SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011187889.1 NCBI__GCF_000025945.1:WP_011187889.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

3al0C Crystal structure of the glutamine transamidosome from thermotoga maritima in the glutamylation state. (see paper)
30% identity, 79% coverage: 2:75/94 of query aligns to 1:83/564 of 3al0C

query
sites
3al0C

K

K

I

V

S

T

E

K

K

D

E

L

V

V

Q

L

H

H

V

L

A

E

H

N

L

L

S

A

R

R

L

L

H

E

L

L

D

S

Q

E

D

D

E

Q

L

R

A

E

S

S

M

L

T

M

E

K

Q

D

L

F

D

Q

G

E

I

I

L

L

S

D

Y

Y

M

V

E

E

K

L

L

L

A

N

E

E

V

V

D

D

T

V

E

E

G

G

V

V

L

E

P

P

T

M

T

Y

H

T

A

P

F

V

S

E

K

D

T

S

N

A

A

K

F

L

R

R

E

K

-

G

-

D

-

P

-

R

-

F

-

F

-

E

-

M

-

R

D

D

I

L

V

I

K

K

D

K

S

N

L

F

S

P

Q

E

E

E

E

K

Sites not aligning to the query:

active site: 110, 335
binding o5'-(l-glutamyl-sulfamoyl)-adenosine: 106, 108, 109, 118, 122, 142, 276, 294, 295, 297, 298, 324, 325, 333
binding : 144, 145, 148, 208, 213, 252, 255, 266, 269, 270, 276, 297, 298, 299, 300, 301, 304, 330, 332, 363, 364, 365, 370, 387, 389, 391, 392, 397, 400, 407, 446, 447, 453, 457, 509, 520, 524, 527, 535, 536, 538, 539

Query Sequence

>WP_011187889.1 NCBI__GCF_000025945.1:WP_011187889.1
MKISEKEVQHVAHLSRLHLDQDELASMTEQLDGILSYMEKLAEVDTEGVLPTTHAFSKTN
AFREDIVKDSLSQEESLANGPVQNGTAFQVPRVI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory