SitesBLAST
Comparing WP_011022378.1 NCBI__GCF_000007345.1:WP_011022378.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 18 hits to proteins with known functional sites (download)
5exeC Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-tpp adduct (see paper)
45% identity, 97% coverage: 1:287/296 of query aligns to 8:297/314 of 5exeC
- active site: N143 (= N131)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-carboxy-4-methyl-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: T50 (= T43), G51 (= G44), C52 (= C45), I74 (≠ F67), G109 (= G97), D110 (= D98), G111 (= G99), Y136 (≠ M124), N138 (= N126), S140 (≠ A128), Y141 (= Y129), A142 (≠ M130), N143 (= N131), T144 (= T132)
- binding magnesium ion: D110 (= D98), D130 (= D118), N138 (= N126), S140 (≠ A128), L211 (≠ T196), Q213 (≠ I198)
- binding iron/sulfur cluster: C24 (= C17), C27 (= C20), P29 (≠ D22), C52 (= C45), C225 (= C210), P226 (≠ T211), K227 (≠ T212)
5exdF Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
45% identity, 97% coverage: 1:287/296 of query aligns to 8:297/310 of 5exdF
- active site: N143 (= N131)
- binding magnesium ion: D110 (= D98), N138 (= N126), S140 (≠ A128)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-[1,1,2-tris(oxidanyl)-2-oxidanylidene-ethyl]-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: T50 (= T43), G51 (= G44), C52 (= C45), I74 (≠ F67), D110 (= D98), G111 (= G99), Y136 (≠ M124), N138 (= N126), S140 (≠ A128), Y141 (= Y129), A142 (≠ M130), N143 (= N131), T144 (= T132)
- binding iron/sulfur cluster: C24 (= C17), C27 (= C20), P29 (≠ D22), C52 (= C45), A142 (≠ M130), C225 (= C210), K227 (≠ T212)
5c4iC Structure of an oxalate oxidoreductase (see paper)
45% identity, 97% coverage: 1:287/296 of query aligns to 8:297/312 of 5c4iC
- active site: N143 (= N131)
- binding magnesium ion: D110 (= D98), N138 (= N126), S140 (≠ A128)
- binding iron/sulfur cluster: C24 (= C17), C27 (= C20), P29 (≠ D22), C52 (= C45), A142 (≠ M130), C225 (= C210), P226 (≠ T211), K227 (≠ T212)
- binding thiamine diphosphate: T50 (= T43), G51 (= G44), C52 (= C45), I74 (≠ F67), G109 (= G97), D110 (= D98), G111 (= G99), Y136 (≠ M124), N138 (= N126), S140 (≠ A128), Y141 (= Y129), A142 (≠ M130), N143 (= N131), T144 (= T132)
7plmA Cryoem reconstruction of pyruvate ferredoxin oxidoreductase (pfor) in anaerobic conditions (see paper)
27% identity, 86% coverage: 16:269/296 of query aligns to 781:1098/1177 of 7plmA
- binding calcium ion: D950 (= D118), N952 (≠ T120), F1026 (≠ I198), G1028 (= G200)
- binding magnesium ion: D930 (= D98), T958 (≠ N126), V960 (≠ A128), S962 (≠ M130)
- binding iron/sulfur cluster: A781 (= A16), C782 (= C17), C785 (= C20), E787 (≠ D22), C810 (= C45), S962 (≠ M130), C1038 (= C210), I1039 (vs. gap)
- binding thiamine diphosphate: E787 (≠ D22), T808 (= T43), G809 (= G44), C810 (= C45), F839 (= F67), G929 (= G97), D930 (= D98), G931 (= G99), V960 (≠ A128), Y961 (= Y129), S962 (≠ M130), N963 (= N131), T964 (= T132)
Sites not aligning to the query:
- binding iron/sulfur cluster: 458, 657, 659, 664, 665, 666, 667, 668, 670, 674, 675, 679, 708, 715, 716, 717, 718, 719, 721, 725, 726, 731, 732
- binding thiamine diphosphate: 27, 28, 29, 63
2c3uA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus, oxygen inhibited form (see paper)
32% identity, 58% coverage: 97:269/296 of query aligns to 961:1136/1231 of 2c3uA
- active site: N995 (= N131)
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: G961 (= G97), D962 (= D98), G963 (= G99), W964 (≠ A100), V992 (≠ A128), Y993 (= Y129), S994 (≠ M130), N995 (= N131), T996 (= T132)
- binding calcium ion: D982 (= D118), N984 (≠ T120), A1055 (= A195), E1056 (≠ T196), F1058 (≠ I198), G1060 (= G200), S1062 (≠ T202)
- binding magnesium ion: D962 (= D98), T990 (≠ N126), V992 (≠ A128)
- binding pyruvic acid: N995 (= N131)
- binding iron/sulfur cluster: C1070 (= C210), I1071 (vs. gap)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: 28, 29, 63, 87, 816, 837, 839, 868, 869
- binding pyruvic acid: 30, 113, 122
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 811, 814, 816, 839
2c3pA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
32% identity, 58% coverage: 97:269/296 of query aligns to 961:1136/1231 of 2c3pA
- active site: N995 (= N131)
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: G961 (= G97), D962 (= D98), G963 (= G99), V992 (≠ A128), Y993 (= Y129), S994 (≠ M130), N995 (= N131), T996 (= T132)
- binding calcium ion: D982 (= D118), V983 (≠ F119), N984 (≠ T120), A1055 (= A195), E1056 (≠ T196), F1058 (≠ I198), G1060 (= G200), S1062 (≠ T202)
- binding magnesium ion: D962 (= D98), T990 (≠ N126), V992 (≠ A128)
- binding iron/sulfur cluster: S994 (≠ M130), C1070 (= C210), I1071 (vs. gap)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: 28, 29, 30, 63, 87, 113, 816, 837, 838, 839, 868, 869
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839
2c3oA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
32% identity, 58% coverage: 97:269/296 of query aligns to 961:1136/1231 of 2c3oA
- active site: N995 (= N131)
- binding calcium ion: D982 (= D118), N984 (≠ T120), E1056 (≠ T196), F1058 (≠ I198), G1060 (= G200)
- binding magnesium ion: D962 (= D98), T990 (≠ N126), V992 (≠ A128)
- binding pyruvic acid: T996 (= T132)
- binding iron/sulfur cluster: C1070 (= C210), I1071 (vs. gap)
- binding thiamine diphosphate: G961 (= G97), D962 (= D98), G963 (= G99), V992 (≠ A128), Y993 (= Y129), S994 (≠ M130), N995 (= N131), T996 (= T132)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding pyruvic acid: 30, 113
- binding iron/sulfur cluster: 458, 681, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 746, 747, 748, 749, 750, 754, 760, 761, 810, 811, 814, 816, 839
- binding thiamine diphosphate: 28, 29, 63, 87, 816, 837, 838, 839, 868
1kekA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase (see paper)
32% identity, 58% coverage: 97:269/296 of query aligns to 961:1136/1231 of 1kekA
- active site: N995 (= N131)
- binding calcium ion: D982 (= D118), N984 (≠ T120), A1055 (= A195), E1056 (≠ T196), F1058 (≠ I198), S1062 (≠ T202)
- binding 2-acetyl-thiamine diphosphate: G961 (= G97), D962 (= D98), G963 (= G99), V992 (≠ A128), Y993 (= Y129), S994 (≠ M130), N995 (= N131), T996 (= T132)
- binding magnesium ion: D962 (= D98), T990 (≠ N126), V992 (≠ A128)
- binding iron/sulfur cluster: C1070 (= C210), I1071 (vs. gap)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 2-acetyl-thiamine diphosphate: 29, 63, 87, 113, 816, 837, 838, 839, 868
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 703, 737, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839
1b0pA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
32% identity, 58% coverage: 97:269/296 of query aligns to 961:1136/1231 of 1b0pA
- active site: N995 (= N131)
- binding calcium ion: D982 (= D118), N984 (≠ T120), A1055 (= A195), E1056 (≠ T196), F1058 (≠ I198), G1060 (= G200)
- binding magnesium ion: D962 (= D98), T990 (≠ N126), V992 (≠ A128)
- binding iron/sulfur cluster: S994 (≠ M130), C1070 (= C210), I1071 (vs. gap)
- binding thiamine diphosphate: G961 (= G97), D962 (= D98), G963 (= G99), V992 (≠ A128), Y993 (= Y129), S994 (≠ M130), N995 (= N131), T996 (= T132)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 737, 744, 745, 747, 748, 750, 754, 755, 760, 811, 814, 816, 839
- binding thiamine diphosphate: 28, 29, 63, 816, 837, 838, 839, 868
P94692 Pyruvate:ferredoxin oxidoreductase; PFOR; POR; Pyruvate synthase; EC 1.2.7.1 from Desulfocurvibacter africanus (Desulfovibrio africanus) (see 3 papers)
32% identity, 58% coverage: 97:269/296 of query aligns to 962:1137/1232 of P94692
- GDGW 962:965 (≠ GDGA 97:100) binding thiamine diphosphate
- D963 (= D98) binding Mg(2+)
- D983 (= D118) binding Ca(2+)
- N985 (≠ T120) binding Ca(2+)
- T991 (≠ N126) binding Mg(2+)
- TEVYSN 991:996 (≠ NEAYMN 126:131) binding thiamine diphosphate
- V993 (≠ A128) binding Mg(2+)
- A1056 (= A195) binding Ca(2+)
- F1059 (≠ I198) binding Ca(2+)
- G1061 (= G200) binding Ca(2+)
- S1063 (≠ T202) binding Ca(2+)
- C1071 (= C210) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 31 binding pyruvate
- 64 binding thiamine diphosphate
- 114 binding pyruvate
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 695 binding [4Fe-4S] cluster
- 699 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 751 binding [4Fe-4S] cluster
- 755 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 815 binding [4Fe-4S] cluster
- 817 binding thiamine diphosphate
- 840 binding [4Fe-4S] cluster; binding thiamine diphosphate
6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound (see paper)
29% identity, 67% coverage: 95:293/296 of query aligns to 963:1160/1165 of 6cipA
Sites not aligning to the query:
- active site: 28, 61, 111
- binding 2-acetyl-thiamine diphosphate: 27, 61, 85, 111, 813, 834, 835, 836, 865
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836
Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
29% identity, 67% coverage: 95:293/296 of query aligns to 964:1165/1171 of Q2RMD6
- D967 (= D98) binding Mg(2+)
- DGW 967:969 (≠ DGA 98:100) binding thiamine diphosphate
- T995 (≠ N126) binding Mg(2+)
- TEVYSN 995:1000 (≠ NEAYMN 126:131) binding thiamine diphosphate
- V997 (≠ A128) binding Mg(2+)
- C1075 (= C210) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 424:428 binding CoA
- 456 binding CoA
- 556 binding CoA
- 598 binding CoA
- 686 binding [4Fe-4S] cluster
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 696 binding [4Fe-4S] cluster
- 742 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 752 binding [4Fe-4S] cluster
- 809 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 814 binding thiamine diphosphate
- 837 binding [4Fe-4S] cluster; binding thiamine diphosphate
6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound (see paper)
29% identity, 67% coverage: 95:293/296 of query aligns to 963:1164/1169 of 6ciqA
- active site: N999 (= N131)
- binding coenzyme a: N999 (= N131)
- binding magnesium ion: D966 (= D98), T994 (≠ N126), V996 (≠ A128)
- binding iron/sulfur cluster: S998 (≠ M130), C1074 (= C210), I1075 (≠ T211)
- binding thiamine diphosphate: G965 (= G97), D966 (= D98), G967 (= G99), V996 (≠ A128), Y997 (= Y129), S998 (≠ M130), N999 (= N131), T1000 (= T132)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding coenzyme a: 28, 423, 424, 427, 428, 553, 586
- binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 696, 700, 734, 741, 742, 743, 744, 745, 747, 751, 757, 807, 808, 811, 813, 836
- binding thiamine diphosphate: 26, 27, 61, 85, 813, 835, 836, 865
6cinB Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
29% identity, 67% coverage: 95:293/296 of query aligns to 963:1164/1169 of 6cinB
- active site: N999 (= N131)
- binding magnesium ion: D966 (= D98), T994 (≠ N126), V996 (≠ A128)
- binding iron/sulfur cluster: S998 (≠ M130), C1074 (= C210), I1075 (≠ T211)
- binding thiamine diphosphate: G965 (= G97), D966 (= D98), G967 (= G99), V996 (≠ A128), Y997 (= Y129), S998 (≠ M130), N999 (= N131), T1000 (= T132)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding iron/sulfur cluster: 455, 678, 685, 686, 687, 688, 689, 691, 695, 700, 741, 742, 743, 744, 745, 746, 747, 751, 752, 757, 758, 807, 808, 811, 813, 836
- binding thiamine diphosphate: 26, 27, 61, 834, 835, 836, 865
6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound (see paper)
28% identity, 67% coverage: 95:293/296 of query aligns to 963:1159/1164 of 6cioA
- active site: N999 (= N131)
- binding magnesium ion: D966 (= D98), T994 (≠ N126), V996 (≠ A128)
- binding iron/sulfur cluster: C1074 (= C210), I1075 (≠ T211)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: G965 (= G97), D966 (= D98), G967 (= G99), V996 (≠ A128), Y997 (= Y129), S998 (≠ M130), N999 (= N131), T1000 (= T132)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: 26, 27, 28, 61, 85, 111, 813, 834, 835, 836, 865
6n2oD 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
26% identity, 78% coverage: 1:230/296 of query aligns to 8:225/291 of 6n2oD
- binding magnesium ion: D101 (= D98), N129 (= N126), I131 (≠ A128)
- binding succinyl-coenzyme a: I57 (≠ T43), R62 (≠ S50), L134 (≠ N131), K136 (≠ G133)
- binding iron/sulfur cluster: W24 (vs. gap), C25 (= C17), C28 (= C20), C59 (= C45), C208 (= C210), T210 (= T212), F211 (= F216)
- binding thiamine diphosphate: I57 (≠ T43), G58 (= G44), C59 (= C45), S60 (≠ V48), H76 (≠ F67), G102 (= G99), D103 (≠ A100), N129 (= N126), I131 (≠ A128), G133 (≠ M130), L134 (≠ N131), T135 (= T132)
6n2oB 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
26% identity, 78% coverage: 1:230/296 of query aligns to 8:225/291 of 6n2oB
- binding 2-oxoglutaric acid: R62 (≠ S50), L134 (≠ N131)
- binding coenzyme a: K136 (≠ G133), Y150 (≠ T147)
- binding magnesium ion: D101 (= D98), N129 (= N126), I131 (≠ A128)
- binding iron/sulfur cluster: W24 (vs. gap), C25 (= C17), C28 (= C20), C59 (= C45), C208 (= C210), T210 (= T212), F211 (= F216)
- binding thiamine diphosphate: I57 (≠ T43), G58 (= G44), C59 (= C45), S60 (≠ V48), H76 (≠ F67), G102 (= G99), D103 (≠ A100), N129 (= N126), I131 (≠ A128), Y132 (= Y129), G133 (≠ M130), L134 (≠ N131), T135 (= T132)
6n2nB Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus (see paper)
26% identity, 78% coverage: 1:230/296 of query aligns to 8:225/291 of 6n2nB
- binding magnesium ion: D101 (= D98), N129 (= N126), I131 (≠ A128)
- binding iron/sulfur cluster: W24 (vs. gap), C25 (= C17), C28 (= C20), H30 (≠ D22), C59 (= C45), C208 (= C210), T210 (= T212), F211 (= F216)
- binding thiamine diphosphate: I57 (≠ T43), G58 (= G44), C59 (= C45), S60 (≠ V48), H76 (≠ F67), G100 (= G97), D101 (= D98), G102 (= G99), D103 (≠ A100), N129 (= N126), I131 (≠ A128), Y132 (= Y129), G133 (≠ M130), L134 (≠ N131), T135 (= T132)
Query Sequence
>WP_011022378.1 NCBI__GCF_000007345.1:WP_011022378.1
MSKTAPKTYITSGHSACPGCCDIFAAKFALMGAGPNCIIVNPTGCLEVTSTPYPKSAWQV
PWIHSLFENGGAVASGVEAGLKALGKKDDIKVIAIAGDGATMDIGIRSISGAFERGHDFT
YICMDNEAYMNTGVQRSSGTPFDASTTTSPPGKFSFGNPLPKKNMPAIMAAHGSPYVATT
TIGFPRDMIRKVKKATEIMGPTYIHAHAPCTTGWGFDTSKTLEVARLAVETCLWPLYEME
NGQITQARKIKNPRPVEEYLRAQKRFQHLFTMEGGEEEIKKIQAMADWNIEYYGLQ
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory