SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_009781200.1 NCBI__GCF_000152985.1:WP_009781200.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8xl8B Structure of human 3-methylcrotonyl-coa carboxylase in complex with propionyl-coa (mcc-pco)
47% identity, 99% coverage: 5:542/542 of query aligns to 20:541/541 of 8xl8B

query
sites
8xl8B

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binding propionyl Coenzyme A: K119 (= K105), G120 (≠ A106), G152 (≠ A138), A154 (≠ V140), A196 (= A182)
binding biotin: G384 (= G384), Q455 (≠ S455), N458 (≠ K458)

8xl6B Structure of human 3-methylcrotonyl-coa carboxylase at apo-state (mcc- apo)
47% identity, 99% coverage: 5:542/542 of query aligns to 20:541/541 of 8xl6B

query
sites
8xl6B

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binding biotin: G384 (= G384), Q455 (≠ S455), N458 (≠ K458)

8k2vG 3-methylcrotonyl-coa carboxylase in mccd state with acetyl coa (see paper)
47% identity, 99% coverage: 5:542/542 of query aligns to 20:541/541 of 8k2vG

query
sites
8k2vG

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I

I

F

F

L

L

A

A

G

G

S

P

Y

P

L

L

V

V

K

K

A

A

A

A

I

T

G

G

E

E

T

E

V

V

D

S

N

A

E

E

T

D

L

L

G

G

G

G

A

A

T

D

T

L

H

H

C

C

E

R

I

K

S

S

G

G

V

V

T

S

D

D

Y

H

K

W

A

A

S

L

D

D

D

D

R

H

D

H

A

A

L

L

T

H

R

L

I

T

K

R

N

K

I

V

M

V

G

R

K

N

I

L

G

-

D

N

F

Y

E

Q

K

K

A

K

G

L

Y

D

N

V

R

T

I

I

E

E

A

-

A

-

K

-

P

P

K

S

E

E

D

E

P

P

-

L

-

F

-

P

-

A

Q

D

D

E

I

L

Y

Y

G

G

I

I

L

V

P

G

A

A

K

N

R

L

S

K

D

R

Q

S

Y

F

D

D

M

V

T

R

E

E

I

V

I

I

K

A

R

R

L

I

V

V

D

D

N

G

S

S

E

R

Y

F

E

T

E

E

Y

F

K

K

E

A

G

F

Y

Y

G

G

Q

D

T

T

L

L

I

V

T

T

A

G

Y

F

A

A

R

R

I

I

D

F

G

G

W

Y

A

P

V

V

G

G

I

I

V

V

A

G

N

N

Q

N

R

-

K

-

I

-

V

-

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G

-

G

G

V

V

I

L

Y

F

S

S

D

E

S

S

A

A

D

K

K

K

A

G

T

T

R

H

F

F

I

V

A

Q

N

L

C

C

N

C

Q

Q

K

R

K

N

I

I

P

P

L

L

V

L

F

F

L

L

Q

Q

D

N

V

I

T

T

G

G

F
|
F

M

M

V
|
V

G

G

S

R

K

E

S

Y

E

E

H

A

G

E

G

G

I

I

I

A

K

K

D

D

G

G

A

A

K

K

M

M

V

V

N

A

A

A

V

V

S

A

N

C

S

A

V

Q

V

V

P

P

K

K

F

I

T

T

I

L

V

I

V

I

G

G

N

G

S

S

Y

Y

G

G

A

A

G

G

N

N

Y

Y

A

G

M

M

C

C

G

G

K

R

A

A

Y

Y

D

S

P

P

R

R

L

F

I

L

A

Y

A

I

W

W

P

P

S

N

A

A

E

R

L

I

A

S

V

V

M

M

S

G

G

G

N

E

S

Q

A

A

A

A

K

N

V

V

L

L

L

A

Q

T

I

I

E

T

T

K

A

D

S

Q

L

R

K

A

K

R

Q

E

G

G

K

K

E

Q

I

F

T

S

P

S

E

A

V

D

E

E

K

A

E

A

L

L

Y

K

D

E

K

P

I

I

K

I

A

K

R

K

Y

F

D

E

E

E

Q

E

V

G

S

N

P

P

Y

Y

Y

Y

A

S

A

S

S

A

R

R

I

V

W

W

T

D

D

D

A

G

I

I

I

I

D

D

P

P

L

A

D

D

T

T

R

R

K

L

W

V

I

L

S

G

T

L

G

S

I

F

E

S

A

A

A

A

N

L

H

N

A

A

P

P

I

I

E

E

K

K

K

T

F

-

N

D

L

F

G

G

V

I

I

F

Q

R

V

M

binding acetyl coenzyme *a: K119 (= K105), G120 (≠ A106), G152 (≠ A138), G153 (= G139), A154 (≠ V140), L156 (= L142), T195 (≠ V181)
binding 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal: F385 (= F385), V387 (= V387)

8j4zJ Human 3-methylcrotonyl-coa carboxylase in bccp-cts state with substrate (see paper)
47% identity, 99% coverage: 5:542/542 of query aligns to 20:541/541 of 8j4zJ

query
sites
8j4zJ

F

Y

N

Q

K

E

N

N

E

Y

D

K

H

Q

N

M

K

K

L

A

L

L

V

V

S

N

D

Q

L

L

K

H

H

E

R

R

L

V

A

E

K

H

V

I

K

K

L

L

G

G

G

G

G

G

E

E

K

K

R

A

I

R

A

A

K

L

H

H

H

I

E

S

K
x
R

G

G

K

K

L

L

T

L

A

P

R

R

E

E

R

R

I

I

D

D

F

N

L

L

L

I

D

D

D

P

A

G

E

S

K

P

A

F

I

L

E

E

I

L

A

S

A

Q

F

F

A

A

G

G

E

Y

G

Q

M

L

Y

Y

E

D

E

N

H

E

G

E

G

-

C

V

P

P

S

G

G

G

G

G

V

I

V

I

V

T

K

G

I

I

G

G

H

R

I

V

S

S

G

G

K

V

Q

E

C

C

I

M

V

I

V

I

A

A

N

N

D

D

A

A

T

T

V

V

K
|
K

A
x
G

G

G

A
|
A

W

Y

F

Y

P

P

I

V

T

T

G

V

K

K

K

K

N

Q

L

L

R

R

A

A

Q

Q

E

E

L

I

S

A

I

M

E

Q

N

N

K

R

L

L

P

P

I

C

I

I

Y

Y

L

L

V

V

D

D

S

S

A
x
G

G
|
G

V
x
A

Y
|
Y

L

L

P

P

M

R

Q

Q

D

A

E

D

I

V

F

F

P

P

D

D

K

R

E

D

H

H

F
|
F

G

G

R

R

I

T

F

F

R

Y

N

N

N

Q

A

A

V

I

M

M

S

S

S

S

M

K

G

N

I

I

T

A

Q

Q

I

I

S

A

A

V

V

V

M

M

G

G

S

S

C

C

V
x
T

A
|
A

G
|
G

G

G

A

A

Y

Y

L

V

P

P

I

A

M

M

S

A

D

D

E

E

A

N

M

I

I

I

V

V

D

R

K

K

T

Q

G

G

S

T

I

I

F

F

L
|
L

A

A

G

G

S

P

Y

P

L
|
L

V

V

K

K

A

A

A

A

I

T

G

G

E

E

T

E

V

V

D

S

N

A

E

E

T

D

L

L

G

G

G

G

A

A

T

D

T

L

H

H

C

C

E

R

I

K

S

S

G

G

V

V

T

S

D

D

Y

H

K

W

A

A

S

L

D

D

D

D

R

H

D

H

A

A

L

L

T

H

R

L

I

T

K

R

N

K

I

V

M

V

G

R

K

N

I

L

G

-

D

N

F

Y

E

Q

K

K

A

K

G

L

Y

D

N

V

R

T

I

I

E

E

A

-

A

-

K

-

P

P

K

S

E

E

D

E

P

P

-

L

-

F

-

P

-

A

Q

D

D

E

I

L

Y

Y

G

G

I

I

L

V

P

G

A

A

K

N

R

L

S

K

D

R

Q

S

Y

F

D

D

M

V

T

R

E

E

I

V

I

I

K

A

R

R

L

I

V

V

D

D

N

G

S

S

E

R

Y

F

E

T

E

E

Y

F

K

K

E

A

G

F

Y

Y

G

G

Q

D

T

T

L

L

I

V

T

T

A

G

Y

F

A

A

R

R

I

I

D

F

G

G

W

Y

A

P

V

V

G

G

I

I

V

V

A

G

N

N

Q

N

R

-

K

-

I

-

V

-

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G

-

G

G

V

V

I

L

Y

F

S

S

D

E

S

S

A

A

D

K

K

K

A

G

T

T

R

H

F

F

I

V

A

Q

N

L

C

C

N

C

Q

Q

K

R

K

N

I

I

P

P

L

L

V

L

F

F

L

L

Q

Q

D

N

V

I

T

T

G
|
G

F
|
F

M

M

V

V

G

G

S

R

K

E

S

Y

E

E

H

A

G

E

G

G

I

I

I

A

K

K

D

D

G

G

A

A

K

K

M

M

V

V

N

A

A

A

V

V

S

A

N

C

S

A

V

Q

V

V

P

P

K

K

F

I

T

T

I

L

V

I

V

I

G

G

N

G

S

S

Y
|
Y

G

G

A
|
A

G

G

N

N

Y

Y

A

G

M

M

C

C

G

G

K

R

A

A

Y

Y

D

S

P

P

R

R

L

F

I

L

A

Y

A

I

W

W

P

P

S

N

A

A

E

R

L

I

A

S

V

V

M

M

S

G

G

G

N

E

S

Q

A

A

A

A

K

N

V

V

L

L

L

A

Q

T

I
|
I

E

T

T

K

A

D

S
x
Q

L

R

K

A

K

R

Q

E

G

G

K

K

E

Q

I

F

T

S

P

S

E

A

V

D

E

E

K

A

E

A

L

L

Y

K

D

E

K

P

I

I

K

I

A

K

R

K

Y

F

D

E

E

E

Q

E

V

G

S

N

P

P

Y

Y

Y

Y

A

S

A

S

S

A

R

R

I

V

W

W

T

D

D

D

A

G

I

I

I

I

D

D

P

P

L

A

D

D

T

T

R

R

K

L

W

V

I

L

S

G

T

L

G

S

I

F

E

S

A

A

A

A

N

L

H

N

A

A

P

P

I

I

E

E

K

K

K

T

F

-

N

D

L

F

G

G

V

I

I

F

Q

R

V

M

binding 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal: L219 (= L205), L224 (= L210), G384 (= G384), F385 (= F385), Y423 (= Y423), A425 (= A425)
binding ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{S},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate: R56 (≠ K41), K119 (= K105), G120 (≠ A106), A122 (= A108), G152 (≠ A138), G153 (= G139), A154 (≠ V140), Y155 (= Y141), F169 (= F155), T195 (≠ V181), A196 (= A182), G197 (= G183), I463 (= I463), Q467 (≠ S467)

3u9sF Crystal structure of p. Aeruginosa 3-methylcrotonyl-coa carboxylase (mcc) 750 kd holoenzyme, coa complex (see paper)
46% identity, 95% coverage: 16:532/542 of query aligns to 28:528/537 of 3u9sF

query
sites
3u9sF

V

V

S

N

D

A

L

L

K

R

H

T

R

L

L

L

A

G

K

R

V

I

K

H

L

E

G

G

G

G

G

G

E

S

K

A

R

A

I

Q

A

A

K
x
R

H

H

H

S

E

A

K

R

G

G

K

K

L

L

T

L

A

V

R

R

E

E

R

R

I

I

D

N

F

R

L

L

L

L

D

D

D

P

A

G

E

S

K

P

A

F

I

L

E

E

I

L

A

S

A

A

F

L

A

A

G

A

E

H

G

E

M

V

Y

Y

E

G

E

E

H

E

G

-

G

-

C

V

P

A

S

A

G

A

G

G

V

I

V

V

V

A

K

G

I

I

G

G

H

R

I

V

S

E

G

G

K

V

Q

E

C

C

I

M

V

I

V

V

A

G

N

N

D

D

A

A

T

T

V

V

K
|
K

A

G

G

G

A
x
T

W

Y

F

Y

P

P

I

L

T

T

G

V

K

K

K

K

N

H

L

L

R

R

A

A

Q

Q

E

A

L

I

S

A

I

L

E

E

N

N

K

R

L

L

P

P

I

C

I

I

Y

Y

L

L

V

V

D

D

S

S

A

G

G

G

V
x
A

Y
x
N

L
|
L

P

P

M

R

Q

Q

D

D

E

E

I

V

F

F

P

P

D

D

K

R

E

E

H

H

F

F

G

G

R

R

I

I

F

F

R

F

N

N

N

Q

A

A

V

N

M

M

S

S

S

A

M

R

G

G

I

I

T

P

Q

Q

I

I

S

A

A

V

V

V

M

M

G

G

S

S

C

C

V

T

A
|
A

G
|
G

G

G

A

A

Y

Y

L

V

P

P

I

A

M

M

S

S

D

D

E

E

A

T

M

V

I

M

V

V

D

R

K

E

T

Q

G

A

S

T

I

I

F

F

L

L

A

A

G

G

S

P

Y

P

L

L

V

V

K

K

A

A

A

A

I

T

G

G

E

E

T

V

V

V

D

S

N

A

E

E

T

E

L

L

G

G

G

G

A

A

T

D

T

V

H

H

C

C

E

K

I

V

S

S

G

G

V

V

T

A

D

D

Y

H

K

Y

A

A

S

E

D

D

D

D

R

D

D

H

A

A

L

L

T

A

R

I

I

A

K

R

N

R

I

C

M

V

G

A

K

N

I

L

G

-

D

N

F

W

E

R

K

K

A

Q

G

G

Y

Q

N

L

R

Q

I

C

E

R

A

A

A

P

K

R

-

A

P

P

K

L

E

Y

D

P

P

A

Q

E

D

E

I

L

Y

Y

G

G

I

V

L

I

P

P

A

A

K

D

R

S

S

K

D

Q

Q

P

Y

Y

D

D

M

V

T

R

E

E

I

V

I

I

K

A

R

R

L

L

V

V

D

D

N

G

S

S

E

E

Y

F

E

D

E

E

Y

F

K

K

E

A

G

L

Y

F

G

G

Q

T

T

T

L

L

I

V

T

C

A

G

Y

F

A

A

R

H

I

L

D

H

G

G

W

Y

A

P

V

I

G

A

I

I

V

L

A

A

N

N

Q

N

R

-

K

-

I

-

V

-

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G

-

G

G

V

I

I

L

Y

F

S

A

D

E

S

A

A

A

D

Q

K

K

A

G

T

A

R

H

F

F

I

I

A

E

N

L

C

A

N

C

Q

Q

K

R

K

G

I

I

P

P

L

L

V

L

F

F

L

L

Q

Q

D

N

V

I

T
|
T

G
|
G

F
|
F

M

M

V

V

G

G

S

Q

K

K

S

Y

E

E

H

A

G

G

G

G

I

I

I

A

K

K

D

H

G

G

A

A

K

K

M

L

V

V

N

T

A

A

V

V

S

A

N

C

S

A

V

R

V

V

P

P

K

K

F

F

T

T

I

V

V

L

V

I

G

G

N

G

S

S

Y

F

G

G

A
|
A

G
|
G

N

N

Y

Y

A

G

M

M

C

C

G

G

K

R

A

A

Y

Y

D

D

P

P

R

R

L

F

I

L

A

W

A

M

W

W

P

P

S

N

A

A

E

R

L

I

A

G

V

V

M
|
M

S

G

G

G

N

E

S

Q

A

A

A

A

K

G

V

V

L

L

L

A

Q

Q

I

V

E

K

T

R

A

E

S

Q

L

A

K

E

K

R

Q

A

G

G

K

Q

E

Q

I

L

T

G

P

V

E

E

V

E

E

E

K

A

E

K

L

I

Y

K

D

A

K

P

I

I

K

L

A

E

R

Q

Y

Y

D

E

E

H

Q

Q

V

G

S

H

P

P

Y

Y

Y

Y

A

S

A

S

S

A

R

R

I

L

W

W

T

D

D

D

A

G

I

V

I

I

D

D

P

P

L

A

D

Q

T

T

R

R

K

E

W

V

I

L

S

A

T

L

G

A

I

L

E

S

A

A

A

A

N

L

H

N

A

A

P

P

I

I

E

E

active site: A150 (≠ V140), A192 (= A182), G193 (= G183), F381 (= F385), A421 (= A425), G422 (= G426)
binding 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal: T379 (= T383), G380 (= G384), F381 (= F385), A421 (= A425), M447 (= M451)
binding coenzyme a: R49 (≠ K37), K115 (= K105), T118 (≠ A108), A150 (≠ V140), N151 (≠ Y141), L152 (= L142)

8jxmC Human 3-methylcrotonyl-coa carboxylase in bccp-h2 state with mcoa (see paper)
45% identity, 99% coverage: 5:542/542 of query aligns to 20:520/520 of 8jxmC

query
sites
8jxmC

F

Y

N

Q

K

E

N

N

E

Y

D

K

H

Q

N

M

K

K

L

A

L

L

V

V

S

N

D

Q

L

L

K

H

H

E

R

R

L

V

A

E

K

H

V

I

K

K

L

L

G

G

G

G

G

G

E

E

K

K

R

A

I

R

A

A

K

L

H

H

H

I

E

S

K
x
R

G

G

K

K

L

L

T

L

A

P

R

R

E

E

R

R

I

I

D

D

F

N

L

L

L

I

D

D

D

P

A

G

E

S

K

P

A

F

I

L

E

E

I

L

A

S

A

Q

F

F

A

A

G

G

E

Y

G

Q

M

L

Y

Y

E

D

E

N

H

E

G

E

G

-

C

V

P

P

S

G

G

G

G

G

V

I

V

I

V

T

K

G

I

I

G

G

H

R

I

V

S

S

G

G

K

V

Q

E

C

C

I

M

V

I

V

I

A

A

N

N

D

D

A

A

T

T

V

V

K
|
K

A
x
G

G

G

A

A

W

Y

F

Y

P

P

I

V

T

T

G

V

K

K

K

K

N

Q

L

L

R

R

A

A

Q

Q

E

E

L

I

S

A

I

M

E

Q

N

N

K

R

L

L

P

P

I

C

I

I

Y

Y

L

L

V

V

D

D

S

S

A
x
G

G

G

V
x
A

Y
|
Y

L

L

P

P

M

R

Q

Q

D

A

E

D

I

V

F
|
F

P

P

D

D

K

R

E

D

H

H

F

F

G

G

R

R

I

T

F

F

R

Y

N

N

N

Q

A

A

V

I

M

M

S

S

S

S

M

K

G

N

I

I

T

A

Q

Q

I

I

S

A

A

V

V

V

M

M

G

G

S

S

C

C

V
x
T

A
|
A

G

G

G

G

A

A

Y

Y

L

V

P

P

I

A

M

M

S

A

D

D

E

E

A

N

M

I

I

I

V

V

D

R

K

K

T

Q

G

G

S

-

I

-

F

-

L

-

A

-

G

-

S

-

Y

-

L

-

V

-

K

-

A

-

A

-

I

-

G

-

E

-

T

-

V

-

D

-

N

-

E

-

T

T

L

I

G

G

G

G

A

A

T

D

T

L

H

H

C

C

E

R

I

K

S

S

G

G

V

V

T

S

D

D

Y

H

K

W

A

A

S

L

D

D

D

D

R

H

D

H

A

A

L

L

T

H

R

L

I

T

K

R

N

K

I

V

M

V

G

R

K

N

I

L

G

-

D

N

F

Y

E

Q

K

K

A

K

G

L

Y

D

N

V

R

T

I

I

E

E

A

-

A

-

K

-

P

P

K

S

E

E

D

E

P

P

-

L

-

F

-

P

-

A

Q

D

D

E

I

L

Y

Y

G

G

I

I

L

V

P

G

A

A

K

N

R

L

S

K

D

R

Q

S

Y

F

D

D

M

V

T

R

E

E

I

V

I

I

K

A

R

R

L

I

V

V

D

D

N

G

S

S

E

R

Y

F

E

T

E

E

Y

F

K

K

E

A

G

F

Y

Y

G

G

Q

D

T

T

L

L

I

V

T

T

A

G

Y

F

A

A

R

R

I

I

D

F

G

G

W

Y

A

P

V

V

G

G

I

I

V

V

A

G

N

N

Q

N

R

-

K

-

I

-

V

-

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G

-

G

G

V

V

I

L

Y

F

S

S

D

E

S

S

A

A

D

K

K

K

A

G

T

T

R

H

F

F

I

V

A

Q

N

L

C

C

N

C

Q

Q

K

R

K

N

I

I

P

P

L

L

V

L

F

F

L

L

Q

Q

D

N

V

I

T
|
T

G
|
G

F
|
F

M

M

V

V

G

G

S

R

K

E

S

Y

E

E

H

A

G

E

G

G

I

I

I

A

K

K

D

D

G

G

A

A

K

K

M

M

V

V

N

A

A

A

V

V

S

A

N

C

S

A

V

Q

V

V

P

P

K

K

F

I

T

T

I

L

V

I

V

I

G

G

N

G

S

S

Y
|
Y

G
|
G

A
|
A

G

G

N

N

Y

Y

A

G

M

M

C

C

G

G

K

R

A

A

Y

Y

D

S

P

P

R

R

L

F

I

L

A

Y

A

I

W

W

P

P

S

N

A

A

E

R

L

I

A

S

V

V

M
|
M

S

G

G

G

N

E

S

Q

A

A

A

A

K

N

V

V

L

L

L

A

Q

T

I
|
I

E

T

T

K

A

D

S
x
Q

L

R

K

A

K

R

Q

E

G

G

K

K

E

Q

I

F

T

S

P

S

E

A

V

D

E

E

K

A

E

A

L

L

Y

K

D

E

K

P

I

I

K

I

A

K

R

K

Y

F

D

E

E

E

Q

E

V

G

S

N

P

P

Y

Y

Y

Y

A

S

A

S

S

A

R

R

I

V

W

W

T

D

D

D

A

G

I

I

I

I

D

D

P

P

L

A

D

D

T

T

R

R

K

L

W

V

I

L

S

G

T

L

G

S

I

F

E

S

A

A

A

A

N

L

H

N

A

A

P

P

I

I

E

E

K

K

K

T

F

-

N

D

L

F

G

G

V

I

I

F

Q

R

V

M

binding 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal: T362 (= T383), G363 (= G384), F364 (= F385), Y402 (= Y423), G403 (= G424), A404 (= A425), M430 (= M451)
binding ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{S},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate: R56 (≠ K41), K119 (= K105), G120 (≠ A106), G152 (≠ A138), A154 (≠ V140), Y155 (= Y141), F163 (= F149), T195 (≠ V181), A196 (= A182), I442 (= I463), Q446 (≠ S467)

8rthF Trypanosoma brucei 3-methylcrotonyl-coa carboxylase (see paper)
45% identity, 97% coverage: 4:530/542 of query aligns to 32:542/542 of 8rthF

query
sites
8rthF

K

E

F

F

N

K

K

A

N

N

E

T

D

E

H

R

N

M

K

K

L

A

L

L

V

T

S

A

D

E

L

L

K

R

H

R

R

R

L

V

A

Q

K

V

V

I

K

V

L

D

G

G

G

D

G

S

E

E

-

A

-

D

K

K

R

R

I

A

A

R

-

D

K

R

H

H

H

I

E

S

K

R

G

G

K

K

L

L

T

L

A

V

R

H

E

Q

R

R

I

I

D

E

F

K

L

L

L

V

D

D

D

P

A

M

E

S

K

P

A

F

I

L

E

E

I

L

A

S

A

Q

F

L

A

A

G

G

E

G

G

D

M

L

Y

Y

E

P

E

G

H

E

G

A

G

-

C

C

P

H

S

R

G

G

G

G

V

I

V

L

V

T

K

G

I

I

G

G

H

V

I

V

S

H

G

G

K

M

Q

R

C

V

I

M

V

I

V

V

A

A

N

N

D

D

A

A

T

T

V

V

K

K

A

G

G

G

A

T

W

Y

F

Y

P

P

I

I

T

T

G

V

K

K

K

K

N

H

L

L

R

R

A

A

Q

Q

E

R

L

I

S

A

I

E

E

E

N

N

K

R

L

L

P

P

I

C

I

I

Y

Y

L

L

V

V

D

D

S

S

A

G

G

G

V

A

Y

N

L

L

P

G

M

M

Q

Q

D

G

E

D

I

V

F

F

P

P

D

D

K

E

E

Q

H

H

F

F

G

G

R

R

I

I

F

F

R

F

N

N

N

Q

A

A

V

N

M

M

S

S

S

A

M

K

G

G

I

I

T

A

Q

Q

I

I

S

A

A

T

V

V

M

M

G

G

S

S

C

C

V

T

A

A

G

G

G

G

A

A

Y

Y

L

V

P

P

I

A

M

M

S

S

D

D

E

E

A

S

M

I

I

I

V

V

D

K

K

G

T

N

G

G

S

T

I

I

F

F

L

L

A

G

G

G

S

P

Y

P

L

L

V

V

K

F

A

A

A

A

I

T

G

G

E

E

T

E

V

V

D

T

N

P

E

E

T

E

L

L

G

G

G

G

A

A

T

D

T

V

H

H

C

C

E

R

I

A

S

S

G

G

V

V

T

T

D

D

Y

Y

K

F

A

A

S

T

D

D

D

D

R

L

D

H

A

A

L

L

T

Y

R

L

I

T

K

R

N

R

I

I

M

V

G

A

K

N

I

L

-

N

-

R

G

N

D

D

F

C

E

E

K

R

A

P

G

C

Y

R

N

G

R

R

I

-

E

E

A

F

A

T

K

P

P

P

K

L

E

Y

D

D

P

P

Q

S

D

E

I

I

Y

G

G

G

I

F

L

I

P

P

A

D

K

M

R

G

S

A

D

D

-

V

-

V

-

K

Q

G

Y

F

D

D

M

V

T

R

E

A

I

V

I

I

K

A

R

R

L

L

V

V

D

D

N

G

S

S

E

E

Y

F

E

D

E

E

Y

F

K

K

E

K

G

L

Y

Y

G

G

Q

D

T

T

L

L

I

V

T

C

A

G

Y

F

A

A

R

R

I

F

D

E

G

G

W

M

A

L

V

V

G

G

I

I

V

V

A

A

N

N

Q

N

R

-

K

-

I

-

V

-

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G

-

G

G

V

I

I

L

Y

Y

S

S

D

E

S

S

A

A

D

L

K

K

A

G

T

A

R

H

F

F

I

V

A

E

N

L

C

C

N

S

Q

H

K

R

K

N

I

I

P

P

L

L

V

L

F

F

L

L

Q

Q

D

N

V

I

T
|
T

G
|
G

F
|
F

M

M

V

V

G

G

S

K

K

T

S

Y

E

E

H

E

G

G

G

G

I

I

I

A

K

K

D

N

G

G

A

A

K

K

M

L

V

V

N

T

A

A

V

V

S

S

N

T

S

T

V

H

V

V

P

P

K

K

F

I

T

T

I

I

V

I

V

I

G

G

N

G

S

S

Y

Y

G

G

A

A

G

G

N

N

Y

Y

A

G

M

M

C

C

G

G

K

R

A

A

Y

F

D

G

P

P

R

R

L

F

I

L

A

F

A

M

W

W

P

P

S

N

A

A

E

R

L

I

A

S

V

V

M

M

S

G

G

G

N
|
N

S
x
Q

A

A

A

A

K

T

V

V

L

-

L

L

Q

A

I

L

E

T

T

N

A

S

S

K

L

L

K

R

K

E

Q

N

G

-

K

-

E

-

I

-

T

-

P

-

E

E

V

V

E

Q

K

-

E

D

L

F

Y

K

D

A

K

K

I

V

K

R

A

S

R

K

Y

Y

D

E

E

Y

Q

E

V

G

S

S

P

C

Y

Y

Y

Y

A

S

A

T

S

A

R

R

I

L

W

W

T

D

D

D

A

G

I

V

I

I

D

A

P

P

L

E

D

D

T

T

R

R

K

A

W

V

I

V

S

V

T

Q

G

A

I

L

E

L

A

S

A

T

N

L

H

S

A

A

P

P

binding 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal: T403 (= T383), G404 (= G384), F405 (= F385), N474 (= N454), Q475 (≠ S455)

8f3dA 3-methylcrotonyl-coa carboxylase in filament, beta-subunit centered (see paper)
43% identity, 98% coverage: 2:530/542 of query aligns to 27:566/566 of 8f3dA

query
sites
8f3dA

D

D

L

P

K

T

F

Y

N

Q

K

E

N

N

E

M

D

A

H

R

N

M

K

E

L

G

L

L

V

V

S

E

D

Q

L

L

K

R

H

A

R

R

L

V

A

R

K

Y

V

V

K

Q

L

A

G

G

G

G

-

V

-

V

-

P

-

E

-

E

-

E

-

A

-

A

-

K

-

A

-

G

-

V

-

S

-

I

-

S

-

S

-

I

-

E

G

A

E

D

K

D

R

R

I

V

A

R

K

K

H

L

H

H

-

L

E

S

K

R

G

G

K

K

L

M

T

L

A

A

R

R

E

D

R

R

I

I

D

E

F

R

L

L

L

I

D

D

D

P

A

G

E

T

K

R

A

F

I

L

E

E

I

L

A

S

A

Q

F

L

A

A

G

G

E

W

G

D

M

L

Y

Y

-

W

-

D

-

D

-

K

-

K

E

K

E

E

H

Y

G

E

G

R

C

C

P

Y

S

S

G

G

G

G

V

I

V

V

V

T

K

G

I

I

G

G

H

L

I

V

S

N

G

G

K

V

Q

R

C

C

I

M

V

L

V

V

A

A

N

N

D

D

A

A

T

T

V

V

K

K

A

G

G

G

A

T

W

Y

F

Y

P

P

I

I

T

T

G

V

K

K

K

K

N

H

L

L

R

R

A

A

Q

Q

E

K

L

I

S

A

I

E

E

Q

N

N

K

H

L

L

P

P

I

C

I

I

Y

Y

L

L

V

V

D

D

S

S

A

G

G

G

V

A

Y

N

L

L

P

S

M

R

Q

Q

D

D

E

D

I

V

F

F

P

P

D

D

K

E

E

Q

H

H

F

F

G

G

R

R

I

I

F

F

R

Y

N

N

N

E

A

A

V

Q

M

M

S

S

S

I

M

K

G

S

I

I

T

S

Q

Q

I

I

S

A

A

V

V

V

M

M

G

G

S

S

C

C

V

T

A

A

G

G

G

G

A

A

Y

Y

L

V

P

P

I

A

M

M

S

A

D

D

E

E

A

N

M

I

I

I

V

V

D

A

K

R

T

N

G

G

S

T

I

I

F

F

L

L

A

G

G

G

S

P

Y

P

L

L

V

V

K

L

A

A

A

A

I

T

G

G

E

E

T

K

V

V

D

S

N

S

E

E

T

E

L

L

G

G

G

G

A

A

T

D

T

V

H

H

C

C

E

R

I

I

S

S

G

G

V

V

T

G

D

D

Y

H

K

Y

A

A

S

T

D

D

D

D

R

L

D

H

A

A

L

L

T

Y

R

L

I

A

K

R

N

R

I

A

M

V

G

A

K

N

I

L

G

N

-

L

-

K

-

E

D

H

F

N

E

E

K

A

A

R

G

N

Y

P

N

T

R

D

I

V

E

K

A

P

A

V

K

P

P

P

K

L

E

Y

D

D

P

P

Q

R

D

E

I

L

Y

G

G

G

I

F

L

I

P

P

A

D

K

M

R

L

S

S

D

D

-

V

-

V

-

K

Q

S

Y

F

D

D

M

V

T

R

E

A

I

I

I

I

K

A

R

R

L

I

V

V

D

D

N

G

S

S

E

R

Y

F

E

D

E

E

Y

F

K

K

E

A

G

L

Y

Y

G

G

Q

N

T

T

L

L

I

V

T

C

A

G

Y

F

A

A

R

R

I

I

D

E

G

G

W

M

A

Q

V

V

G

G

I

I

V

I

A

A

N

N

Q

Q

R

-

K

-

I

-

V

-

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G

-

G

G

V

I

I

L

Y

Y

S

S

D

E

S

S

A

A

D

L

K

K

A

G

T

A

R

H

F

F

I

I

A

G

N

L

C

C

N

T

Q

Q

K

R

K

N

I

V

P

P

L

L

V

L

F

F

L

L

Q

Q

D

N

V

I

T

T

G

G

F
|
F

M

M

V

V

G

G

S

K

K

K

S

Y

E

E

H

E

G

G

G

G

I

I

I

A

K

R

D

N

G

G

A

A

K

R

M

L

V

V

N

M

A

A

V

V

S

S

N

S

S

A

V

P

V

V

P

P

K

K

F

V

T

T

I

V

V

L

V

I

G

G

N

G

S

S

Y

Y

G

G

A

A

G

G

N

N

Y

Y

A

G

M

M

C

C

G

G

K

R

A

A

Y

F

D

E

P

P

R

R

L

F

I

L

A

F

A

M

W

W

P

P

S

N

A

A

E

R

L

I

A

S

V

V

M

M

S

G

G

G

N

T

S
x
Q

A

A

A

A

K

T

V

V

L

L

L

-

Q

-

I

-

E

-

T

-

A

-

S

T

L

L

K

T

K

N

Q

R

G

N

K

L

E

K

I

N

T

A

P

S

E

E

V

A

E

E

K

I

E

A

L

A

Y

F

-

K

D

D

K

K

I

V

K

K

A

K

R

K

Y

Y

D

E

E

K

Q

E

V

G

S

S

P

C

Y

Y

Y

Y

A

S

A

T

S

A

R

R

I

L

W

W

T

D

D

D

A

G

I

V

I

I

D

A

P

P

L

E

D

D

T

T

R

R

K

V

W

V

I

V

S

A

T

E

G

A

I

L

E

R

A

A

A

T

N

R

H

L

A

A

P

P

binding 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal: F426 (= F385), Q496 (≠ S455)

1vrgA Crystal structure of propionyl-coa carboxylase, beta subunit (tm0716) from thermotoga maritima at 2.30 a resolution
33% identity, 94% coverage: 16:524/542 of query aligns to 7:496/515 of 1vrgA

query
sites
1vrgA

V

I

S

E

D

E

L

L

K

K

H

K

R

I

L

E

A

K

K

E

V

I

K

E

L

Q

G

G

G

G

G

G

E

P

K

E

R

K

I

V

A

E

K

K

H

Q

H

H

E

R

K

A

G

G

K

K

L

L

T

T

A

A

R

W

E

E

R

R

I

L

D

E

F

L

L

L

L

L

D

D

D

P

A

G

E

-

K

T

A

F

I

V

E

E

I

I

A

D

A

K

F

F

A

V

G

-

E

-

G

-

M

-

Y

-

E

-

E

E

H

H

G

R

G

N

C

T

-

Y

-

F

-

G

-

L

-

D

-

K

-

V

-

K

-

L

P

P

S

R

G

D

G

G

V

V

V

I

V

T

K

G

I

V

G

G

H

E

I

I

S

N

G

G

K

R

Q

K

C

V

I

A

V

V

V

F

A

S

N

Q

D

D

A

F

T

T

V

V

K

M

A

G

G

G

A

S

W

L

F

G

P

E

I

M

T

H

G

A

K

K

K

K

N

I

L

V

R

K

A

L

Q

L

E

D

L

L

S

A

I

L

E

K

N

M

K

G

L

I

P

P

I

V

I

I

Y

G

L

I

V

N

D

D

S

S

A

G

G

G

V
x
A

Y

R

L

I

P

-

M

-

Q

-

D

Q

E

E

I

G

F

V

P

D

D

A

K

L

E

A

H

G

F

Y

G

G

R

E

I

I

F

F

R

L

N

R

N

N

A

T

V

L

M

A

S

S

S

G

M

V

G

-

I

V

T

P

Q

Q

I

I

S

T

A

V

V

I

M

A

G

G

S

P

C

C

V

A

A
x
G

G
|
G

G

A

A

V

Y

Y

L

S

P

P

I

A

M

L

S

T

D

D

E

F

A

I

M

V

I

M

V

V

D

D

K

Q

T

T

G

A

S

R

I

M

F

F

L

I

A

T

G
|
G

S

P

Y
x
N

L
x
V

V

I

K

K

A

A

A

V

I

T

G

G

E

E

T

E

V

I

D

S

N

Q

E

E

T

D

L

L

G

G

G

G

A

A

T

M

T

V

H

H

C

N

E

Q

I

K

S

S

G

G

V

N

T

A

D

H

Y

F

K

L

A

A

S

D

D

N

D

D

R

E

D

K

A

A

L

M

T

S

R

L

I

V

K

R

N

T

I

L

M

L

G

S

K

Y

I

L

G

P

D

S

F

N

E

N

K

A

A

E

G

E

Y

P

N

P

R

V

I

E

E

D

A

P

A

D

K

T

P

S

K

L

E

E

D

T

P

P

Q

E

D

D

I

I

Y

L

G

D

I

I

L

L

P

P

A

D

K

N

R

P

S

N

D

K

Q

G

Y

Y

D

D

M

V

T

R

E

D

I

V

I

I

K

K

R

R

L

V

V

V

D

D

N

H

S

G

E

E

Y

F

E

F

E

E

Y

V

K

Q

E

P

G

Y

Y

F

G

A

Q

K

T

N

L

I

I

V

T

I

A

G

Y

F

A

A

R

R

I

I

D

Q

G

G

W

K

A

T

V

V

G

G

I

I

V

V

A

A

N

N

Q

Q

R

P

K

S

I

V

V

L

K

-

T

-

K

-

K

-

G

-

E

-

M

-

Q

-

F

-

G