SitesBLAST

O25511 UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Pseudaminic acid biosynthesis protein B; UDP-GlcNAc-inverting 4,6-dehydratase; EC 4.2.1.115 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
43% identity, 87% coverage: 1:295/340 of query aligns to 7:297/333 of O25511

query
sites
O25511

M

M

F

L

Q

D

N

N

K

Q

T

T

I

I

L

L

I

I

T

T

G

G

T
|
T

G
|
G

S
|
S

W
x
F

G

G

H

K

E

C

L

F

V

V

K

R

K

K

L

V

L

L

-

D

P

T

F

T

Q

N

P

A

K

K

E

K

I

I

R

I

I

V

F

Y

S
|
S

R
|
R

N
x
D

E
|
E

F
x
L

A
x
K

Q

Q

V

S

K

E

M

M

K

A

R

M

A

E

F

F

L

-

D

N

D

D

S

P

Y

R

I

M

K

R

F

F

V

F

I

I

G

G

D
|
D

V
|
V

R

R

D

D

F

L

E

E

A

R

V

L

N

N

E

Y

A

A

A

L

M

E

N

G

V

V

D

D

Y

I

I

C

F

I

H

H

L
x
A

S

A

A

A

L

L

K
|
K

H

H

V

V

P

P

I

I

C

A

E

E

D

Y

Q

N

P

P

S

L

E

E

A

C

L

I

K

K

T

T

N

N

V

I

Y

M

G

G

T

A

E

S

N

N

I

V

I

I

K

N

A

A

S

C

L

L

N

K

Q

N

N

A

V

I

K

S

K

Q

V

V

I

I

D

A

V
x
L

S
|
S

T

T

D

D

K
|
K

A

A

V

A

E

N

P

P

I

I

N

N

F

L

Y
|
Y

G

G

L

A

T

T

K
|
K

A

L

I

C

G

S

E

D

K

K

L

L

I

F

I

V

Q

S

A

A

N

N

Q

N

L

F

-

K

-

G

S

S

N

S

H

Q

T

T

R

Q

F

F

V

S

C

V

I

V

R

R

G

Y

G

G

N

N

V
|
V

I
x
V

G
|
G

T
x
S

N
x
R

G

G

S

S

V

V

I

V

P

P

F

F

K

K

E

K

Q

L

M

V

T

Q

S

N

H

K

H

A

T

S

-

E

V

I

P

P

L

I

T

T

S

D

K

I

E

R

M

M

T

T

R

R

F

F

F

W

L

I

T

T

V

L

S

D

Q

E

A

G

I

V

D

S

L

F

L

V

L

L

Y

K

A

S

S

L

E

K

Q

R

A

M

I

H

G

G

E

E

I

I

F

F

V

V

M

P

K

K

M

I

K

P

A

S

C

M

R

K

I

M

V

T

D

D

L

L

V

A

E

K

V

A

L

L

E

A

R

P

H

N

F

T

A

P

T

T

K

K

D

I

V

I

A

-

I

-

N

-

E

-

F

-

G

G

I

I

R

R

P

P

G

G

E

E

K

K

L

L

H

H

E

E

V

V

L

M

V

I

S

P

N

K

A

D

E

E

S

S

R

H

N

L

T

A

Y

L

K

E

F

F

D

-

E

E

N

D

Y

F

V

I

I

I

L

Q

P

P

E

T

D

-

I

I

S

S

E

F

K

Q

V

T

R

P

K

K

R

D

Y

Y

TGSF 19:22 (≠ TGSW 13:16) binding NADP(+)
SRDELK 43:48 (≠ SRNEFA 36:41) binding NADP(+)
DV 67:68 (= DV 61:62) binding NADP(+)
A87 (≠ L81) binding NADP(+)
K91 (= K85) binding NADP(+)
LS 129:130 (≠ VS 123:124) binding NADP(+)
K133 (= K127) mutation K->A,E: Loss of activity.
Y141 (= Y135) binding NADP(+)
K145 (= K139) binding NADP(+)
VVGSR 174:178 (≠ VIGTN 166:170) binding NADP(+)

6bwcC X-ray structure of pen from bacillus thuringiensis (see paper)
37% identity, 96% coverage: 2:329/340 of query aligns to 3:327/327 of 6bwcC

query
sites
6bwcC

F

F

Q

K

N

D

K

K

T

N

I

V

L

L

I

I

T

I

G
|
G

G

G

T
|
T

G
|
G

S
x
T

W
x
I

G

G

H

K

E

S

L

I

V

L

K

S

K

N

L

V

L

L

P

Q

F

E

Q

K

P

P

K

K

E

V

I

V

R

R

I

V

F

F

S
|
S

R
|
R

N
x
S

E

E

F

Y

A

N

Q

Q

V

F

K

L

M

L

K

Q

R

E

A

E

F

F

L

R

D

D

-

K

D

N

S

R

Y

N

I

I

K

R

F

Y

V

L

I

I

G

G

D
|
D

V
x
I

R

R

D

N

F

Y

E

D

A

R

V

V

N

F

E

S

A

A

A

M

M

E

N

N

V

I

D

D

Y

Y

I

V

F

F

H

H

L
x
V

S
x
A

A

A

L

M

K
|
K

H
|
H

V

V

P

S

I

F

C

C

E

E

D

Y

Q

N

P

P

S

F

E

E

A

A

L

V

K

L

T

T

N

N

V

I

Y

F

G

G

T

T

E

Q

N

N

I

V

I

I

K

K

A

A

S

A

L

I

N

A

Q

Q

N

K

V

V

K

K

V

V

I

V

D

F

V
x
T

S

S

T
x
S

D
x
N

K

A

A

A

V

I

E

S

P

P

I

T

N

N

F

N

Y
|
Y

G

G

L

A

T

T

K
|
K

A

L

I

T

G

A

E

E

K

R

L

L

I

I

I

T

Q

S

A

A

-

E

-

Y

N

S

Q

K

L

G

S

S

N

S

H

E

T

T

R

T

F

F

V

T

C

S

I

V

R

R

G
x
F

G

G

N
|
N

V
|
V

I

M

G

G

T
x
S

N
x
R

G

G

S
|
S

V
|
V

I

I

P

P

F
x
L

F

F

K

E

E

N

Q

Q

M

I

T

K

S

E

H

N

H

Q

T

K

V

I

P
x
T

L

V

T
|
T

S

D

K

L

E

S

M
|
M

T

S

R
|
R

F

F

F

M

L

M

T

T

V

L

S

N

Q

Q

A

A

I

T

D

M

L

L

L

T

L

I

Y

E

A

A

S

M

E

K

Q

I

A

A

I

K

G

G

E

E

I

T

F

F

V

I

M

L

K

K

M

M

K

P

A

V

C

I

R

S

I
x
L

V

N

D

D

L

L

V

S

E

E

V

V

L

M

-

I

-

E

-

V

E

T

R

K

H

L

F

Y

A

G

T

L

K

E

D

N

V

I

A

K

I

I

N

E

E

E

F

I

G

G

I

L

R

K

P

P

G

G

E
|
E

K

K

L

M

H

Y

E

E

V

E

L

L

V

M

S

T

N

H

A

D

E

E

S

S

R

L

N

Q

T

A

Y

F

K

E

F

L

D

P

E

D

N

M

Y

F

Y

-

V

-

I

I

L

I

P

P

E

S

D

P

I

L

S

K

E

A

K

K

V

-

R

-

K

-

R

-

Y

-

E

-

H

-

L

R

P

A

K

K

V

A

T

G

F

F

N

Y

R

R

Y

-

Q

S

S

D

N

N

D

Q

E

N

L

A

M

I

S

S

F

K

S

E

E

E

I

L

E

R

Q

N

I

L

L

I

M

L

N

N

A

Q

N

Q

F

L

I

L

T

T

binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G11), T14 (= T13), G15 (= G14), T16 (≠ S15), I17 (≠ W16), S37 (= S36), R38 (= R37), S39 (≠ N38), D63 (= D61), I64 (≠ V62), V83 (≠ L81), A84 (≠ S82), K87 (= K85), T125 (≠ V123), S127 (≠ T125), Y137 (= Y135), K141 (= K139), F167 (≠ G163), V170 (= V166), S173 (≠ T169), R174 (≠ N170)
binding uridine-diphosphate-n-acetylglucosamine: K87 (= K85), H88 (= H86), S127 (≠ T125), N128 (≠ D126), Y137 (= Y135), N169 (= N165), S176 (= S172), V177 (= V173), L180 (≠ F176), T192 (≠ P188), T194 (= T190), M198 (= M194), R200 (= R196), L234 (≠ I230), E265 (= E257)

4g5hA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with by-product (see paper)
37% identity, 96% coverage: 2:328/340 of query aligns to 11:339/346 of 4g5hA

query
sites
4g5hA

F

F

Q

D

N

D

K

K

T

I

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

W
x
F

G

G

H

N

E

A

L

V

V

M

K

K

K

R

L

F

L

L

P

D

F

S

Q

N

P

I

K

K

E

E

I

I

R

R

I

I

F

F

S
|
S

R
|
R

N
x
D

E

E

F

K

A
x
K

Q

Q

V

D

K

D

M

I

K

R

R

K

A

K

F

Y

L

-

D

N

S

S

Y

K

I

L

K

K

F

F

V

Y

I

I

G

G

D
|
D

V
|
V

R

R

D

D

F

S

E

Q

A

S

V

V

N

E

E

T

A

A

A

M

M

R

N

D

V

V

D

D

Y

Y

I

V

F

F

H

H

L
x
A

S
x
A

A
|
A

L

L

K
|
K

H
x
Q

V
|
V

P

P

I

S

C

C

E

E

D

F

Q

F

P

P

S

V

E

E

A

A

L

V

K

K

T

T

N

N

V

I

Y

I

G

G

T

T

E

E

N

N

I

V

I

L

K

Q

A

S

S

A

L

I

N

H

Q

Q

N

N

V

V

K

K

V

V

I

I

D

C

V
x
L

S

S

T
|
T

D

D

K
|
K

A

A

V

A

E

Y

P

P

I

I

N

N

F

A

Y

M

G

G

L

I

T

S

K
|
K

A

A

I

M

G

M

E

E

K

K

L

V

I

F

I

V

-

A

Q

K

A

S

N

R

Q

N

L

I

S

R

N

S

H

E

T

Q

R

T

F

L

V

I

C

C

-

G

I

T

R

R

G
x
Y

G

G

N
|
N

V

V

I

M

G

A

T

S

N

R

G

G

S
|
S

V
|
V

I

I

P

P

F
x
L

F

F

K

I

E

D

Q

K

M

I

T

K

S

A

H

G

H

E

T

P

V

L

P
x
T

L

I

T
|
T

S

D

K

P

E

D

M
|
M

T

T

R

R

F

F

F

L

L

M

T

S

V

L

S

E

Q

D

A

A

I

V

D

E

L

L

L

V

Y

H

A

A

S

F

E

K

Q

H

A

A

I

E

G

T

G

G

E

D

I

I

F

M

V

V

M

Q

K

K

M

A

K

P

A

S

C

S

R

T

I
x
V

V

G

D

D

L

L

V

A

E

T

V

A

L

L

E

L

R

E

H

L

F

F

A

E

T

A

K

-

D

D

V

N

A

A

I

I

N

E

E

I

F

I

G

G

I

T

R
|
R

P

H

G

G

E
|
E

K

K

L

K

H

A

E

E

V

T

L

L

V

L

S

T

N

R

A

E

E

E

S
x
Y

R

A

N

Q

T

C

Y

E

K

-

F

-

D

D

E

M

N

G

Y

D

Y

Y

V

F

I

R

L

V

P

P

E

A

D

D

I

S

-

R

-

D

-

L

-

N

-

Y

-

S

-

N

-

Y

-

V

-

E

-

T

-

G

S

N

E

E

K

K

V

I

R

T

K

Q

R
x
S

Y
|
Y

E
|
E

H
x
Y

L

-

P

-

K

-

V

-

T

-

F

-

N

-

R

-

Y

N

Q

S

S

D

N
|
N

D

T

E

H

L

I

M

L

S

T

F

V

S

E

E

E

I

I

E

K

Q

E

I

K

L

L

M

L

N

T

A

L

N

E

F

Y

I

V

binding nadp nicotinamide-adenine-dinucleotide phosphate: G20 (= G11), T22 (= T13), G23 (= G14), S24 (= S15), F25 (≠ W16), S45 (= S36), R46 (= R37), D47 (≠ N38), K50 (≠ A41), D69 (= D61), V70 (= V62), A89 (≠ L81), A90 (≠ S82), A91 (= A83), K93 (= K85), L131 (≠ V123), T133 (= T125), K147 (= K139), Y173 (≠ G163)
binding [(2R,3R,4R,6R)-3-acetamido-6-methyl-4-oxidanyl-5-oxidanylidene-oxan-2-yl] [[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: Q94 (≠ H86), V95 (= V87), K135 (= K127), N175 (= N165), S182 (= S172), V183 (= V173), L186 (≠ F176), T198 (≠ P188), T200 (= T190), M204 (= M194), V240 (≠ I230), R263 (= R254), E266 (= E257), Y278 (≠ S269), S313 (≠ R294), Y314 (= Y295), E315 (= E296), Y316 (≠ H297), N320 (= N309)

3w1vA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in complex with inihibitor (see paper)
37% identity, 96% coverage: 2:328/340 of query aligns to 11:339/347 of 3w1vA

query
sites
3w1vA

F

F

Q

D

N

D

K

K

T

I

I

L

L

L

I

I

T

T

G

G

T

T

G

G

S

S

W

F

G

G

H

N

E

A

L

V

V

M

K

K

K

R

L

F

L

L

P

D

F

S

Q

N

P

I

K

K

E

E

I

I

R

R

I

I

F

F

S

S

R

R

N

D

E

E

F

K

A

K

Q

Q

V

D

K

D

M

I

K

R

R

K

A

K

F

Y

L

-

D

N

S

S

Y

K

I

L

K

K

F

F

V

Y

I

I

G

G

D

D

V

V

R

R

D

D

F

S

E

Q

A

S

V

V

N

E

E

T

A

A

A

M

M

R

N

D

V

V

D

D

Y

Y

I

V

F

F

H

H

L

A

S

A

A

A

L

L

K
|
K

H
x
Q

V

V

P

P

I

S

C

C

E

E

D

F

Q

F

P

P

S

V

E

E

A

A

L

V

K

K

T

T

N

N

V

I

Y

I

G

G

T

T

E

E

N

N

I

V

I

L

K

Q

A

S

S

A

L

I

N

H

Q

Q

N

N

V

V

K

K

V

V

I

I

D

C

V

L

S

S

T

T

D

D

K

K

A

A

V

A

E

Y

P

P

I

I

N

N

F

A

Y

M

G

G

L

I

T

S

K

K

A

A

I

M

G

M

E

E

K

K

L

V

I

F

I

V

-

A

Q

K

A

S

N

R

Q

N

L

I

S

R

N

S

H

E

T

Q

R

T

F

L

V

I

C

C

-

G

I

T

R

R

G

Y

G

G

N
|
N

V

V

I

M

G

A

T
x
S

N
x
R

G

G

S
|
S

V
|
V

I

I

P

P

F
x
L

F

F

K

I

E

D

Q

K

M

I

T

K

S

A

H

G

H

E

T

P

V

L

P
x
T

L
x
I

T
|
T

S

D

K

P

E

D

M
|
M

T

T

R
|
R

F

F

F

L

L

M

T

S

V

L

S

E

Q

D

A

A

I

V

D

E

L

L

L

V

Y

H

A

A

S

F

E

K

Q

H

A

A

I

E

G

T

G

G

E

D

I

I

F

M

V

V

M

Q

K

K

M

A

K

P

A

S

C

S

R

T

I
x
V

V

G

D

D

L

L

V

A

E

T

V

A

L

L

E

L

R

E

H

L

F

F

A

E

T

A

K

-

D

D

V

N

A

A

I

I

N

E

E

I

F

I

G

G

I

T

R
|
R

P

H

G

G

E
|
E

K

K

L

K

H

A

E

E

V

T

L

L

V

L

S

T

N

R

A

E

E

E

S

Y

R

A

N

Q

T

C

Y

E

K

-

F

-

D

D

E

M

N

G

Y

D

Y

Y

V

F

I

R

L

V

P

P

E

A

D

D

I

S

-

R

-

D

-

L

-

N

-

Y

-

S

-

N

-

Y

-

V

-

E

-

T

-

G

S

N

E

E

K

K

V

I

R

T

K

Q

R

S

Y

Y

E

E

H

Y

L

-

P

-

K

-

V

-

T

-

F

-

N

-

R

-

Y

N

Q

S

S

D

N

N

D

T

E

H

L

I

M

L

S

T

F

V

S

E

E

E

I

I

E

K

Q

E

I

K

L

L

M

L

N

T

A

L

N

E

F

Y

I

V

binding [(2R,3S,4R,5R,6R)-5-acetamido-6-[[[(2R,3S,4R,5R)-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,4-bis(oxidanyl)oxan-2-yl]methylimino-azanylidene-azanium: K93 (= K85), Q94 (≠ H86), N175 (= N165), S179 (≠ T169), R180 (≠ N170), S182 (= S172), V183 (= V173), L186 (≠ F176), T198 (≠ P188), I199 (≠ L189), T200 (= T190), M204 (= M194), R206 (= R196), V240 (≠ I230), R263 (= R254), E266 (= E257)

3vvcA Crystal structure of capsular polysaccharide synthesizing enzyme cape , k126e, in apo form (see paper)
39% identity, 85% coverage: 2:291/340 of query aligns to 3:305/318 of 3vvcA

query
sites
3vvcA

F

F

Q

D

N

D

K

K

T

I

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S

S

W
x
F

G

G

H

N

E

A

L

V

V

M

K

K

K

R

L

F

L

L

P

D

F

S

Q

N

P

I

K

K

E

E

I

I

R

R

I

I

F

F

S
|
S

R
|
R

N
x
D

E

E

F

K

A
x
K

Q

Q

V

D

K

D

M

I

K

R

R

K

A

K

F

Y

L

-

D

N

S

S

Y

K

I

L

K

K

F

F

V

Y

I

I

G

G

D
|
D

V
|
V

R
|
R

D

D

F

S

E

Q

A

S

V

V

N

E

E

T

A

A

A

M

M

R

N

D

V

V

D

D

Y

Y

I

V

F

F

H

H

L
x
A

S
x
A

A
|
A

L

L

K
|
K

H

Q

V

V

P

P

I

S

C

C

E

E

D

F

Q

F

P

P

S

V

E

E

A

A

L

V

K

K

T

T

N

N

V

I

Y

I

G

G

T

T

E

E

N

N

I

V

I

L

K

Q

A

S

S

A

L

I

N

H

Q

Q

N

N

V

V

K

K

V

V

I

I

D

C

V

L

S
|
S

T
|
T

D

D

K

E

A

A

V

A

E

Y

P

P

I

I

N

N

F

A

Y

M

G

G

L

I

T

S

K
|
K

A

A

I

M

G

M

E

E

K

K

L

V

I

F

I

V

-

A

Q

K

A

S

N

R

Q

N

L

I

S

R

N

S

H

E

T

Q

R

T

F

L

V

I

C

C

-

G

I

T

R

R

G
x
Y

G
|
G

N

N

V

V

I

M

G

A

T

S

N

R

G

G

S

S

V

V

I

I

P

P

F

L

F

F

K

I

E

D

Q

K

M

I

T

K

S

A

H

G

H

E

T

P

V

L

P

T

L

I

T

T

S

D

K

P

E

D

M

M

T

T

R

R

F

F

F

L

L

M

T

S

V

L

S

E

Q

D

A

A

I

V

D

E

L

L

L

V

Y

H

A

A

S

F

E

K

Q

H

A

A

I

E

G

T

G

G

E

D

I

I

F

M

V

V

M

Q

K

K

M

A

K

P

A

S

C

S

R

T

I

V

V

G

D

D

L

L

V

A

E

T

V

A

L

L

E

L

R

E

H

L

F

F

A

E

T

A

K

-

D

D

V

N

A

A

I

I

N

E

E

I

F

I

G

G

I

T

R

R

P

H

G

G

E

E

K

K

L

K

H

A

E

E

V

T

L

L

V

L

S

T

N

R

A

E

E

E

S

Y

R

A

N

Q

T

C

-

E

-

D

-

M

-

G

-

D

-

Y

-

F

-

R

-

V

-

P

-

A

-

D

Y

Y

K

E

F

Y

D

N

-

S

E

D

N

N

Y

T

Y

H

V

I

I

L

L

T

P

V

E

E

D

E

I

I

S

K

E

E

K

K

V

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G11), T14 (= T13), G15 (= G14), F17 (≠ W16), S37 (= S36), R38 (= R37), D39 (≠ N38), K42 (≠ A41), D61 (= D61), V62 (= V62), R63 (= R63), A81 (≠ L81), A82 (≠ S82), A83 (= A83), K85 (= K85), S124 (= S124), T125 (= T125), K139 (= K139), Y165 (≠ G163), G166 (= G164)

3vvbA Crystal structure of capsular polysaccharide synthesizing enzyme cape from staphylococcus aureus in apo form (see paper)
41% identity, 69% coverage: 2:237/340 of query aligns to 1:213/270 of 3vvbA

query
sites
3vvbA

F

F

Q

D

N

D

K

K

T

I

I

L

L

L

I

I

T

T

G
|
G

G

G

T
|
T

G
|
G

S
|
S

W
x
F

G

G

H

N

E

A

L

V

V

M

K

K

K

R

L

F

L

L

P

D

F

S

Q

N

P

I

K

K

E

E

I

I

R

R

I

I

F

F

S
|
S

R
|
R

N
x
D

E

E

F

K

A
x
K

Q

Q

V

D

K

D

M

I

K

R

R

K

A

K

F

Y

L

-

D

N

S

S

Y

K

I

L

K

K

F

F

V

Y

I

I

G

G

D
|
D

V
|
V

R

R

D

D

F

S

E

Q

A

S

V

V

N

E

E

T

A

A

A

M

M

R

N

D

V

V

D

D

Y

Y

I

V

F

F

H

H

L

A

S
x
A

A
|
A

L

L

K
|
K

H

Q

V

V

P

P

I

S

C

C

E

E

D

F

Q

F

P

P

S

V

E

E

A

A

L

V

K

K

T

T

N

N

V

I

Y

I

G

G

T

T

E

E

N

N

I

V

I

L

K

Q

A

S

S

A

L

I

N

H

Q

Q

N

N

V

V

K

K

V

V

I

I

D

C

V
x
L

S

S

T
|
T

D

D

K

K

A

A

V

A

E

Y

P

P

I

I

N

N

F

A

Y

M

G

G

L

I

T

S

K
|
K

A

A

I

M

G

M

E

E

K

K

L

V

I

F

I

V

-

A

Q

K

A

S

N

R

Q

N

L

I

S

R

N

S

H

E

T

Q

R

T

F

L

V

I

C

C

I

-

R

-

G

-

N

-

V

-

I

-

G

G

T

T

N

R

-
x
Y

G
|
G

S

N

V

V

I

M

P

P

F

-

K

-

E

-

Q

-

M

-

T

-

S

-

H

-

T

-

V

-

P

-

L

-

T

-

S

-

K

-

E

D

M

M

T

T

R

R

F

F

F

L

L

M

T

S

V

L

S

E

Q

D

A

A

I

V

D

E

L

L

L

V

Y

H

A

A

S

F

E

K

Q

H

A

A

I

E

G

T

G

G

E

D

I

I

F

M

V

V

M

Q

K

K

M

A

K

P

A

S

C

S

R

T

I

V

V

G

D

D

L

L

V

A

E

T

V

A

L

L

binding nadp nicotinamide-adenine-dinucleotide phosphate: G10 (= G11), T12 (= T13), G13 (= G14), S14 (= S15), F15 (≠ W16), S35 (= S36), R36 (= R37), D37 (≠ N38), K40 (≠ A41), D59 (= D61), V60 (= V62), A80 (≠ S82), A81 (= A83), K83 (= K85), L121 (≠ V123), T123 (= T125), K137 (= K139), Y163 (vs. gap), G164 (= G171)

5bjuA X-ray structure of the pglf dehydratase from campylobacter jejuni in complex with udp and NAD(h) (see paper)
32% identity, 80% coverage: 2:274/340 of query aligns to 22:297/340 of 5bjuA

query
sites
5bjuA

F

L

Q

K

N

D

K

K

T

V

I

V

L

L

I

V

T

S

G
|
G

G

A

T

G

G
|
G

S
x
T

W
x
I

G

G

H

S

E

E

L

L

V

C

K

K

K

Q

L

C

L

I

P

K

F

F

Q

G

P

A

K

K

E

H

I

L

R

I

I

M

F

V

S
x
D

R
x
H

N

S

E

E

F

Y

A

N

Q

L

V

Y

K

K

M

I

K

N

R

D

A

D

F

L

-

N

L

L

D

Y

D

K

S

E

Y

K

I

I

K

T

F

P

V

I

I

L

G

L

D
x
S

V
x
I

R

L

D

D

F

K

E

Q

A

S

V

L

N

D

E

E

A

V

-

L

-

K

A

T

M

Y

N

K

V

P

D

E

Y

L

I

I

F

L

H

H

L
x
A

S
x
A

A
|
A

L

Y

K
|
K

H

H

V

V

P

P

I

L

C

C

E

E

D

Q

Q

N

P

P

S

H

E

S

A

A

L

V

K

I

T
x
N

N

N

V

I

Y

L

G

G

T

T

E

K

N

I

I

L

I

C

K

D

A

S

S

A

L

K

N

E

Q

N

N

K

V

V

K

A

K

K

V

F

I

V

D

M

V
x
I

S

S

T

T

D

D

K
|
K

A

A

V

V

E

R

P

P

I

T

N

N

F

I

Y

M

G

G

L

C

T

T

K
|
K

A

R

I

V

G

C

E

E

K

L

L

Y

I

T

I

L

Q

S

A

M

N

S

Q

D

L

-

S

-

N

E

H

N

T

F

R

E

F

V

V

A

C

C

I

V

R

R

G
x
F

G
|
G

N
|
N

V
|
V

I

L

G

G

T
x
S

N
x
S

G

G

S
|
S

V
|
V

I

I

P

P

F

K

F

F

K

K

E

A

Q

Q

M

I

T

A

S

N

H

N

H

E

T

P

V

L

P
x
T

L
|
L

T
|
T

S

H

K

P

E

D

M
x
I

T

V

R
|
R

F

Y

F

F

L

M

T

L

V

V

S

A

Q

E

A

A

I

V

D

Q

L

L

L

V

L

L

Y

Q

A

A

S

G

E

A

Q

I

A

A

I

K

G

G

E

E

I

L

F

F

V

V

M

L

K

D

M

M

-

G

K

K

A

P

C

V

R

K

I

I

V

I

D

D

L

L

V

A

E

K

V

K

L

M

E

L

R

L

H

L

F

S

A

N

T

R

K

N

D

D

V

L

A

E

I

I

N

K

E

I

F

T

G

G

I

L

R

R

P

K

G

G

E
|
E

K

K

L

L

H

Y

-

E

E

E

V

L

L

L

V

I

S

D

N

E

A

N

E

D

S

A

R

K

N

T

T

Q

Y

Y

K

E

binding nicotinamide-adenine-dinucleotide: G31 (= G11), G34 (= G14), T35 (≠ S15), I36 (≠ W16), D56 (≠ S36), H57 (≠ R37), S82 (≠ D61), I83 (≠ V62), A104 (≠ L81), A105 (≠ S82), A106 (= A83), K108 (= K85), N123 (≠ T100), I146 (≠ V123), K162 (= K139), F184 (≠ G163), G185 (= G164), N186 (= N165), V187 (= V166), S190 (≠ T169), S191 (≠ N170)
binding uridine-5'-diphosphate: K150 (= K127), N186 (= N165), S193 (= S172), V194 (= V173), T209 (≠ P188), L210 (= L189), T211 (= T190), I215 (≠ M194), R217 (= R196), E279 (= E257)

4tqgA Crystal structure of megavirus udp-glcnac 4,6-dehydratase, 5-epimerase mg534 (see paper)
33% identity, 94% coverage: 2:322/340 of query aligns to 3:295/297 of 4tqgA

query
sites
4tqgA

F

I

Q

N

N

D

K

K

T

T

I

I

L

M

I

I

T

F

G
|
G

G

G

T
x
S