SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011187683.1 NCBI__GCF_000025945.1:WP_011187683.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
45% identity, 96% coverage: 14:394/397 of query aligns to 4:376/376 of O66442

query
sites
O66442

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GT 96:97 (≠ GA 105:106) binding pyridoxal 5'-phosphate
K242 (= K248) modified: N6-(pyridoxal phosphate)lysine
T271 (= T277) binding pyridoxal 5'-phosphate

2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
45% identity, 96% coverage: 14:394/397 of query aligns to 3:375/375 of 2eh6A

query
sites
2eh6A

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active site: F127 (= F134), E179 (= E186), D212 (= D219), Q215 (= Q222), K241 (= K248), T270 (= T277), R352 (= R371)
binding pyridoxal-5'-phosphate: G95 (= G105), T96 (≠ A106), F127 (= F134), H128 (= H135), E179 (= E186), D212 (= D219), V214 (= V221), K241 (= K248)

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
44% identity, 96% coverage: 14:395/397 of query aligns to 11:391/393 of 2ordA

query
sites
2ordA

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active site: F134 (= F134), E186 (= E186), D219 (= D219), Q222 (= Q222), K248 (= K248), T276 (= T277), R367 (= R371)
binding pyridoxal-5'-phosphate: G102 (= G105), T103 (≠ A106), F134 (= F134), H135 (= H135), E186 (= E186), D219 (= D219), V221 (= V221), Q222 (= Q222), K248 (= K248)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
44% identity, 96% coverage: 14:395/397 of query aligns to 3:383/385 of Q9X2A5

query
sites
Q9X2A5

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A

A

E

E

L

L

L

L

V

S

E

K

N

N

S

T

F

F

G

G

D

G

K

K

V

V

F

F

F

F

C

A

N

N

S

T

G
|
G

A
x
T

E

E

A

A

N

N

E

E

A

A

A

A

I

I

K

K

L

I

A

A

R

R

I

K

H

Y

A

G

P

K

A

K

G

K

K

S

N

E

-

K

-

K

-

Y

K

R

I

I

I

L

S

S

L

A

T

H

G

N

A

S

F

F

H

H

G

G

R

R

T

T

M

L

V

G

T

S

L

L

A

T

A

A

T

T

G

G

Q

Q

A

P

R

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F

Y

C

Q

A

K

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F

F

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E

P

P

I

L

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V

T

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G

G

F

F

A

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A

Y

A

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P

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F

A

N

D

N

L

V

D

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A

D

L

L

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A

R

M

K

I

M

D

S

D

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T

D

V

V

C

C

A

A

V

V

L

F

C

L

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E

P

P

L

I

Q

Q

G

G

E

E

G

S

G

G

V

I

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V

P

P

L

A

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T

R

K

E

E

Y

F

L

L

Q

E

G

E

I

A

R

R

D

K

I

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C

C

D

D

R

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H

Y

G

D

V

A

L

L

L

L

I

V

F

F

D

D

E

E

V

V

Q

Q

T

C

G

G

V

M

G

G

R

R

S

T

G

G

S

K

L

L

F

F

A

A

H

Y

Q

Q

V

K

F

Y

G

G

V

V

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V

P

P

D

D

I

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M

L

T

T

L

T

A

A

K

K

G

G

L

L

A

G

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G

G

G

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P

P

I

I

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G

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A

I

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I

I

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N

D

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A

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-

A

A

A

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V

L

L

V

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P

G

G

S

D

H

H

G

G

S

T

T
|
T

F

F

G

G

G

G

N

N

P

P

V

L

V

A

C

C

A

R

A

A

A

G

S

V

T

T

N

V

L

I

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K

V

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I

L

L

T

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D

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G

G

F

F

L

L

A

E

E

E

V

V

K

E

S

E

V

K

A

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N

H

Y

L

L

A

M

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K

S

K

L

L

G

Q

K

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L

M

V

K

K

E

E

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Y

P

D

A

V

I

V

F

-

T

A

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D

E

V

R

R

G

G

L

M

G

G

L

L

L

M

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I

G

G

L

I

V

Q

M

F

T

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E

E

E

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G

-

K

-

K

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S

S

G

N

S

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K

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I

V

V

A

M

T

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M

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L

F

E

E

K

N

G

K

F

L

L

L

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N

V

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A

A

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G

G

N

V

N

A

T

L

I

R

R

F

F

A

L

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P

P

P

L

L

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T

V

V

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Y

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D

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L

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A

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A

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A

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L

L

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K

V

V

L

L

S

Q

GT 94:95 (≠ GA 105:106) binding pyridoxal 5'-phosphate
T268 (= T277) binding pyridoxal 5'-phosphate

4adbB Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
43% identity, 98% coverage: 6:395/397 of query aligns to 4:400/401 of 4adbB

query
sites
4adbB

V

T

K

R

E

E

R

N

A

F

D

D

K

E

V

W

L

M

V

I

G

P

N

V

Y

Y

G

A

R

P

Y

A

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V

F

A

I

F

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V

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G

G

T

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G

G

C

S

V

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L

L

T

W

D

D

A

Q

N

Q

G

G

K

K

K

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Y

Y

V

I

D

D

F

F

L

A

A

G

G

G

I

I

A

A

V

V

C

N

S

A

L

L

G

G

H

H

C

A

H

H

P

P

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I

L

V

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N

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A

A

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L

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N

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Q

Q

S

A

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S

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K

L

F

I

W

H

H

V

T

S

G

N

N

L

G

Y

Y

Y

T

T

N

E

E

A

P

Q

V

T

L

R

R

L

L

A

A

E

K

L

K

L

L

V

I

E

D

N

A

S

T

F

F

G

A

D

D

K

R

V

V

F

F

F

F

C

C

N

N

S
|
S

G
|
G

A
|
A

E

E

A

A

N

N

E

E

A

A

A

A

I

L

K

K

L

L

A

A

R

R

-

K

-

F

I

A

H

H

A

D

P

R

A

Y

G

G

K

S

N

H

K

K

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S

-

G

I

I

I

V

S

A

L

F

T

K

G

N

A

A

F
|
F

H
|
H

G

G

R

R

T

T

M

L

V

F

T

T

L

V

A

S

A

A

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G

G

G

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Q

A

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R

A

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Y

C

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A

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G

D

F

F

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A

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P

I

L

P

P

T

A

G

D

F

I

A

R

A

H

A

A

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A

F

Y

A

N

D

D

L

I

D

N

A

S

L

A

E

S

A

A

M

L

I

I

D

D

D

D

T

S

V

T

C

C

A

A

V

V

L

I

C

V

E
|
E

P

P

L

I

Q

Q

G

G

E

E

G

G

G

G

V

V

R

V

P

P

L

A

G

S

R

N

E

A

Y

F

L

L

Q

Q

G

G

I

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R

R

D

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I

L

C

C

D

N

R

R

H

H

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N

V

A

L

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

V

V

G

G

R

R

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G

G

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L

L

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Y

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A

H

Y

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M

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Y

G

G

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V

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P

P

D

D

I

L

M

L

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T

L

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A

A

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|
K

G

A

L

L

A

G

S

G

G

G

M

F

P

P

I

V

G

G

A

A

I

L

I

L

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A

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A

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A

A

A

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L

M

V

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V

G

G

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H

H

G

G

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T
|
T

F

Y

G

G

G

G

N

N

P

P

V

L

V

A

C

S

A

A

A

V

A

A

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L

L

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I

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M

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L

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K

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L

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N

K

T

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-

A

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I

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F

F

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E

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R

G

G

L

L

G

G

L

L

L

L

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I

G

G

L

C

V

V

M

L

T

N

E

A

E

D

G

Y

K

A

K

G

S

Q

G

A

S

K

K

Q

I

I

V

S

M

Q

E

E

M

A

L

A

E

K

K

A

G

G

F

V

L

M

I

V

N

L

F

I

A

A

G

G

G

G

V

N

A

V

L

V

R
|
R

F

F

A

A

P

P

P

A

L

L

V

N

V

V

S

S

R

E

E

E

Q

E

C

V

-

T

-

T

-

G

-

L

D

D

S

R

L

F

A

A

A

A

A

A

L

C

R

E

E

H

V

F

L

V

S

S

active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T279 (= T277), R372 (= R371)
binding pyridoxal-5'-phosphate: S102 (= S104), G103 (= G105), A104 (= A106), F136 (= F134), H137 (= H135), D221 (= D219), V223 (= V221), Q224 (= Q222), K250 (= K248)

4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
43% identity, 98% coverage: 6:395/397 of query aligns to 4:400/400 of 4addA

query
sites
4addA

V

T

K

R

E

E

R

N

A

F

D

D

K

E

V

W

L

M

V

I

G

P

N

V

Y
|
Y

G

A

R

P

Y

A

P

P

V

F

A

I

F

P

T

V

E

R

G

G

T

E

G

G

C

S

V

R

L

L

T

W

D

D

A

Q

N

Q

G

G

K

K

K

E

Y

Y

V

I

D

D

F

F

L

A

A

G

G

G

I

I

A

A

V

V

C

N

S

A

L

L

G

G

H

H

C

A

H

H

P

P

R

E

I

L

V

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N

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A

A

I

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Q

Q

S

A

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S

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L

F

I

W

H

H

V

T

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G

N

N

L

G

Y

Y

Y

T

T

N

E

E

A

P

Q

V

T

L

R

R

L

L

A

A

E

K

L

K

L

L

V

I

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D

N

A

S

T

F

F

G

A

D

D

K

R

V

V

F

F

F

F

C

C

N

N

S

S

G
|
G

A
|
A

E

E

A

A

N

N

E

E

A

A

A

A

I

L

K

K

L

L

A

A

R

R

-

K

-

F

I

A

H

H

A

D

P

R

A

Y

G

G

K

S

N

H

K

K

-

S

-

G

I

I

I

V

S

A

L

F

T

K

G

N

A

A

F
|
F

H
|
H

G

G

R
|
R

T

T

M

L

V

F

T

T

L

V

A

S

A

A

T

G

G

G

Q

Q

A

P

R

A

F

Y

C

S

A

Q

G

D

F

F

E

A

P

P

I

L

P

P

T

A

G

D

F

I

A

R

A

H

A

A

P

A

F

Y

A

N

D

D

L

I

D

N

A

S

L

A

E

S

A

A

M

L

I

I

D

D

D

D

T

S

V

T

C

C

A

A

V

V

L

I

C

V

E
|
E

P

P

L

I

Q

Q

G

G

E

E

G

G

G

G

V

V

R

V

P

P

L

A

G

S

R

N

E

A

Y

F

L

L

Q

Q

G

G

I

L

R

R

D

E

I

L

C

C

D

N

R

R

H

H

G

N

V

A

L

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

V

V

G

G

R

R

S

T

G

G

S

E

L

L

F

Y

A

A

H

Y

Q

M

V

H

F

Y

G

G

V

V

E

T

P

P

D

D

I

L

M

L

T

T

L

T

A

A

K
|
K

G

A

L

L

A

G

S

G

G

G

M

F

P

P

I

V

G

G

A

A

I

L

I

L

T

A

R

T

D

E

A

E

V

C

A

A

A

R

S

V

L

M

V

T

P

V

G

G

S

T

H

H

G

G

S

T

T
|
T

F

Y

G

G

G

G

N

N

P

P

V

L

V

A

C

S

A

A

A

V

A

A

S

G

T

K

N

V

L

L

E

E

V

L

I

I

L

N

E

T

D

P

G

E

F

M

L

L

A

N

E

G

V

V

K

K

S

Q

V

R

A

H

E

D

H

W

L

F

A

V

Q

E

S

R

L

L

G

N

K

T

L

I

V

N

K

H

E

R

F

Y

P

-

A

G

I

L

F

F

T

S

E

E

E

V

R

R

G

G

L

L

G

G

L

L

L

L

R

I

G

G

L

C

V

V

M

L

T

N

E

A

E

D

G

Y

K

A

K

G

S

Q

G

A

S

K

K

Q

I

I

V

S

M

Q

E

E

M

A

L

A

E

K

K

A

G

G

F

V

L

M

I

V

N

L

F

I

A

A

G

G

G

G

V

N

A

V

L

V

R
|
R

F

F

A

A

P

P

P

A

L

L

V

N

V

V

S

S

R

E

E

E

Q

E

C

V

-

T

-

T

-

G

-

L

D

D

S

R

L

F

A

A

A

A

A

A

L

C

R

E

E

H

V

F

L

V

S

S

active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T279 (= T277), R372 (= R371)
binding pyridoxal-5'-phosphate: G103 (= G105), A104 (= A106), F136 (= F134), H137 (= H135), D221 (= D219), V223 (= V221), K250 (= K248)
binding n~2~-(3-carboxypropanoyl)-l-ornithine: Y16 (= Y18), F136 (= F134), R139 (= R137)

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
44% identity, 98% coverage: 5:394/397 of query aligns to 2:383/390 of A0QYS9

query
sites
A0QYS9

S

T

V

L

K

Q

E

S

R

R

A

W

D

E

K

A

V

V

L

M

V

M

G

N

N

N

Y

Y

G

G

R

T

Y

P

P

P

V

L

A

S

F

L

T

V

E

S

G

G

T

E

G

G

C

A

V

V

L

V

T

T

D

D

A

A

N

D

G

G

K

R

K

E

Y

Y

V

L

D

D

F

L

L

L

A

G

G

G

I

I

A

A

V

V

C

N

S

L

L

L

G

G

H

H

C

R

H

H

P

P

R

A

I

V

V

I

N

E

A

A

I

V

R

T

E

T

Q

Q

S

L

E

D

R

T

L

L

I

G

H

H

V

T

S

S

N

N

L

L

Y

Y

Y

A

T

T

E

E

A

P

Q

G

T

I

R

A

L

L

A

A

E

E

L

A

L

L

V

V

-

G

E

Q

N

L

S

G

F

T

G

Q

D

A

K

R

V

V

F

F

F

F

C

C

N

N

S

S

G

G

A

T

E

E

A

A

N

N

E

E

A

V

A

A

I

F

K

K

L

I

A

T

R

R

I

L

H

-

A

-

P

-

A

T

G

G

K

K

N

T

K

K

I

I

I

V

S

A

L

A

T

E

G

G

A

A

F

F

H

H

G

G

R

R

T

T

M

M

V

G

T

S

L

L

A

A

A

L

T

T

G

G

Q

Q

A

P

R

S

F

K

C

Q

A

A

G

P

F

F

E

E

P

P

I

L

P

P

T

G

G

N

F

V

A

M

A

H

A

V

P

P

F

Y

A

G

D

D

L

V

D

A

A

A

L

L

E

E

A

A

M

A

I

V

D

D

D

D

T

Q

V

T

C

A

A

A

V

V

L

F

C

L

E

E

P

P

L

I

Q

M

G

G

E

E

G

G

G

G

V

V

R

V

P

V

L

P

G

P

R

A

E

G

Y

Y

L

L

Q

V

G

A

I

A

R

R

D

E

I

I

C

T

D

S

R

K

H

H

G

G

V

A

L

L

L

L

I

V

F

L

D

D

E

E

V

V

Q

Q

T

T

G

G

V

V

G

G

R

R

S

T

G

G

S

A

L

F

F

F

A

A

H

H

Q

Q

V

H

F

D

G

G

V

I

E

V

P

P

D

D

I

V

M

V

T

T

L

M

A

A

K

K

G

G

L

L

A

G

S

G

G

G

M

L

P

P

I

I

G

G

A

A

I

C

I

L

T

A

R

V

D

G

A

A

V

T

A

G

A

D

S

L

L

L

V

T

P

P

G

G

S

L

H

H

G

G

S

S

T

T

F

F

G

G

G

G

N

N

P

P

V

V

V

C

C

T

A

A

A

A

A

G

S

L

T

A

N

V

L

L

E

K

V

T

I

L

L

A

E

A

D

E

G

D

F

L

L

V

A

A

E

R

V

A

K

G

S

V

V

L

A

G

E
x
K

H

T

L

L

A

S

Q

H

S

G

L

I

G

E

K

E

L

L

V

G

K

H

E

P

F

-

P

-

A

-

I

L

F

V

T

D

E

K

E

V

R

R

G

G

L

K

G

G

L

L

L

L

R

Q

G

G

L

I

V

V

M

L

T

T

E

V

E

P

G

S

K

A

K

K

S

A

G

-

S

-

K

-

I

V

V

E

M

T

E

A

M

A

L

R

E

D

K

A

G

G

F

F

L

L

I

V

N

N

F

A

A

A

G

A

G

P

V

E

A

V

L

V

R

R

F

L

A

A

P

P

P

P

L

L

V

I

V

I

S

T

R

E

E

G

Q

Q

C

I

D

E

S

A

L

F

A

I

A

T

A

A

L

L

R

P

E

A

V

V

L

L

K304 (≠ E309) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
42% identity, 96% coverage: 2:384/397 of query aligns to 3:388/405 of P40732

query
sites
P40732

T

T

N

E

E

Q

S

T

V

A

K

I

E

T

R

R

A

A

-

T

-

F

D

D

K

E

V

V

L

I

V

L

G

P

N

V

Y

Y

G

A

R

P

Y

A

P

D

V

F

A

I

F

P

T

V

E

K

G

G

T

K

G

G

C

S

V

R

L

V

T

W

D

D

A

Q

N

Q

G

G

K

K

K

E

Y

Y

V

I

D

D

F

F

L

A

A

G

G

G

I

I

A

A

V

V

C

T

S

A

L

L

G

G

H

H

C

C

H

H

P

P

R

A

I

L

V

V

N

E

A

A

I

L

R

K

E

S

Q

Q

S

G

E

E

R

T

L

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

T

N

E

E

A

P

Q

A

T

L

R

R

L

L

A

G

E

R

L

K

L

L

V

I

E

D

N

A

S

T

F

F

G

A

D

E

K

R

V

V

F

L

F

F

C

M

N

N

S

S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

I

H

-

Y

-

A

-

C

-

V

-

R

H

H

A

S

P

P

A

F

G

-

K

K

N

T

K

K

I

I

I

I

S

A

L

F

T

H

G

N

A

A

F

F

H

H

G

G

R

R

T

S

M

L

V

F

T

T

L

V

A

S

A

V

T

G

G

G

Q

Q

A

P

R

K

F

Y

C

S

A

D

G

G

F

F

E

G

P

P

I

K

P

P

T

A

G

D

F

I

A

I

A

H

A

V

P

P

F

F

A

N

D

D

L

L

D

H

A

A

L

V

E

K

A

A

M

V

I

M

D

D

D

D

T

H

V

T

C

C

A

A

V

V

L

V

C

V

E

E

P

P

L

I

Q

Q

G

G

E

E

G

G

G

G

V

V

R

Q

P

A

L

A

G

T

R

P

E

E

Y

F

L

L

Q

K

G

G

I

L

R

R

D

D

I

L

C

C

D

D

R

E

H

H

G

Q

V

A

L

L

L

L

I

V

F

F

D

D

E

E

V

V

Q

Q

T

C

G

G

V

M

G

G

R

R

S

T

G

G

S

D

L

L

F

F

A

A

H

Y

Q

M

V

H

F

Y

G

G

V

V

E

T

P

P

D

D

I

I

M

L

T

T

L

S

A

A

K
|
K

G

A

L

L

A

G

S

G

G

G

M

F

P

P

I

V

G

S

A

A

I

M

I

L

T

T

R

T

D

Q

A

E

V

I

A

A

A

S

S

A

L

F

V

H

P

V

G

G

S

S

H

H

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

P

P

V

L

V

A

C

C

A

A

A

V

A

A

S

G

T

A

N

A

L

F

E

D

V

I

I

I

L

N

E

T

D

P

G

E

F

V

L

L

A

Q

E

G

V

I

K

H

S

T

V

K

A

R

E

Q

H

Q

L

F

A

V

Q

Q

S

H

L

L

G

Q

K

A

L

I

V

D

K

E

E

Q

F

F

P

D

A

-

I

I

F

F

T

S

E

D

E

I

R

R

G

G

L

M

G

G

L

L

L

L

R

I

G

G

L

A

V

E

M

L

T

K

E

P

E

K

G

Y

K

K

K

G

S

R

G

A

S

R

K

D

I

F

V

L

M

Y

E

A

M

G

L

A

E

E

K

A

G

G

F

V

L

M

I

V

N

L

F

N

A

A

G

G

G

A

V

D

A

V

L

M

R

R

F

F

A

A

P

P

P

S

L

L

V

V

V

V

S

-

R

-

E

E

Q

E

C

A

D

D

GT 108:109 (≠ GA 105:106) binding pyridoxal 5'-phosphate
K255 (= K248) modified: N6-(pyridoxal phosphate)lysine
T284 (= T277) binding pyridoxal 5'-phosphate

4jevB N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
42% identity, 94% coverage: 11:384/397 of query aligns to 9:383/402 of 4jevB

query
sites
4jevB

D

D

K

E

V

V

L

I

V

L

G

P

N

V

Y

Y

G

A

R

P

Y

A

P

D

V

F

A

I

F

P

T

V

E

K

G

G

T

K

G

G

C

S

V

R

L

V

T

W

D

D

A

Q

N

Q

G

G

K

K

K

E

Y

Y

V

I

D

D

F

F

L

A

A

G

G

G

I
|
I

A

A

V

V

C

T

S

A

L

L

G

G

H

H

C

C

H

H

P

P

R

A

I

L

V

V

N

E

A

A

I

L

R

K

E

S

Q

Q

S

G

E

E

R

T

L

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

T

N

E

E

A

P

Q

A

T

L

R

R

L

L

A

G

E

R

L

K

L

L

V

I

E

D

N

A

S

T

F

F

G

A

D

E

K

R

V

V

F

L

F

F

C

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

I

H

-

Y

-

A

-

C

-

V

-

R

H

H

A

S

P

P

A

F

G

-

K

K

N

T

K

K

I

I

I

I

S

A

L

F

T

H

G

N

A

A

F
|
F

H
|
H

G

G

R

R

T

S

M

L

V

F

T

T

L

V

A

S

A

V

T

G

G

G

Q

Q

A

P

R

K

F

Y

C

S

A

D

G

G

F

F

E

G

P

P

I

K

P

P

T

A

G

D

F

I

A

I

A

H

A

V

P

P

F

F

A

N

D

D

L

L

D

H

A

A

L

V

E

K

A

A

M

V

I

M

D

D

D

D

T

H

V

T

C

C

A

A

V

V

L

V

C

V

E
|
E

P

P

L

I

Q

Q

G

G

E
|
E

G

G

G

G

V

V

R

Q

P

A

L

A

G

T

R

P

E

E

Y

F

L

L

Q

K

G

G

I

L

R

R

D

D

I

L

C

C

D

D

R

E

H

H

G

Q

V

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

V

M

G

G

R

R

S

T

G

G

S

D

L

L

F

F

A

A

H

Y

Q

M

V

H

F

Y

G

G

V

V

E

T

P

P

D

D

I

I

M

L

T

T

L

S

A

A

K
|
K

G

A

L

L

A

G

S

G

G

G

M

F

P

P

I

V

G

S

A

A

I

M

I

L

T

T

R

T

D

Q

A

E

V

I

A

A

A

S

S

A

L

F

V

H

P

V

G

G

S

S

H

H

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

P

P

V

L

V

A

C

C

A

A

A

V

A

A

S

G

T

A

N

T

L

F

E

D

V

I

I

I

L

N

E

T

D

P

G

E

F

V

L

L

A

Q

E

G

V

I

K

H

S

T

V

K

A

R

E

Q

H

Q

L

F

A

V

Q

Q

S

H

L

L

G

Q

K

A

L

I

V

D

K

E

E

Q

F

F

P

D

A

-

I

I

F

F

T

S

E

D

E

I

R

R

G

G

L

M

G

G

L

L

L

L

R

I

G

G

L

A

V

E

M

L

T

K

E

P

E

K

G

Y

K

K

K

G

S

R

G

A

S

R

K

D

I

F

V

L

M

Y

E

A

M

G

L

A

E

E

K

A

G

G

F

V

L

M

I

V

N

L

F

N

A

A

G

G

G

A

V

D

A

V

L

M

R
|
R

F

F

A

A

P

P

P

S

L

L

V

V

V

V

S

-

R

-

E

E

Q

E

C

A

D

D

active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T279 (= T277), R372 (= R371)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: I46 (= I48), S102 (= S104), G103 (= G105), T104 (≠ A106), F136 (= F134), H137 (= H135), E188 (= E186), E193 (= E191), D221 (= D219), V223 (= V221), Q224 (= Q222), K250 (= K248), R372 (= R371)

4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
42% identity, 94% coverage: 11:384/397 of query aligns to 9:378/397 of 4jewA

query
sites
4jewA

D

D

K

E

V

V

L

I

V

L

G

P

N

V

Y

Y

G

A

R

P

Y

A

P

D

V

F

A

I

F

P

T

V

E
x
K

G

G

T
x
K

G

G

C

S

V

R

L

V

T
x
W

D

D

A

Q

N

Q

G

G

K

K

K

E

Y

Y

V

I

D

D

F

F

L

A

A

G

G

G

I

I

A

A

V

V

C

T

S

A

L

L

G

G

H

H

C

C

H

H

P

P

R

A

I

L

V

V

N

E

A

A

I

L

R

K

E

S

Q

Q

S

G

E

E

R

T

L

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

T

N

E

E

A

P

Q

A

T

L

R

R

L

L

A

G

E

R

L

K

L

L

V

I

E

D

N

A

S

T

F

F

G

A

D

E

K

R

V

V

F

L

F

F

C

M

N

N

S

S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

I

H

-

Y

-

A

-

C

-

V

-

R

H

H

A

S

P

P

A

F

G

-

K

K

N

T

K

K

I

I

I

I

S

A

L

F

T

H

G

N

A

A

F
|
F

H
|
H

G

G

R
|
R

T

S

M

L

V

F

T

T

L

V

A

S

A

V

T

G

G

G

Q

Q

A

P

R

K

F

Y

C

S

A

D

G

G

F

F

E

G

P

P

I

K

P

P

T

A

G

D

F

I

A

I

A

H

A

V

P

P

F

F

A

N

D

D

L

L

D

H

A

A

L

V

E

K

A

A

M

V

I

M

D

D

D

D

T

H

V

T

C

C

A

A

V

V

L

V

C

V

E
|
E

P

P

L

I

Q

Q

G

G

E
|
E

G

G

G

G

V

V

R

Q

P

A

L

A

G

T

R

P

E

E

Y

F

L

L

Q

K

G

G

I

L

R

R

D

D

I

L

C

C

D

D

R

E

H

H

G

Q

V

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

V

M

G

G

R

R

S

T

G

G

S

D

L

L

F

F

A

A

H

Y

Q

M

V

H

F

Y

G

G

V

V

E

T

P

P

D

D

I

I

M

L

T

T

L

S

A

A

K
|
K

G

A

L

L

A

G

S

G

G

G

M

F

P

P

I

V

G

S

A

A

I

M

I

L

T

T

R

T

D

Q

A

E

V

I

A

A

A

S

S

A

L

F

V

-

P

-

G

-

S

-

H

-

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

P

P

V

L

V

A

C

C

A

A

A

V

A

A

S

G

T

A

N

T

L

F

E

D

V

I

I

I

L

N

E

T

D

P

G

E

F

V

L

L

A

Q

E

G

V

I

K

H

S

T

V

K

A

R

E

Q

H

Q

L

F

A

V

Q

Q

S

H

L

L

G

Q

K

A

L

I

V

D

K

E

E

Q

F

F

P

D

A

-

I

I

F

F

T

S

E

D

E

I

R

R

G

G

L

M

G

G

L

L

L

L

R

I

G

G

L

A

V

E

M

L

T

K

E

P

E

K

G

Y

K

K

K

G

S

R

G

A

S

R

K

D

I

F

V

L

M

Y

E

A

M

G

L

A

E

E

K

A

G

G

F

V

L

M

I

V

N

L

F

N

A

A

G

G

G

A

V

D

A

V

L

M

R
|
R

F

F

A

A

P

P

P

S

L

L

V

V

V

V

S

-

R

-

E

E

Q

E

C

A

D

D

active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T274 (= T277), R367 (= R371)
binding (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid: G103 (= G105), T104 (≠ A106), F136 (= F134), H137 (= H135), R139 (= R137), E188 (= E186), E193 (= E191), D221 (= D219), V223 (= V221), K250 (= K248)
binding picric acid: K25 (≠ E27), K27 (≠ T29), W32 (≠ T34)

2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding (see paper)
42% identity, 94% coverage: 11:384/397 of query aligns to 3:372/389 of 2pb0A

query
sites
2pb0A

D

D

K

E

V

V

L

I

V

L

G

P

N

V

Y

Y

G

A

R

P

Y

A

P

D

V

F

A

I

F

P

T

V

E

K

G

G

T

K

G

G

C

S

V

R

L

V

T

W

D

D

A

Q

N

Q

G

G

K

K

K

E

Y

Y

V

I

D

D

F

F

L

A

A

G

G

G

I

I

A

A

V

V

C

T

S

A

L

L

G

G

H

H

C

C

H

H

P

P

R

A

I

L

V

V

N

E

A

A

I

L

R

K

E

S

Q

Q

S

G

E

E

R

T

L

L

I

W

H

H

V

T

S

S

N

N

L

V

Y

F

Y

T

T

N

E

E

A

P

Q

A

T

L

R

R

L

L

A

G

E

R

L

K

L

L

V

I

E

D

N

A

S

T

F

F

G

A

D

E

K

R

V

V

F

L

F

F

C

M

N

N

S
|
S

G
|
G

A
x
T

E

E

A

A

N

N

E

E

A

T

A

A

I

F

K

K

L

L

A

A

R

R

I

H

-

Y

-

A

-

C

-

V

-

R

H

H

A

S

P

P

A

F

G

-

K

K

N

T

K

K

I

I

I

I

S

A

L

F

T

H

G

N

A

A

F
|
F

H
|
H

G

G

R

R

T

S

M

L

V

F

T

T

L

V

A

S

A

V

T

G

G

G

Q

Q

A

P

R

K

F

Y

C

S

A

D

G

G

F

F

E

G

P

P

I

K

P

P

T

A

G

D

F

I

A

I

A

H

A

V

P

P

F

F

A

N

D

D

L

L

D

H

A

A

L

V

E

K

A

A

M

V

I

M

D

D

D

D

T

H

V

T

C

C

A

A

V

V

L

V

C

V

E
|
E

P

P

L

I

Q

Q

G

G

E

E

G

G

G

G

V

V

R

Q

P

A

L

A

G

T

R

P

E

E

Y

F

L

L

Q

K

G

G

I

L

R

R

D

D

I

L

C

C

D

D

R

E

H

H

G

Q

V

A

L

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

Q
|
Q

T

C

G

G

V

M

G

G

R

R

S

T

G

G

S

D

L

L

F

F

A

A

H

Y

Q

M

V

H

F

Y

G

G

V

V

E

T

P

P

D

D

I

I

M

L

T

T

L

S

A

A

K
|
K

G

A

L

L

A

G

S

G

G

G

M

F

P

P

I

V

G

S

A

A

I

M

I

L

T

T

R

T

D

Q

A

E

V

I

A

A

A

S

S

A

L

F

V

-

P

-

G

-

S

-

H

-

G

G

S

S

T
|
T

F

Y

G

G

G

G

N

N

P

P

V

L

V

A

C

C

A

A

A

V

A

A

S

G

T

A

N

A

L

F

E

D

V

I

I

I

L

N

E

T

D

P

G

E

F

V

L

L

A

Q

E

G

V

I

K

H

S

T

V

K

A

R

E

Q

H

Q

L

F

A

V

Q

Q

S

H

L

L

G

Q

K

A

L

I

V

D

K

E

E

Q

F

F

P

D

A

-

I

I

F

F

T

S

E

D

E

I

R

R

G

G

L

M

G

G

L

L

L

L

R

I

G

G

L

A

V

E

M

L

T

K

E

P

E

K

G

Y

K

K

K

G

S

R

G

A

S

R

K

D

I

F

V

L

M

Y

E

A

M

G

L

A

E

E

K

A

G

G

F

V

L

M

I

V

N

L

F

N

A

A

G

G

G

A

V

D

A

V

L

M

R
|
R

F

F

A

A

P

P

P

S

L

L

V

V

V

V

S

-

R

-

E

E

Q

E

C

A

D

D

active site: F130 (= F134), E182 (= E186), D215 (= D219), Q218 (= Q222), K244 (= K248), T268 (= T277), R361 (= R371)
binding pyridoxal-5'-phosphate: S96 (= S104), G97 (= G105), T98 (≠ A106), F130 (= F134), H131 (= H135), E182 (= E186), D215 (= D219), V217 (= V221), Q218 (= Q222), K244 (= K248)

8ht4B Crystal structure of acetylornithine aminotransferase complex with plp from corynebacterium glutamicum (see paper)
42% identity, 98% coverage: 5:395/397 of query aligns to 1:390/390 of 8ht4B

query
sites
8ht4B

S

S

V

T

K

L

E

E

R

T

A

W

D

P

K

Q

V

V

L

I

V

I

G

N

N

T

Y

Y

G

G

R

T

Y

P

P

P

V

V

A

E

F

L

T

V

E

S

G

G

T

K

G

G

C

A

V

T

L

V

T

T

D

D

A

D

N

Q

G

G

K

N

K

V

Y

Y

V

I

D

D

F

L

L

L

A

A

G

G

I

I

A

A

V

V

C

N

S

A

L

L

G

G

H

H

C

A

H

H

P

P

R

A

I

I

V

I

N

E

A

A

I

V

R

T

E

N

Q

Q

S

I

E

G

R

Q

L

L

I

G

H

H

V

V

S

S

N

N

L

L

Y

F

Y

A

T

S

E

R

A

P

Q

V

T

V

R

E

L

V

A

A

E

E

L

E

L

L

V

I

E

K

N

R

-

F

S

S

F

L

G

D

D

D

-

A

-

T

-

L

-

A

-

A

-

Q

-

T

K

R

V

V

F

F

F

F

C

C

N

N

S
|
S

G
|
G

A
|
A

E

E

A

A

N

N

E

E

A

A

A

A

I

F

K

K

L

I

A

A

R

R

I

L

H

-

A

-

P

-

A

T

G

G

K

R

N

S

K

R

I

I

I

L

S

A

L

A

T

V

G

H

A

G

F
|
F

H
|
H

G

G

R

R

T

T

M

M

V

G

T

S

L

L

A

A

A

L

T

T

G

G

Q

Q

A

P

R

D

F

K

C

R

A

E

G

A

F

F

E

L

P

P

I

M

P

P

T

S

G

G

F

V

A

E

A

F

A

Y

P

P

F

Y

A

G

D

D

L

T

D

D

A

Y

L

L

E

R

A

K

M

M

I

V

D

E

D

T

T

N

-

P

-

T

-

D

V

V

C

A

A

A

V

I

L

F

C

L

E
|
E

P

P

L

I

Q

Q

G

G

E

E

G

T

G

G

V

V

R

V

P

P

L

A

G

P

R

E

E

G

Y

F

L

L

Q

K

G

A

I

V

R

R

D

E

I

L

C

C

D

D

R

E

H

Y

G

G

V

I

L

L

L

M

I

I

F

T

D
|
D

E

E

V
|
V

Q
|
Q

T

T

G

G

V

V

G

G

R

R

S

T

G

G

S

D

L

F

F

F

A

A

H

H

Q

Q

V

H

F

D

G

G

V

V

E

V

P

P

D

D

I

V

M

V

T

T

L

M

A

A

K
|
K

G

G

L

L

A

G

S

G

G

G

M

L

P

P

I

I

G

G

A

A

I

C

I

L

T

A

R

T

D

G

A

R

V

A

A

A

A

E

S

L

L

M

V

T

P

P

G

G

S

K

H

H

G

G

S

T

T

T

F