SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_011188233.1 NCBI__GCF_000025945.1:WP_011188233.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
42% identity, 61% coverage: 130:333/336 of query aligns to 19:213/214 of 4ymwC

query
sites
4ymwC
L
 
L
W
 
I
I
 
M
T
 
T
L
 
L
K
 
K
V
 
L
S
 
T
F
 
F
F
 
L
A
 
A
I
 
V
I
 
T
I
 
I
G
 
G
I
 
V
T
 
L
L
 
M
G
 
G
I
 
L
L
 
F
T
 
I
G
 
A
L
 
L
S
 
M
R
 
K
V
 
M
S
 
S
E
 
S
N
 
I
P
 
K
L
 
P
L
 
I
K
 
K
W
 
L
F
 
V
S
 
A
I
 
S
I
 
S
Y
 
Y
I
 
I
E
 
E
L
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
 
P
L
 
L
M
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
L
 
L
W
 
I
Y
 
Y
F
 
-
V
 
-
V
 
-
G
 
-
N
 
-
L
 
-
I
 
-
N
 
N
A
 
G
F
 
-
L
 
L
T
 
M
Q
 
Q
I
 
F
G
 
G
I
 
M
G
 
N
G
 
-
V
 
I
P
 
P
P
 
A
L
 
F
W
 
T
F
 
A
G
 
G
V
 
V
I
 
S
A
 
A
L
 
L
A
 
A
T
 
I
F
x
N
T
 
S
G
 
S
A
 
A
Y
|
Y
T
 
V
A
 
A
E
 
E
I
 
I
V
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
V
 
V
H
 
D
R
 
P
G
 
G
Q
 
Q
M
 
N
E
 
E
A
 
A
A
 
A
R
 
R
S
 
S
L
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
A
 
A
E
 
M
S
 
A
M
 
M
R
 
R
K
 
Y
V
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
L
 
I
R
 
K
R
 
N
I
 
I
M
 
L
P
 
P
P
 
A
L
 
L
A
 
G
G
 
N
Q
x
E
F
 
F
I
 
I
S
 
V
L
 
M
I
 
L
K
 
K
D
x
E
S
 
S
S
 
A
L
 
I
L
 
V
G
 
S
V
 
V
I
 
I
A
 
G
I
 
F
R
 
A
E
 
D
V
 
L
T
 
T
K
 
R
A
 
Q
T
 
A
R
 
D
E
 
I
I
 
I
V
 
Q
S
 
S
S
 
V
S
 
T
L
 
Y
M
 
R
P
 
Y
Y
 
F
E
 
E
M
 
P
W
 
Y
I
 
I
T
 
I
C
 
I
A
 
A
L
 
A
L
 
I
Y
 
Y
L
 
F
V
 
V
L
 
M
T
 
T
F
 
L
A
 
T
L
 
F
S
 
S
L
 
K
C
 
L
V
 
L
Q
 
S
H
 
L
L
 
F
E
 
E
R
 
R
K
 
R

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
42% identity, 61% coverage: 130:333/336 of query aligns to 19:213/215 of 4ymtC

query
sites
4ymtC
L
 
L
W
 
I
I
 
M
T
 
T
L
 
L
K
 
K
V
 
L
S
 
T
F
 
F
F
 
L
A
 
A
I
 
V
I
 
T
I
 
I
G
 
G
I
 
V
T
 
L
L
 
M
G
 
G
I
 
L
L
 
F
T
 
I
G
 
A
L
 
L
S
 
M
R
 
K
V
 
M
S
 
S
E
 
S
N
 
I
P
 
K
L
 
P
L
 
I
K
 
K
W
 
L
F
 
V
S
 
A
I
 
S
I
 
S
Y
 
Y
I
 
I
E
 
E
L
 
V
I
 
I
R
 
R
G
 
G
T
 
T
P
|
P
L
|
L
M
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
L
 
L
W
 
I
Y
 
Y
F
 
-
V
 
-
V
 
-
G
 
-
N
 
-
L
 
-
I
 
-
N
 
N
A
 
G
F
 
-
L
 
L
T
 
M
Q
 
Q
I
 
F
G
 
G
I
 
M
G
 
N
G
 
-
V
 
I
P
 
P
P
 
A
L
 
F
W
 
T
F
 
A
G
 
G
V
 
V
I
 
S
A
 
A
L
 
L
A
 
A
T
 
I
F
x
N
T
 
S
G
 
S
A
 
A
Y
|
Y
T
 
V
A
 
A
E
 
E
I
 
I
V
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
V
 
V
H
 
D
R
 
P
G
 
G
Q
 
Q
M
 
N
E
 
E
A
 
A
A
 
A
R
 
R
S
 
S
L
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
A
 
A
E
 
M
S
 
A
M
 
M
R
 
R
K
 
Y
V
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
L
 
I
R
 
K
R
 
N
I
 
I
M
 
L
P
 
P
P
 
A
L
 
L
A
 
G
G
 
N
Q
x
E
F
 
F
I
 
I
S
 
V
L
x
M
I
 
L
K
|
K
D
x
E
S
 
S
S
 
A
L
 
I
L
 
V
G
 
S
V
 
V
I
 
I
A
 
G
I
 
F
R
 
A
E
 
D
V
 
L
T
 
T
K
 
R
A
 
Q
T
 
A
R
 
D
E
 
I
I
 
I
V
 
Q
S
 
S
S
 
V
S
 
T
L
 
Y
M
 
R
P
 
Y
Y
 
F
E
 
E
M
 
P
W
 
Y
I
 
I
T
 
I
C
 
I
A
 
A
L
 
A
L
 
I
Y
 
Y
L
 
F
V
 
V
L
 
M
T
 
T
F
 
L
A
 
T
L
 
F
S
 
S
L
 
K
C
 
L
V
 
L
Q
 
S
H
 
L
L
 
F
E
 
E
R
 
R
K
 
R

Query Sequence

>WP_011188233.1 NCBI__GCF_000025945.1:WP_011188233.1
MSRYSGLDAPKSRGYFMFWRSAIVVCMLVVIGFTYVASSYVEYNWNWKQVPQYFWLDKTI
EVRAEVAGDIEKIIKGPEGYSISIMDGAYTETLQAPADAEILLTEGDYAYEGDLVASYKV
SQPGMLLISLWITLKVSFFAIIIGITLGILTGLSRVSENPLLKWFSIIYIELIRGTPLMV
QIFLWYFVVGNLINAFLTQIGIGGVPPLWFGVIALATFTGAYTAEIVRAGIQSVHRGQME
AARSLGLTYAESMRKVILPQALRRIMPPLAGQFISLIKDSSLLGVIAIREVTKATREIVS
SSLMPYEMWITCALLYLVLTFALSLCVQHLERKSLR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory