SitesBLAST
Comparing WP_010877086.1 NCBI__GCF_000008645.1:WP_010877086.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6hulB Sulfolobus solfataricus tryptophan synthase ab complex (see paper)
55% identity, 96% coverage: 12:421/429 of query aligns to 4:410/416 of 6hulB
- binding pyridoxal-5'-phosphate: H103 (= H109), K104 (= K110), Q131 (= Q137), S220 (= S227), G255 (= G262), G256 (= G263), G257 (= G264), S258 (= S265), N259 (= N266), E371 (= E382), S400 (= S411), G401 (= G412)
- binding serine: K104 (= K110), T127 (= T133), G128 (= G134), A129 (= A135), G130 (= G136), W132 (= W138)
4qysB Trpb2 enzymes (see paper)
49% identity, 98% coverage: 4:425/429 of query aligns to 3:416/418 of 4qysB
- active site: K101 (= K110), E123 (= E132), S402 (= S411)
- binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: H100 (= H109), K101 (= K110), G252 (= G262), G253 (= G263), G254 (= G264), S255 (= S265), N256 (= N266), E373 (= E382), S402 (= S411)
4qysA Trpb2 enzymes (see paper)
48% identity, 98% coverage: 4:425/429 of query aligns to 3:406/408 of 4qysA
- active site: K108 (= K110), E130 (= E132), S392 (= S411)
- binding pyridoxal-5'-phosphate: H107 (= H109), K108 (= K110), G242 (= G262), G243 (= G263), G244 (= G264), S245 (= S265), N246 (= N266), E363 (= E382), S392 (= S411)
- binding phosphoserine: K108 (= K110), G132 (= G134), A133 (= A135), Q135 (= Q137), W136 (= W138), G316 (= G335), R318 (= R337), E363 (= E382)
5vm5D Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9, with ser bound (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:376/383 of 5vm5D
- active site: K82 (= K110), E104 (= E132), S369 (= S411)
- binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: H81 (= H109), K82 (= K110), T105 (= T133), G106 (= G134), A107 (= A135), Q109 (= Q137), H110 (≠ W138), S185 (= S227), G227 (= G262), G229 (= G264), S230 (= S265), N231 (= N266), G296 (= G335), E343 (= E382), S369 (= S411)
7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:378/384 of 7rnpA
5ey5B Lbcats
34% identity, 81% coverage: 74:419/429 of query aligns to 47:379/383 of 5ey5B
- binding pyridoxal-5'-phosphate: H81 (= H109), K82 (= K110), Q109 (= Q137), S185 (= S227), G227 (= G262), G229 (= G264), S230 (= S265), N231 (= N266), E345 (= E382), S371 (= S411), G372 (= G412)
6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2) (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:378/385 of 6am8B
- active site: K82 (= K110), E104 (= E132), S371 (= S411)
- binding [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-l-tryptophane: H81 (= H109), K82 (= K110), E104 (= E132), T105 (= T133), G106 (= G134), A107 (= A135), Q109 (= Q137), H110 (≠ W138), L161 (= L194), S185 (= S227), V187 (≠ L229), G227 (= G262), G228 (= G263), G229 (= G264), S230 (= S265), N231 (= N266), G298 (= G335), Y301 (= Y338), E345 (= E382), S371 (= S411), G372 (= G412)
- binding tryptophan: L169 (≠ M212), S274 (≠ T310), H275 (≠ A311)
Sites not aligning to the query:
5ixjD Tryptophan synthase beta-subunit from pyrococcus furiosus with l- threonine non-covalently bound in the active site (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:376/394 of 5ixjD
5t6mA Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:376/383 of 5t6mA
8vhhA Engineered holo tryptophan synthase (tm9d8 ) Derived from t. Maritima trpb (see paper)
33% identity, 90% coverage: 33:419/429 of query aligns to 6:375/389 of 8vhhA
- binding pyridoxal-5'-phosphate: H81 (= H109), K82 (= K110), Q109 (= Q137), S185 (= S227), G228 (= G263), G229 (= G264), S230 (= S265), N231 (= N266), G297 (= G335), E344 (= E382), S367 (= S411)
5t6mB Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:378/386 of 5t6mB
1v8zA X-ray crystal structure of the tryptophan synthase b2 subunit from hyperthermophile, pyrococcus furiosus (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:378/386 of 1v8zA
- active site: K82 (= K110), E104 (= E132), S371 (= S411)
- binding pyridoxal-5'-phosphate: H81 (= H109), K82 (= K110), Q109 (= Q137), S185 (= S227), G227 (= G262), G228 (= G263), G229 (= G264), S230 (= S265), N231 (= N266), E345 (= E382), S371 (= S411), G372 (= G412)
5dw0A Trpb from pyrococcus furiosus with l-serine bound as the external aldimine (see paper)
33% identity, 80% coverage: 75:418/429 of query aligns to 48:378/388 of 5dw0A
- active site: K82 (= K110), E104 (= E132), S371 (= S411)
- binding [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine: H81 (= H109), K82 (= K110), T105 (= T133), G106 (= G134), A107 (= A135), Q109 (= Q137), H110 (≠ W138), S185 (= S227), G227 (= G262), G229 (= G264), S230 (= S265), N231 (= N266), G298 (= G335), D300 (≠ R337), E345 (= E382), S371 (= S411)
5dw3A Tryptophan synthase beta-subunit from pyrococcus furiosus with product l-tryptophan non-covalently bound in the active site (see paper)
32% identity, 80% coverage: 75:418/429 of query aligns to 48:377/383 of 5dw3A
- active site: K82 (= K110), E104 (= E132), S370 (= S411)
- binding tryptophan: K82 (= K110), E104 (= E132), T105 (= T133), G106 (= G134), A107 (= A135), Q109 (= Q137), H110 (≠ W138), S185 (= S227), G228 (= G263), Y300 (= Y338)
8eh1A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with 4-hydroxyquinoline (see paper)
33% identity, 90% coverage: 33:419/429 of query aligns to 5:374/383 of 8eh1A
- binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: H80 (= H109), K81 (= K110), T104 (= T133), G105 (= G134), A106 (= A135), Q108 (= Q137), H109 (≠ W138), S184 (= S227), G228 (= G264), S229 (= S265), N230 (= N266), G296 (= G335), E343 (= E382), S366 (= S411)
- binding quinolin-4-ol: G103 (≠ E132), L160 (= L194), I164 (= I208), G183 (= G226), S184 (= S227), Y299 (= Y338)
8eh0A Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate and complexed with quinoline n-oxide (see paper)
33% identity, 90% coverage: 33:419/429 of query aligns to 5:374/385 of 8eh0A
- binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: H80 (= H109), K81 (= K110), T104 (= T133), G105 (= G134), A106 (= A135), Q108 (= Q137), H109 (≠ W138), S184 (= S227), G228 (= G264), S229 (= S265), N230 (= N266), G296 (= G335), E343 (= E382), S366 (= S411), G367 (= G412)
- binding 1-oxo-1lambda~5~-quinoline: L160 (= L194), I164 (= I208), Y180 (= Y223), P182 (≠ L225), G183 (= G226), S184 (= S227), V186 (≠ L229), Y299 (= Y338)
8egzA Engineered tyrosine synthase (tmtyrs1) derived from t. Maritima trpb with ser bound as the amino-acrylate intermediate (see paper)
33% identity, 90% coverage: 33:419/429 of query aligns to 5:374/385 of 8egzA
- binding 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid: H80 (= H109), K81 (= K110), T104 (= T133), G105 (= G134), A106 (= A135), Q108 (= Q137), H109 (≠ W138), S184 (= S227), S226 (≠ G262), G228 (= G264), S229 (= S265), N230 (= N266), G296 (= G335), E343 (= E382), S366 (= S411)
5tciH Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
31% identity, 80% coverage: 75:419/429 of query aligns to 64:395/406 of 5tciH
Sites not aligning to the query:
6uapB Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
31% identity, 80% coverage: 75:419/429 of query aligns to 63:394/405 of 6uapB
- active site: K97 (= K110), E119 (= E132), S386 (= S411)
- binding (2R,3S,4R)-3-(4'-chloro-2',6'-difluoro[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile: I180 (= I208), N181 (≠ S209), F184 (≠ M212), Y196 (= Y223), F198 (≠ L225), P204 (vs. gap), F207 (vs. gap), H290 (≠ A300)
6u6cB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
31% identity, 80% coverage: 75:419/429 of query aligns to 64:395/405 of 6u6cB
- active site: K98 (= K110), E120 (= E132), S387 (= S411)
- binding 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid: H97 (= H109), K98 (= K110), T121 (= T133), G122 (= G134), A123 (= A135), Q125 (= Q137), H126 (≠ W138), T201 (≠ S227), G243 (= G262), G245 (= G264), S246 (= S265), N247 (= N266), G314 (= G335), E361 (= E382), S387 (= S411)
- binding 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide: F185 (≠ M212), W188 (≠ A215), Y197 (= Y223), F199 (≠ L225), G204 (vs. gap), P205 (vs. gap), H291 (≠ A300), G292 (= G301)
Sites not aligning to the query:
Query Sequence
>WP_010877086.1 NCBI__GCF_000008645.1:WP_010877086.1
MMNKIVLDENEIPKKWYNINPDLPSPLPEPKNPEGGKNIENLPRVFSRGVLEQEMSMERW
IKIPREVMDVYKMIGRPTPLFRAKGLEEMLDTPARIYYKREDYSPTGSHKLNTAIAQAYY
ARKDGAERLTTETGAGQWGTALSLACSLMDLQCKVYMVRVSFNQKPFRKTIMQLYGGEVV
PSPSNHTEFGRRMLKEDPEHPGSLGIAISEAMEEALQEENVYYSLGSVLNHVLLHQTVIG
LETKKQLEIAGETPDIMIGCVGGGSNFGGAIFPFVKDKLDGKLDCEFIAAEPKSCPTLTA
GEYRYDFGDTAGMTPLLKMYTLGHDFVPPSVHAGGLRYHGMSPQVALLVREGVINARAVP
QHTIFESGVKFAKAEGVVPAPETCHAISVAIDEARKCRETGEEKTIVISFSGHGLLDLKG
YGDYLEGKI
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory