SitesBLAST
Comparing WP_011188872.1 NCBI__GCF_000025945.1:WP_011188872.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5ey5B Lbcats
60% identity, 94% coverage: 5:388/410 of query aligns to 1:382/383 of 5ey5B
- binding pyridoxal-5'-phosphate: H81 (= H85), K82 (= K86), Q109 (= Q113), S185 (≠ T189), G227 (= G231), G229 (= G233), S230 (= S234), N231 (= N235), E345 (= E351), S371 (= S377), G372 (= G378)
5ocwB Structure of mycobacterium tuberculosis tryptophan synthase in space group f222 (see paper)
56% identity, 95% coverage: 2:391/410 of query aligns to 6:396/399 of 5ocwB
- active site: K93 (= K86), E115 (= E108), S382 (= S377)
- binding 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid: H92 (= H85), K93 (= K86), T116 (= T109), G117 (= G110), A118 (= A111), Q120 (= Q113), H121 (= H114), T196 (= T189), G238 (= G231), G240 (= G233), S241 (= S234), N242 (= N235), G309 (= G304), E356 (= E351), S382 (= S377)
5tciH Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form (see paper)
56% identity, 95% coverage: 2:391/410 of query aligns to 11:401/406 of 5tciH
- active site: K98 (= K86), E120 (= E108), S387 (= S377)
- binding (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile: P28 (= P16), L31 (= L19), Y197 (= Y185), F199 (≠ L187), P205 (= P193), F208 (= F196), H291 (≠ Q281)
6usaB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form (see paper)
56% identity, 95% coverage: 2:391/410 of query aligns to 10:400/404 of 6usaB
- active site: K97 (= K86), E119 (= E108), S386 (= S377)
- binding 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid: H96 (= H85), K97 (= K86), T120 (= T109), G121 (= G110), A122 (= A111), G123 (= G112), Q124 (= Q113), H125 (= H114), T200 (= T189), G242 (= G231), G244 (= G233), S245 (= S234), N246 (= N235), G313 (= G304), E360 (= E351), S386 (= S377)
- binding (3R,4R)-4-[4-(2-Chlorophenyl)piperazin-1-yl]-1,1-dioxothiolan-3-ol: F184 (= F173), W187 (= W176), Y196 (= Y185), F198 (≠ L187), G203 (= G192), P204 (= P193), F207 (= F196), H290 (≠ Q281), G291 (= G282)
6dweB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
56% identity, 95% coverage: 2:391/410 of query aligns to 10:400/404 of 6dweB
- active site: K97 (= K86), E119 (= E108), S386 (= S377)
- binding (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile: F184 (= F173), Y196 (= Y185), F198 (≠ L187), P204 (= P193), F207 (= F196), H290 (≠ Q281)
- binding 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid: H96 (= H85), K97 (= K86), T120 (= T109), G121 (= G110), A122 (= A111), G123 (= G112), Q124 (= Q113), H125 (= H114), T200 (= T189), G242 (= G231), G244 (= G233), S245 (= S234), N246 (= N235), G313 (= G304), E360 (= E351), S386 (= S377)
6uapB Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
56% identity, 95% coverage: 2:391/410 of query aligns to 10:400/405 of 6uapB
- active site: K97 (= K86), E119 (= E108), S386 (= S377)
- binding (2R,3S,4R)-3-(4'-chloro-2',6'-difluoro[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile: I180 (= I169), N181 (= N170), F184 (= F173), Y196 (= Y185), F198 (≠ L187), P204 (= P193), F207 (= F196), H290 (≠ Q281)
6u6cB Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form (see paper)
56% identity, 95% coverage: 2:391/410 of query aligns to 11:401/405 of 6u6cB
- active site: K98 (= K86), E120 (= E108), S387 (= S377)
- binding 2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]acrylic acid: H97 (= H85), K98 (= K86), T121 (= T109), G122 (= G110), A123 (= A111), Q125 (= Q113), H126 (= H114), T201 (= T189), G243 (= G231), G245 (= G233), S246 (= S234), N247 (= N235), G314 (= G304), E361 (= E351), S387 (= S377)
- binding 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide: Y26 (= Y14), F185 (= F173), W188 (= W176), Y197 (= Y185), F199 (≠ L187), G204 (= G192), P205 (= P193), H291 (≠ Q281), G292 (= G282)
7rnpA Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9_h275e with 4-cl-trp non-covalently bound (see paper)
53% identity, 94% coverage: 6:390/410 of query aligns to 2:384/384 of 7rnpA
5dw0A Trpb from pyrococcus furiosus with l-serine bound as the external aldimine (see paper)
54% identity, 93% coverage: 6:387/410 of query aligns to 2:381/388 of 5dw0A
- active site: K82 (= K86), E104 (= E108), S371 (= S377)
- binding [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine: H81 (= H85), K82 (= K86), T105 (= T109), G106 (= G110), A107 (= A111), Q109 (= Q113), H110 (= H114), S185 (≠ T189), G227 (= G231), G229 (= G233), S230 (= S234), N231 (= N235), G298 (= G304), D300 (= D306), E345 (= E351), S371 (= S377)
5t6mB Structure of the tryptophan synthase b-subunit from pyroccus furiosus with b-methyltryptophan non-covalently bound (see paper)
54% identity, 93% coverage: 6:387/410 of query aligns to 2:381/386 of 5t6mB
1v8zA X-ray crystal structure of the tryptophan synthase b2 subunit from hyperthermophile, pyrococcus furiosus (see paper)
54% identity, 93% coverage: 6:387/410 of query aligns to 2:381/386 of 1v8zA
- active site: K82 (= K86), E104 (= E108), S371 (= S377)
- binding pyridoxal-5'-phosphate: H81 (= H85), K82 (= K86), Q109 (= Q113), S185 (≠ T189), G227 (= G231), G228 (= G232), G229 (= G233), S230 (= S234), N231 (= N235), E345 (= E351), S371 (= S377), G372 (= G378)
6am8B Engineered tryptophan synthase b-subunit from pyrococcus furiosus, pftrpb2b9 with trp bound as e(aex2) (see paper)
53% identity, 94% coverage: 6:390/410 of query aligns to 2:384/385 of 6am8B