SitesBLAST
Comparing WP_011187683.1 NCBI__GCF_000025945.1:WP_011187683.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
45% identity, 96% coverage: 14:394/397 of query aligns to 4:376/376 of O66442
- GT 96:97 (≠ GA 105:106) binding pyridoxal 5'-phosphate
- K242 (= K248) modified: N6-(pyridoxal phosphate)lysine
- T271 (= T277) binding pyridoxal 5'-phosphate
2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
45% identity, 96% coverage: 14:394/397 of query aligns to 3:375/375 of 2eh6A
- active site: F127 (= F134), E179 (= E186), D212 (= D219), Q215 (= Q222), K241 (= K248), T270 (= T277), R352 (= R371)
- binding pyridoxal-5'-phosphate: G95 (= G105), T96 (≠ A106), F127 (= F134), H128 (= H135), E179 (= E186), D212 (= D219), V214 (= V221), K241 (= K248)
2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
44% identity, 96% coverage: 14:395/397 of query aligns to 11:391/393 of 2ordA
- active site: F134 (= F134), E186 (= E186), D219 (= D219), Q222 (= Q222), K248 (= K248), T276 (= T277), R367 (= R371)
- binding pyridoxal-5'-phosphate: G102 (= G105), T103 (≠ A106), F134 (= F134), H135 (= H135), E186 (= E186), D219 (= D219), V221 (= V221), Q222 (= Q222), K248 (= K248)
Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
44% identity, 96% coverage: 14:395/397 of query aligns to 3:383/385 of Q9X2A5
- GT 94:95 (≠ GA 105:106) binding pyridoxal 5'-phosphate
- T268 (= T277) binding pyridoxal 5'-phosphate
4adbB Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
43% identity, 98% coverage: 6:395/397 of query aligns to 4:400/401 of 4adbB
- active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T279 (= T277), R372 (= R371)
- binding pyridoxal-5'-phosphate: S102 (= S104), G103 (= G105), A104 (= A106), F136 (= F134), H137 (= H135), D221 (= D219), V223 (= V221), Q224 (= Q222), K250 (= K248)
4addA Structural and functional study of succinyl-ornithine transaminase from e. Coli (see paper)
43% identity, 98% coverage: 6:395/397 of query aligns to 4:400/400 of 4addA
- active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T279 (= T277), R372 (= R371)
- binding pyridoxal-5'-phosphate: G103 (= G105), A104 (= A106), F136 (= F134), H137 (= H135), D221 (= D219), V223 (= V221), K250 (= K248)
- binding n~2~-(3-carboxypropanoyl)-l-ornithine: Y16 (= Y18), F136 (= F134), R139 (= R137)
A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
44% identity, 98% coverage: 5:394/397 of query aligns to 2:383/390 of A0QYS9
- K304 (≠ E309) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
P40732 Acetylornithine/succinyldiaminopimelate aminotransferase; ACOAT; DapATase; Succinyldiaminopimelate transferase; EC 2.6.1.11; EC 2.6.1.17 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
42% identity, 96% coverage: 2:384/397 of query aligns to 3:388/405 of P40732
- GT 108:109 (≠ GA 105:106) binding pyridoxal 5'-phosphate
- K255 (= K248) modified: N6-(pyridoxal phosphate)lysine
- T284 (= T277) binding pyridoxal 5'-phosphate
4jevB N-acetylornithine aminotransferase from s. Typhimurium complexed with gabaculine
42% identity, 94% coverage: 11:384/397 of query aligns to 9:383/402 of 4jevB
- active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T279 (= T277), R372 (= R371)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: I46 (= I48), S102 (= S104), G103 (= G105), T104 (≠ A106), F136 (= F134), H137 (= H135), E188 (= E186), E193 (= E191), D221 (= D219), V223 (= V221), Q224 (= Q222), K250 (= K248), R372 (= R371)
4jewA N-acetylornithine aminotransferase from s. Typhimurium complexed with l-canaline
42% identity, 94% coverage: 11:384/397 of query aligns to 9:378/397 of 4jewA
- active site: F136 (= F134), E188 (= E186), D221 (= D219), Q224 (= Q222), K250 (= K248), T274 (= T277), R367 (= R371)
- binding (2S)-2-azanyl-4-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxy-butanoic acid: G103 (= G105), T104 (≠ A106), F136 (= F134), H137 (= H135), R139 (= R137), E188 (= E186), E193 (= E191), D221 (= D219), V223 (= V221), K250 (= K248)
- binding picric acid: K25 (≠ E27), K27 (≠ T29), W32 (≠ T34)
2pb0A Structure of biosynthetic n-acetylornithine aminotransferase from salmonella typhimurium: studies on substrate specificity and inhibitor binding (see paper)
42% identity, 94% coverage: 11:384/397 of query aligns to 3:372/389 of 2pb0A
- active site: F130 (= F134), E182 (= E186), D215 (= D219), Q218 (= Q222), K244 (= K248), T268 (= T277), R361 (= R371)
- binding pyridoxal-5'-phosphate: S96 (= S104), G97 (= G105), T98 (≠ A106), F130 (= F134), H131 (= H135), E182 (= E186), D215 (= D219), V217 (= V221), Q218 (= Q222), K244 (= K248)
8ht4B Crystal structure of acetylornithine aminotransferase complex with plp from corynebacterium glutamicum (see paper)
42% identity, 98% coverage: 5:395/397 of query aligns to 1:390/390 of 8ht4B
7nncC Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal-5'-phosphate and 6-methoxyquinoline-3-carboxylic acid
44% identity, 99% coverage: 2:395/397 of query aligns to 1:388/391 of 7nncC
7nn4A Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal 5'-phosphate and 3-hydroxy-2-naphthoic acid.
44% identity, 99% coverage: 2:395/397 of query aligns to 1:388/391 of 7nn4A
P9WPZ7 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
44% identity, 99% coverage: 2:395/397 of query aligns to 7:394/400 of P9WPZ7
- K314 (≠ E309) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylthreonine; partial
Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
42% identity, 99% coverage: 3:397/397 of query aligns to 58:456/457 of Q9M8M7
Sites not aligning to the query:
- 1:41 modified: transit peptide, Chloroplast and mitochondrion
- 42 modified: N-acetylvaline; in Acetylornithine aminotransferase, chloroplastic
3nx3A Crystal structure of acetylornithine aminotransferase (argd) from campylobacter jejuni
37% identity, 96% coverage: 14:395/397 of query aligns to 4:386/388 of 3nx3A
- active site: F127 (= F134), E179 (= E186), D212 (= D219), Q215 (= Q222), K241 (= K248), T271 (= T277), R362 (= R371)
- binding magnesium ion: N191 (≠ G198), F194 (≠ Y201), I313 (≠ V319), F316 (= F322), D317 (≠ P323), C319 (≠ T327), Q370 (≠ S379), K371 (≠ R380)
2byjA Ornithine aminotransferase mutant y85i (see paper)
36% identity, 100% coverage: 2:397/397 of query aligns to 4:397/404 of 2byjA
- active site: F142 (= F134), E195 (= E186), D228 (= D219), Q231 (= Q222), K257 (= K248), T287 (= T277), R378 (= R371)
- binding pyridoxal-5'-phosphate: G107 (= G105), V108 (≠ A106), F142 (= F134), W143 (≠ H135), D228 (= D219), I230 (≠ V221), Q231 (= Q222), K257 (= K248)
P04181 Ornithine aminotransferase, mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; EC 2.6.1.13 from Homo sapiens (Human) (see 8 papers)
36% identity, 100% coverage: 2:397/397 of query aligns to 39:432/439 of P04181
- G51 (≠ L14) to D: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs11553554
- Y55 (= Y18) to H: in HOGA; decreased protein abundance; dbSNP:rs121965037
- N89 (≠ S52) to K: in HOGA; no effect on protein abundance; dbSNP:rs386833602
- Q90 (≠ L53) to E: in HOGA; mistargeted, accumulates in cytoplasm; dbSNP:rs121965060
- C93 (= C56) to F: in HOGA; no effect on protein abundance; dbSNP:rs121965038
- Q104 (= Q67) to R: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833604
- R154 (= R117) to L: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965039
- R180 (= R137) to T: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965040
- A184 (≠ T141) natural variant: Missing (in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965035)
- P199 (= P156) to Q: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs267606925
- A226 (= A182) to V: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965059
- P241 (≠ L197) to L: in HOGA; no effect on protein abundance; dbSNP:rs121965051
- Y245 (= Y201) to C: in HOGA; no effect on protein abundance; dbSNP:rs121965046
- R250 (= R206) to P: in HOGA; no effect on protein abundance; dbSNP:rs121965052
- T267 (= T223) to I: in HOGA; decreased protein abundance; dbSNP:rs386833618
- A270 (≠ G226) to P: decreased protein abundance; dbSNP:rs121965041
- R271 (= R227) to K: in HOGA; no effect on protein abundance; loss of ornithine aminotransferase activity; dbSNP:rs121965042
- K292 (= K248) modified: N6-(pyridoxal phosphate)lysine
- E318 (≠ S273) to K: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833621
- V332 (≠ A287) to M: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965047
- G353 (≠ A308) to D: in HOGA; decreased protein abundance; dbSNP:rs121965053
- G375 (= G333) to A: in HOGA; decreased protein abundance; dbSNP:rs121965045
- C394 (≠ V352) to R: in HOGA; no effect on protein abundance; dbSNP:rs121965054; to Y: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833597
- L402 (≠ F360) to P: in HOGA; may affect protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965043
- P417 (= P375) to L: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs121965044
Sites not aligning to the query:
- 1:35 modified: transit peptide, Mitochondrion; in renal form
- 436 I → N: in HOGA; loss of protein stability; loss of ornithine aminotransferase activity; dbSNP:rs386833598
- 437 L → F: in HOGA; likely benign; no effect on protein stability; no effect on ornithine aminotransferase activity; dbSNP:rs1800456
8ez1B Human ornithine aminotransferase (hoat) co-crystallized with its inactivator 3-amino-4-fluorocyclopentenecarboxylic acid (see paper)
36% identity, 100% coverage: 2:397/397 of query aligns to 2:395/402 of 8ez1B
- binding (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid: Y48 (≠ I48), T104 (≠ S104), G105 (= G105), V106 (≠ A106), F140 (= F134), W141 (≠ H135), E198 (= E191), D226 (= D219), I228 (≠ V221), Q229 (= Q222), K255 (= K248), R376 (= R371)
Query Sequence
>WP_011187683.1 NCBI__GCF_000025945.1:WP_011187683.1
MTNESVKERADKVLVGNYGRYPVAFTEGTGCVLTDANGKKYVDFLAGIAVCSLGHCHPRI
VNAIREQSERLIHVSNLYYTEAQTRLAELLVENSFGDKVFFCNSGAEANEAAIKLARIHA
PAGKNKIISLTGAFHGRTMVTLAATGQARFCAGFEPIPTGFAAAPFADLDALEAMIDDTV
CAVLCEPLQGEGGVRPLGREYLQGIRDICDRHGVLLIFDEVQTGVGRSGSLFAHQVFGVE
PDIMTLAKGLASGMPIGAIITRDAVAASLVPGSHGSTFGGNPVVCAAASTNLEVILEDGF
LAEVKSVAEHLAQSLGKLVKEFPAIFTEERGLGLLRGLVMTEEGKKSGSKIVMEMLEKGF
LINFAGGVALRFAPPLVVSREQCDSLAAALREVLSVL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory