SitesBLAST
Comparing WP_011033509.1 NCBI__GCF_000007065.1:WP_011033509.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3d31A Modbc from methanosarcina acetivorans (see paper)
33% identity, 99% coverage: 3:353/353 of query aligns to 1:347/348 of 3d31A
2d62A Crystal structure of multiple sugar binding transport atp- binding protein
34% identity, 100% coverage: 1:353/353 of query aligns to 4:366/375 of 2d62A
1g291 Malk (see paper)
30% identity, 100% coverage: 1:353/353 of query aligns to 1:363/372 of 1g291
- binding magnesium ion: D69 (≠ N68), E71 (≠ S70), K72 (≠ N71), K79 (≠ R78), D80 (vs. gap), E292 (≠ D280), D293 (≠ E281), K359 (≠ A349)
- binding pyrophosphate 2-: S38 (≠ T38), G39 (= G39), C40 (≠ S40), G41 (= G41), K42 (= K42), T43 (= T43), T44 (≠ V44)
1vciA Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
32% identity, 99% coverage: 4:353/353 of query aligns to 7:344/353 of 1vciA
P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12) (see paper)
35% identity, 63% coverage: 13:236/353 of query aligns to 20:252/257 of P0AAH0
- G48 (= G41) mutation to I: Loss of phosphate transport.
- K49 (= K42) mutation to Q: Loss of phosphate transport.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
36% identity, 67% coverage: 1:237/353 of query aligns to 1:235/369 of P19566
- L86 (= L89) mutation to F: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- P160 (= P162) mutation to L: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- D165 (= D167) mutation to N: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
Sites not aligning to the query:
- 306 E→K: Loss of transport. No effect on ATP-binding and ATP hydrolysis. Retains repressor activity.
P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 5 papers)
36% identity, 67% coverage: 1:237/353 of query aligns to 1:235/371 of P68187
- A85 (≠ P88) mutation to M: Suppressor of EAA loop mutations in MalFG.
- K106 (≠ R108) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V114 (≠ I116) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V117 (≠ L119) mutation to M: Suppressor of EAA loop mutations in MalFG.
- E119 (= E121) mutation to K: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- A124 (≠ P126) mutation to T: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- G137 (= G139) mutation to A: Loss of maltose transport. Has greater ability to decrease mal gene expression than wild-type MalK.
- D158 (= D160) mutation to N: Loss of maltose transport but retains ability to repress mal genes.
- R228 (= R230) mutation to C: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
Sites not aligning to the query:
- 241 F→I: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 267 W→G: Normal maltose transport but constitutive mal gene expression.
- 278 G→P: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 282 S→L: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 284 G→S: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 302 G→D: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 308 E→Q: Maltose transport is affected but retains ability to interact with MalT.
- 322 S→F: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 340 G→A: Maltose transport is affected but retains ability to interact with MalT.
- 346 G→S: Normal maltose transport but constitutive mal gene expression.
- 355 F→Y: Maltose transport is affected but retains ability to interact with MalT.
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state (see paper)
36% identity, 66% coverage: 4:237/353 of query aligns to 3:234/371 of 3puyA
- binding phosphoaminophosphonic acid-adenylate ester: W12 (≠ Y13), S37 (≠ T38), G38 (= G39), C39 (≠ S40), G40 (= G41), K41 (= K42), S42 (≠ T43), T43 (≠ V44), Q81 (= Q86), R128 (= R131), A132 (≠ K135), S134 (= S137), G136 (= G139), Q137 (≠ E140), E158 (= E161), H191 (= H194)
- binding magnesium ion: S42 (≠ T43), Q81 (= Q86)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3 (see paper)
36% identity, 66% coverage: 4:237/353 of query aligns to 3:234/371 of 3puxA
- binding adenosine-5'-diphosphate: W12 (≠ Y13), G38 (= G39), C39 (≠ S40), G40 (= G41), K41 (= K42), S42 (≠ T43), T43 (≠ V44), R128 (= R131), S134 (= S137), Q137 (≠ E140)
- binding beryllium trifluoride ion: S37 (≠ T38), G38 (= G39), K41 (= K42), Q81 (= Q86), S134 (= S137), G136 (= G139), H191 (= H194)
- binding magnesium ion: S42 (≠ T43), Q81 (= Q86)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4 (see paper)
36% identity, 66% coverage: 4:237/353 of query aligns to 3:234/371 of 3puwA
- binding adenosine-5'-diphosphate: W12 (≠ Y13), V17 (= V18), G38 (= G39), C39 (≠ S40), G40 (= G41), K41 (= K42), S42 (≠ T43), T43 (≠ V44), R128 (= R131), A132 (≠ K135), S134 (= S137), Q137 (≠ E140)
- binding tetrafluoroaluminate ion: S37 (≠ T38), G38 (= G39), K41 (= K42), Q81 (= Q86), S134 (= S137), G135 (= G138), G136 (= G139), E158 (= E161), H191 (= H194)
- binding magnesium ion: S42 (≠ T43), Q81 (= Q86)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4 (see paper)
36% identity, 66% coverage: 4:237/353 of query aligns to 3:234/371 of 3puvA
- binding adenosine-5'-diphosphate: W12 (≠ Y13), V17 (= V18), G38 (= G39), C39 (≠ S40), G40 (= G41), K41 (= K42), S42 (≠ T43), T43 (≠ V44), R128 (= R131), A132 (≠ K135), S134 (= S137), Q137 (≠ E140)
- binding magnesium ion: S42 (≠ T43), Q81 (= Q86)
2awnB Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
36% identity, 66% coverage: 4:237/353 of query aligns to 3:234/374 of 2awnB
1q12A Crystal structure of the atp-bound e. Coli malk (see paper)
36% identity, 66% coverage: 4:237/353 of query aligns to 1:232/367 of 1q12A
- binding adenosine-5'-triphosphate: W10 (≠ Y13), S35 (≠ T38), G36 (= G39), C37 (≠ S40), G38 (= G41), K39 (= K42), S40 (≠ T43), T41 (≠ V44), R126 (= R131), A130 (≠ K135), S132 (= S137), G134 (= G139), Q135 (≠ E140)
4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
35% identity, 65% coverage: 8:236/353 of query aligns to 6:236/240 of 4ymuJ
- binding adenosine-5'-triphosphate: F11 (≠ Y13), V16 (= V18), S36 (≠ T38), G37 (= G39), S38 (= S40), G39 (= G41), K40 (= K42), S41 (≠ T43), T42 (≠ V44), E162 (= E161), H194 (= H194)
- binding magnesium ion: S41 (≠ T43), E162 (= E161)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 96% coverage: 14:353/353 of query aligns to 16:350/353 of 1oxvD
Sites not aligning to the query:
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 96% coverage: 14:353/353 of query aligns to 16:350/353 of 1oxvA
Sites not aligning to the query:
1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 96% coverage: 14:353/353 of query aligns to 16:350/353 of 1oxuA
Sites not aligning to the query:
Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
29% identity, 96% coverage: 14:353/353 of query aligns to 16:350/353 of Q97UY8
- S142 (= S137) mutation to A: Decrease in ATPase activity. Can form dimers.
- G144 (= G139) mutation to A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
- E166 (= E161) mutation to A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144.; mutation to Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+).
P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
32% identity, 80% coverage: 3:284/353 of query aligns to 17:301/378 of P69874
- C26 (≠ N12) mutation to A: Lower ATPase activity and transport efficiency.
- F27 (≠ Y13) mutation to L: Lower ATPase activity and transport efficiency.
- F45 (≠ S31) mutation to L: Lower ATPase activity and transport efficiency.
- C54 (≠ S40) mutation to T: Loss of ATPase activity and transport.
- L60 (= L46) mutation to F: Lower ATPase activity and transport efficiency.
- L76 (≠ F62) mutation to P: Lower ATPase activity and transport efficiency.
- V135 (≠ I123) mutation to M: Loss of ATPase activity and transport.
- D172 (= D160) mutation to N: Loss of ATPase activity and transport.
- C276 (≠ I261) mutation to A: Lower ATPase activity and transport efficiency.
- E297 (≠ D280) mutation E->K,D: Lower ATPase activity and transport efficiency.; mutation to Q: Loss of ATPase activity and transport.
6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
31% identity, 67% coverage: 2:236/353 of query aligns to 1:242/344 of 6cvlD
- binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y13), Q14 (≠ K15), I19 (≠ L16), S41 (≠ T38), G42 (= G39), A43 (≠ S40), G44 (= G41), K45 (= K42), S46 (≠ T43), T47 (≠ V44), N141 (≠ K135), S143 (= S137), Q146 (≠ E140), H200 (= H194)
Query Sequence
>WP_011033509.1 NCBI__GCF_000007065.1:WP_011033509.1
MHIVELEEIYKNYGKLEVLKNINLQIEKGTSTALVGPTGSGKTVMLRLIDLLEKPSSGTV
YFEGADANESNNTRLEVRRQIGMVFQKPLAFKASVYDNIAYGLKIRGRKENMDGRIKELL
EMIGLPGYENRNALKLSGGETQRLALARAMITEPRLLLLDEPTANLDPISKKKLEELILK
INRESETTIIMTTHDLLQGQRLAENMVILYNGQILQSGTPDQIFRKPKNRFVADFVGIQN
LMSGIIEDSSNGLAAIKTDSITVFAVTEKEGKVHFAIRPDEITISREKVQTSARNTIQGK
VDEIIDTGSLIKLTVNTGELFTVFITRESLNELNISIGTSIWLYFKASAVHVF
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory