Comparing WP_010964258.1 NCBI__GCF_000008765.1:WP_010964258.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4tx9A Crystal structure of hisap from streptomyces sviceus with degraded profar (see paper)
35% identity, 99% coverage: 3:238/239 of query aligns to 11:246/246 of 4tx9A
3zs4A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound prfar
35% identity, 99% coverage: 1:237/239 of query aligns to 3:243/244 of 3zs4A
2y88A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase (variant d11n) with bound prfar (see paper)
35% identity, 99% coverage: 1:237/239 of query aligns to 3:243/244 of 2y88A
5dn1A Crystal structure of phosphoribosyl isomerase a from streptomyces coelicolor (see paper)
35% identity, 97% coverage: 3:233/239 of query aligns to 6:236/240 of 5dn1A
P16250 Phosphoribosyl isomerase A; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16; EC 5.3.1.24 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
35% identity, 97% coverage: 3:233/239 of query aligns to 6:236/240 of P16250
2y85A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound rcdrp (see paper)
35% identity, 99% coverage: 1:237/239 of query aligns to 3:234/234 of 2y85A
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
29% identity, 97% coverage: 2:233/239 of query aligns to 1:239/246 of 5abtA
Q9X0C7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
31% identity, 93% coverage: 1:222/239 of query aligns to 1:226/241 of Q9X0C7
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
28% identity, 97% coverage: 2:233/239 of query aligns to 1:236/241 of 5ab3A
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
30% identity, 82% coverage: 3:198/239 of query aligns to 7:206/253 of 1h5yB
Sites not aligning to the query:
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
23% identity, 96% coverage: 3:231/239 of query aligns to 6:243/258 of P60664
Sites not aligning to the query:
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
23% identity, 91% coverage: 14:231/239 of query aligns to 9:227/244 of 3zr4E
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
23% identity, 96% coverage: 3:231/239 of query aligns to 6:236/252 of 7ac8A
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
23% identity, 96% coverage: 3:231/239 of query aligns to 6:236/253 of Q9X0C6
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
23% identity, 96% coverage: 3:231/239 of query aligns to 6:236/250 of 7qc8A
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
22% identity, 96% coverage: 3:231/239 of query aligns to 6:236/253 of 1gpwC
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
24% identity, 71% coverage: 63:231/239 of query aligns to 49:222/237 of 2wjzE
Sites not aligning to the query:
4ewnD Structure of hisf-d130v+d176v with bound rcdrp (see paper)
21% identity, 96% coverage: 3:231/239 of query aligns to 5:229/243 of 4ewnD
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
22% identity, 96% coverage: 3:231/239 of query aligns to 4:234/251 of 5d2tA
3iivB Evolutionary optimization of computationally designed enzymes: kemp eliminases of the ke07 series (see paper)
23% identity, 84% coverage: 32:231/239 of query aligns to 32:235/262 of 3iivB
>WP_010964258.1 NCBI__GCF_000008765.1:WP_010964258.1
MIILPAIDIKQGKCVRLYQGRFEKSSVVAESPALTAKSFENDGAKYIHVVDLDGALEGEI
INLDAVKSIVQVTSVPIELGGGIRNIKVVEKLINIGVKRIILGTAALKDKEFTREAIKEY
GKSIAVGIDAKDGYVAVNGWLNVSKINYIEFAKIMEDMGTEDIILTDISKDGTLKGPNFD
MLKKLQENVNCNITASGGIKDLDDLIKLKEMNIYGAIVGKAIYSEKINLKEAIAVIEKR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory