SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011279595.1 NCBI__GCF_000012305.1:WP_011279595.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 11 hits to proteins with known functional sites (download)

5z16B A novel dimeric isocitrate dehydrogenase from acinetobacter baumannii
76% identity, 100% coverage: 2:739/739 of query aligns to 1:738/739 of 5z16B

query
sites
5z16B

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binding magnesium ion: D347 (= D348), D546 (= D547), D550 (= D551)

5kvuA Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from mycobacterium tuberculosis
72% identity, 100% coverage: 4:739/739 of query aligns to 4:738/738 of 5kvuA

query
sites
5kvuA

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T

T

G

G

A

A

G

G

G
|
G

S
|
S

A
|
A

P

P

K

K

H
|
H

V

V

Q

K

Q

Q

L

L

V

V

E

E

E

E

N

N

H

H

L

L

R
|
R

W
|
W

D
|
D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

L

L

T

G

V

A

S

G

L

F

E

E

H

D

L

I

A

G

Q

I

N

K

D

T

G

G

N

N

A

E

K

R

A

A

Q

K

V

L

L

L

A

G

D

K

T

T

L

L

D

D

T

A

A

A

T

I

E

G

K

K

L

L

L

L

L

D

D

N

D

D

K

K

S

S

P

P

S

S

R
|
R

K

K

T

T

G

G

E

E

L

L

D

D

N

N

R

R

G

G

S

S

H

Q

F

F

Y

Y

L

L

A

A

M

M

Y

Y

W

W

A

A

Q

Q

E

E

L

L

A

A

A

A

Q

Q

D

T

K

D

D

D

S

Q

E

Q

L

L

K

A

A

E

Q

H

F

F

A

A

P

S

L

L

A

A

Q

D

N

V

L

L

A

T

D

K

N

N

E

E

A

D

A

V

I

I

I

V

K

R

E

E

L

L

N

T

D

E

A

V

Q

Q

G

G

K

E

P

P

M

V

D

D

L

I

K

G

G

G

Y

Y

Y

Y

L

A

A

P

D

D

E

S

S

D

L

M

V

T

E

T

Q

A

A

V

M

M

R

R

P

P

S

S

T

K

L

T

F

F

N

N

A

A

A

A

I

L

A

E

S

A

L

V

binding nadp nicotinamide-adenine-dinucleotide phosphate: P82 (= P82), N83 (= N83), S85 (= S85), N132 (= N133), I345 (= I346), A348 (= A349), T559 (= T560), A561 (= A562), G582 (= G583), S583 (= S584), A584 (= A585), H587 (= H588), R598 (= R599), W599 (= W600), D600 (= D601), R647 (= R648)

4zdaA Crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. Smegmatis
71% identity, 99% coverage: 4:736/739 of query aligns to 3:735/735 of 4zdaA

query
sites
4zdaA

I

I

I

I

Y

Y

T

T

K

L

T

T

D

D

E

E

A

A

P

P

A

L

L

L

A

A

T

T

V

Y

S

A

F

F

L

L

P

P

I

V

V

V

K

R

A

K

F

F

T

A

Q

E

T

A

A

A

G

G

I

I

E

D

V

V

D

K

T

T

I

S

D

D

I

I

S

S

V

V

A

A

A

A

R

R

V

I

L

L

A

A

E

E

F

F

P

G

E

D

F

H

L

L

S

T

E

E

E

E

Q

Q

R

R

V

V

P

P

D

D

N

N

L

L

A

G

E

E

L

L

G

G

R

A

L

L

T

T

Q

Q

D

D

P

P

N

S

T

A

N

N

I

I

I

I

K

K

L

L

P

P

N

N

I

I

S

S

A

A

S

S

V

V

Q

P

Q

Q

L

L

K

L

A

A

A

A

I

I

K

K

E

E

L

L

Q

Q

G

G

K

K

G

G

Y

Y

A

N

I

V

P

P

D

D

F

Y

P

P

E

A

D

N

P

P

Q

K

T

T

D

D

K

D

E

E

I

K

E

K

I

I

R

K

Q

D

R

R

Y

Y

G

A

K

K

S

I

L

L

G

G

S

S

S

A

V

V

N

N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

K

A

A

V

V

K

K

N

E

Y

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

S

M

M

G

G

E

E

W

W

K

S

Q

Q

W

A

S

S

Q

R

T

T

H

H

V

V

S

A

H

T

M

M

H

K

S

T

G

G

D

D

F

F

Y

Y

D

H

G

G

E

E

Q

K

S

S

I

M

T

T

L

L

D

D

K

R

A

D

R

R

T

R

V

V

R

K

M

M

E

V

R

L

L

K

A

T

D

K

D

S

G

G

T

E

V

E

N

I

V

V

F

L

K

K

T

P

G

E

L

V

A

K

L

L

L

D

D

A

K

G

E

D

V

I

I

I

D

D

L

S

M

M

F

Y

M

M

S

S

K

K

K

K

A

A

L

L

L

I

E

A

F

F

Y

Y

E

E

R

E

E

Q

M

I

E

E

D

D

C

A

R

Y

E

K

A

T

G

G

I

V

L

M

F

F

S

S

L

L

H

H

V

V

K

K

A

A

T

T

M

M

M

M

K

K

V

V

S

S

H

H

P

P

I

I

V

V

F

F

G

G

H

H

A

A

V

V

K

K

T

V

Y

F

Y

Y

K

K

E

D

A

A

F

F

N

A

K

K

H

H

G

E

A

K

F

L

F

F

D

D

E

E

L

L

G

G

I

V

N

N

V

V

N

N

N

N

G

G

M

L

V

S

D

D

L

L

Y

Y

D

D

K

K

I

I

S

E

K

A

L

L

P

P

A

A

S

S

T

Q

R

R

E

E

E

E

I

I

E

I

R

E

D

D

L

L

H

H

A

K

C

C

Q

H

V

E

H

H

R

R

P

P

R

E

L

L

A

A

M

M

V

V

D

D

S

S

S

A

K

K

G

G

I

I

T

S

N

N

F

F

H

H

S

S

P

P

S

S

D

D

I

V

I

I

V

V

D
|
D

A

A

S

S

M

M

P

P

A

A

M

M

I

I

R

R

N

L

G

G

G

G

K

K

M

M

W

Y

G

G

A

A

D

D

G

G

K

R

P

T

Y

K

D

D

C

T

K

K

A

A

V

V

M

N

P

P

E

E

S

S

T

T

F

F

A

S

R

R

I

M

Y

Y

Q

Q

E

E

M

M

I

I

N

N

F

F

C

C

K

K

W

T

H

H

G

G

N

Q

F

F

D

D

P

P

T

T

T

T

M

M

G

G

T

T

V

V

P

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y

Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

E

A

I

S

P

D

E

N

D

G

G

I

V

A

A

R

D

I

I

V

V

D

D

E

I

E

D

T

T

N

G

E

E

I

V

L

L

L

L

E

T

Q

Q

R

N

V

V

E

E

K

E

G

G

D

D

I

I

W

W

R

R

M

M

C

P

Q

I

V

V

K

K

D

D

E

A

P

P

I

I

Q

R

D

D

W

W

V

V

K

K

L

L

A

A

V

V

R

T

R

R

A

A

R

R

E

L

S

S

N

G

T

M

P

P

V

V

I

V

F

F

W

W

L

L

D

D

P

T

Y

E

R

R

P

P

H

H

E

E

N

V

E

E

L

L

I

R

K

K

K

K

V

V

K

K

M

E

Y

Y

L

L

K

K

D

D

H

H

D

D

T

T

T

E

G

G

L

L

H

K

I

I

E

Q

I

I

M

M

S

P

Q

Q

V

V

R

W

A

A

M

M

R

R

Y

Y

T

T

L

L

E

E

R

R

V

V

A

V

R

R

G

G

L

K

D

D

T

T

I

I

S

A

A

A

T

T

G

G

N

N

I

I

L

L

R

R

D
|
D

Y

Y

L

L

T

T

D
|
D

L

L

F

F

P

P

I

I

L

L

E

E

L

L

G

G

T

T

S

S

A

A

K

K

M

M

L

L

S

S

V

I

V

V

P

P

L

L

M

M

K

A

G

G

G

G

G

G

L

L

F

Y

E

E

T

T

G

G

A

A

G

G

G

G

S

S

A

A

P

P

K

K

H

H

V

V

Q

H

Q

Q

L

L

V

V

E

E

E

E

N

N

H

H

L

L

R

R

W

W

D

D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

L

L

T

G

V

A

S

S

L

L

E

E

H

D

L

M

A

G

Q

N

N

K

D

T

G

G

N

N

A

E

K

K

A

A

Q

K

V

V

L

L

A

A

D

K

T

A

L

L

D

D

T

T

A

A

T

T

E

G

K

K

L

L

L

L

L

E

D

E

D

N

K

K

S

S

P

P

S

S

R

R

K

R

T

T

G

G

E

E

L

L

D

D

N

N

R

R

G

G

S

S

H

Q

F

F

Y

Y

L

L

A

S

M

L

Y

F

W

W

A

A

Q

Q

E

A

L

L

A

A

A

E

Q

Q

D

T

K

E

D

D

S

A

E

E

L

L

K

A

A

E

Q

R

F

F

A

K

P

P

L

L

A

A

Q

K

N

A

L

L

A

A

D

E

N

Q

E

E

A

E

A

A

I

I

I

V

K

S

E

E

L

L

N

N

D

S

A

V

Q

Q

G

G

K

K

P

T

M

V

D

D

L

I

K

G

G

G

Y

Y

Y

Y

L

Y

A

P

D

D

E

P

S

E

L

K

V

T

E

S

Q

E

A

V

M

M

R

R

P

P

S

S

T

K

L

T

F

F

N

N

A

T

A

T

I

L

binding manganese (ii) ion: D347 (= D348), D546 (= D547), D550 (= D551)

6g3uA Structure of pseudomonas aeruginosa isocitrate dehydrogenase, idh (see paper)
67% identity, 100% coverage: 2:739/739 of query aligns to 1:736/737 of 6g3uA

query
sites
6g3uA

S

S

K

K

I

I

I

T

Y

Y

T

T

K

F

T

T

D

D

E

E

A

A

P

P

A

A

L

L

A

A

T

T

V

Y

S

S

F

L

L

L

P

P

I

I

V

V

K

K

A

A

F

F

T

A

Q

A

T

S

A

A

G

G

I

I

E

D

V

V

D

E

T

T

I

S

D

D

I

I

S

S

V

L

A

A

A

G

R

R

V

I

L

L

A

A

E

N

F

F

P

A

E

D

F

R

L

L

S

E

E

A

E

D

Q

Q

R

R

V

I

P

E

D

D

N

D

L

L

A

A

E

R

L

L

G

A

R

V

L

L

T

A

Q

T

D

S

P

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

Q

P

Q

Q

L

L

K

K

A

G

A

A

I

I

K

A

E

E

L

L

Q

Q

G

G

K

L

G

G

Y

Y

A

K

I

V

P

P

D

D

F

F

P

P

E

E

D

D

P

P

Q

Q

T

T

D

D

K

E

E

E

I

K

E

E

I

V

R

R

Q

A

R

R

Y

Y

G

A

K

K

S

I

L

L

G

G

S
|
S

S

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R
|
R

R

R

A

A

P

P

K

A

A

A

V

V

K

K

N

A

Y

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

S

M

M

G

G

E

K

W

W

K

S

Q

M

W

A

S

S

Q

R

T

S

H

H

V

A

S

D

H

Y

M

M

H

R

S

G

G

G

D

D

F

F

Y

F

D

S

G

S

E

E

Q

Q

S

S

I

I

T

T

L

M

D

A

K

K

A

A

R

G

T

D

V

V

R

R

M

I

E

E

R

F

L

V

A

G

D

K

D

D

G

G

T

K

V

V

N

E

V

V

F

-

K

K

T

K

G

Q

L

L

A

S

L

L

L

Q

D

E

K

G

E

E

V

V

I

L

D

D

L

S

M

M

F

F

M

M

S

S

K

C

K

G

A

K

L

L

L

R

E

D

F

F

Y

F

E

E

R

K

E

T

M

L

E

Q

D

D

C

C

R

K

E

E

A

T

G

G

I

V

L

M

F

W

S

S

L

L

H

H

V

V

K
|
K

A

A

T

T

M

M

M

M

K

K

V

I

S

S

H

H

P

P

I

I

V

V

F

F

G

G

H

H

A

A

V

V

K

S

T

V

Y

Y

Y

Y

K

K

E

D

A

V

F

F

N

D

K

K

H

W

G

G

A

Q

F

L

F

F

D

E

E

E

L

L

G

G

I

V

N

N

V

P

N

N

N

N

G

G

M

I

V

S

D

S

L

V

Y

Y

D

D

K

K

I

I

S

K

K

S

L

L

P

P

A

A

S

S

T

Q

R

Q

E

E

E

E

I

I

E

L

R

H

D

D

L

I

H

H

A

E

C

V

Q

Y

V

S

H

H

R

R

P

P

R

E

L

M

A

A

M

M

V

V

D

D

S

S

S

V

K

K

G

G

I

I

T

T

N

N

F

L

H

H

S

I

P

P

S

S

D

D

I

V

I
|
I

V

V

D

D

A
|
A

S

S

M

M

P

P

A

A

M

M

I

I

R

R

N

N

G

S

G

G

K

Q

M

M

W

W

G

G

A

K

D

D

G

G

K

K

P

Q

Y

K

D

D

C

T

K

K

A

A

V

V

M

M

P

P

E

E

S

S

T

T

F

Y

A

A

R

R

I

I

Y

Y

Q

Q

E

E

M

M

I

I

N

N

F

F

C

C

K

K

W

T

H

N

G

G

N

A

F

F

D

D

P

P

T

T

T

T

M

M

G

G

T

S

V

V

P

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y
|
Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

E

A

M

S

T

D

A

N

D

G

G

I

T

A

M

R

R

I

V

V

V

D

L

E

A

E

D

T

-

N

G

E

S

I

V

L

L

L

M

E

Q

Q

H

R

K

V

V

E

E

K

T

G

G

D

D

I

I

W

W

R

R

M

A

C

C

Q

Q

V

T

K

K

D

D

E

A

P

P

I

I

Q

R

D

D

W

W

V

V

K

K

L

L

A

A

V

V

R

T

R

R

A

A

R

R

E

Q

S

S

N

D

T

T

P

P

V

A

I

I

F

F

W

W

L

L

D

D

P

P

Y

E

R

R

P

A

H

H

E

D

N

R

E

E

L

L

I

R

K

K

K

K

V

V

K

E

M

L

Y

Y

L

L

K

K

D

D

H

H

D

D

T

L

T

T

G

G

L

L

H

D

I

I

E

S

I

I

M

M

S

G

Q

Y

V

N

R

E

A

A

M

I

R

R

Y

V

T

S

L

M

E

E

R

R

V

L

A

I

R

R

G

G

L

K

D

D

T

T

I

I

S

S

A

V

T

T

G

G

N

N

I

V

L

L

R
|
R

D
|
D

Y

Y

L

L

T

T

D

D

L

L

F

F

P

P

I

I

L

M

E

E

L

L

G

G

T
|
T

S

S

A
|
A

K

K

M

M

L

L

S

S

V

I

V

V

P

P

L

L

M

M

K

A

G

G

G

G

G

G

L

M

F

Y

E

E

T

T

G

G

A

A

G
|
G

G
|
G

S
|
S

A
|
A

P
|
P

K

K

H
|
H

V

V

Q

Q

Q

Q

L

L

V

V

E

E

E

E

N

N

H

Y

L

L

R
|
R

W
|
W

D
|
D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

L

L

T

A

V

V

S

S

L

L

E

E

H

E

L

T

A

G

Q

I

N

K

D

T

G

G

N

N

A

A

K

K

A

A

Q

K

V

L

L

L

A

G

D

K

T

A

L

L

D

D

T

E

A

A

T

T

E

G

K

K

L

L

L

L

L

D

D

N

D

N

K

K

S

S

P

P

S

S

R
|
R

K

K

T

V

G

G

E

D

L

I

D

D

N

N

R

R

G

G

S

S

H

H

F

F

Y

Y

L

L

A

A

M

M

Y

Y

W

W

A

A

Q

Q

E

A

L

L

A

A

A

A

Q

Q

D

N

K

E

D

D

S

A

E

E

L

L

K

K

A

A

Q

H

F

F

A

A

P

P

L

L

A

A

Q

K

N

A

L

L

A

T

D

E

N

Q

E

E

A

A

A

T

I

I

I

V

K

A

E

E

L

L

N

N

D

A

A

V

Q

Q

G

G

K

K

P

P

M

A

D

E

L

I

K

G

G

G

Y

Y

Y

Y

L

R

A

S

D

N

E

P

S

E

L

L

V

T

E

S

Q

K

A

V

M

M

R

R

P

P

S

S

T

A

L

T

F

F

N

N

A

A

A

A

I

I

A

D

S

S

L

L

binding 2-oxoglutaric acid: S84 (= S85), S129 (= S130), R142 (= R143), K251 (= K253), Y416 (= Y418), R543 (= R546), D544 (= D547)
binding nadp nicotinamide-adenine-dinucleotide phosphate: P81 (= P82), N82 (= N83), S84 (= S85), N132 (= N133), I344 (= I346), A347 (= A349), T557 (= T560), A559 (= A562), G579 (= G582), G580 (= G583), S581 (= S584), A582 (= A585), P583 (= P586), H585 (= H588), R596 (= R599), W597 (= W600), D598 (= D601), R645 (= R648)

1itwA Crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and mn (see paper)
62% identity, 100% coverage: 3:739/739 of query aligns to 4:739/740 of 1itwA

query
sites
1itwA

K

K

I

I

I

I

Y

Y

T

T

K

L

T

T

D

D

E

E

A

A

P

P

A

A

L

L

A

A

T

T

V

Y

S

S

F

L

L

L

P

P

I

I

V

I

K

K

A

A

F

F

T

T

Q

G

T

S

A

S

G

G

I

I

E

A

V

V

D

E

T

T

I

R

D

D

I

I

S

S

V

L

A

A

A

G

R

R

V

L

L

I

A

A

E

T

F

F

P

P

E

E

F

Y

L

L

S

T

E

D

E

T

Q

Q

R

K

V

I

P

S

D

D

N

D

L

L

A

A

E

E

L

L

G

G

R

K

L

L

T

A

Q

T

D

T

P

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P

P

N

N

I

I

S

S

A

A

S

S

V

V

Q

P

Q

Q

L

L

K

K

A

A

A

A

I

I

K

K

E

E

L

L

Q

Q

G

Q

K

Q

G

G

Y

Y

A

K

I

L

P

P

D

D

F

Y

P

P

E

E

D

E

P

P

Q

K

T

T

D

D

K

T

E

E

I

K

E

D

I

V

R

K

Q

A

R

R

Y

Y

G

D

K

K

S

I

L

K

G

G

S

S

S

A

V

V

N

N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

L

A

S

V

V

K

K

N

N

Y

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

K

M

M

G

G

E

A

W

W

K

S

Q

A

W

D

S

S

Q

K

T

S

H

H

V

V

S

A

H

H

M

M

H

D

S

N

G

G

D

D

F

F

Y

Y

D

G

G

S

E

E

Q

K

S

A

I

A

T

L

L

I

D

G

K

A

A

P

R

G

T

S

V

V

R

K

M

I

E

E

R

L

L

I

A

A

D

K

D

D

G

G

T

S

V

S

N

T

V

V

F

L

K

K

T

A

G

K

L

T

A

S

L

V

L

Q

D

A

K

G

E

E

V

I

I

I

D

D

L

S

M

S

F

V

M

M

S

S

K

K

K

N

A

A

L

L

L

R

E

N

F

F

Y

I

E

A

R

A

E

E

M

I

E

E

D

D

C

A

R

K

E

K

A

Q

G

G

I

V

L

L

F

L

S

S

L

V

H

H

V

L

K

K

A

A

T

T

M

M

M

M

K

K

V

V

S

S

H

D

P

P

I

I

V

M

F

F

G

G

H

Q

A

I

V

V

K

S

T

E

Y

F

Y

Y

K

K

E

D

A

A

F

L

N

T

K

K

H

H

G

A

A

E

F

V

F

L

D

K

E

Q

L

I

G

G

I

F

N

D

V

V

N

N

N

N

G

G

M

I

V

G

D

D

L

L

Y

Y

D

A

K

R

I

I

S

K

K

T

L

L

P

P

A

E

S

A

T

K

R

Q

E

K

E

E

I

I

E

E

R

A

D

D

L

I

H

Q

A

A

C

V

Q

Y

V

A

H

Q

R

R

P

P

R

Q

L

L

A

A

M

M

V

V

D

N

S

S

S

D

K

K

G

G

I

I

T

T

N

N

F

L

H

H

S

V

P

P

S

S

D

D

I

V

I

I

V

V

D
|
D

A

A

S

S

M

M

P

P

A

A

M

M

I

I

R

R

N

D

G

S

G

G

K

K

M

M

W

W

G

G

A

P

D

D

G

G

K

K

P

L

Y

H

D

D

C

T

K

K

A

A

V

V

M

I

P

P

E

D

S

R

T

C

F

Y

A

A

R

G

I

V

Y

Y

Q

Q

E

V

M

V

I

I

N

E

F

D

C

C

K

K

W

Q

H

H

G

G

N

A

F

F

D

D

P

P

T

T

T

T

M

M

G

G

T

S

V

V

P

P

N

N

V

V

G

G

L

L

M

M

A

A

Q

Q

K

K

A

A

E

E

E

E

Y

Y

G

G

S

S

H

H

D

D

K

K

T

T

F

F

E

Q

A

I

S

P

D

A

N

D

G

G

I

V

A

V

R

R

I

V

V

T

D

D

E

-

E

E

T

S

N

G

E

K

I

L

L

L

L

L

E

E

Q

Q

R

S

V

V

E

E

K

A

G

G

D

D

I

I

W

W

R

R

M

M

C

C

Q

Q

V

A

K

K

D

D

E

A

P

P

I

I

Q

Q

D

D

W

W

V

V

K

K

L

L

A

A

V

V

R

N

R

R

A

A

R

R

E

A

S

T

N

N

T

T

P

P

V

A

I

V

F

F

W

W

L

L

D

D

P

P

Y

A

R

R

P

A

H

H

E

D

N

A

E

Q

L

V

I

I

K

A

K

K

V

V

K

E

M

R

Y

Y

L

L

K

K

D

D

H

Y

D

D

T

T

T

S

G

G

L

L

H

D

I

I

E

R

I

I

M

L

S

S

Q

P

V

V

R

E

A

A

M

T

R

R

Y

F

T

S

L

L

E

A

R

R

V

I

A

R

R

E

G

G

L

K

D

D

T

T

I

I

S

S

A

V

T

T

G

G

N

N

I

V

L

L

R

R

D
|
D

Y

Y

L

L

T

T

D

D

L

L

F

F

P

P

I

I

L

M

E

E

L

L

G

G

T

T

S

S

A

A

K

K

M

M

L

L

S

S

V

I

V

V

P

P

L

L

M

M

K

S

G

G

G

G

G

G

L

L

F

F

E

E

T

T

G

G

A

A

G

G

G

G

S

S

A

A

P

P

K

K

H

H

V

V

Q

Q

Q

Q

L

F

V

L

E

E

E

E

N

G

H

Y

L

L

R

R

W

W

D

D

S

S

L

L

G

G

E

E

F

F

L

L

A

A

L

L

T

A

V

A

S

S

L

L

E

E

H

H

L

L

A

G

Q

N

N

A

D

Y

G

K

N

N

A

P

K

K

A

A

Q

L

V

V

L

L

A

A

D

S

T

T

L

L

D

D

T

Q

A

A

T

T

E

G

K

K

L

I

L

L

L

D

D

N

D

N

K

K

S

S

P

P

S

A

R

R

K

K

T

V

G

G

E

E

L

I

D

D

N

N

R

R

G

G

S

S

H

H

F

F

Y

Y

L

L

A

A

M

L

Y

Y

W

W

A

A

Q

Q

E

A

L

L

A

A

A

A

Q

Q

D

T

K

E

D

D

S

K

E

E

L

L

K

Q

A

A

Q

Q

F

F

A

T

P

G

L

I

A

A

Q

K

N

A

L

L

A

T

D

D

N

N

E

E

A

T

A

K

I

I

I

V

K

G

E

E

L

L

N

A

D

A

A

A

Q

Q

G

G

K

K

P

P

M

V

D

D

L

I

K

A

G

G

Y

Y

Y

Y

L

H

A

P

D

N

E

T

S

D

L

L

V

T

E

S

Q

K

A

A

M

M

R

R

P

P

S

S

T

A

L

T

F

F

N

N

A

A

A

A

I

L

A

A

S

P

L

L

binding manganese (ii) ion: D349 (= D348), D547 (= D547)

1j1wA Crystal structure of the monomeric isocitrate dehydrogenase in complex with NADP+ (see paper)
62% identity, 100% coverage: 3:739/739 of query aligns to 3:738/738 of 1j1wA

query
sites
1j1wA

K

K

I

I

I

I

Y

Y

T

T

K

L

T

T

D

D

E

E

A

A

P

P

A

A

L

L

A

A

T

T

V

Y

S

S

F

L

L

L

P

P

I

I

V

I

K

K

A

A

F

F

T

T

Q

G

T

S

A

S

G

G

I

I

E

A

V

V

D

E

T

T

I

R

D

D

I

I

S

S

V

L

A

A

A

G

R

R

V

L

L

I

A

A

E

T

F

F

P

P

E

E

F

Y

L

L

S

T

E

D

E

T

Q

Q

R

K

V

I

P

S

D

D

N

D

L

L

A

A

E

E

L

L

G

G

R

K

L

L

T

A

Q

T

D

T

P

P

N

D

T

A

N

N

I

I

I

I

K

K

L

L

P
|
P

N
|
N

I

I

S
|
S

A

A

S

S

V

V

Q

P

Q

Q

L

L

K

K

A

A

A

A

I

I

K

K

E

E

L

L

Q

Q

G

Q

K

Q

G

G

Y

Y

A

K

I

L

P

P

D

D

F

Y

P

P

E

E

D

E

P

P

Q

K

T

T

D

D

K

T

E

E

I

K

E

D

I

V

R

K

Q

A

R

R

Y

Y

G

D

K

K

S

I

L

K

G

G

S

S

S

A

V

V

N
|
N

P

P

V

V

L

L

R

R

E

E

G

G

N

N

S

S

D

D

R

R

R

R

A

A

P

P

K

L

A

S

V

V

K

K

N

N

Y

Y

A

A

R

R

K

K

H

H

P

P

H

H

S

K

M

M

G

G

E

A

W

W

K

S

Q

A

W

D

S

S

Q

K

T

S

H

H

V

V

S

A

H

H

M

M

H

D

S

N

G

G

D

D

F

F

Y

Y

D

G

G

S

E

E

Q

K

S

A

I

A

T

L

L

I

D

G

K

A

A

P

R

G

T

S

V

V

R

K

M

I

E

E

R

L

L

I

A

A

D

K

D

D

G

G

T

S

V

S

N

T

V

V

F

L

K

K

T

A

G

K

L

T

A

S

L

V

L

Q

D

A

K

G

E

E

V

I

I

I

D

D

L

S

M

S

F

V

M

M

S

S

K

K

K

N

A

A

L

L

L

R

E

N

F

F

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binding nadp nicotinamide-adenine-dinucleotide phosphate: P82 (= P82), N83 (= N83), S85 (= S85), N133 (= N133), T559 (= T560), A561 (= A562), G581 (= G582), G582 (= G583), S583 (= S584), H587 (= H588), R598 (= R599), W599 (= W600), D600 (= D601), R647 (= R648)

P16100 Isocitrate dehydrogenase [NADP]; IDH; Oxalosuccinate decarboxylase; EC 1.1.1.42 from Azotobacter vinelandii (see 2 papers)
62% identity, 100% coverage: 3:739/739 of query aligns to 5:740/741 of P16100

query
sites
P16100

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