Comparing WP_011188120.1 NCBI__GCF_000025945.1:WP_011188120.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q42565 Anthranilate synthase beta subunit 1, chloroplastic; Anthranilate synthase component 2-1; Anthranilate synthase, glutamine amidotransferase component 2-1; Protein TRYPTOPHAN BIOSYNTHESIS 4; Protein WEAK ETHYLENE INSENSITIVE 7; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
39% identity, 97% coverage: 6:191/192 of query aligns to 75:266/276 of Q42565
P00903 Aminodeoxychorismate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85 from Escherichia coli (strain K12) (see paper)
39% identity, 96% coverage: 6:189/192 of query aligns to 2:185/187 of P00903
P00900 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Serratia marcescens (see 3 papers)
40% identity, 96% coverage: 6:190/192 of query aligns to 4:188/193 of P00900
Sites not aligning to the query:
1i7qB Anthranilate synthase from s. Marcescens (see paper)
39% identity, 96% coverage: 6:190/192 of query aligns to 3:187/192 of 1i7qB
8hx8A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae co-crystallized with chorismate (see paper)
37% identity, 97% coverage: 5:191/192 of query aligns to 5:190/673 of 8hx8A
Sites not aligning to the query:
7yc6A Crystal structure of d110p mutant of gatase subunit of methanocaldococcus jannaschii gmp synthetase
34% identity, 97% coverage: 6:192/192 of query aligns to 2:178/183 of 7yc6A
2ywcA Crystal structure of gmp synthetase from thermus thermophilus in complex with xmp
30% identity, 97% coverage: 6:192/192 of query aligns to 2:184/475 of 2ywcA
Sites not aligning to the query:
8hx9A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae with chorismate (see paper)
29% identity, 97% coverage: 5:191/192 of query aligns to 4:147/632 of 8hx9A
Sites not aligning to the query:
P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see paper)
30% identity, 94% coverage: 5:185/192 of query aligns to 177:349/2225 of P08955
Sites not aligning to the query:
P0A6F1 Carbamoyl phosphate synthase small chain; Carbamoyl phosphate synthetase glutamine chain; EC 6.3.5.5 from Escherichia coli (strain K12) (see paper)
31% identity, 75% coverage: 48:191/192 of query aligns to 234:373/382 of P0A6F1
Sites not aligning to the query:
1ce8B Carbamoyl phosphate synthetase from escherichis coli with complexed with the allosteric ligand imp (see paper)
31% identity, 75% coverage: 48:191/192 of query aligns to 233:372/379 of 1ce8B
Sites not aligning to the query:
P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 7 papers)
29% identity, 78% coverage: 37:185/192 of query aligns to 207:349/2225 of P27708
Sites not aligning to the query:
P49915 GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; EC 6.3.5.2 from Homo sapiens (Human) (see paper)
33% identity, 74% coverage: 47:189/192 of query aligns to 69:207/693 of P49915
Sites not aligning to the query:
2vxoB Human gmp synthetase in complex with xmp (see paper)
33% identity, 74% coverage: 47:189/192 of query aligns to 47:182/658 of 2vxoB
Sites not aligning to the query:
Q9LVW7 Carbamoyl phosphate synthase small chain, chloroplastic; Carbamoyl phosphate synthetase glutamine chain; Protein VENOSA 6; EC 6.3.5.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 89% coverage: 10:180/192 of query aligns to 235:410/430 of Q9LVW7
Q09794 Multifunctional protein ura1; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
30% identity, 68% coverage: 45:175/192 of query aligns to 299:425/2244 of Q09794
Sites not aligning to the query:
1c3oB Crystal structure of the carbamoyl phosphate synthetase: small subunit mutant c269s with bound glutamine (see paper)
31% identity, 75% coverage: 48:191/192 of query aligns to 233:372/379 of 1c3oB
Sites not aligning to the query:
P07259 Multifunctional protein URA2; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
33% identity, 68% coverage: 45:175/192 of query aligns to 263:389/2214 of P07259
Sites not aligning to the query:
Q18990 Multifunctional protein pyr-1; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Caenorhabditis elegans (see 3 papers)
27% identity, 80% coverage: 21:174/192 of query aligns to 191:341/2198 of Q18990
Sites not aligning to the query:
1gpmA Escherichia coli gmp synthetase complexed with amp and pyrophosphate (see paper)
24% identity, 98% coverage: 3:190/192 of query aligns to 5:197/501 of 1gpmA
Sites not aligning to the query:
>WP_011188120.1 NCBI__GCF_000025945.1:WP_011188120.1
MAKRKIVLLDNNDSFTYNIVDYLRGMTEVQFRVINTHELDIEELDKYDGIIISPGPELPK
DFPKLFEVLQRYHRTKPILGICLGHQAIAQFFGADLSQQLPVVHGQAVPMQVLRDDSLFS
GLPREFRVGLYHSWLVDPKTIPARLVVTALSARGVIMAIRVTDLPIWGIQFHPESHITEH
GLKILENFIKLT
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory