Comparing WP_010875848.1 NCBI__GCF_000008645.1:WP_010875848.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4ygrA Crystal structure of had phosphatase from thermococcus onnurineus (see paper)
31% identity, 86% coverage: 2:195/226 of query aligns to 1:186/215 of 4ygrA
6q7oA Crystal structure of oe1 (see paper)
35% identity, 86% coverage: 1:195/226 of query aligns to 1:200/230 of 6q7oA
6q7nA Crystal structure of bh32 alkylated with the mechanistic inhibitor 2- bromoacetophenone (see paper)
35% identity, 86% coverage: 1:195/226 of query aligns to 1:200/230 of 6q7nA
8bp1A Crystal structure of bhmehis1.0, an engineered enzyme for the morita- baylis-hillman reaction (see paper)
35% identity, 86% coverage: 1:195/226 of query aligns to 1:200/231 of 8bp1A
3vayA Crystal structure of 2-haloacid dehalogenase from pseudomonas syringae pv. Tomato dc3000 (see paper)
28% identity, 100% coverage: 1:226/226 of query aligns to 1:226/230 of 3vayA
4knvA The crystal structure of apo human hdhd4 from se-mad (see paper)
26% identity, 85% coverage: 2:193/226 of query aligns to 1:202/241 of 4knvA
3qnmA Haloalkane dehalogenase family member from bacteroides thetaiotaomicron of unknown function
26% identity, 85% coverage: 3:195/226 of query aligns to 4:205/231 of 3qnmA
3i76B The crystal structure of the orthorhombic form of the putative had- hydrolase yfnb from bacillus subtilis bound to magnesium reveals interdomain movement
26% identity, 42% coverage: 103:198/226 of query aligns to 107:203/229 of 3i76B
Sites not aligning to the query:
Q51645 (S)-2-haloacid dehalogenase 4A; 2-haloalkanoic acid dehalogenase IVA; Halocarboxylic acid halidohydrolase IVA; L-2-haloacid dehalogenase IVA; EC 3.8.1.2 from Burkholderia cepacia (Pseudomonas cepacia) (see 2 papers)
28% identity, 46% coverage: 93:197/226 of query aligns to 95:198/231 of Q51645
Sites not aligning to the query:
2no5B Crystal structure analysis of a dehalogenase with intermediate complex (see paper)
28% identity, 46% coverage: 93:197/226 of query aligns to 95:198/226 of 2no5B
Sites not aligning to the query:
3umbA Crystal structure of the l-2-haloacid dehalogenase rsc1362
25% identity, 86% coverage: 2:195/226 of query aligns to 3:198/227 of 3umbA
P95649 Protein CbbY; RuCbby; EC 3.1.3.- from Cereibacter sphaeroides (Rhodobacter sphaeroides) (see paper)
27% identity, 98% coverage: 1:222/226 of query aligns to 1:217/230 of P95649
4uasA Crystal structure of cbby from rhodobacter sphaeroides in complex with phosphate (see paper)
27% identity, 98% coverage: 1:222/226 of query aligns to 1:217/225 of 4uasA
Q3UGR5 Haloacid dehalogenase-like hydrolase domain-containing protein 2 from Mus musculus (Mouse)
47% identity, 21% coverage: 150:196/226 of query aligns to 179:225/259 of Q3UGR5
Sites not aligning to the query:
P9WPI9 Tyrosine-protein kinase PtkA; Protein tyrosine kinase A; EC 2.7.10.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
25% identity, 98% coverage: 5:226/226 of query aligns to 82:289/291 of P9WPI9
4uauA Crystal structure of cbby (mutant d10n) from rhodobacter sphaeroides in complex with xylulose-(1,5)bisphosphate, crystal form ii (see paper)
26% identity, 98% coverage: 1:222/226 of query aligns to 1:217/226 of 4uauA
4o8cB Structure of the h170y mutant of thermostable p-nitrophenylphosphatase from bacillus stearothermophilus (see paper)
35% identity, 24% coverage: 150:203/226 of query aligns to 181:234/255 of 4o8cB
Sites not aligning to the query:
3ddhA The structure of a putative haloacid dehalogenase-like family hydrolase from bacteroides thetaiotaomicron vpi-5482
26% identity, 98% coverage: 1:222/226 of query aligns to 5:227/229 of 3ddhA
Q53464 (S)-2-haloacid dehalogenase; 2-haloalkanoic acid dehalogenase; Halocarboxylic acid halidohydrolase; L-2-haloacid dehalogenase; L-DEX; EC 3.8.1.2 from Pseudomonas sp. (strain YL) (see 2 papers)
29% identity, 46% coverage: 93:195/226 of query aligns to 94:195/232 of Q53464
Sites not aligning to the query:
1zrmA Crystal structure of the reaction intermediate of l-2-haloacid dehalogenase with 2-chloro-n-butyrate (see paper)
29% identity, 46% coverage: 93:195/226 of query aligns to 92:193/220 of 1zrmA
Sites not aligning to the query:
>WP_010875848.1 NCBI__GCF_000008645.1:WP_010875848.1
MLKAVFFDIDDTLYDTSGFAKLARKAALNVMIDAGLPLTQEEAYKLLREIISEKGSNYDR
HFNVLTKTVFGEEKPLLIALGMITYHNVKFALLRPFPNTTSTLIDLKSKGYRLGVISNGI
TIKQWEKLIRLGIHHFFDEVVTSDEVGFEKPNIRIFEEALRRMGCKPERSVMVGNKFNED
ILGATNAGMSAILVNSELTEAERDHVEKNGLDVTVIDDISQLKEIL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory