

L

V

A

W

Q

E

S

D

L

V

G

G

S

G

K

V

V

V

Y

E

T

Y

C

M

S

S

P

P

E

E

I

L

H

H

D

D

Q

Y

A

V

V

F

A

G

W

V

I

V

S

S

H

H

L

L

P

P

V

H

M

A

V

V

S

A

A

F

S

A

L

L

I

V

A

D

A

T

C

L

V

I

G

H

E

M

K

S

E

T

K

P

T

E

V

V

L

D

N

L

L

F

A

-

Q

-

Q

K

L

Y

A

P

S

G

S
x
G

G
|
G

F

F

K

K

D

D

T

F

S

T

R

R

V

I

G

A

G

K

G

S

N

D

P

P

E

I

L
x
M

G

W

L

R

M

D

M

I

A

F

Q

L

Y

E

N

N

K

K

T

E

G

N

L

V

L

M

H

K

S

A

L

I

Q

E

G

G

Y

F

R

E

Q

K

Q

S

L

L

D

N

E

H

V

L

I

K

E

E

Y

L

I

I

N

V

R

R

E

E

E

A

W

E

D

E

S

E

L

L

E

V

Q

E

L

Y

L

L

M

K

M

E

T

V

Q

K

K

I

K

K

R

R

binding hydroxyphenyl propionic acid: G218 (≠ S210), G219 (= G211)
binding nicotinamide-adenine-dinucleotide: V13 (≠ L8), G14 (= G9), F15 (≠ L10), M16 (≠ I11), D37 (≠ S30), I38 (≠ R31), S42 (≠ T35), S73 (≠ C64), S74 (≠ T65), P75 (= P66), T78 (≠ L69), Q99 (≠ V90), S101 (= S92), G131 (= G121), M233 (≠ L225)

3gggD The crystal structure of a. Aeolicus prephenate dehydrogenase in complex with tyrosine and NAD+ (see paper)
29% identity, 95% coverage: 5:274/284 of query aligns to 18:290/293 of 3gggD

query
sites
3gggD

I

I

I

V

G

G

L
x
V

G
|
G

L
x
F

I
x
M

G

G

G

G

S

S

L

F

G

A

F

K

D

S

L

L

R

R

N

R

C

S

G

G

H

F

I

K

-

G

-

K

I

I

Y

Y

G

G

V

Y

S
x
D

R
x
I

K

N

E

P

S

E

T
x
S

C

I

Q

S

R

K

A

A

I

V

E

D

R

L

E

G

V

I

V

I

D

D

H

E

A

G

S

T

I

T

N

S

I

I

N

A

S

K

L

V

S

E

T

D

V

F

-

S

-

P

D

D

L

F

I

V

F

M

I

L

C
x
S

T
x
S

P
|
P

I
x
V

T

R

L
x
T

I

F

S

R

S

E

T

I

L

A

K

K

Q

K

L

L

T

S

S

Y

N

I

L

L

R

S

P

E

E

D

V

A

I

T

I

V

T

T

D

D

V
x
Q

G

G

S
|
S

V

V

K

K

T

G

A

K

I

L

V

V

K

Y

E

D

C

L

E

E

P

N

-

I

L

L

W

G

S

K

N

R

F

F

V

V

G

G

G

G

H

H

P

P

M

I

A

A

G
|
G

T
|
T

A

E

E

K

Q

S

G

G

I

V

E

E

A

Y

A

S

Q

L

K

D

N

N

L

L

F

Y

K

E

A

G

A

K

P

K

Y

V

V

I

I

L

T

T

P

P

T

T

E

K

N

K

T

T

P

D

K

K

N

K

S

R

I

L

K

K

I

L

L

V

E

K

Q

R

L

V

A

W

Q

E

S

D

L

V

G

G

S

G

K

V

V

V

Y

E

T

Y

C

M

S

S

P

P

E

E

I

L

H

H

D

D

Q

Y

A

V

V

F

A

G

W

V

I

V

S

S

H

H

L

L

P

P

V

H

M

A

V

V

S

A

A

F

S

A

L

L

I

V

A

D

A

T

C

L

V

I

G

H

E

M

K

S

E

T

K

P

T

E

V

V

L

D

N

L

L

F

A

-

Q

-

Q

K

L

Y

A

P

S
x
G

S
x
G

G

G

F

F

K

K

D

D

T

F

S

T

R

R

V

I

G

A

G

K

G

S

N

D

P

P

E

I

L

M

G

W

L

R

M

D

M

I

A

F

Q

L

Y

E

N

N

K

K

T

E

G

N

L

V

L

M

H

K

S

A

L

I

Q

E

G

G

Y

F

R

E

Q

K

Q

S

L

L

D

N

E

H

V

L

I

K

E

E

Y

L

I

I

N

V

R

R

E

E

E

A

W

E

D

E

S

E

L

L

E

V

Q

E

L

Y

L

L

M

K

M

E

T

V

Q

K

K

I

K

K

R

R

binding nicotinamide-adenine-dinucleotide: V21 (≠ L8), G22 (= G9), F23 (≠ L10), M24 (≠ I11), D45 (≠ S30), I46 (≠ R31), S50 (≠ T35), S81 (≠ C64), S82 (≠ T65), P83 (= P66), V84 (≠ I67), T86 (≠ L69), Q107 (≠ V90), S109 (= S92), G134 (= G116), T135 (= T117)
binding tyrosine: G225 (≠ S209), G226 (≠ S210)

4wjiA Crystal structure of cyclohexadienyl dehydrogenase from sinorhizobium meliloti in complex with NADP and tyrosine
28% identity, 96% coverage: 3:274/284 of query aligns to 7:283/293 of 4wjiA

query
sites
4wjiA

I

I

G

A

I

L

I

I

G
|
G

L

I

G
|
G

L
|
L

I
|
I

G

G

G

S

S

S

L

I

G

A

F

R

D

D

L

I

R

R

N

E

-

K

-

Q

-

L

C

A

G

G

H

T

I

I

I

V

Y

V

G

-

V

T

S
x
T

R
|
R

K
x
S

E

E

S

A

T
|
T

C

L

Q

K

R

R

A

A

I

G

E

E

R

L

E

G

V

L

V

G

D

D

H

R

A

Y

S

T

I

L

N

S

I

A

-

A

N

E

S

A

L

V

S

E

T

G

V

A

D

D

L

L

I

V

F

V

I

V

C
x
S

T
x
V

P
|
P

I

V

T

G

L
x
A

I

S

S

G

S

A

T

V

L

A

K

A

Q

E

L

I

T

A

S

A

N

H

L

L

R

K

P

P

E

G

V

A

I

I

I

V

T

T

D

D

V
|
V

G

G

S
|
S

V

T

K

K

T

G

A

S

I

V

V

I

K

A

E

Q

C

M

E

A

P

P

L

H

W

L

S

P

-

K

-

D

-

V

N

H

F

F

V

V

G

P

G

G

H
|
H

P

P

M

I

A
|
A

G

G

T
|
T

A

E

E

H

Q
x
S

G

G

I

P

E

D

A

A

A

G

Q

F

K

A

N

G

L

L

F

F

K

R

A

G

A

R

P

W

Y

C

V

I

I

L

T

T

P

P

T

P

E

A

N

G

T

T

P

D

K

E

N

E

S

A

I

V

K

A

I

R

L

L

E

R

Q

L

L

F

A

W

Q

E

S

T

L

L

G

G

S

S

K

M

V

V

Y

D

T

E

C

M

S

D

P

P

E

K

I

H

H

H

D

D

Q

K

A

V

V

L

A

A

W

I

I

V

S

S

H

H

L

L

P

P

V

H

M

I

V

I

S

A

A

Y

S

N

L

I

I

V

A

G

A

T

C

A

V

-

G

D

E

D

K

L

E

E

K

T

T

V

V

T

L

E

N

S

L

E

A

V

Q

I

Q

K

L

Y

A

S

S

A

S

S

G

G

F

F

K

R

D

D

T

F

S

T

R
|
R

V

L

G

A

G

A

G

S

N

D

P

P

E

T

L
x
M

G

W

L

R

M

D

M

V

A

C

Q

L

Y

H

N

N

K

K

T

D

G

A

L

I

L

L

H

E

S

M

L

L

Q

A

G

R

Y

F

R

S

Q

E

Q

D

L

L

D

A

E

S

V

L

I

Q

E

R

Y

A

I

I

N

R

R

W

E

G

E

D

W

G

D

D

S

K

L

L

E

F

Q

D

L

L

L

F

M

T

M

R

T

T

Q

R

K

A

K

I

R

R

binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G7), G13 (= G9), L14 (= L10), I15 (= I11), T36 (≠ S30), R37 (= R31), S38 (≠ K32), T41 (= T35), S71 (≠ C64), V72 (≠ T65), P73 (= P66), A76 (≠ L69), V97 (= V90), S99 (= S92), A125 (= A115), S130 (≠ Q120), M234 (≠ L225)
binding tyrosine: S99 (= S92), H122 (= H112), A125 (= A115), T127 (= T117), R226 (= R217)

3b1fA Crystal structure of prephenate dehydrogenase from streptococcus mutans (see paper)
30% identity, 96% coverage: 3:274/284 of query aligns to 9:282/286 of 3b1fA

query
sites
3b1fA

I

I

G

Y

I

I

I

A

G

G

L

L

G
|
G

L
|
L

I
|
I

G

G

G

A

S

S

L

L

G

A

F

L

D

G

L

I

-

K

R

R

N

D

C

H

G

P

H

H

I

Y

-

K

I

I

Y

V

G

G

V

Y

S
x
N

R
|
R

K

S

E

D

S

R

T

S

C

R

Q

D

R

I

A

A

I

L

E

E

R

R

E

G

V

I

V

V

D

D

H

E

A

A

S

T

I

A

N

D

I

F

N

K

S

V

L

F

S

A

T

A

V

L

-

A

D

D

L

V

I

I

F

I

I

L

C

A

T

V

P
|
P

I

I

T

K

L
x
K

I

T

S

I

S

D

T

F

L

I

K

K

Q

I

L

L

T

A

S

D

-

L

N

D

L

L

R

K

P

E

E

D

V

V

I

I

I

I

T

T

D

D

V
x
A

G

G

S
|
S

V

T

K

K

T

Y

A

E

I

I

V

V

K

R

E

A

C

A

E

E

P

Y

L

Y

W

L

S

K

N

D

-

K

-

P

-

V

-

Q

F

F

V

V

G

G

G

S

H

H

P

P

M

M

A

A

G

S

T

-

A

-

E

-

Q

-

G

G

I

A

E

V

A

A

A

A

Q

N

K

V

N

N

L

L

F

F

K

E

A

N

A

A

P

Y

Y

Y

V

I

I

F

T

S

P

P

T

S

E

C

N

L

T

T

P

K

K

P

N

N

S

T

I

I

K

P

I

A

L

L

E

Q

Q

D

L

L

A

L

Q

S

S

G

L

L

G

H

S

A

K

R

V

Y

Y

V

T

E

C

I

S

D

P

A

E

A

I

E

H

H

D

D

Q

C

A

V

V

T

A

S

W

Q

I

I

S

S

H

H

L

F

P

P

V

H

M

I

V

I

S

A

A

S

S

S

L

L

I

M

A

K

A

Q

C

A

V

G

G

D

E

F

K

S

E

E

K

S

T

H

V

-

L

-

N

E

L

M

A

T

Q

K

Q

H

L

F

A

A

S

A

S

G

G

G

F

F

K

R

D

D

T

M

S

T

R

R

V

I

G

A

G

E

G

S

N

E

P

P

E

G

L
x
M

G

W

L

T

M

S

M

I

A

L

Q

L

Y

T

N

N

K

Q

T

E

G

A

L

V

L

L

H

D

S

R

L

I

Q

E

G

N

Y

F

R

K

Q

Q

Q

R

L

L

D

D

E

E

V

V

I

S

E

N

Y

L

I

I

N

K

R

A

E

R

E

D

W

E

D

N

S

A

L

I

E

W

Q

A

L

F

L

F

M

N

M

Q

T

S

Q

R

K

Q

K

I

R

R

binding nicotinamide-adenine-dinucleotide: G15 (= G9), L16 (= L10), I17 (= I11), N38 (≠ S30), R39 (= R31), P75 (= P66), K78 (≠ L69), A100 (≠ V90), S102 (= S92), M233 (≠ L225)

2pv7B Crystal structure of chorismate mutase / prephenate dehydrogenase (tyra) (1574749) from haemophilus influenzae rd at 2.00 a resolution (see paper)
26% identity, 63% coverage: 2:180/284 of query aligns to 11:167/280 of 2pv7B

query
sites
2pv7B

K

K

I

I

G

V

I

I

I

V

G
|
G

-

G

L

Y

G
|
G

L
x
K

I
x
L

G

G

G

G

S

L

L

F

G

A

F

R

D

Y

L

L

R

R

N

A

C

S

G

G

H

Y

I

P

I

I

Y

S

G

I

V

L

S
x
D

R
|
R

K

E

E

D

S

W

T

A

C

V

Q

A

R

E

A

S

I

I

E

-

R

-

E

-

V

-

V

-

D

-

H

-

A

-

S

-

I

-

N

-

I

-

N

-

S

-

L

L

S

A

T

N

V

A

D

D

L

V

I

V

F

I

I

V

C

S

T
x
V

P
|
P

I
|
I

T

N

L

L

I

T

S

L

S

E

T

T

L

I

K

E

Q

R

L

L

T

K

S

P

N

Y

L

L

R

T

P

E

E

N

V

M

I

L

I

L

T

A

D

D

V
x
L

G
x
T

S
|
S

V

V

K

K

T

R

A

E

-

P

I

L

V

A

K

K

E

M

C

L

E

E

P

V

L

H

W

T

S

G

N

A

F

V

V

L

G

G

G

L

H
|
H

P

P

M

M

A
x
F

G

G

T

A

A

-

E

-

Q

-

G

D

I

I

E

A

A

S

A

M

Q

A

K

K

N

Q

L

V

F

-

K

-

A

-

A

-

P

-

Y

-

V

V

I

V

T

R

P

C

T

D

E

G

N

R

T

F

P

P

K

E

N

R

S

Y

I

E

K

W

I

L

L

L

E

E

Q

Q

L

I

A

-

Q

Q

S

I

L

W

G

G

S

A

K

K

V

I

Y

Y

T

Q

C

T

S

N

P

A

E

T

I

E

H

H

D

D

Q

H

A

N

V

M

A

T

W

Y

I

I

S
x
Q

H

A

L

L

binding nicotinamide-adenine-dinucleotide: G16 (= G7), G19 (= G9), K20 (≠ L10), L21 (≠ I11), D40 (≠ S30), R41 (= R31), V61 (≠ T65), P62 (= P66), I63 (= I67), L86 (≠ V90), T87 (≠ G91), S88 (= S92)
binding tyrosine: S88 (= S92), H109 (= H112), F112 (≠ A115), Q165 (≠ S178)

Sites not aligning to the query:

Query Sequence

>WP_009543483.1 NCBI__GCF_000017845.1:WP_009543483.1
MKIGIIGLGLIGGSLGFDLRNCGHIIYGVSRKESTCQRAIEREVVDHASININSLSTVDL
IFICTPITLISSTLKQLTSNLRPEVIITDVGSVKTAIVKECEPLWSNFVGGHPMAGTAEQ
GIEAAQKNLFKAAPYVITPTENTPKNSIKILEQLAQSLGSKVYTCSPEIHDQAVAWISHL
PVMVSASLIAACVGEKEKTVLNLAQQLASSGFKDTSRVGGGNPELGLMMAQYNKTGLLHS
LQGYRQQLDEVIEYINREEWDSLEQLLMMTQKKRPPFIGGQKNS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory