SitesBLAST

P22256 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 from Escherichia coli (strain K12) (see 2 papers)
31% identity, 96% coverage: 4:413/429 of query aligns to 3:410/426 of P22256

query
sites
P22256

S

S

N

N

A

K

E

E

L

L

I

M

A

Q

D

R

R

R

A

S

R

Q

L

A

L

I

G

P

P

R

N

G

V

V

S

G

T

Q

F

I

Y

H

D

-

N

-

P

P

V

I

H

F

I

A

V

D

K

R

G

A

E

E

G

N

V

C

W

R

L

V

W

W

D

D

A

V

D

E

G

G

R

R

K

E

Y

Y

L

L

D

D

C

F

Y

A

N

G

V
x
I

P

A

-

V

-

L

H

N

V

T

G

G

H

H

C

L

N

H

P

P

R

K

V

V

D

A

A

A

I

V

C

E

R

A

Q

Q

A

L

N

K

T

K

L

L

N

-

T

S

H

H

T

T

R

C

Y

F

-

Q

-

V

-

L

L

A

H

Y

D

E

G

P

I

Y

L

L

D

E

Y

L

V

C

E

E

K

I

L

M

T

N

S

Q

T

K

V

V

-

P

D

G

D

D

H

F

L

A

D

K

T

K

A

T

I

L

L

L

T

V

C

T

T

T

G
|
G

S
|
S

E

E

A

A

N

V

D

E

I

N

A

A

L

V

R

K

M

I

A

A

E

R

S

A

M

A

T

T

G

K

K

R

R

S

G

G

I

T

I

I

A

A

T

F

D

S

A

G

T

A

Y

Y

H

H

G

G

N

R

T

T

S

H

L

Y

V

T

S

L

Q

A

L

L

S

T

-

G

K

K

S

V

N

N

V

P

P

Y

T

S

V

A

G

G

F

M

G

G

L

L

-

M

-

P

G

G

Q

H

F

V

F

Y

R

R

F

A

V

L

G

-

A

-

P

-

D

-

S

-

Y

-

R

-

N

Y

P

P

D

C

P

P

-

L

E

H

G

G

M

I

R

S

F

E

A

D

E

D

S

A

V

I

A

A

E

S

-

I

-

H

Q

R

I

I

A

F

E

K

H

N

E

D

K

A

S

A

G

P

I

E

G

D

F

I

A

A

L

I

V

V

V

I

C

E

P

P

Y

V

F

Q

L

G

N
x
E

E

G

G

G

F

F

P

Y

D

A

N

S

P

S

D

P

G

A

W

F

L

M

K

Q

P

R

T

L

A

R

E

A

V

L

V

C

R

D

K

E

A

H

G

G

G

I

L

M

L

L

I

I

C

A

D

D

E

E

V
|
V

Q
|
Q

S

S

G

G

F

A

G

G

R

R

T

T

G

G

T

T

H

-

M

L

W

F

A

A

H

M

Q

E

K

Q

M

M

G

G

V

V

V

A

P

P

D

D

V

L

M

T

T

T

L

F

G

A

K
|
K

P

S

M

I

G

A

N

G

G

G

H

F

P

P

I

L

G

A

G

G

V

V

V

T

T

G

N

R

S

A

E

E

I

V

L

M

G

D

T

A

F

V

R

A

K

P

G

G

Y

-

R

G

Y

L

F

G

N

G

T
|
T

F

Y

G

A

G

G

N

N

P

P

V

I

S

A

C

C

A

V

A

A

I

L

A

E

V

V

L

L

E

K

E

V

I

F

E

E

D

Q

K

E

H

N

L

L

E

Q

N

K

A

A

R

N

K

D

V

L

G

G

A

Q

H

K

A

L

R

K

M

D

R

G

I

L

T

L

R

A

L

I

A

A

K

E

K

K

H

H

E

P

F

E

I

I

G

G

D

D

V

V

R

R

G

G

S

L

G

G

L

A

I

M

F

I

G

A

A

I

E

E

M

L

V

F

L

E

D

D

R

G

E

D

T

H

K

N

Q

K

P

P

A

D

S

A

A

K

F

L

T

T

D

A

R

E

V

I

I

V

N

A

G

R

M

A

R

R

E

D

R

K

G

G

V

L

I

I

H

L

S

L

K

S

L

C

G

G

R

P

H

Y

K

Y

N

N

T

V

L

L

K

R

I

I

R

L

P

-

M

V

P

P

F

L

S

T

I

I

E

E

N

D

A

A

D

Q

L

I

I50 (≠ V53) mutation to Q: 3-fold decrease in catalytic activity and 12-fold decrease in affinity for GABA.
GS 111:112 (= GS 109:110) binding pyridoxal 5'-phosphate
E211 (≠ N210) mutation to S: 100-fold decrease in catalytic activity and 15-fold decrease in affinity for GABA.
V241 (= V240) mutation to A: 25-fold decrease in catalytic activity and 5-fold decrease in affinity for GABA.
Q242 (= Q241) binding pyridoxal 5'-phosphate
K268 (= K268) modified: N6-(pyridoxal phosphate)lysine
T297 (= T298) binding pyridoxal 5'-phosphate

1zobA Crystal structure of dialkylglycine decarboxylases bound with calcium ion
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1zobA

query
sites
1zobA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V

Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T
x
L

H

F

T
x
S

R

E

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

A

S

N
|
N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N

S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding calcium ion: L76 (≠ T76), S78 (≠ T78), V303 (≠ G300), S304 (≠ G301), D305 (≠ N302)
binding pyridoxal-5'-phosphate: T108 (= T108), A110 (≠ S110), N113 (= N113), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268)

Sites not aligning to the query:

active site: 19

1zc9A The crystal structure of dialkylglycine decarboxylase complex with pyridoxamine 5-phosphate (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1zc9A

query
sites
1zc9A

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V

Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N

S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G109 (= G109), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268)

Sites not aligning to the query:

active site: 19

1m0qA Structure of dialkylglycine decarboxylase complexed with s-1- aminoethanephosphonate (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1m0qA

query
sites
1m0qA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V
x
Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N
x
S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding (1s)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]ethylphosphonic acid: Q50 (≠ V53), T108 (= T108), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), S213 (≠ N210), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)

Sites not aligning to the query:

active site: 19

1m0pA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- phenylethanephosphonate (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1m0pA

query
sites
1m0pA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V
x
Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N
x
S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-phenylethylphosphonic acid: Q50 (≠ V53), T108 (= T108), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), S213 (≠ N210), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)

Sites not aligning to the query:

active site: 19

1m0oA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- methylpropanephosphonate (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1m0oA

query
sites
1m0oA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V
x
Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N

S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V

A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-methylpropylphosphonic acid: Q50 (≠ V53), G109 (= G109), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), R404 (≠ K399)

Sites not aligning to the query:

active site: 19

1m0nA Structure of dialkylglycine decarboxylase complexed with 1- aminocyclopentanephosphonate (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1m0nA

query
sites
1m0nA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V
x
Q

P
x
M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G

G

S
x
A

E

E

A

S

N
|
N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N
x
S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding 1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]cyclopentylphosphonic acid: Q50 (≠ V53), M51 (≠ P54), A110 (≠ S110), N113 (= N113), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), S213 (≠ N210), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)

Sites not aligning to the query:

active site: 19

1dgdA An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1dgdA

query
sites
1dgdA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V

Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-

H

T

L

H

F

T

S

R

G

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T
|
T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N

S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding pyridoxal-5'-phosphate: T108 (= T108), G109 (= G109), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268)

Sites not aligning to the query:

active site: 19

1d7vA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with nma (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1d7vA

query
sites
1d7vA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V

Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-
x
H

T
x
L

H
x
F

T
x
S

R

G

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G

G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N
x
S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F
x
H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding potassium ion: H75 (vs. gap), L76 (≠ T76), F77 (≠ H77), S78 (≠ T78), T301 (= T298), H302 (≠ F299), V303 (≠ G300), S304 (≠ G301), D305 (≠ N302)
binding n-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-2-methylalanine: A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), S213 (≠ N210), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)

Sites not aligning to the query:

active site: 19

1d7uA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with lcs (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1d7uA

query
sites
1d7uA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V

Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-
x
H

T
x
L

H
x
F

T
x
S

R

G

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N

S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F
x
H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding potassium ion: H75 (vs. gap), L76 (≠ T76), F77 (≠ H77), S78 (≠ T78), T301 (= T298), H302 (≠ F299), V303 (≠ G300), S304 (≠ G301), D305 (≠ N302)
binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: G109 (= G109), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)

Sites not aligning to the query:

active site: 19

1d7sA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with dcs (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1d7sA

query
sites
1d7sA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V
x
Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-
x
H

T
x
L

H
x
F

T
x
S

R

G

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N

S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F
x
H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

G

E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding d-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-n,o-cycloserylamide: Q50 (≠ V53), G109 (= G109), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)
binding potassium ion: H75 (vs. gap), L76 (≠ T76), F77 (≠ H77), S78 (≠ T78), T301 (= T298), H302 (≠ F299), V303 (≠ G300), S304 (≠ G301), D305 (≠ N302)

Sites not aligning to the query:

active site: 19

1d7rA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with 5pa (see paper)
31% identity, 93% coverage: 26:425/429 of query aligns to 23:430/431 of 1d7rA

query
sites
1d7rA

N

E

P

P

V

M

H

I

I

I

V

E

K

R

G

A

E

K

G

G

V

S

W

F

L

V

W

Y

D

D

A

A

D

D

G

G

R

R

K

A

Y

I

L

L

D

D

C

F

Y

T

N

S

N

G

V

Q

P

M

H

S

-

A

-

V

V

L

G

G

H

H

C

C

N

H

P

P

R

E

V

I

V

V

D

S

A

V

I

I

C

G

R

E

Q

Y

A

A

N

G

T

K

L

L

N

D

-
x
H

T
x
L

H
x
F

T
x
S

R

G

Y

M

L

L

H

S

D

R

G

P

I

V

L

V

D

D

Y

L

V

A

E

T

K

R

L

L

T

A

S

N

T

I

V

T

D

P

H

G

L

L

D

D

T

R

A

A

I

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

I

A

A

A

L

I

R

R

M

M

A

A

E

K

S

L

M

V

T

T

G

G

K

K

R

Y

G

E

I

I

I

V

A

G

T

F

D

A

A

Q

T

S

Y
x
W

H
|
H

G

G

N

M

T

T

S

G

L

A

V

A

S

A

Q

S

L

A

S

T

K

Y

S

S

N

-

V

A

P

G

T

R

V

K

G

G

F

V

G

G

L

P

G

A

Q

A

F

V

F

G

R

S

F

F

-

A

V

I

G

P

A

A

P

P

D

F

S

T

Y

Y

R

R

N

-

P

P

D

R

P

F

E

E

G

R

M

N

R

G

F

A

A

Y

E

D

S

Y

V

L

A

A

E

E

-

L

-

D

-

Y

-

A

-

F

Q

D

I

L

A

I

E

D

H

R

E

Q

K

S

S

S

G

G

I

-

G

N

F

L

A

A

L

F

V

I

V

A

C
x
E

P

P

Y

I

F

L

L

S

N
x
S

E

G

G

G

F

I

P

I

D

E

N

L

P

P

D

D

G

G

W

Y

L

M

K

A

P

A

T

L

A

K

E

R

V

K

V

C

R

E

K

A

A

R

G

G

G

M

L

L

I

I

C

L

D
|
D

E

E

V
x
A

Q
|
Q

S

T

G

G

F

V

G

G

R

R

T

T

G

G

T

T

H

-

M

M

W

F

A

A

H

C

Q

Q

K

R

M

D

G

G

V

V

V

T

P

P

D

D

V

I

M

L

T

T

L

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

I

L

G

A

V

I

V

V

T

T

N

S

S

A

E

A

I

I

L

E

G

E

T

R

F

A

R

H

K

E

-

L

G

G

Y

Y

R

L

Y

F

F

Y

N

T

T
|
T

F
x
H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

C

A

A

A

A

V

A

G

I

L

A

R

V

V

L

L

E

D

E

V

I

V

E

Q

D

R

K

D

H

G

L

L

L

V

E

A

N

R

A

A

R

N

K

V

V

M

G

G

A

D

H

R

A

L

R

R

M

R

R

G

I

L

T

L

R

D

L

L

A

M

K

E

K

R

H

F

E

D

F

C

I

I

G

G

D

D

V

V

R

R

G

G

S

R

G

G

L

L

I

L

F

L

G

G

A

V

E

E

M

I

V

V

L

K

D

D

R

R

E

R

T

T

K

K

Q

E

P

P

A

A

S

D

A

G

F

L

T

G

D

A

R

K

V

I

I

T

N

R

G

E

M

C

R

M

E

N

R

L

G

G

V

L

I

S

H

M

S

N

-

I

-

V

K

Q

L

L

G

P

R

G

H

M

K

G

N

G

T

V

L

F

K
x
R

I

I

R

A

P

P

M

L

P

T

F

V

S

S

I

E

E

D

N

E

A

I

D

D

L

L

L

G

F

L

D

S

T

L

L

L

D

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E

Q

V

A

L

I

A

E

K

R

T

A

active site: W136 (≠ Y136), E208 (≠ C205), D241 (= D238), Q244 (= Q241), K270 (= K268), T301 (= T298), R404 (≠ K399)
binding n-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-y-lmethyl]-1-amino-cyclopropanecarboxylic acid: G109 (= G109), A110 (≠ S110), W136 (≠ Y136), H137 (= H137), E208 (≠ C205), S213 (≠ N210), D241 (= D238), A243 (≠ V240), Q244 (= Q241), K270 (= K268), R404 (≠ K399)
binding potassium ion: H75 (vs. gap), L76 (≠ T76), F77 (≠ H77), S78 (≠ T78), T301 (= T298), H302 (≠ F299), V303 (≠ G300), S304 (≠ G301), D305 (≠ N302)

Sites not aligning to the query:

active site: 19

7vo1A Structure of aminotransferase-substrate complex (see paper)
33% identity, 92% coverage: 30:422/429 of query aligns to 38:440/452 of 7vo1A

query
sites
7vo1A

I

I

V

E

K

R

G

A

E

E

G

G

V

V

W

Y

L

W

W

I

D

D

A

V

D

D

G

G

R

N

K

V

Y

L

L

L

D

D

C

F

Y

S

N

S

N

G

-
x
I

-

G

V

V

P

M

H

N

V

V

G

G

H

L

C

R

N

N

P

P

R

K

V

V

V

I

D

E

A

A

I

I

C

K

R

K

Q

Q

A

L

N

D

T

L

L

V

-

L

-

H

N

A

T

A

H

G

T

T

R

D

Y

Y

L

Y

H

N

D

P

G

Y

I

Q

L

V

D

E

Y

L

V

A

E

K

K

K

L

L

T

V

S

E

T

I

V

A

D

P

D

G

H

D

L

I

D

E

T

R

A

K

I

V

-

F

L

L

T

S

C

N

T
x
S

G
|
G

S
x
T

E

E

A

A

N

N

D

E

I

A

A

A

L

L

R

K

M

I

A

A

E

K

S

W

M

S

T

T

G

N

K

R

R

K

G

M

I

F

I

I

A

A

T

F

D

I

A

G

T

A

Y
x
F

H
|
H

G

G

N
x
R

T

T

S

H

L

G

V

T

S

M

Q

S

L

L

S

T

K

A

S

S

N

K

-

P

-

V

-

Q

-

R

-

S

-

R

-

M

V

F

P

P

T

T

-

M

-

P

-

G

-

V

V

V

G

H

F

V

G

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L

Y

G

P

Q

N

F

P

F

Y

R

R

F

N

V

P

G

W

A

G

P

I

D

D

S

G

Y

Y

R

E

N

N

P

P

D

D

P

E

E

L

G

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F

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A

I

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D

S

Y

V

I

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E

E

E

Q

Y

I

L

A

F

E

E

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H

E

Y

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G

A

I

E

G

E

F

V

A

A

A

G

L

I

V

F

C

E

P

P

Y

I

F

Q

L

G

N
x
E

E

G

G

G

F

Y

P

V

D

V

N

P

P

P

D

K

G

N

W

F

L

F

K

K

P

E

T

L

A

K

E

K

V

L

V

A

R

D

K

K

A

H

G

G

G

I

L

L

I

I

C

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|
D

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|
V

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Q

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M

G

G

F

M

G

G

R

R

T

T

G

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T

-

H

R

M

M

W

W

A

A

H

I

Q

E

K

H

M

F

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D

V

I

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P

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D

V

I

M

V

T

T

L

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|
K

P

A

M

L

G

G

N

G

G

G

H

I

P

P

I

I

G

G

G

A

V

T

V

I

T

F

N

R

S

A

E

D

I

L

L

-

G

-

T

D

F

F

R

G

K

V

G

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Y

G

R

V

Y

H

F

S

N
|
N

T
|
T

F

F

G

G

N

N

P

T

V

V

S

A

C

A

A

A

I

L

A

A

V

V

L

I

E

E

I

L

E

Q

D

N

K

G

H

-

L

L

L

I

E

E

N

N

A

A

R

Q

K

K

V

L

G

E

A

P

H

L

A

F

R

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M

E

R

R

I

L

T

E

R

E

L

M

A

K

K

E

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K

H

Y

E

E

F

I

I

I

G

G

D

D

V

V

R

R

G

G

S

L

G

G

L

L

I

A

F

W

G

G

A

V

E

E

M

F

V

V

L

K

D

D

R

R

E

K

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T

K

K

Q

E

P

Y

A

A

S

T

A

K

F

E

T

R

D

G

R

E

V

I

I

V

N

V

G

E

M

A

R

L

E

K

R

R

G

G

V

L

I

-

H

-

S

A

K

L

L

L

G

G

R

C

H

G

K

K

N

S

T

A

L

I

K
x
R

I

L

R

I

P

P

M

L

P

I

F

I

S

S

I

E

E

E

N

E

A

A

D

K

L

M

L

G

F

L

D

D

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L

F

D

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E

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A

L

I

binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: I61 (vs. gap), S121 (≠ T108), G122 (= G109), T123 (≠ S110), F149 (≠ Y136), H150 (= H137), R152 (≠ N139), E234 (≠ N210), D262 (= D238), V264 (= V240), Q265 (= Q241), K291 (= K268), N318 (= N297), T319 (= T298), R417 (≠ K399)

7vntA Structure of aminotransferase-substrate complex (see paper)
33% identity, 92% coverage: 30:422/429 of query aligns to 38:440/452 of 7vntA

query
sites
7vntA

I

I

V

E

K

R

G

A

E

E

G

G

V

V

W

Y

L

W

W

I

D

D

A

V

D

D

G

G

R

N

K

V

Y

L

L

L

D

D

C

F

Y

S

N

S

N

G

-

I

-

G

V

V

P

M

H

N

V

V

G

G

H

L

C

R

N

N

P

P

R

K

V

V

V

I

D

E

A

A

I

I

C

K

R

K

Q

Q

A

L

N

D

T

L

L

V

-

L

-

H

N

A

T

A

H

G

T

T

R

D

Y

Y

L

Y

H

N

D

P

G

Y

I

Q

L

V

D

E

Y

L

V

A

E

K

K

K

L

L

T

V

S

E

T

I

V

A

D

P

D

G

H

D

L

I

D

E

T

R

A

K

I

V

-

F

L

L

T

S

C

N

T

S

G
|
G

S
x
T

E

E

A

A

N

N

D

E

I

A

A

A

L

L

R

K

M

I

A

A

E

K

S

W

M

S

T

T

G

N

K

R

R

K

G

M

I

F

I

I

A

A

T

F

D

I

A

G

T

A

Y
x
F

H
|
H

G

G

N
x
R

T

T

S

H

L

G

V

T

S

M

Q

S

L

L

S

T

K

A

S

S

N

K

-

P

-

V

-

Q

-

R

-

S

-

R

-

M

V

F

P

P

T

T

-

M

-

P

-

G

-

V

V

V

G

H

F

V

G

P

L

Y

G

P

Q

N

F

P

F

Y

R

R

F

N

V

P

G

W

A

G

P

I

D

D

S

G

Y

Y

R

E

N

N

P

P

D

D

P

E

E

L

G

I

M

N

R

R

F

V

A

I

E

D

S

Y

V

I

A

E

E

E

Q

Y

I

L

A

F

E

E

H

H

E

Y

K

V

S

P

G

A

I

E

G

E

F

V

A

A

A

G

L

I

V

F

C
x
E

P

P

Y

I

F

Q

L

G

N
x
E

E

G

G

G

F

Y

P

V

D

V

N

P

P

P

D

K

G

N

W

F

L

F

K

K

P

E

T

L

A

K

E

K

V

L

V

A

R

D

K

K

A

H

G

G

G

I

L

L

I

I

C

D

D
|
D

E

E

V
|
V

Q
|
Q

S

M

G

G

F

M

G

G

R

R

T

T

G

G

T

-

H

R

M

M

W

W

A

A

H

I

Q

E

K

H

M

F

G

D

V

I

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V

P

P

D

D

V

I

M

V

T

T

L

V

G

A

K
|
K

P

A

M

L

G

G

N

G

G

G

H

I

P

P

I

I

G

G

G

A

V

T

V

I

T

F

N

R

S

A

E

D

I

L

L

-

G

-

T

D

F

F

R

G

K

V

G

S

Y

G

R

V

Y

H

F

S

N

N

T

T

F

F

G

G

N

N

P

T

V

V

S

A

C

A

A

A

I

L

A

A

V

V

L

I

E

E

I

L

E

Q

D

N

K

G

H

-

L

L

L

I

E

E

N

N

A

A

R

Q

K

K

V

L

G

E

A

P

H

L

A

F

R

R

M

E

R

R

I

L

T

E

R

E

L

M

A

K

K

E

K

K

H

Y

E

E

F

I

I

I

G

G

D

D

V

V

R

R

G

G

S

L

G

G

L

L

I

A

F

W

G

G

A

V

E

E

M

F

V

V

L

K

D

D

R

R

E

K

T

T

K

K

Q

E

P

Y

A

A

S

T

A

K

F

E

T

R

D

G

R

E

V

I

I

V

N

V

G

E

M

A

R

L

E

K

R

R

G

G

V

L

I

-

H

-

S

A

K

L

L

L

G

G

R

C

H

G

K

K

N

S

T

A

L

I

K

R

I

L

R

I

P

P

M

L

P

I

F

I

S

S

I

E

E

E

N

E

A

A

D

K

L

M

L

G

F

L

D

D

T

I

L

F

D

E

E

E

V

A

L

I

binding L-ornithine: F149 (≠ Y136), R152 (≠ N139), E234 (≠ N210), K291 (= K268)
binding pyridoxal-5'-phosphate: G122 (= G109), T123 (≠ S110), F149 (≠ Y136), H150 (= H137), E229 (≠ C205), D262 (= D238), V264 (= V240), Q265 (= Q241), K291 (= K268)

Query Sequence

>WP_010443480.1 NCBI__GCF_000192475.1:WP_010443480.1
MTRSNAELIADRARLLGPNVSTFYDNPVHIVKGEGVWLWDADGRKYLDCYNNVPHVGHCN
PRVVDAICRQANTLNTHTRYLHDGILDYVEKLTSTVDDHLDTAILTCTGSEANDIALRMA
ESMTGKRGIIATDATYHGNTSLVSQLSKSNVPTVGFGLGQFFRFVGAPDSYRNPDPEGMR
FAESVAEQIAEHEKSGIGFAALVVCPYFLNEGFPDNPDGWLKPTAEVVRKAGGLLICDEV
QSGFGRTGTHMWAHQKMGVVPDVMTLGKPMGNGHPIGGVVTNSEILGTFRKGYRYFNTFG
GNPVSCAAAIAVLEEIEDKHLLENARKVGAHARMRITRLAKKHEFIGDVRGSGLIFGAEM
VLDRETKQPASAFTDRVINGMRERGVIHSKLGRHKNTLKIRPPMPFSIENADLLFDTLDE
VLAKTPLDA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory