SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_010933753.1 NCBI__GCF_000006985.1:WP_010933753.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
57% identity, 98% coverage: 4:426/431 of query aligns to 48:469/472 of Q42522

query
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Q42522

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R92 (≠ T48) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G119) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
56% identity, 98% coverage: 1:421/431 of query aligns to 1:419/430 of 3bs8A

query
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3bs8A

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active site: V22 (= V22), Y145 (= Y146), E207 (= E208), D240 (= D241), M243 (= M244), K268 (= K269), G401 (≠ A403)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), H146 (= H147), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), K268 (= K269)

P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 98% coverage: 4:426/431 of query aligns to 50:471/474 of P42799

query
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P42799

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E

E

D

D

L

I

E

Q

K

L

T

T

V

I

K

A

A

A

N

A

Y

E

N

R

A

V

L

L

K314 (= K269) modified: N6-(pyridoxal phosphate)lysine

5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
56% identity, 99% coverage: 4:428/431 of query aligns to 1:420/420 of 5i92F

query
sites
5i92F

L

M

T

S

R

R

S

S

A

E

E

T

L

L

F

F

E

N

K

N

A

A

K

Q

K

K

F

H

I

I

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

T

P

P

I

L

Y

F

M

F

A

K

K

H

G

A

Q

E

G

G

A

A

Y

Y

M

V

T

L

D

D

V

E

D

D

G

D

N

K

T

R

Y

Y

L

V

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

F

M

I

I

L

L

G

G

S

H

M

S

H

H

P

P

R

D

V

V

T

L

A

D

A

A

I

V

E

R

Y

R

T

Q

L

L

R

D

N

H

I

-

G

G

T

L

S

S

F

Y

G

G

T

A

P

P

I

T

E

A

L

L

E

E

I

V

E

E

I

M

A

A

E

D

L

L

L

V

C

C

K

S

I

M

V

V

P

P

S

S

L

M

E

E

M

M

V

V

R

R

M

M

V

V

N

S

S

S

G

G

T

T

E

E

A

A

T

T

M

M

S

S

A

A

V

I

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

K

R

D

D

K

S

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

S

D

D

S

S

F

L

L

L

I

V

K

K

A

A

G

G

S

S

G

-

V

-

L

-

T

T

L

F

G

G

D

V

P

P

D

N

S

S

P

P

G

G

V

V

T

P

K

A

G

A

T

F

A

A

N

K

D

H

T

T

L

L

N

T

A

L

T

P

Y

F

N

N

D

D

I

I

E

E

S

A

V

V

K

R

A

K

I

T

V

L

N

G

E

E

N

V

K

G

G

K

Q

E

V

V

A

A

A

C

I

I

I

I

I

V

E
|
E

P

P

V

V

A

A

G

G

N

N

T

M

G

N

V

C

I

V

P

P

A

P

K

A

K

P

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

A

C

C

D

D

A

E

E

H

G

G

I

V

V

V

L

L

I

I

F

F

D
|
D

E

E

V

V

M
|
M

C

T

G

G

F

F

R

R

V

V

A

A

L

L

G

G

G

G

A

A

Q

Q

E

A

L

Y

Y

Y

G

G

V

V

T

T

P

P

D

D

L

L

T

S

T

T

M

F

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

M

P

P

V

V

G

G

A

A

F

F

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

Q

I

I

A

S

P

P

L

L

G

G

S

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

-

S

-

G

G

N

N

P

P

L

L

A

A

L

M

T

A

A

A

G

G

L

L

E

T

T

T

L

L

K

R

I

L

L

I

M

S

E

R

E

P

N

G

P

F

Y

H

P

D

E

E

L

L

E

T

R

A

K

Y

A

T

A

T

F

R

L

M

E

L

A

D

G

G

F

L

K

Q

A

Q

N

R

M

A

E

D

K

A

L

A

G

G

L

I

N

P

Y

F

T

V

Q

T

N

T

R

Q

V

A

G

G

S

G

M

M

A

F

C

G

L

L

F

Y

F

F

T

S

-

G

E

A

T

D

P

A

V

I

V

V

D

T

Y

F

K

E

S

D

A

V

I

M

T

A

A

S

D

D

T

V

A

E

K

R

Y

F

G

K

K

R

Y

F

F

F

H

H

S

L

M

M

L

L

D

D

Q

G

G

G

I

V

Y

Y

L

L

A

A

P

P

S

S

Q

A

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

I

A

A

H

H

T

G

D

D

E

K

D

E

L

L

E

E

K

I

T

T

V

L

K

N

A

A

N

A

Y

E

N

K

A
|
A

L
x
F

V

A

A
|
A

active site: V19 (= V22), Y142 (= Y146), E201 (= E208), D234 (= D241), M237 (= M244), K262 (= K269), A395 (= A403)
binding leucine: A417 (= A425), F418 (≠ L426), A420 (= A428)

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
55% identity, 98% coverage: 4:426/431 of query aligns to 4:425/428 of 5hdmB

query
sites
5hdmB

L

L

T

Q

R

K

S

S

A

E

E

E

L

A

F

F

E

N

K

A

A

A

K

K

K

N

F

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

V

Y

L

M

I

A

D

K

S

G

V

Q

K

G

G

A

S

Y

K

M

M

T

W

D

D

V

I

D

D

G

G

N

N

T

E

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

F

A

I

I

L

I

G

G

S

H

M

A

H

D

P

D

R

E

V

V

T

L

A

A

A

A

I

L

E

A

Y

E

T

T

L

M

R

K

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

L

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

I

K

S

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

V

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

K

K

D

E

K

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

N

S

A

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

D

S

S

P

P

G

G

V

V

T

P

K

K

G

A

T

A

A

T

N

S

D

D

T

T

L

L

N

T

A

A

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

E

A

K

I

L

V

F

N

A

E

A

N

H

K

K

G

G

Q

E

V

I

A

S

A

A

I

V

I

I

I

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

P

A

P

K

T

K

P

E

E

F

F

L

I

V

N

A

G

L

L

R

R

E

Q

L

L

C

T

D

K

A

D

E

N

G

G

I

V

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

L

A

A

L

Y

G

G

G

G

A

A

Q

Q

E

E

L

Y

Y

F

G

G

V

I

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

H

D

I

I

M

M

E

E

N

M

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

H

T

T

L

L

K

K

I

R

L

L

M

K

E

Q

E

A

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

K

K

I

A

T

A

K

F

E

L

L

E

T

A

N

G

G

F

I

K

L

A

E

N

A

M

G

E

K

K

K

L

T

G

G

L

H

N

P

Y

M

T

C

Q

G

N

G

R

Y

V

I

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

A

E

E

T

G

P

P

V

V

V

Y

D

N

Y

F

K

A

S

D

A

S

I

K

T

K

A

S

D

D

T

T

A

E

K

K

Y

F

G

G

K

R

Y

F

F

F

H

R

S

G

M

M

L

L

D

E

Q

E

G

G

I

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

P

E

E

D

D

L

I

E

Q

K

L

T

T

V

I

K

A

A

A

N

A

Y

E

N

R

A

V

L

L

active site: V22 (= V22), Y145 (= Y146), E207 (= E208), D240 (= D241), M243 (= M244), K268 (= K269), A402 (= A403)
binding pyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), M243 (= M244), K268 (= K269)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), M243 (= M244), K268 (= K269)

5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
55% identity, 98% coverage: 4:426/431 of query aligns to 4:425/428 of 5hdmA

query
sites
5hdmA

L

L

T

Q

R

K

S

S

A

E

E

E

L

A

F

F

E

N

K

A

A

A

K

K

K

N

F

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

V

Y

L

M

I

A

D

K

S

G

V

Q

K

G

G

A

S

Y

K

M

M

T

W

D

D

V

I

D

D

G

G

N

N

T

E

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

F

A

I

I

L

I

G

G

S

H

M

A

H

D

P

D

R

E

V

V

T

L

A

A

A

A

I

L

E

A

Y

E

T

T

L

M

R

K

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

L

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

I

K

S

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

V

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

K

K

D

E

K

K

I

F

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G
|
G

H

H

G

A

D

N

S

A

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

D

S

S

P

P

G

G

V

V

T

P

K

K

G

A

T

A

A

T

N

S

D

D

T

T

L

L

N

T

A

A

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

E

A

K

I

L

V

F

N

A

E

A

N

H

K

K

G

G

Q

E

V

I

A

S

A

A

I

V

I

I

I

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

P

A

P

K

T

K

P

E

E

F

F

L

I

V

N

A

G

L

L

R

R

E

Q

L

L

C

T

D

K

A

D

E

N

G

G

I

V

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

L

A

A

L

Y

G

G

G

G

A

A

Q

Q

E

E

L

Y

Y

F

G

G

V

I

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

H

D

I

I

M

M

E

E

N

M

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

H

T

T

L

L

K

K

I

R

L

L

M

K

E

Q

E

A

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

K

K

I

A

T

A

K

F

E

L

L

E

T

A

N

G

G

F

I

K

L

A

E

N

A

M

G

E

K

K

K

L

T

G

G

L

H

N

P

Y

M

T

C

Q

G

N

G

R

Y

V

I

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

A

E

E

T

G

P

P

V

V

V

Y

D

N

Y

F

K

A

S

D

A

S

I

K

T

K

A

S

D

D

T

T

A

E

K

K

Y

F

G

G

K

R

Y

F

F

F

H

R

S

G

M

M

L

L

D

E

Q

E

G

G

I

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

P

E

E

D

D

L

I

E

Q

K

L

T

T

V

I

K

A

A

A

N

A

Y

E

N

R

A

V

L

L

active site: V22 (= V22), Y145 (= Y146), E207 (= E208), D240 (= D241), M243 (= M244), K268 (= K269), A402 (= A403)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), G147 (= G148), E207 (= E208), N212 (= N213), D240 (= D241), V242 (= V243), K268 (= K269)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
56% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 2gsaB

query
sites
2gsaB

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), E206 (= E208), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding pyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
56% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 2gsaA

query
sites
2gsaA

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), E206 (= E208), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), N211 (= N213), D239 (= D241), V241 (= V243), K267 (= K269)

3usfA Crystal structure of dava-4
55% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 3usfA

query
sites
3usfA

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S
|
S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E

E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S24), V25 (= V26), S157 (= S159), K267 (= K269), E400 (= E402)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), N211 (= N213), D239 (= D241), V241 (= V243), K267 (= K269)

3fq7A Gabaculine complex of gsam (see paper)
55% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 3fq7A

query
sites
3fq7A

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: S23 (= S24), V25 (= V26), W61 (= W62), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269), G298 (= G300), T299 (= T301), E400 (= E402)

2hp2A Inter-subunit signaling in gsam (see paper)
55% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 2hp2A

query
sites
2hp2A

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding (4s)-4,5-diaminopentanoic acid: G298 (= G300), T299 (= T301)
binding (4r)-5-amino-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S24), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269)
binding pyridoxal-5'-phosphate: G298 (= G300), T299 (= T301)

2hp1A Inter-subunit signaling in gsam (see paper)
55% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 2hp1A

query
sites
2hp1A

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E
|
E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: S23 (= S24), V25 (= V26), W61 (= W62), S116 (= S118), G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), E206 (= E208), N211 (= N213), D239 (= D241), V241 (= V243), M242 (= M244), K267 (= K269), E400 (= E402)

2hozA Inter-subunit signaling in gsam (see paper)
55% identity, 98% coverage: 6:428/431 of query aligns to 5:426/427 of 2hozA

query
sites
2hozA

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E
|
E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G
|
G

S
|
S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T
x
P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V

V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D
x
N

Y

Y

K
x
E

S

D

A

A

I
x
K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), D239 (= D241), M242 (= M244), K267 (= K269), A401 (= A403)
binding (4s)-4,5-diaminopentanoic acid: E141 (= E143), G156 (= G158), S157 (= S159), P182 (≠ T184), N368 (≠ D370), E370 (≠ K372), K373 (≠ I375)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), G146 (= G148), E206 (= E208), N211 (= N213), D239 (= D241), G298 (= G300), T299 (= T301)

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
55% identity, 97% coverage: 4:421/431 of query aligns to 1:418/426 of P23893

query
sites
P23893

L

M

T

S

R

K

S

S

A

E

E

N

L

L

F

Y

E

S

K

A

A

A

K

R

K

E

F

L

I

I

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

T

S

G

V

V

G

G

G

G

T

T

P

P

I

L

Y

F

M

I

A

E

K

K

G

A

Q

D

G

G

A

A

Y

Y

M

L

T

Y

D

D

V

V

D

D

G

G

N

K

T

A

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

F

M

I

V

L

L

G

G

S

H

M

N

H

H

P

P

R

A

V

I

-

R

T

N

A

A

A

V

I

I

E

E

Y

A

T

A

L

E

R

R

N

-

I

-

G

G

T

L

S

S

F

F

G

G

T

A

P

P

I

T

E

E

L

M

E

E

I

V

E

K

I

M

A

A

E

Q

L

L

L

V

C

T

K

E

I

L

V

V

P

P

S

T

L

M

E

D

M

M

V

V

R

R

M

M

V

V

N

N

S

S

G

G

T

T

E

E

A

A

T

T

M

M

S

S

A

A

V

I

R

R

L

L

A

A

R

R

G

G

Y

F

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y

Y

H

H

G

G

H

H

G

A

D

D

S

C

F

L

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

A

L

L

T

T

L

L

G

G

D

Q

P

P

D

N

S

S

P

P

G

G

V

V

T

P

K

A

G

D

T

F

A

A

N

K

D

Y

T

T

L

L

N

T

A

C

T

T

Y

Y

N

N

D

D

I

L

E

A

S

S

V

V

K

R

A

A

I

A

V

F

N

E

E

Q

N

Y

K

P

G

Q

Q

E

V

I

A

A

A

C

I

I

I

I

I

V

E

E

P

P

V

V

A

A

G

G

N

N

T

M

G

N

V

C

I

V

P

P

A

P

K

L

K

P

E

E

F

F

L

L

V

P

A

G

L

L

R

R

E

A

L

L

C

C

D

D

A

E

E

F

G

G

I

A

V

L

L

L

I

I

F

I

D

D

E

E

V

V

M

M

C

T

G

G

F

F

R

R

V

V

A

A

L

L

G

A

G

G

A

A

Q

Q

E

D

L

Y

Y

Y

G

G

V

V

T

V

P

P

D

D

L

L

T

T

T

C

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

M

P

P

V

V

G

G

A

A

F

F

G

G

G

G

K

R

R

R

H

D

I

V

M

M

E

D

N

A

I

L

A

A

P

P

L

T

G

G

S

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

I

A

A

L

M

T

A

A

A

G

G

L

F

E

A

T

C

L

L

K

N

I

E

L

V

M

A

E

Q

E

P

N

G

P

V

Y

H

P

E

E

T

L

L

E

D

R

E

K

L

A

T

A

T

F

R

L

L

E

A

A

E

G

G

F

L

K

L

A

E

N

A

M

A

E

E

K

E

L

A

G

G

L

I

N

P

Y

L

T

V

Q

V

N

N

R

H

V

V

G

G

S

G

M

M

A

F

C

G

L

I

F

F

F

F

T

T

E

D

T

A

-

E

P

S

V

V

V

T

D

C

Y

Y

K

Q

S

D

A

V

I

M

T

A

A

C

D

D

T

V

A

E

K

R

Y

F

G

K

K

R

Y

F

F

F

H

H

S

M

M

M

L

L

D

D

Q

E

G

G

I

V

Y

Y

L

L

A

A

P

P

S

S

Q

A

F

F

E

E

A

A

M

G

F

F

T

M

S

S

F

V

A

A

H

H

T

S

D

M

E

E

D

D

L

I

E

N

K

N

T

T

V

I

K

D

A

A

K265 (= K269) mutation to R: 2% of wild-type activity.

3fqaA Gabaculien complex of gabaculine resistant gsam version (see paper)
55% identity, 98% coverage: 6:428/431 of query aligns to 4:425/426 of 3fqaA

query
sites
3fqaA

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V

V

R
|
R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

D

S

M

F

F

L

L

I

V

K

K

A

A

G

G

S

S

G

G

V

V

L

A

T

T

L

L

G

G

D

L

P

P

D

S

S

S

P

P

G

G

V

V

T

P

K

K

G

K

T

T

A

T

N

A

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
x
I

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V20 (= V22), Y143 (= Y146), D238 (= D241), I241 (≠ M244), K266 (= K269), A400 (= A403)
binding 3-aminobenzoic acid: S22 (= S24), R25 (= R27), W60 (= W62)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G116 (= G119), T117 (= T120), Y143 (= Y146), E205 (= E208), N210 (= N213), D238 (= D241), V240 (= V243), I241 (≠ M244)

3k28A Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
56% identity, 96% coverage: 1:414/431 of query aligns to 1:407/423 of 3k28A

query
sites
3k28A

M

M

P

R

V

K

L

F

T

D

R

K

S

S

A

I

E

A

L

A

F

F

E

E

K

E

A

A

K

Q

K

D

F

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

M

T

N

P

P

I

L

Y

F

M

M

A

E

K

R

G

G

Q

K

G

G

A

S

Y

K

M

V

T

Y

D

D

V

I

D

D

G

G

N

N

T

E

Y

Y

L

I

D

D

Y

Y

V

V

G

L

S

S

W

W

G

G

P

P

F

L

I

I

L

H

G

G

S

H

M

A

H

N

P

D

R

R

V

V

T

V

A

E

A

A

I

L

E

K

Y

-

T

A

L

V

R

A

N

E

I

R

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

T

E

E

L

I

E

E

I

N

E

K

I

L

A

A

E

K

L

L

L

V

C
x
I

K

E

I

R

V
|
V

P
|
P

S

S

L
x
I

E

E

M

I

V

V

R

R

M

M

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

V

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

K

R

D

N

K

K

I

I

I

L

K

K

F

F

E

I

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

G

G

D

D

S

S

F

L

L

L

I

I

K

K

A

A

G

G

S

S

G

G

V

V

L

-

T

-

L

-

G

-

D

-

P

P

D

D

S

S

P

P

G

G

V

V

T

P

K

E

G

G

T

V

A

A

N

K

D

N

T

T

L

I

N

T

A

V

T

A

Y

Y

N

N

D

D

I

L

E

E

S

S

V

V

K

K

A

Y

I

A

V

F

N

E

E

Q

N

F

K

G

G

D

Q

D

V

I

A

A

A

C

I

V

I

I

I

V

E
|
E

P

P

V

V

A

A

G

G

N

N

T

M

G

G

V

V

I

V

P

P

A

P

K

Q

K

P

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

V

C

T

D

E

A

Q

E

N

G

G

I

A

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

V

A

A

L

Y

G

N

G

C

A

G

Q

Q

E

G

L

Y

Y

Y

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

C

M

L

G

G

K
|
K

I

V

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

A

H

E

I

I

M

M

E

R

N

Q

I

V

A

A

P

P

L

S

G

G

S

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

A

A

A

G

G

L

Y

E

E

T

T

L

L

K

V

I

Q

L

L

M

T

E

P

E

E

N

S

P

-

Y

Y

P

V

E

E

L

F

E

E

R

R

K

K

A

A

A

E

F

M

L

L

E

E

A

A

G

G

F

L

K

R

A

K

N

A

M

A

E

E

K

K

L

H

G

G

L

I

N

P

Y

H

T

H

Q

I

N

N

R

R

V

A

G

G

S

S

M

M

A

I

C

G

L

I

F

F

F

F

T

T

E

D

T

E

P

P

V

V

V

I

D

N

Y

Y

K

D

S

A

A

A

I

K

T

S

A

S

D

N

T

L

A

Q

K

F

Y

F

G

A

K

A

Y

Y

F

Y

H

R

S

E

M

M

L

V

D

E

Q

Q

G

G

I

V

Y

F

L

L

A

P

P

P

S

S

Q

Q

F

F

E

E

A
x
G

M

L

F

F

T

L

S

S

F

T

A

V

H

H

T

S

D

D

E

A

D

D

active site: V22 (= V22), Y145 (= Y146), E202 (= E208), D235 (= D241), M238 (= M244), K263 (= K269), G396 (≠ A403)
binding calcium ion: I103 (≠ C104), V106 (= V107), P107 (= P108), I109 (≠ L110)
binding pyridoxal-5'-phosphate: G118 (= G119), T119 (= T120), Y145 (= Y146), H146 (= H147), G147 (= G148), E202 (= E208), D235 (= D241), V237 (= V243), M238 (= M244), K263 (= K269)

2e7uA Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from thermus thermophilus hb8
56% identity, 97% coverage: 7:426/431 of query aligns to 6:424/424 of 2e7uA

query
sites
2e7uA

S

S

A

E

E

A

L

Y

F

F

E

Q

K

E

A

A

K

K

K

R

F

H

I

I

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

A

V

V

G

G

G

G

T

T

P

P

I

P

Y

F

M

L

A

V

K

R

G

G

Q

E

G

G

A

A

Y

Y

M

V

T

W

D

D

V

A

D

D

G

G

N

N

T

R

Y

Y

L

L

D

D

Y

Y

V

V

G

M

S

S

W

W

G

G

P

P

F

L

I

I

L

L

G

G

S

H

M

A

H

H

P

P

R

K

V

V

T

L

A

A

A

R

I

V

E

R

Y

E

T

T

L

L

R

E

N

R

I

-

G

G

T

L

S

T

F

F

G

G

T

A

P

P

I

S

E

P

L

L

E

E

I

V

E

A

I

L

A

A

E

K

L

K

L

V

C

K

K

R

I

A

V

Y

P

P

S

F

L

V

E

D

M

L

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

V

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

K

R

D

P

K

Y

I

I

I

V

K

K

F

F

E

R

G

G

C

N

Y
|
Y

H
|
H

G

G

H

H

G

A

D

D

S

G

F

L

L

L

I

V

K

E

A

A

G

G

S

S

G

G

V

A

L

L

T

T

L

L

G

G

D

V

P

P

D

S

S

S

P

A

G

G

V

V

T

P

K

E

G

E

T

Y

A

A

N

K

D

L

T

T

L

L

N

V

A

L

T

E

Y

Y

N

N

D

D

I

P

E

E

S

G

V

L

K

R

A

E

I

V

V

L

N

K

E

R

N

R

K

G

G

E

Q

E

V

I

A

A

A

A

I

I

I

I

I

F

E
|
E

P

P

V

V

A

V

G

G

N
|
N

T

A

G

G

V

V

I

L

P

V

A

P

K

T

K

E

E

D

F

F

L

L

V

K

A

A

L

L

R

H

E

E

L

-

C

A

D

K

A

A

E

Y

G

G

I

V

V

L

L

L

I

I

F

A

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

L

A

A

L

F

G

G

G

G

A

A

Q

T

E

E

L

L

Y

L

G

G

V

L

T

K

P

P

D

D

L

L

T

V

T

T

M

L

G

G

K
|
K

I

I

I

L

G

G

G

G

G

G

L

L

P

P

V

A

G

A

A

A

F

Y

G

A

G

G

K

R

R

R

H

E

I

I

M

M

E

E

N

K

I

V

A

A

P

P

L

L

G

G

S

P

V

V

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

A

A

A

G

G

L

L

E

A

T

T

L

L

K

E

I

-

L

L

M

L

E

E

E

E

N

N

P

P

-

G

-

Y

Y

Y

P

A

E

Y

L

L

E

E

R

D

K

L

A

G

A

A

F

R

L

L

E

E

A

A

G

G

F

L

K

K

A

E

N

V

M

L

E

K

K

E

L

K

G

G

L

L

N

P

Y

H

T

T

Q

V

N

N

R

R

V

V

G

G

S

S

M

M

A

I

C

T

L

V

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

V

D

T

Y

F

K

Q

S

D

A

A

I

R

T

R

A

T

D

D

T

T

A

E

K

L

Y

F

G

K

K

R

Y

F

F

F

H

H

S

G

M

L

L

L

D

D

Q

R

G

G

I

I

Y

Y

L

W

A

P

P

P

S

S

Q

N

F

F

E

E

A
|
A

M

A

F

F

T

L

S

S

F

V

A

A

H

H

T

R

D

E

E

E

D

D

L

V

E

E

K

K

T

T

V

L

K

E

A

A

N

L

Y

R

N

K

A

A

L

L

active site: V21 (= V22), Y144 (= Y146), E206 (= E208), D238 (= D241), M241 (= M244), K266 (= K269), A401 (= A403)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), H145 (= H147), N211 (= N213), D238 (= D241), V240 (= V243)

6w80A Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from stenotrophomonas maltophilia k279a in complex with plp
55% identity, 96% coverage: 6:419/431 of query aligns to 10:419/430 of 6w80A

query
sites
6w80A

R

Q

S

S

A

H

E

A

L

L

F

F

E

S

K

R

A

A

K

Q

K

Q

F

L

I

L

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

E

P

P

I

F

Y

F

M

V

A

E

K

R

G

A

Q

D

G

G

A

A

Y

Y

M

L

T

Y

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

F

M

I

I

L

V

G

G

S

H

M

N

H

H

P

P

R

A

V

V

T

R

A

Q

A

A

I

V

E

K

Y

K

T

A

L

I

R

D

N

N

I

-

G

G

T

L

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

G

E

E

I

V

E

T

I

M

A

A

E

E

L

T

L

I

C

T

K

R

I

L

V

V

P

P

S

S

L

C

E

E

M

M

V

V

R

R

M

M

V

V

N

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

T

M

L

S

S

A

A

V

I

R

R

L

L

A

A

R

R

G

G

Y

A

T

T

G

G

K

R

D

N

K

R

I

I

I

V

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H
|
H

G

G

H

H

G

G

D

D

S

S

F

F

L

L

I

V

K

K

A

A

G

-

S

-

G

-

V

M

L

L

T

T

L

L

G

G

D

V

P

P

D

T

S

S

P

P

G

G

V

V

T

P

K

A

G

G

T

L

A

S

N

E

D

L

T

T

L

L

N

T

A

L

T

P

Y

Y

N

N

D

D

I

F

E

E

S

A

V

A

K

T

A

A

I

L

V

F

N

E

E

Q

N

Q

K

G

G

D

Q

D

V

I

A

A

A

G

I

L

I

I

I

I

E
|
E

P

P

V

V

A

V

G

G

N
|
N

T

A

G

N

V

C

I

I

P

P

A

P

K

R

K

E

E

G

F

Y

L

L

V

Q

A

H

L

L

R

R

E

A

L

L

C

C

D

T

A

K

E

H

G

G

I

A

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M

M

C

T

G

G

F

F

R

R

V

V

A

A

L

L

G

G

G

G

A

A

Q

Q

E

A

L

H

Y

Y

G

G

V

I

T

T

P

P

D

D

L

L

T

T

T

T

M

F

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

M

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

R

R

H

E

I

L

M

M

E

Q

N

Q

I

I

A

A

P

P

L

A

G

G

S

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

V

A

A

L

M

T

A

A

A

G

G

L

L

E

A

T

M

L

L

K

E

I

L

L

V

M

Q

E

Q

E

P

N

G

P

F

Y

H

P

A

E

D

L

L

E

A

R

E

K

R

A

T

A

A

F

R

L

L

E

C

A

A

G

G

F

L

K

E

A

A

N

A

M

A

E

A

K

D

L

A

G

G

L

V

N

A

Y

V

T

T

Q

T

N

T

R

R

V

V

G

G

S

A

M

M

A

F

C

G

L

L

F

F

F

F

T

T

E

S

T

E

P

K

V

V

V

E

D

T

Y

Y

K

A

S

Q

A

A

I

T

T

A

A

C

D

D

T

I

A

P

K

A

Y

F

G

N

K

R

Y

F

F

F

H

H

S

A

M

M

L

L

D

E

Q

Q

G

G

I

V

Y

F

L

L

A

A

P

P

S

S

Q

A

F

Y

E

E

A

A

M

G

F

F

T

L

S

S

F

S

A

A

H

H

T

D

D

D

E

A

D

V

L

I

E

E

K

A

T

T

V

L

active site: V26 (= V22), Y149 (= Y146), D241 (= D241), K269 (= K269)
binding pyridoxal-5'-phosphate: S121 (= S118), G122 (= G119), T123 (= T120), Y149 (= Y146), H150 (= H147), E208 (= E208), N213 (= N213), D241 (= D241), V243 (= V243), K269 (= K269)

3usfB Crystal structure of dava-4
52% identity, 98% coverage: 6:428/431 of query aligns to 5:401/402 of 3usfB

query
sites
3usfB

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

A

D

D

S

-

F

-

L

-

I

-

K

-

A

-

G

-

S

-

G

-

V

-

L

-

T

-

L

-

G

-

D

-

P

-

D

-

S

-

P

-

G

-

V

-

T

-

K

-

G

-

T

T

A

A

N

N

D

-

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), E181 (= E208), D214 (= D241), M217 (= M244), K242 (= K269), A376 (= A403)
binding (4s)-4,5-diaminopentanoic acid: G273 (= G300), T274 (= T301)
binding (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate: G117 (= G119), T118 (= T120), Y144 (= Y146), E181 (= E208), N186 (= N213), D214 (= D241), V216 (= V243), M217 (= M244), K242 (= K269)

2hp1B Inter-subunit signaling in gsam (see paper)
51% identity, 98% coverage: 6:428/431 of query aligns to 5:397/398 of 2hp1B

query
sites
2hp1B

R

K

S

S

A

D

E

E

L

I

F

F

E

A

K

A

A

A

K

Q

K

K

F

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R
|
R

A

A

F

F

K

K

S

S

V

V

G

G

G

G

T

Q

P

P

I

I

Y

V

M

F

A

D

K

R

G

V

Q

K

G

D

A

A

Y

Y

M

A

T

W

D

D

V

V

D

D

G

G

N

N

T

R

Y

Y

L

I

D

D

Y

Y

V

V

G

G

S

T

W
|
W

G

G

P

P

F

A

I

I

L

C

G

G

S

H

M

A

H

H

P

P

R

E

V

V

T

I

A

E

A

A

I

L

E

K

Y

V

T

A

L

M

R

E

N

K

I

-

G

G

T

T

S

S

F

F

G

G

T

A

P

P

I

C

E

A

L

L

E

E

I

N

E

V

I

L

A

A

E

E

L

M

L

V

C

N

K

D

I

A

V

V

P

P

S

S

L

I

E

E

M

M

V

V

R

R

M

F

V

V

N

N

S
|
S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

V

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

K

R

D

D

K

K

I

I

I

I

K

K

F

F

E

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

G

-

D

-

S

-

F

-

L

-

I

-

K

-

A

-

G

-

S

-

G

-

V

-

L

-

T

-

L

-

G

-

D

-

P

-

D

-

S

-

P

-

G

-

V

-

T

-

K

-

G

-

T

-

A

-

N

-

D

N

T

T

L

L

N

T

A

T

T

P

Y

Y

N

N

D

D

I

L

E

E

S

A

V

V

K

K

A

A

I

L

V

F

N

A

E

E

N

N

K

P

G

G

Q

E

V

I

A

A

A

G

I

V

I

I

I

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

T

S

G

G

V

F

I

I

P

V

A

P

K

D

K

A

E

G

F

F

L

L

V

E

A

G

L

L

R

R

E

E

L

I

C

T

D

L

A

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

C

T

G

G

F

F

R

R

V

I

A

A

L

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

G

G

V

V

T

T

P

P

D

D

L

L

T

T

T

T

M

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

R

R

H

E

I

I

M

M

E

Q

N

L

I

V

A

A

P

P

L

A

G

G

S

P

V

M

Y

Y

Q

Q

A

A

G
|
G

T
|
T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

L

M

T

T

A

A

G

G

L

I

E

K

T

T

L

L

K

E

I

L

L

L

M

R

E

Q

E

P

N

G

P

T

Y

Y

P

E

E

Y

L

L

E

D

R

Q

K

I

A

T

A

K

F

R

L

L

E

S

A

D

G

G

F

L

K

L

A

A

N

I

M

A

E

Q

K

E

L

T

G

G

L

H

N

A

Y

A

T

C

Q

G

N

G

R

Q

V

V

G

S

S

G

M

M

A

F

C

G

L

F

F

F

F

F

T

T

E

E

T

G

P

P

V

V

V

H

D

N

Y

Y

K

E

S

D

A

A

I

K

T

K

A

S

D

D

T

L

A

Q

K

K

Y

F

G

S

K

R

Y

F

F

H

H

R

S

G

M

M

L

L

D

E

Q

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

A
|
A

M

G

F

F

T

T

S

S

F

L

A

A

H

H

T

T

D

E

E

E

D

D

L

I

E

D

K

A

T

T

V

L

K

A

A

A

N

A

Y

R

N

T

A

V

L

M

V

S

A

A

active site: V21 (= V22), Y144 (= Y146), E177 (= E208), D210 (= D241), M213 (= M244), K238 (= K269), A372 (= A403)
binding (4s)-4-amino-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid: G269 (= G300), T270 (= T301)
binding (4s)-4,5-diaminopentanoic acid: S23 (= S24), V25 (= V26), R26 (= R27), W61 (= W62), Y144 (= Y146)
binding pyridoxal-5'-phosphate: S116 (= S118), G117 (= G119), T118 (= T120), Y144 (= Y146), E177 (= E208), N182 (= N213), D210 (= D241), V212 (= V243), M213 (= M244), K238 (= K269)

Query Sequence

>WP_010933753.1 NCBI__GCF_000006985.1:WP_010933753.1
MPVLTRSAELFEKAKKFIPGGVNSPVRAFKSVGGTPIYMAKGQGAYMTDVDGNTYLDYVG
SWGPFILGSMHPRVTAAIEYTLRNIGTSFGTPIELEIEIAELLCKIVPSLEMVRMVNSGT
EATMSAVRLARGYTGKDKIIKFEGCYHGHGDSFLIKAGSGVLTLGDPDSPGVTKGTANDT
LNATYNDIESVKAIVNENKGQVAAIIIEPVAGNTGVIPAKKEFLVALRELCDAEGIVLIF
DEVMCGFRVALGGAQELYGVTPDLTTMGKIIGGGLPVGAFGGKRHIMENIAPLGSVYQAG
TLSGNPLALTAGLETLKILMEENPYPELERKAAFLEAGFKANMEKLGLNYTQNRVGSMAC
LFFTETPVVDYKSAITADTAKYGKYFHSMLDQGIYLAPSQFEAMFTSFAHTDEDLEKTVK
ANYNALVAATK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory