SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011188115.1 NCBI__GCF_000025945.1:WP_011188115.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6lpiB Crystal structure of ahas holo-enzyme (see paper)
28% identity, 91% coverage: 2:546/598 of query aligns to 2:507/539 of 6lpiB

query
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6lpiB

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active site: I27 (= I27), G29 (= G29), G30 (≠ S30), S31 (≠ A31), I32 (≠ M32), E53 (= E52), C76 (≠ Q75), F115 (= F114), Q116 (= Q115), E117 (= E116), K165 (≠ R163), M256 (≠ Y254), A283 (≠ S281), V375 (≠ I408), G401 (= G434), M403 (≠ C436), D428 (= D461), N455 (= N489), A457 (≠ Q491), L458 (≠ W492), L460 (≠ A494), V461 (≠ E495), Q464 (≠ N498)
binding flavin-adenine dinucleotide: R155 (= R152), G212 (= G208), G213 (≠ A209), G214 (= G210), T236 (≠ G234), L237 (≠ Y235), M238 (≠ Q236), L254 (= L252), M256 (≠ Y254), H257 (≠ N255), G276 (= G274), A277 (≠ T275), R278 (= R276), D280 (≠ N278), R282 (≠ F280), A283 (≠ S281), D300 (= D301), I301 (= I302), D319 (= D320), V320 (≠ A321), M380 (≠ A413), G398 (= G431)
binding magnesium ion: D428 (= D461), N455 (= N489)
binding thiamine diphosphate: E53 (= E52), C76 (≠ Q75), P79 (= P78), G376 (= G409), Q377 (≠ N410), H378 (≠ N411), G401 (= G434), M403 (≠ C436), G427 (= G460), D428 (= D461), G429 (= G462), S430 (≠ A463), M433 (≠ I466), N455 (= N489), A457 (≠ Q491), L458 (≠ W492), G459 (= G493), L460 (≠ A494), V461 (≠ E495)

6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
26% identity, 94% coverage: 6:566/598 of query aligns to 14:561/599 of 6denA

query
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6denA

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active site: Y35 (≠ I27), G37 (= G29), G38 (≠ S30), A39 (= A31), I40 (≠ M32), E61 (= E52), T84 (≠ Q75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (≠ R163), K230 (= K218), M266 (≠ Y254), V293 (≠ S281), V409 (≠ I408), L434 (≠ F433), G435 (= G434), M437 (≠ C436), D462 (= D461), N489 (= N489), E491 (≠ Q491), Q492 (≠ W492), M494 (≠ A494), V495 (≠ E495), W498 (≠ N498), L520 (≠ I521), N525 (≠ G526), V526 (≠ L527)
binding flavin-adenine dinucleotide: R163 (= R152), G219 (= G208), A220 (= A209), G221 (= G210), N224 (≠ L213), T246 (≠ G234), L247 (≠ Y235), Q248 (= Q236), L264 (= L252), G286 (= G274), A287 (≠ T275), R288 (= R276), D290 (≠ N278), R292 (≠ F280), V293 (≠ S281), E319 (≠ D301), I320 (= I302), N324 (≠ R306), D338 (= D320), V339 (≠ A321), M414 (≠ A413), G432 (= G431)
binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ Y254), D291 (≠ P279), R292 (≠ F280), W498 (≠ N498)
binding magnesium ion: D462 (= D461), N489 (= N489), E491 (≠ Q491)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (≠ I408), G410 (= G409), Q411 (≠ N410), H412 (≠ N411), G435 (= G434), M437 (≠ C436), G461 (= G460), D462 (= D461), A463 (≠ G462), S464 (≠ A463), N489 (= N489), E491 (≠ Q491), Q492 (≠ W492), G493 (= G493), M494 (≠ A494), V495 (≠ E495)

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
26% identity, 94% coverage: 6:566/598 of query aligns to 12:559/597 of 6demA

query
sites
6demA

M

L

T

T

T

G

E

G

E

E

A

I

F

F

I

H

T

E

V

M

L

M

Q

L

M

R

H

H

G

K

I

V

E

D

H

T

A

V

F

F

G

G

I
x
Y

I

A

G
|
G

S
x
G

A
|
A

M
x
I

M

L

P

P

I

V

S

F

D

D

-

A

L

I

F

Y

P

N

K

S

A

D

G

K

I

F

T

K

F

F

W

V

D

L

C

P

A

R

H

H

E
|
E

G

Q

N

G

A

A

G

G

M

H

M

M

A

A

D

E

G

G

Y

Y

T

A

R

R

A

A

S

S

G

G

K

K

M

P

S

G

M

V

V

L

A

V

Q
x
T

N

S

G

G

P

P

G

G

I

A

T

T

N

N

F

V

I

I

T

T

P

P

V

M

K

A

T

D

A

A

Y

L

W

M

N

D

H

G

T

V

P

P

L

L

L

V

V

F

T

S

P

G

Q

Q

A

V

A

P

N

T

A

T

T

A

M

I

G

G

Q

T

G

D

G

A

F
|
F

Q
|
Q

E
|
E

V

A

E

D

Q

I

M

V

A

G

V

I

F

S

K

R

D

S

M

C

V

T

A

K

Y

W

Q

N

E

V

E

M

V

V

R

K

D

N

-

V

-

A

-

E

-

L

P

P

R

R

M

I

A

N

E

E

V

A

L

F

N

E

R

-

V

-

I

I

M

A

Q

T

A

T

K

G

R
|
R

A

-

S

P

A

G

P

P

A

V

Q

L

I

V

N

D

I

L

P

P

R
x
K

D

D

Y

V

W

T

T

A

Q

S

V

I

-

L

-

R

-

E

-

S

-

I

-

P

I

I

E

N

I

T

E

T

L

L

P

P

A

S

I

V

V

S

D

E

F

F

E

T

R

-

P

-

A

-

G

-

E

S

K

E

A

A

L

I

E

K

K

R

A

A

E

N

L

I

L

L

S

N

K

K

A

A

K

K

F

K

P

P

V

I

I

I

L

Y

N

A

G
|
G

A
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A

G
|
G

V

I

I

L

L
x
N

G

N

-

E

G

Q

A

G

I

P

K
|
K

D

L

T

L

I

K

E

E

L

L

A

A

E

D

R

K

L

A

D

N

A

I

P

P

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C

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G
x
T

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x
L

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Q

H

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N

L

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A

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F

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D

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P

L

K

A

S

A

L

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M

L
|
L

G

G

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x
M

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H

G

G

S

S

K

A

A

A

G

A

M

N

E

T

L

A

I

I

A

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Q

N

A

A

D

D

V

C

V

I

L

I

A

A

L

L

G
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G

T
x
A

R
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R

L

F

N
x
D

P
x
D

F
x
R

S
x
V

T

T

L

-

P

-

G

G

Y

N

G

I

I

S

D

K

Y

F

W

A

P

P

Q

E

-

A

-

K

-

L

-

A

-

S

-

E

-

G

N

R

A

G

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I

I

L

Q

H

V

F

D
x
E

I
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I

N

S

P

P

D

K

R
x
N

I

I

G

N

L

K

T

V

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A

E

V

A

K

T

V

E

G

A

I

I

I

E

G

G

D
|
D

A
x
V

K

T

K

A

V

N

A

L

R

Q

G

S

I

F

L

I

N

-

R

P

L

L

T

V

A

D

T

S

A

I

G

E

D

N

T

R

D

P

R

E

E

W

I

F

R

N

K

K

A

I

N

N

I

E

G

W

K

K

T

K

K

K

A

Y

E

P

W

Y

S

S

V

Y

E

Q

L

L

A

-

N

-

L

-

V

-

H

-

E

-

D

E

D

T

P

P

G

G

T

S

S

L

W

I

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A

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R

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D

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R

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E

E

P

I

D

S

K

D

M

Q

S

A

P

-

R

-

E

Q

A

T

W

Y

N

N

A

-

M

-

K

-

S

-

V

-

I

-

P

-

E

K

N

E

A

V

I

I

I

V

S

T

D

G

I
x
V

G
|
G

N
x
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x
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x
M

I

W

G

A

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A

A

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W

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P

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R

K

T

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M

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G

M

G

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x
L

G
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G

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x
M

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G

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Y

G

G

F

L

P

P

A

A

I

A

C

I

G

G

A

A

K

Q

I

V

A

A

Q

K

P

P

D

D

V

A

P

I

V

V

I

I

G

D

M

I

A

D

G
|
G

D
|
D

G
x
A

A
x
S

F

F

G

N

I
x
M

S

T

M

L

N

T

E

E

M

L

V

-

S

S

C

S

G

A

R

V

K

Q

D

A

W

G

P

A

P

P

I

I

T

K

M

V

I

C

I

V

F

L

R

N

N
|
N

Y

E

Q
x
E

W
x
Q

G
|
G

A
x
M

E
x
V

K

T

R

Q

N
x
W

T

Q

T

S

L

L

W

F

Y

Y

S

E

D

H

N

R

F

Y

V

S

G

H

T

T

E

H

L

-

D

Q

P

S

N

N

V

P

S

D

Y

F

A

M

K

K

I
x
L

A

A

Q

E

A

S

C

M

G
x
N

L
x
V

I

K

G

G

V

I

Q

R

A

I

T

T

C

N

T

Q

D

Q

D

E

L

L

T

K

A

S

Q

G

L

V

K

K

E

E

A

F

V

-

R

-

V

-

Q

-

M

L

E

D

E

A

G

T

K

E

T

P

T

V

F

L

I

L

E

E

V

V

L

I

V

V

N

E

Q

K

E

K

L

V

active site: Y33 (≠ I27), G35 (= G29), G36 (≠ S30), A37 (= A31), I38 (≠ M32), E59 (= E52), T82 (≠ Q75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (≠ R163), K228 (= K218), M264 (≠ Y254), V291 (≠ S281), V407 (≠ I408), L432 (≠ F433), G433 (= G434), M435 (≠ C436), D460 (= D461), N487 (= N489), E489 (≠ Q491), Q490 (≠ W492), M492 (≠ A494), V493 (≠ E495), W496 (≠ N498), L518 (≠ I521), N523 (≠ G526), V524 (≠ L527)
binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ Y254), D289 (≠ P279), R290 (≠ F280), M492 (≠ A494), W496 (≠ N498)
binding flavin-adenine dinucleotide: R161 (= R152), G217 (= G208), A218 (= A209), G219 (= G210), N222 (≠ L213), T244 (≠ G234), L245 (≠ Y235), Q246 (= Q236), L262 (= L252), G284 (= G274), A285 (≠ T275), R286 (= R276), D288 (≠ N278), R290 (≠ F280), V291 (≠ S281), E317 (≠ D301), I318 (= I302), N322 (≠ R306), D336 (= D320), V337 (≠ A321), M412 (≠ A413), G430 (= G431)
binding magnesium ion: D460 (= D461), N487 (= N489), E489 (≠ Q491)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ I408), G408 (= G409), Q409 (≠ N410), H410 (≠ N411), M435 (≠ C436), G459 (= G460), D460 (= D461), A461 (≠ G462), S462 (≠ A463), M465 (≠ I466), N487 (= N489), E489 (≠ Q491), Q490 (≠ W492), G491 (= G493), M492 (≠ A494), V493 (≠ E495)

Sites not aligning to the query:

binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: 567

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
26% identity, 94% coverage: 6:566/598 of query aligns to 12:559/597 of 6delA

query
sites
6delA

M

L

T

T

T

G

E

G

E

E

A

I

F

F

I

H

T

E

V

M

L

M

Q

L

M

R

H

H

G

K

I

V

E

D

H

T

A

V

F

F

G

G

I
x
Y

I

A

G
|
G

S
x
G

A
|
A

M
x
I

M

L

P

P

I

V

S

F

D

D

-

A

L

I

F

Y

P

N

K

S

A

D

G

K

I

F

T

K

F

F

W

V

D

L

C

P

A

R

H

H

E
|
E

G

Q

N

G

A

A

G

G

M

H

M

M

A

A

D

E

G

G

Y

Y

T

A

R

R

A

A

S

S

G

G

K

K

M

P

S

G

M

V

V

L

A

V

Q
x
T

N

S

G

G

P

P

G

G

I

A

T

T

N

N

F

V

I

I

T

T

P

P

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M

K

A

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D

A

A

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D

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G

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P

P

L

L

L

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V

F

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A

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A

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C

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M

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D

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-

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-

A

-

E

-

L

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P

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R

M

I

A

N

E

E

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A

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F

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E

R

-

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-

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A

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R

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K

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I

-

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I

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L

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P

A

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S

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-

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-

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-

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-

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K

E

A

A

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A

A

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I

L

L

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N

K

K

A

A

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I

I

L

Y

N

A

G
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G

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A

G
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G

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I

I

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x
N

G

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-

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G

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K

D

L

T

L

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K

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A

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L

G

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x
M

N

H

G

G

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S

K

A

A

A

G

A

M

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T

L

A

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A

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I

L

I

A

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L

L

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G

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x
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R

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x
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P
x
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x
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x
V

T

T

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-

P

-

G

G

Y

N

G

I

I

S

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K

Y

F

W

A

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P

Q

E

-

A

-

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-

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-

A

-

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-

E

-

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I

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I

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A

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x
V

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-

R

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L

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A

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N

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W

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K

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K

K

K

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-

L

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H

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K

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Y

N

N

A

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M

-

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I

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N

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A

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G

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x
V

G
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G

N
x
Q

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x
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C

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x
M

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W

G

A

N

A

A

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W

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Y

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L

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G

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x
L

G
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G

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x
M

G

G

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Y

G

G

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L

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P

A

A

I

A

C

I

G

G

A

A

K

Q

I

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A

A

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P

P

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D

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A

P

I

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V

I

I

G

D

M

I

A

D

G
|
G

D
|
D

G
x
A

A
x
S

F

F

G

N

I
x
M

S

T

M

L

N

T

E

E

M

L

V

-

S

S

C

S

G

A

R

V

K

Q

D

A

W

G

P

A

P

P

I

I

T

K

M

V

I

C

I

V

F

L

R

N

N
|
N

Y

E

Q
x
E

W
x
Q

G
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G

A
x
M

E
x
V

K

T

R

Q

N
x
W

T

Q

T

S

L

L

W

F

Y

Y

S

E

D

H

N

R

F

Y

V

S

G

H

T

T

E

H

L

-

D

Q

P

S

N

N

V

P

S

D

Y

F

A

M

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K

I
x
L

A

A

Q

E

A

S

C

M

G
x
N

L
x
V

I

K

G

G

V

I

Q

R

A

I

T

T

C

N

T

Q

D

Q

D

E

L

L

T

K

A

S

Q

G

L

V

K

K

E

E

A

F

V

-

R

-

V

-

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-

M

L

E

D

E

A

G

T

K

E

T

P

T

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F

L

I

L

E

E

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V

L

I

V

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E

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E

K

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active site: Y33 (≠ I27), G35 (= G29), G36 (≠ S30), A37 (= A31), I38 (≠ M32), E59 (= E52), T82 (≠ Q75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (≠ R163), K228 (= K218), M264 (≠ Y254), V291 (≠ S281), V407 (≠ I408), L432 (≠ F433), G433 (= G434), M435 (≠ C436), D460 (= D461), N487 (= N489), E489 (≠ Q491), Q490 (≠ W492), M492 (≠ A494), V493 (≠ E495), W496 (≠ N498), L518 (≠ I521), N523 (≠ G526), V524 (≠ L527)
binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (≠ P279), R290 (≠ F280), W496 (≠ N498)
binding flavin-adenine dinucleotide: R161 (= R152), G217 (= G208), A218 (= A209), G219 (= G210), N222 (≠ L213), T244 (≠ G234), L245 (≠ Y235), Q246 (= Q236), L262 (= L252), G284 (= G274), A285 (≠ T275), R286 (= R276), D288 (≠ N278), R290 (≠ F280), V291 (≠ S281), E317 (≠ D301), I318 (= I302), N322 (≠ R306), D336 (= D320), V337 (≠ A321), M412 (≠ A413), G430 (= G431)
binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ I408), G408 (= G409), Q409 (≠ N410), H410 (≠ N411), G433 (= G434), M435 (≠ C436), G459 (= G460), D460 (= D461), A461 (≠ G462), S462 (≠ A463), M465 (≠ I466), N487 (= N489), E489 (≠ Q491), Q490 (≠ W492), G491 (= G493), M492 (≠ A494), V493 (≠ E495)
binding magnesium ion: D460 (= D461), N487 (= N489), E489 (≠ Q491)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ I408), G408 (= G409), Q409 (≠ N410), H410 (≠ N411), G433 (= G434), M435 (≠ C436), G459 (= G460), D460 (= D461), A461 (≠ G462), S462 (≠ A463), M465 (≠ I466), N487 (= N489), E489 (≠ Q491), Q490 (≠ W492), G491 (= G493), M492 (≠ A494), V493 (≠ E495)

6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
26% identity, 94% coverage: 6:566/598 of query aligns to 14:563/601 of 6deqA

query
sites
6deqA

M

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x
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x
L

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V

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M

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active site: Y35 (≠ I27), G37 (= G29), G38 (≠ S30), A39 (= A31), I40 (≠ M32), E61 (= E52), T84 (≠ Q75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (≠ R163), K232 (= K218), M268 (≠ Y254), V295 (≠ S281), V411 (≠ I408), L436 (≠ F433), G437 (= G434), M439 (≠ C436), D464 (= D461), N491 (= N489), E493 (≠ Q491), Q494 (≠ W492), M496 (≠ A494), V497 (≠ E495), W500 (≠ N498), L522 (≠ I521), N527 (≠ G526), V528 (≠ L527)
binding flavin-adenine dinucleotide: R163 (= R152), G221 (= G208), A222 (= A209), G223 (= G210), N226 (≠ L213), T248 (≠ G234), L249 (≠ Y235), Q250 (= Q236), L266 (= L252), G288 (= G274), A289 (≠ T275), R290 (= R276), D292 (≠ N278), R294 (≠ F280), V295 (≠ S281), E321 (≠ D301), I322 (= I302), D340 (= D320), V341 (≠ A321), M416 (≠ A413), G434 (= G431)
binding magnesium ion: D464 (= D461), N491 (= N489), E493 (≠ Q491)
binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ Y254), R294 (≠ F280), M496 (≠ A494), V497 (≠ E495), W500 (≠ N498)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (≠ I408), G412 (= G409), Q413 (≠ N410), H414 (≠ N411), M439 (≠ C436), G463 (= G460), D464 (= D461), A465 (≠ G462), S466 (≠ A463), N491 (= N489), E493 (≠ Q491), Q494 (≠ W492), G495 (= G493), M496 (≠ A494), V497 (≠ E495)

Sites not aligning to the query:

binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: 571

6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
26% identity, 94% coverage: 6:566/598 of query aligns to 10:555/593 of 6deoA

query
sites
6deoA

M

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active site: Y31 (≠ I27), G33 (= G29), G34 (≠ S30), A35 (= A31), I36 (≠ M32), E57 (= E52), T80 (≠ Q75), F119 (= F114), Q120 (= Q115), E121 (= E116), K169 (≠ R163), K224 (= K218), M260 (≠ Y254), V287 (≠ S281), V403 (≠ I408), L428 (≠ F433), G429 (= G434), M431 (≠ C436), D456 (= D461), N483 (= N489), E485 (≠ Q491), Q486 (≠ W492), M488 (≠ A494), V489 (≠ E495), W492 (≠ N498), L514 (≠ I521), N519 (≠ G526), V520 (≠ L527)
binding flavin-adenine dinucleotide: R159 (= R152), G213 (= G208), A214 (= A209), G215 (= G210), N218 (≠ L213), T240 (≠ G234), L241 (≠ Y235), Q242 (= Q236), L258 (= L252), G280 (= G274), A281 (≠ T275), R282 (= R276), D284 (≠ N278), R286 (≠ F280), V287 (≠ S281), E313 (≠ D301), I314 (= I302), N318 (≠ R306), D332 (= D320), V333 (≠ A321), M408 (≠ A413), G426 (= G431)
binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ Y254), D285 (≠ P279), R286 (≠ F280), M488 (≠ A494), W492 (≠ N498)
binding magnesium ion: D456 (= D461), N483 (= N489), E485 (≠ Q491)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ I408), G404 (= G409), Q405 (≠ N410), H406 (≠ N411), G429 (= G434), M431 (≠ C436), G455 (= G460), D456 (= D461), A457 (≠ G462), S458 (≠ A463), M461 (≠ I466), N483 (= N489), E485 (≠ Q491), Q486 (≠ W492), G487 (= G493), M488 (≠ A494), V489 (≠ E495)

6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
26% identity, 94% coverage: 6:566/598 of query aligns to 14:562/600 of 6derA

query
sites
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