SitesBLAST

P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
22% identity, 98% coverage: 3:364/370 of query aligns to 12:371/376 of P9WQ73

query
sites
P9WQ73

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T154 (= T143) binding pyridoxal 5'-phosphate
D176 (= D166) binding pyridoxal 5'-phosphate
Q199 (= Q189) binding pyridoxal 5'-phosphate

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

1bt4A Phosphoserine aminotransferase from bacillus circulans subsp. Alkalophilus
22% identity, 95% coverage: 12:363/370 of query aligns to 7:354/361 of 1bt4A

query
sites
1bt4A

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active site: W102 (= W101), D172 (= D166), K196 (= K190)
binding pyridoxal-5'-phosphate: A76 (≠ D72), S77 (≠ T73), W102 (= W101), D172 (= D166), S174 (≠ T168), Q195 (= Q189), K196 (= K190)

Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human) (see 6 papers)
24% identity, 45% coverage: 36:202/370 of query aligns to 43:212/370 of Q9Y617

query
sites
Q9Y617

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S43 (= S36) to R: in PSATD; reduced O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; 3-fold increase of KM for 3-phosphohydroxypyruvate; 5-fold increase of KM for L-glutamate; decreased function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization; does not affect thermal stability
H44 (= H37) binding in other chain
R45 (= R38) binding in other chain
Y70 (= Y63) to N: in NLS2; uncertain significance
G79 (≠ D72) binding pyridoxal 5'-phosphate; to W: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway
C80 (≠ T73) binding pyridoxal 5'-phosphate
P87 (≠ L80) to A: has no effect on O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; does not affect KM for 3-phosphohydroxypyruvate; does not affect KM for L-glutamate; no effect on function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization; does not affect thermal stability; dbSNP:rs11540974
A99 (≠ V89) to V: in NLS2; does not affect secondary structure; does not affect dimerization; increased thermal stability; dbSNP:rs587777778
D100 (= D90) to A: in PSATD; has no effect on O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; does not affect KM for 3-phosphohydroxypyruvate; does not affect KM for L-glutamate; does not affect secondary structure; results in increased protein aggregation as shown by dynamic light scattering; dbSNP:rs118203967
W107 (≠ F97) binding pyridoxal 5'-phosphate
E155 (≠ G142) to Q: in NLS2; uncertain significance
T156 (= T143) binding pyridoxal 5'-phosphate
D176 (= D166) binding pyridoxal 5'-phosphate
S179 (= S169) to L: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; dbSNP:rs587777777
Q199 (= Q189) binding pyridoxal 5'-phosphate
K200 (= K190) modified: N6-(pyridoxal phosphate)lysine

Sites not aligning to the query:

241 binding in other chain
242 binding in other chain
245 C → R: in NLS2; reduced O-phospho-L-serine:2-oxoglutarate aminotransferase catalytic efficiency; 9-fold increase of KM for L-glutamate; does not affect KM for 3-phosphohydroxypyruvate; decreased function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; does not affect secondary structure; does not affect dimerization
335 binding O-phospho-L-serine
336 binding O-phospho-L-serine
342 binding O-phospho-L-serine; R → W: in NLS2; loss of O-phospho-L-serine:2-oxoglutarate aminotransferase activity; loss of function in L-serine biosynthesis shown through in vitro reconstruction of the phosphorylated pathway; dbSNP:rs202103028

8a5wC Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
24% identity, 45% coverage: 36:202/370 of query aligns to 38:207/365 of 8a5wC

query
sites
8a5wC

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Sites not aligning to the query:

8a5wA Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
24% identity, 45% coverage: 36:202/370 of query aligns to 38:207/365 of 8a5wA

query
sites
8a5wA

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M

L

L

L

G

A

L

V

P

P

S

D

D

N

Y

Y

L

K

V

V

G

I

I

F

V

L

P

Q

A

G

S
x
G

D
x
G

T
x
C

G

G

A

Q

F

F

E

S

M

A

C

V

L

P

W

L

S

N

M

L

L

I

G

G

C

L

-

K

-

A

-

G

R

R

G

C

V

A

D

D

V

Y

L

V

V

V

W

T

E

G

S

A

F
x
W

S

S

K

A

E

K

W

A

A

A

T

E

D

E

I

A

T

K

K

K

Q

F

L

G

K

T

L

I

K

N

D

I

T

V

R

H

V

P

F

K

E

L

A

G

E

S

Y

Y

G

T

K

K

L

I

P

P

D

D

L

P

E

S

N

T

V

W

D

N

F

L

K

N

N

P

D

D

V

A

V

S

F

Y

V

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

P

P

D

D

S

V

R

K

E

G

G

A

L

V

T

L

L

V

C

C

D
|
D

A

M

T
x
S

S

S

A

N

V

F

F

L

A

S

M

K

D

P

I

V

P

D

Y

V

H

S

K

K

L

F

D

G

V

V

L

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

V

G

G

G

S

E

A

G

G

A

V

H

T

G

V

M

V

L

I

I

V

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G73 (≠ S71), G74 (≠ D72), C75 (≠ T73), W102 (≠ F97), T151 (= T143), D171 (= D166), S173 (≠ T168), Q194 (= Q189), K195 (= K190)
binding phosphoserine: H39 (= H37), R40 (= R38)

Sites not aligning to the query:

binding phosphoserine: 330, 337

8a5vA Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
24% identity, 45% coverage: 36:202/370 of query aligns to 38:207/365 of 8a5vA

query
sites
8a5vA

S

S

H

H

R

R

S

S

K

S

P

D

G

F

K

A

E

K

K

I

L

I

A

N

E

N

A

T

I

E

K

N

R

L

T

V

R

R

D

E

M

L

L

L

G

A

L

V

P

P

S

D

D

N

Y

Y

L

K

V

V

G

I

I

F

V

L

P

Q

A

G

S

G

D

G

T

C

G

G

A

Q

F

F

E

S

M

A

C

V

L

P

W

L

S

N

M

L

L

I

G

G

C

L

-

K

-

A

-

G

R

R

G

C

V

A

D

D

V

Y

L

V

V

V

W

T

E

G

S

A

F

W

S

S

K

A

E

K

W

A

A

A

T

E

D

E

I

A

T

K

K

K

Q

F

L

G

K

T

L

I

K

N

D

I

T

V

R

H

V

P

F

K

E

L

A

G

E

S

Y

Y

G

T

K

K

L

I

P

P

D

D

L

P

E

S

N

T

V

W

D

N

F

L

K

N

N

P

D

D

V

A

V

S

F

Y

V

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T

T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

P

P

D

D

S

V

R

K

E

G

G

A

L

V

T

L

L

V

C

C

D

D

A

M

T

S

S

S

A

N

V

F

F

L

A

S

M

K

D

P

I

V

P

D

Y

V

H

S

K

K

L

F

D

G

V

V

L

I

T

F

F

A

S

G

W

A

Q

Q

K

K

V

N

L

V

G

G

G

S

E

A

G

G

A

V

H

T

G

V

M

V

L

I

I

V

Sites not aligning to the query:

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: 236, 237

8a5vE Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
24% identity, 45% coverage: 36:202/370 of query aligns to 39:208/366 of 8a5vE

query
sites
8a5vE

S

S

H

H

R

R

S

S

K

S

P

D

G

F

K

A

E

K

K

I

L

I

A

N

E

N

A

T

I

E

K

N

R

L

T

V

R

R

D

E

M

L

L

L

G

A

L

V

P

P

S

D

D

N

Y

Y

L

K

V

V

G

I

I

F

V

L

P

Q

A

G

S

G

D

G

T

C

G

G

A

Q

F

F

E

S

M

A

C

V

L

P

W

L

S

N

M

L

L

I

G

G

C

L

-

K

-

A

-

G

R

R

G

C

V

A

D

D

V

Y

L

V

V

V

W

T

E

G

S

A

F
x
W

S

S

K

A

E

K

W

A

A

A

T

E

D

E

I

A

T

K

K

K

Q

F

L

G

K

T

L

I

K

N

D

I

T

V

R

H

V

P

F

K

E

L

A

G

E

S

Y

Y

G

T

K

K

L

I

P

P

D

D

L

P

E

S

N

T

V

W

D

N

F

L

K

N

N

P

D

D

V

A

V

S

F

Y

V

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T

T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

P

P

D

D

S

V

R

K

E

G

G

A

L

V

T

L

L

V

C

C

D

D

A

M

T

S

S

S

A

N

V

F

F

L

A

S

M

K

D

P

I

V

P

D

Y

V

H

S

K

K

L

F

D

G

V

V

L

I

T

F

F

A

S

G

W

A

Q

Q

K

K

V

N

L

V

G

G

G

S

E

A

G

G

A

V

H

T

G

V

M

V

L

I

I

V

binding sulfate ion: W103 (≠ F97)

Sites not aligning to the query:

binding sulfate ion: 332

3e77A Human phosphoserine aminotransferase in complex with plp
24% identity, 45% coverage: 36:202/370 of query aligns to 36:205/363 of 3e77A

query
sites
3e77A

S

S

H

H

R

R

S

S

K

S

P

D

G

F

K

A

E

K

K

I

L

I

A

N

E

N

A

T

I

E

K

N

R

L

T

V

R

R

D

E

M

L

L

L

G

A

L

V

P

P

S

D

D

N

Y

Y

L

K

V

V

G

I

I

F

V

L

P

Q

A

G

S
x
G

D
x
G

T
x
C

G

G

A

Q

F

F

E

S

M

A

C

V

L

P

W

L

S

N

M

L

L

I

G

G

C

L

-

K

-

A

-

G

R

R

G

C

V

A

D

D

V

Y

L

V

V

V

W

T

E

G

S

A

F
x
W

S

S

K

A

E

K

W

A

A

A

T

E

D

E

I

A

T

K

K

K

Q

F

L

G

K

T

L

I

K

N

D

I

T

V

R

H

V

P

F

K

E

L

A

G

E

S

Y

Y

G

T

K

K

L

I

P

P

D

D

L

P

E

S

N

T

V

W

D

N

F

L

K

N

N

P

D

D

V

A

V

S

F

Y

V

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

P

P

D

D

S

V

R

K

E

G

G

A

L

V

T

L

L

V

C

C

D
|
D

A

M

T
x
S

S

S

A

N

V

F

F

L

A

S

M

K

D

P

I

V

P

D

Y

V

H

S

K

K

L

F

D

G

V

V

L

I

T

F

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

V

G

G

G

S

E

A

G

G

A

V

H

T

G

V

M

V

L

I

I

V

active site: W100 (≠ F97), D169 (= D166), K193 (= K190)
binding pyridoxal-5'-phosphate: G71 (≠ S71), G72 (≠ D72), C73 (≠ T73), W100 (≠ F97), T149 (= T143), D169 (= D166), S171 (≠ T168), Q192 (= Q189), K193 (= K190)

Sites not aligning to the query:

binding pyridoxal-5'-phosphate: 234, 235

8a5wE Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
24% identity, 46% coverage: 36:206/370 of query aligns to 39:208/365 of 8a5wE

query
sites
8a5wE

S

S

H
|
H

R
|
R

S

S

K

S

P

D

G

F

K

A

E

K

K

I

L

I

A

N

E

N

A

T

I

E

K

N

R

L

T

V

R

R

D

E

M

L

L

L

G

A

L

V

P

P

S

D

D

N

Y

Y

L

K

V

V

G

I

I

F

V

L

P

Q

A

G

S
x
G

D
x
G

T
x
C

G

G

A

Q

F

F

E

S

M

A

C

V

L

P

W

L

S

N

M

L

L

I

G

G

C

L

-

K

-

A

-

G

R

R

G

C

V

A

D

D

V

Y

L

V

V

V

W

T

E

G

S

A

F
x
W

S

S

K

A

E

K

W

A

A

A

T

E

D

E

I

A

T

K

K

K

Q

F

L

G

K

T

L

I

K

N

D

I

T

V

R

H

V

P

F

K

E

L

A

G

E

S

Y

Y

G

T

K

K

L

I

P

P

D

D

L

P

E

S

N

T

V

W

D

N

F

L

K

N

N

P

D

D

V

A

V

S

F

Y

V

V

W

Y

-

Y

-

C

-

A

N

N

G

E

T
|
T

T

V

S

H

G

G

V

V

K

E

V

F

P

-

N

-

G

-

D

D

W

F

I

I

P

P

D

D

S

V

R

K

E

G

G

A

L

V

T

L

L

V

C

C

D

D

A

M

T
x
S

S

S

A

N

V

F

F

L

A

S

M

K

D

P

I

V

P

D

Y

V

H

S

K

K

L

F

D

G

V

V

L

I

T

F

F

A

S

G

W
x
A

Q
|
Q

K
x
N

V

V

L

-

G

-

E

-

G

G

A

S

H

A

G

G

M

V

L

T

I

V

L

V

S

I

P

V

R

R

binding (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid: H40 (= H37), R41 (= R38)
binding (2~{S})-2-[[(~{R})-[[(5~{S})-5-azanyl-6-oxidanylidene-hexyl]amino]-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]-3-phosphonooxy-propanoic acid: G74 (≠ S71), G75 (≠ D72), C76 (≠ T73), W103 (≠ F97), T152 (= T143), S174 (≠ T168), A194 (≠ W188), Q195 (= Q189), N196 (≠ K190)

Sites not aligning to the query:

1w23B Crystal structure of phosphoserine aminotransferase from bacillus alcalophilus (see paper)
20% identity, 83% coverage: 12:318/370 of query aligns to 7:307/357 of 1w23B

query
sites
1w23B

F

F

S

N

S

A

G

G

P

P

C

S

A

A

K

L

H

-

P

P

G

K

Y

P

S

A

I

L

E

E

-

R

-

A

-

Q

-

K

-

E

-

L

D

N

L

F

N

N

D

D

A

T

P

Q

F

M

G

S

-

V

-

M

-

E

R

L

S

S

H

H

R

R

S

S

K

Q

P

S

G

Y

K

E

E

E

K

V

L

H

A

E

E

Q

A

A

I

Q

K

N

R

L

T

L

R

R

D

E

M

L

L

L

G

Q

L

I

P

P

S

N

D

D

Y

Y

L

Q

V

I

G

L

I

F

V

L

P

Q

A

G

S

G

D
x
A

T
x
S

G

L

A

Q

F

F

E

T

M

M

C

L

L

P

W

M

S

N

M

L

L

L

-

T

-

K

G

G

C

T

R

I

G

G

V

N

D

Y

V

V

L

L

V

-

W

-

E

-

S

-

F

-

S

T

K

G

E

S

W
|
W

A

S

T

E

D

K

I

A

T

L

K

K

Q

E

L

A

K

K

-

L

L

L

K

G

D

E

T

T

R

H

V

I

F

A

E

A

A

S

-

T

-

K

-

A

-

N

E

S

Y
|
Y

G

Q

K

S

L

I

P

P

D

D

L

F

E

S

N

E

V

F

D

Q

F

L

K

N

N

E

D

N

V

D

V

A

F

Y

V

L

W

H

-

I

-

T

-

S

N

N

G

N

T
|
T

T

I

S
x
Y

G

G

V

T

K

Q

V

Y

P

Q

N

N

G

-

D

-

W

-

I

F

P

P

D

E

S

I

R

N

E

H

G

A

L

P

T

L

L

I

C

A

D
|
D

A

M

T
x
S

S

S

A

D

V

I

F

L

A

S

M

R

D

P

I

L

P

K

Y

V

H

N

K

Q

L

F

D

G

V

M

L

I

T

Y

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

L

G

G

G

P

E

S

G

G

A

V

H

T

G

V

M

V

L

I

I

V

L

K

S

K

P

D

R

L

A

L

V

V

Q

E

R

Q

L

-

E

-

S

-

Y

-

T

-

P

-

A

-

W

-

P

-

L

V

P

P

K

T

I

M

F

L

R

Q

L

Y

T

A

K

-

G

-

K

-

L

-

N

-

K

T

E

H

I

I

F

K

E

S

G

D

S

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

M

T

L

F

A

S

N

I

E

Y

D

M

W

L

L

R

A

N

T

V

L

L

K

D

W

W

A

I

E

K

S

D

V

L

G

G

L

A

K

E

Q

A

L

I

I

A

Q

K

R

Q

T

N

N

E

E

E

N

K

L

A

A

K

V

I

F

I

E

Y

A

D

F

T

V

I

A

D

K

E

N

S

N

N

W

G

I

F

H

Y

F

V

L

G

A
x
H

E
x
A

T

E

K

K

E

G

I

S

R

R

S

S

S

L

T

M

S

N

V

V

C

T

F

F

K

-

V

-

D

N

L

L

S

R

E

N

E

E

K

E

L

L

K

N

E

Q

active site: W102 (= W101), D172 (= D166), K196 (= K190)
binding magnesium ion: Y127 (= Y121), Y154 (≠ S145), H285 (≠ A294), A286 (≠ E295)
binding pyridoxal-5'-phosphate: A76 (≠ D72), S77 (≠ T73), W102 (= W101), T152 (= T143), D172 (= D166), S174 (≠ T168), Q195 (= Q189), K196 (= K190), N234 (= N243), T235 (= T244)

4azjA Structural basis of l-phosphoserine binding to bacillus alcalophilus phosphoserine aminotransferase (see paper)
20% identity, 83% coverage: 12:318/370 of query aligns to 7:310/360 of 4azjA

query
sites
4azjA

F

F

S

N

S

A

G

G

P

P

C

S

A

A

K

L

H

-

P

P

G

K

Y

P

S

A

I

L

E

E

-

R

-

A

-

Q

-

K

-

E

-

L

D

N

L

F

N

N

D

D

A

T

P

Q

F

M

G

S

-

V

-

M

-

E

R

L

S

S

H
|
H

R
|
R

S

S

K

Q

P

S

G

Y

K

E

E

E

K

V

L

H

A

E

E

Q

A

A

I

Q

K

N

R

L

T

L

R

R

D

E

M

L

L

L

G

Q

L

I

P

P

S

N

D

D

Y

Y

L

Q

V

I

G

L

I

F

V

L

P

Q

A

G

S

G

D
x
A

T
x
S

G

L

A

Q

F

F

E

T

M

M

C

L

L

P

W

M

S

N

M

L

L

L

-

T

-

K

G

G

C

T

R

I

G

G

V

N

D

Y

V

V

L

L

V

-

W

-

E

-

S

-

F

-

S

T

K

G

E

S

W
|
W

A

S

T

E

D

K

I

A

T

L

K

K

Q

E

L

A

K

K

-

L

L

L

K

G

D

E

T

T

R

H

V

I

F

A

E

A

A

S

-

T

-

K

-

A

-

N

E

S

Y

Y

G

Q

K

S

L

I

P

P

D

D

L

F

E

S

N

E

V

F

D

Q

F

L

K

N

N

E

D

N

V

D

V

A

F

Y

V

L

W

H

-

I

-

T

-

S

N

N

G

N

T
|
T

T

I

S

Y

G

G

V

T

K

Q

V

Y

P

Q

N

N

G

-

D

-

W

-

I

F

P

P

D

E

S

I

R

N

E

H

G

A

L

P

T

L

L

I

C

A

D
|
D

A

M

T
x
S

S

S

A

D

V

I

F

L

A

S

M

R

D

P

I

L

P

K

Y

V

H

N

K

Q

L

F

D

G

V

M

L

I

T

Y

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

L

G

G

G

P

E

S

G

G

A

V

H

T

G

V

M

V

L

I

I

V

L

K

S

K

P

D

R

L

A

L

V

N

Q

T

R

K

L

V

E

E

S

Q

Y

-

T

-

P

-

A

-

W

-

P

-

L

V

P

P

K

T

I

M

F

L

R

Q

L

Y

T

A

K

-

G

-

K

-

L

-

N

-

K

T

E

H

I

I

F

K

E

S

G

D

S

S

T

L

I

Y

N
|
N

T
|
T

P

P

S

P

M

T

L

F

A

S

N

I

E

Y

D

M

W

L

L

R

A

N

T

V

L

L

K

D

W

W

A

I

E

K

S

D

V

L

G

G

L

A

K

E

Q

A

L

I

I

A

Q

K

R

Q

T

N

N

E

E

E

N

K

L

A

A

K

V

I

F

I

E

Y

A

D

F

T

V

I

A

D

K

E

N

S

N

N

W

G

I

F

H

Y

F

V

L

G

A

H

E

A

T

E

K

K

E

G

I

S

R

R

S

S

S

L

T

M

S

N

V

V

C

T

F

F

K

-

V

-

D

N

L

L

S

R

E

N

E

E

K

E

L

L

K

N

E

Q

active site: W102 (= W101), D172 (= D166), K196 (= K190)
binding pyridoxal-5'-phosphate: A76 (≠ D72), S77 (≠ T73), W102 (= W101), T152 (= T143), D172 (= D166), S174 (≠ T168), Q195 (= Q189), K196 (= K190), N237 (= N243), T238 (= T244)
binding phosphoserine: H41 (= H37), R42 (= R38), W102 (= W101), T152 (= T143), K196 (= K190)

Sites not aligning to the query:

binding phosphoserine: 327, 328, 334

5yb0B Crystal structure of wild type phosphoserine aminotransferase (psat) from e. Histolytica (see paper)
22% identity, 88% coverage: 36:361/370 of query aligns to 36:347/349 of 5yb0B

query
sites
5yb0B

S

S

H

H

R

R

S

S

K

K

P

E

G

W

K

I

E

N

K

V

L

M

A

N

E

E

A

T

I

K

K

A

R

L

T

M

R

K

D

E

M

V

L

M

G

D

L

I

P

P

S

E

D

G

Y

Y

L

E

V

I

G

L

I

F

V

F

P

G

A

G

S

G

D
x
A

T
x
S

G

L

A

Q

F

F

E

L

M

M

C

V

L

A

W

M

S

N

M

L

L

L

G

N

C

K

R

K

G

A

-

C

-

Y

V

L

D

D

V

T

L

G

V

V

W
|
W

E

A

S

S

F

K

S

A

K

I

E

K

W

E

A

A

T

E

D

N

I

I

T

G

K

-

Q

E

L

V

K

K

L

I

K

I

D

G

T

T

R

S

V

K

F

-

E

D

A

K

E

N

Y

Y

G

T

K

Y

L

I

P

P

D

E

L

Y

E

Q

N

I

V

P

D

S

F

D

K

Y

N

D

D

Y

V

F

V

H

F

I

V

T

W

T

N

N

G

N

T
|
T

T

I

S

Y

G

G

V

T

K

E

V

I

P

R

N

K

G

D

D

I

W

E

I

S

P

P

D

I

S

P

R

-

E

-

G

-

L

-

T

L

L

V

C

A

D
|
D

A

M

T
x
S

S

S

A

D

V

I

F

L

A

S

M

K

D

P

I

I

P

D

Y

I

H

S

K

K

L

Y

D

S

V

L

L

I

T

Y

F

A

S

G

W

A

Q
|
Q

K
|
K

V

N

L

C

G

G

G

A

E

A

G

G

A

V

H

-

G

T

M

I

L

V

I

I

L

I

S

K

P

K

R

E

A

I

V

L

Q

G

R

K

L

V

E

Q

S

R

Y

K

T

I

P

P

A

I

W

I

P

L

L

D

P

Y

K

Q

I

V

F

-

R

-

L

-

T

-

K

-

G

-

K

-

L

-

N

-

K

-

E

H

I

I

F

L

E

N

G

N

S

S

T

M

I

Y

N
|
N

T
|
T

P

P

S

P

M

V

L

I

A

S

N

I

E

F

D

T

W

V

L

N

A

Q

T

T

L

L

K

K

W

Y

A

I

E

K

S

K

V

I

G

G

L

L

K

K

Q

K

L

I

I

Q

Q

E

R

L

T

N

N

E

E

E

N

K

L

A

A

R

V

L

F

L

E

Y

A

A

F

E

V

I

A

D

K

R

N

N

N

K

W

I

I

F

H

R

F

G

L

T

A

V

E

R

T

K

K

K

E

D

I

-

R

R

S

S

S

I

T

M

S

N

V

V

C

C

F

F

K

-

V

-

D

-

L

V

S

M

E

E

K

Q

L

Y

K

K

E

Q

L

-

I

-

K

-

M

-

L

L

E

E

N

N

E

E

K

F

V

S

A

E

Y

Y

-

A

-

L

-

Q

-

K

-

G

-

I

D

G

I

I

G

K

S

G

Y

H

R

R

D

S

A

V

P

-

S

G

G

G

L

F

R

R

-

A

-

S

I

I

W

Y

C

N

G

A

A

V

T

T

I

I

E

E

K

S

E

V

D

Q

-

A

-

L

L

I

E

K

C

C

L

M

C

H

E

D

W

F

binding pyridoxal-5'-phosphate: A72 (≠ D72), S73 (≠ T73), W96 (= W94), T143 (= T143), D162 (= D166), S164 (≠ T168), Q185 (= Q189), K186 (= K190), N227 (= N243), T228 (= T244)

Query Sequence

>WP_011034813.1 NCBI__GCF_000007065.1:WP_011034813.1
MKPTRVPKNPCFSSGPCAKHPGYSIEDLNDAPFGRSHRSKPGKEKLAEAIKRTRDMLGLP
SDYLVGIVPASDTGAFEMCLWSMLGCRGVDVLVWESFSKEWATDITKQLKLKDTRVFEAE
YGKLPDLENVDFKNDVVFVWNGTTSGVKVPNGDWIPDSREGLTLCDATSAVFAMDIPYHK
LDVLTFSWQKVLGGEGAHGMLILSPRAVQRLESYTPAWPLPKIFRLTKGGKLNKEIFEGS
TINTPSMLANEDWLATLKWAESVGGLKQLIQRTNENLAVFEAFVAKNNWIHFLAETKEIR
SSTSVCFKVDLSEEKLKELIKMLENEKVAYDIGSYRDAPSGLRIWCGATIEKEDLECLCE
WIEWAYDLVK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory