Comparing WP_011033329.1 NCBI__GCF_000007065.1:WP_011033329.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 16 hits to proteins with known functional sites (download)
2du3A Crystal structure of archaeoglobus fulgidus o-phosphoseryl-tRNA synthetase complexed with trnacys and o-phosphoserine (see paper)
59% identity, 100% coverage: 1:539/539 of query aligns to 1:534/534 of 2du3A
O30126 O-phosphoserine--tRNA(Cys) ligase; O-phosphoserine--tRNA ligase; Non-canonical O-phosphoseryl-tRNA(Cys) synthetase; O-phosphoseryl-tRNA(Cys) synthetase; SepRS; EC 6.1.1.27 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
59% identity, 100% coverage: 1:539/539 of query aligns to 1:534/534 of O30126
5x6cA Crystal structure of seprs-sepcyse from methanocaldococcus jannaschii (see paper)
50% identity, 100% coverage: 1:539/539 of query aligns to 1:539/539 of 5x6cA
2du4A Crystal structure of archaeoglobus fulgidus o-phosphoseryl-tRNA synthetase complexed with trnacys (see paper)
62% identity, 70% coverage: 165:539/539 of query aligns to 90:466/466 of 2du4A
2du3B Crystal structure of archaeoglobus fulgidus o-phosphoseryl-tRNA synthetase complexed with trnacys and o-phosphoserine (see paper)
62% identity, 68% coverage: 176:539/539 of query aligns to 105:465/465 of 2du3B
3l4gC Crystal structure of homo sapiens cytoplasmic phenylalanyl-tRNA synthetase (see paper)
29% identity, 39% coverage: 177:385/539 of query aligns to 316:508/508 of 3l4gC
Sites not aligning to the query:
Q9Y285 Phenylalanine--tRNA ligase alpha subunit; CML33; Phenylalanyl-tRNA synthetase alpha subunit; PheRS; EC 6.1.1.20 from Homo sapiens (Human) (see 3 papers)
29% identity, 39% coverage: 177:385/539 of query aligns to 316:508/508 of Q9Y285
Sites not aligning to the query:
A5K9S0 Phenylalanine--tRNA ligase alpha subunit; Phenylalanine tRNA-synthetase alpha subunit; FRS; PheRS; Phenylalanyl-tRNA synthetase alpha subunit; EC 6.1.1.20 from Plasmodium vivax (strain Salvador I) (see paper)
29% identity, 31% coverage: 181:348/539 of query aligns to 399:562/569 of A5K9S0
Q9W3J5 Phenylalanine--tRNA ligase alpha subunit; Phenylalanyl-tRNA synthetase alpha subunit; PheRS; EC 6.1.1.20 from Drosophila melanogaster (Fruit fly) (see paper)
28% identity, 33% coverage: 177:353/539 of query aligns to 315:482/498 of Q9W3J5
7dpiC Plasmodium falciparum cytoplasmic phenylalanyl-tRNA synthetase in complex with brd7929 (see paper)
25% identity, 33% coverage: 173:348/539 of query aligns to 118:287/292 of 7dpiC
P15625 Phenylalanine--tRNA ligase alpha subunit; Phenylalanyl-tRNA synthetase alpha subunit; PheRS; EC 6.1.1.20 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 30% coverage: 185:348/539 of query aligns to 328:479/503 of P15625
Sites not aligning to the query:
7by6A Plasmodium vivax cytoplasmic phenylalanyl-tRNA synthetase in complex with brd1389 (see paper)
29% identity, 31% coverage: 181:348/539 of query aligns to 129:292/299 of 7by6A
3pcoC Crystal structure of e. Coli phenylalanine-tRNA synthetase complexed with phenylalanine and amp (see paper)
26% identity, 31% coverage: 181:348/539 of query aligns to 158:311/323 of 3pcoC
Sites not aligning to the query:
6p26A Escherichia coli tRNA synthetase in complex with compound 1 (see paper)
26% identity, 31% coverage: 181:348/539 of query aligns to 76:229/241 of 6p26A
Sites not aligning to the query:
6p24A Escherichia coli tRNA synthetase (see paper)
26% identity, 31% coverage: 181:348/539 of query aligns to 76:229/241 of 6p24A
Sites not aligning to the query:
6oz5A Escherichia coli tRNA synthetase in complex with compound 3 (see paper)
26% identity, 31% coverage: 181:348/539 of query aligns to 76:229/241 of 6oz5A
>WP_011033329.1 NCBI__GCF_000007065.1:WP_011033329.1
MKFDPEKIKKDAKENFDHAWNEGKKMVKTPTLNERYPRTTLRYGKAHPVYDTIQKLREAY
MRMGFEEMMNPLIVDEKEVHKQFGSEALAVLDRCFYLAGLPRPNVGISDERIAQITEILG
DIGEEGIDKIRKELHAYKKGKIEGDDLVPEISAALEVSDALVADMIDRVFPEFKELIPQA
STKTLRSHMTSGWFISLGALLEREEPPFQFFSIDRCFRREQQEDASRLMTYYSASCVIMD
EDVTVDHGKAVSEGLLSQFGFEKFLFRPDEKRSKYYVPDTQTEVFAFHPKLVGSNSKYSD
GWIEVATFGIYSPTALAEYDIPYPVMNLGLGVERLAMILHDAPDVRSLTYPQIPQYSEWE
MSDSGLAKQVFVDRMPETPEGQEIASAVVAQCELHGEEPSPCEFPAWEGEVCGRKVKVSV
IEPEENTKLCGPAAFNEVVAYQGDILGIPNNKKWQKAFENHSARAGIRFIEAFAAQAARE
IEEAAMSGADEHIVRIRIVKVPSEVNLKIGATAQRYITGKNKKIDIRGPVFTSVKAEFE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory