SitesBLAST

S109 (= S5) to W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
N127 (≠ Q23) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G27) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
I147 (≠ S43) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (vs. gap) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ T66) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (≠ A83) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A100) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ G126) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
G233 (≠ A128) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
169:521 natural variant: Missing (in D2HGA1; uncertain significance)
375 D → Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
386 binding (R)-2-hydroxyglutarate; binding (R)-lactate; binding (R)-malate; R→A: Loss of catalytic activity.
390 binding (R)-2-hydroxyglutarate; binding (R)-malate; T→A: Significantly reduced catalytic activity.
399 V → M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
401 binding (R)-2-hydroxyglutarate; binding (R)-malate; K→A: Loss of catalytic activity.
419 R → H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
426 A → T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
434 binding Zn(2+); H→A: Loss of catalytic activity.
436 G → V: slight reduction in catalytic activity
439 N → D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
441 binding Zn(2+); H→A: Loss of catalytic activity.
443 binding (R)-2-hydroxyglutarate; N→A: Significantly reduced catalytic activity.
444 V → A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
446 A → V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
475 binding Zn(2+); E→A: Loss of catalytic activity.
476 binding (R)-2-hydroxyglutarate; binding (R)-lactate; binding (R)-malate; H→A: Loss of catalytic activity.
477 G → R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
27% identity, 36% coverage: 50:177/352 of query aligns to 101:226/467 of 7qh2C

query
sites
7qh2C

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binding flavin-adenine dinucleotide: P137 (≠ T88), G138 (≠ F89), E139 (≠ N90), A142 (= A93), T143 (= T94), G146 (= G97), N147 (≠ T98), S149 (≠ A100), T150 (≠ C101), A152 (≠ L103), G153 (≠ S104), E203 (≠ M154), G204 (= G155), I209 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 73, 75, 76, 77, 78, 79, 80, 83, 84, 422, 423
binding fe (iii) ion: 377, 384, 422

3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
28% identity, 49% coverage: 5:176/352 of query aligns to 50:222/465 of 3pm9A

query
sites
3pm9A

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active site: A149 (≠ L103), L159 (≠ S113)
binding flavin-adenine dinucleotide: P69 (≠ I24), Q70 (≠ M25), G71 (= G26), G72 (= G27), N73 (≠ G28), T74 (≠ S29), G75 (≠ K30), L76 (≠ Q31), G79 (= G34), Q80 (≠ R35), L91 (= L44), L133 (≠ P86), G134 (≠ P87), A135 (≠ T88), C139 (≠ A93), T140 (= T94), G142 (= G96), G143 (= G97), S146 (≠ A100), T147 (≠ C101), A149 (≠ L103), G150 (≠ S104), E200 (≠ M154), G201 (= G155), I205 (= I159), I206 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 423

P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
24% identity, 48% coverage: 5:173/352 of query aligns to 76:246/496 of P39976

query
sites
P39976

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Sites not aligning to the query:

17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
24% identity, 47% coverage: 6:170/352 of query aligns to 50:214/459 of P9WIT1

query
sites
P9WIT1

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Sites not aligning to the query:

354 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

2uuvC Alkyldihydroxyacetonephosphate synthase in p1 (see paper)
28% identity, 54% coverage: 5:193/352 of query aligns to 126:322/491 of 2uuvC

query
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2uuvC

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binding flavin-adenine dinucleotide: P146 (vs. gap), G148 (= G26), G149 (= G27), G150 (= G28), S151 (= S29), N152 (≠ K30), I153 (≠ Q31), A156 (≠ G34), I157 (≠ R35), P211 (= P86), D212 (≠ P87), S213 (≠ T88), S217 (≠ A93), T218 (= T94), G221 (= G97), A224 (= A100), T225 (≠ C101), S227 (≠ L103), S228 (= S104), E270 (≠ M154), G271 (= G155), I276 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 402

2uuuA Alkyldihydroxyacetonephosphate synthase in p212121 (see paper)
27% identity, 54% coverage: 5:193/352 of query aligns to 138:335/550 of 2uuuA

query
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2uuuA

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-

M

-

K

-

N

-

V

-

A

-

G

G

Y

I

D

N

V

Y

S

K

R

H

M

I

Q

I

A

L

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I
|
I

T

T

E

E

V

A

S

V

L

M

K

K

V

V

-

H

-

A

-

V

-

P

-

Q

-

A

-

V

-

E

-

Y

-

G

-

F

-

L

M

F

P

P

K

T

P

F

A

A

A

H

T

A

V

V

T

S

I

A

K

L

Q

Q

E

Q

M

I

D

R

A

S

K

E

A

V

I

I

E

P

T

T

M

M

N

I

R

R

L

V

binding flavin-adenine dinucleotide: P158 (vs. gap), G160 (= G26), G161 (= G27), G162 (= G28), S163 (= S29), N164 (≠ K30), I165 (≠ Q31), A168 (≠ G34), I169 (≠ R35), P225 (= P86), D226 (≠ P87), S227 (≠ T88), S231 (≠ A93), T232 (= T94), G235 (= G97), W236 (≠ T98), A238 (= A100), T239 (≠ C101), S241 (≠ L103), S242 (= S104), E283 (≠ M154), G284 (= G155), I288 (= I159), I289 (= I160)
binding hexadecan-1-ol: I165 (≠ Q31)

Sites not aligning to the query:

8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/455 of 8jdpA

query
sites
8jdpA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 369, 413, 450
binding deaminohydroxyvaline: 319, 414

8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/455 of 8jdtA

query
sites
8jdtA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding 2-ketobutyric acid: 318, 369, 376, 414
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 322, 413, 414, 450
binding manganese (ii) ion: 369, 376, 413

8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/455 of 8jdxA

query
sites
8jdxA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 32, 68, 70, 71, 72, 73, 74, 78, 79, 322, 413, 414, 450
binding 3-methyl-2-oxobutanoic acid: 318, 369, 376, 414
binding manganese (ii) ion: 369, 376, 413

8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/456 of 8jdsA

query
sites
8jdsA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 32, 68, 70, 71, 72, 73, 74, 78, 79, 323, 414, 415, 451
binding manganese (ii) ion: 370, 377, 414
binding pyruvic acid: 319, 370, 377, 415

8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/456 of 8jdrA

query
sites
8jdrA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 324, 370, 414, 451
binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: 319, 323, 415

8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/456 of 8jdqA

query
sites
8jdqA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding (2R)-2-hydroxy-4-methylpentanoic acid: 319, 323, 370, 415
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 370, 414, 451

8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/456 of 8jdoA

query
sites
8jdoA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding (2R)-2-hydroxyhexanoic acid: 319, 323, 415
binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 324, 370, 414, 451

8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
27% identity, 39% coverage: 39:175/352 of query aligns to 85:221/456 of 8jdnA

query
sites
8jdnA

G

G

D

V

P

C

I

I

S

N

L
|
L

S

T

E

H

H

M

K

D

G

Q

I

I

I

T

S

E

Y

L

E

N

P

T

I

E

E

D

L

F

V

S

L

V

T

V

A

V

R

E

A

P

G

G

T

V

P

T

I

R

S

K

E

A

I

L

N

N

S

T

A

H

L

L

A

R

E

D

H

S

N

G

Q

L

C

W

L

F

A

P

F

V

E

D

P
|
P

P

-

T

-

F

-

N
x
G

G
x
A

Q

D

A

A

T

S

L

L

G

C

G
|
G

T
x
M

L

A

A
|
A

C
x
T

H

G

L
x
A

S
|
S

G

G

P

T

A

N

R

A

P

V

W

R

S

Y

G

G

S

T

I

M

R

R

D

D

H

N

V

V

L

I

G

N

I

L

R

E

L

V

I

V

N

L

G

P

H

D

A

G

E

R

E

L

L

L

R

H

F

T

G

A

G

G

Q

R

-

G

-

R

-

H

V

Y

M

R

K

K

N

S

V

A

A

A

G

G

Y

Y

D

N

V

L

S

T

R

G

M

L

Q

F

A

V

G

G

A

S

M
x
E

G
|
G

T

T

L

L

G

G

I

I

I
|
I

T

T

E

S

V

T

S

T

L

L

K

R

V

L

M

H

P

P

K

A

P

P

A

E

A

A

T

T

V

V

binding flavin-adenine dinucleotide: L90 (= L44), P132 (= P86), G133 (≠ N90), A134 (≠ G91), G140 (= G97), M141 (≠ T98), A143 (= A100), T144 (≠ C101), A146 (≠ L103), S147 (= S104), E200 (≠ M154), G201 (= G155), I206 (= I160)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 68, 70, 71, 72, 73, 74, 78, 79, 370, 414, 451
binding (2R)-2-oxidanylpentanoic acid: 319, 323, 415

SitesBLAST – Find functional sites

SitesBLAST

Query Sequence