SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011317102.1 NCBI__GCF_000204075.1:WP_011317102.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O50131 Ornithine aminotransferase; Orn-AT; Ornithine delta-aminotransferase; EC 2.6.1.13 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
42% identity, 96% coverage: 17:431/431 of query aligns to 7:443/454 of O50131

query
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O50131

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T92 (= T100) mutation to V: Slightly increases the specific activity. Increases KM for L-ornithine.
D93 (= D101) mutation to L: Reduces the specific activity. Increases KM for L-ornithine.
G124 (= G132) binding pyridoxal 5'-phosphate
T125 (≠ A133) binding pyridoxal 5'-phosphate
Q267 (= Q257) binding pyridoxal 5'-phosphate
K293 (= K283) modified: N6-(pyridoxal phosphate)lysine
T321 (= T311) binding pyridoxal 5'-phosphate

7vo1A Structure of aminotransferase-substrate complex (see paper)
42% identity, 96% coverage: 17:431/431 of query aligns to 5:441/452 of 7vo1A

query
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7vo1A

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binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: I61 (= I71), S121 (= S131), G122 (= G132), T123 (≠ A133), F149 (= F159), H150 (= H160), R152 (= R162), E234 (= E226), D262 (= D254), V264 (= V256), Q265 (= Q257), K291 (= K283), N318 (≠ T310), T319 (= T311), R417 (= R407)

7vntA Structure of aminotransferase-substrate complex (see paper)
42% identity, 96% coverage: 17:431/431 of query aligns to 5:441/452 of 7vntA

query
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7vntA

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A

S

T

K

K

L

E

R

R

D

G

R

E

I

I

I

V

Q

V

E

E

A

A

F

L

Y

K

H

R

G

G

L

L

L

A

L

L

G

G

C

C

G

G

K

K

A

S

A

A

I

I

R

R

F

L

C

I

P

P

L

L

V

I

I

I

N

S

R

E

E

E

Q

E

I

A

Q

K

T

M

T

G

L

L

D

D

I

I

L

F

A

E

E

E

I

A

L

I

R

K

binding L-ornithine: F149 (= F159), R152 (= R162), E234 (= E226), K291 (= K283)
binding pyridoxal-5'-phosphate: G122 (= G132), T123 (≠ A133), F149 (= F159), H150 (= H160), E229 (= E221), D262 (= D254), V264 (= V256), Q265 (= Q257), K291 (= K283)

7vnoA Structure of aminotransferase (see paper)
42% identity, 96% coverage: 17:431/431 of query aligns to 5:441/452 of 7vnoA

query
sites
7vnoA

V

V

T

K

S

E

L

I

P

P

G

G

P

P

R

K

A

A

K

R

A

K

I

V

V

I

E

E

R

E

D

H

R

H

A

K

-

Y

-

M

V

A

T

T

S

T

P

T

S

N

Y

D

T

P

R

N

D

E

Y

Y

P

F

L

L

V

V

V

I

N

E

R

R

G

A

E

E

G

G

C

V

M

Y

V

W

E

I

D

D

V

V

D

D

G

G

N

N

V

V

F

L

L

L

D

D

M

F

T

S

A

S

G

G

I

I

A

G

V

V

T

M

A

N

T

V

G

G

H

L

A

R

H

N

P

P

E

K

V

V

V

I

R

E

A

A

I

I

Q

K

E

K

Q

Q

S

L

A

D

R

L

L

V

I

L

H

H

M

A

S

A

G

G

T

T

D

D

F

Y

Y

Y

Y

N

E

P

P

Y

M

Q

V

V

E

E

L

L

A

A

E

K

N

K

L

L

A

V

S

E

Q

I

A

A

P

P

F

G

V

D

H

I

D

E

T

R

K

K

V

V

F

F

F

L

T

S

N

N

S

S

G
|
G

A
x
T

E

E

S

A

N
|
N

E

E

G

A

A

A

I

L

K

K

L

I

A

A

R

K

Y

W

Y

S

T

T

K

N

R

R

S

K

L

M

I

F

I

I

A

A

F

F

L

I

G

G

A

A

F
|
F

H
|
H

G

G

R

R

T

T

Y

H

G

G

A

T

M

M

S

S

L

L

T

T

G

A

S

S

K

K

T

P

V

V

Q

Q

R

R

A

S

N

R

F

M

G

F

P

P

L

T

V

M

P

P

G

G

V

V

T

V

H

H

I

V

P

P

Y

Y

G

P

T

N

-

P

-

Y

-

R

-

N

-

P

-

W

-

G

-

I

-

D

-

G

-

Y

-

E

-

N

-

P

-

D

-

E

-

L

-

I

H

N

A

R

S

V

L

I

D

D

Y

Y

L

I

E

E

N

E

N

Y

L

L

L

F

T

E

T

H

I

Y

I

V

P

P

A

A

H

E

E

E

V

V

A

A

A

G

I

I

V

F

E
|
E

P

P

I

I

Q

Q

G

G

E

E

G

G

Y

Y

I

V

V

V

P

P

E

P

D

K

G

N

F

F

L

F

Q

K

R

E

I

L

R

K

N

K

I

L

C

A

D

D

R

K

Y

H

G

G

I

I

L

L

M

L

V

I

V

D

D
|
D

E

E

V
|
V

Q
|
Q

S

M

G

G

M

M

G

G

R

R

T

T

G

G

R

R

L

M

F

W

A

A

I

I

E

E

H

H

W

F

N

D

V

I

T

V

P

P

D

D

I

I

I

V

T

T

T

V

A

A

K
|
K

G

A

I

L

A

G

S

G

G

G

M

I

P

P

L

I

G

G

A

A

I

T

L

I

A

F

R

R

A

A

E

D

L

L

M

D

T

F

W

G

P

V

P

S

G

G

S

V

H

H

A

S

T

N

T

T

F

F

G

G

N

N

P

T

V

V

A

A

C

A

A

A

G

A

I

L

V

A

T

V

L

I

K

E

L

E

L

L

E

Q

S

N

G

G

L

L

M

I

D

E

N

N

A

A

T

Q

Q

K

M

L

G

E

E

P

L

L

L

F

Q

R

T

E

G

R

L

L

T

E

Q

E

L

M

H

K

Q

E

Q

K

F

Y

P

E

R

I

M

I

S

G

L

D

P

V

R

R

G

G

K

L

G

G

L

L

M

A

V

W

A

G

V

V

D

E

L

F

L

V

D

K

E

D

-

R

-

K

D

T

G

K

N

E

F

Y

D

A

S

T

K

K

L

E

R

R

D

G

R

E

I

I

I

V

Q

V

E

E

A

A

F

L

Y

K

H

R

G

G

L

L

L

A

L

L

G

G

C

C

G

G

K

K

A

S

A

A

I

I

R

R

F

L

C

I

P

P

L

L

V

I

I

I

N

S

R

E

E

E

Q

E

I

A

Q

K

T

M

T

G

L

L

D

D

I

I

L

F

A

E

E

E

I

A

L

I

R

K

binding pyridoxal-5'-phosphate: G122 (= G132), T123 (≠ A133), N126 (= N136), F149 (= F159), H150 (= H160), E229 (= E221), D262 (= D254), V264 (= V256), Q265 (= Q257), K291 (= K283)

O58478 Alanine/serine racemase; ASR; Ala/Ser racemase; EC 5.1.1.-; EC 5.1.1.1 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
38% identity, 98% coverage: 10:431/431 of query aligns to 17:459/474 of O58478

query
sites
O58478

L

L

P

M

H

E

T

Y

P

P

H

K

L

I

V

V

T

V

S

K

L

P

P

P

G

G

P

P

R

R

A

A

K

K

A

E

I

L

V

I

E

E

R

R

D

E

R

K

A

K

V

V

T

L

S

S

P

T

S

G

Y

I

-

G

T

V

R

K

D

L

Y

F

P

P

L

L

V

V

V

P

N

K

R

R

G

G

E

F

G

G

C

P

M

F

V

I

E

E

D

D

V

V

D

D

G

G

N

N

V

V

F

F

L

I

D

D

M

F

T

L

A

A

G

G

I

A

A

A

V

A

T

A

A

S

T

T

G

G

H

Y

A

A

H

H

P

P

E

K

V

L

V

V

R

K

A

A

I

V

Q

K

E

E

Q

Q

S

V

A

E

R

L

L

I

I

Q

H

H

M

S

S

M

G

I

T

G

D

Y

F

T

Y

H

Y

S

E

E

P

R

M

A

V

I

E

R

L

V

A

A

E

E

N

K

L

L

A

V

S

E

Q

I

A

S

P

P

F

-

V

I

H

E

D

N

T

S

K

K

V

V

F

I

F

F

T

G

N

L

S

S

G

G

A

S

E

D

S

A

N

V

E

D

G

M

A

A

I

I

K

K

L

V

A

S

R

K

Y

F

Y

S

T

T

K

R

R

R

S

P

L

W

I

I

I

L

A

A

F

F

L

I

G

G

A

A

F

Y

H

H

G

G

R

Q

T

T

Y

L

G

G

A

A

M

T

S

S

L

V

T

A

G

S

S

F

K

Q

T

V

V

S

Q

Q

R

K

A

R

N

G

F

Y

G

S

P

P

L

L

V

M

P

P

G

N

V

V

T

F

H

W

I

I

P

P

Y

Y

G

P

T

N

-

P

-

F

-

R

-

N

-

I

-

W

-

G

-

I

-

N

-

G

-

Y

-

E

-

P

-

D

-

E

-

L

-

I

H

N

A

R

S

V

L

L

D

D

Y

Y

L

L

E

E

N

Y

L

V

L

F

T

S

T

H

I

V

P

P

A

P

H

D

E

E

V

V

A

A

I

L

V

F

V

A

E

E

P

P

I

I

Q

Q

G

G

E
x
D

G

A

G

G

Y

I

I

V

V

V

P

P

E

P

D

E

G

N

F

F

L

F

Q

K

R

E

I

L

R

K

N

K

I

L

C

L

D

E

R

E

Y

Y

G

G

I

I

L

L

M

L

V

V

V

M

D

D

E

E

V

V

Q

Q

S

T

G

G

M

I

G

G

R

R

T

T

G

G

R

K

L

W

F

F

A

A

I

S

E

E

H

W

W

F

N

N

V

V

T

K

P

P

D

D

I

M

I

I

T

I

T

F

A

G

K
|
K

G

G

I

V

A

A

S

S

G

G

M

M

P

G

L

L

G

S

A

G

I

V

L

I

A

G

R

R

A

K

E

E

L

I

M

M

T

D

W

I

P

T

P

S

G

G

S

S

H

A

A

L

T

L

T

T

F

P

G

A

N

N

P

P

V

V

A

I

C

S

A

A

G

A

I

E

V

A

T

T

L

L

K

E

L

I

-

E

E

E

S

E

G

N

L

L

M

L

D

K

N

N

A

A

T

L

Q

E

M

V

G

G

E

E

L

F

L

I

Q

M

T

G

G

R

L

L

T

K

Q

E

L

I

H

K

Q

E

Q

R

F

F

P

E

R

I

M

I

S

G

L

D

P

V

R

R

G

G

K

K

G

G

L

L

M

M

V

I

A

G

V

V

D

E

L

I

L

V

D

K

E

E

D

N

G

G

N

R

F

P

D

D

S

P

K

E

L

M

R

T

D

G

R

K

I

I

I

C

Q

W

E

R

A

A

F

F

Y

E

H

L

G

G

L

L

L

I

L

L

-

P

-

S

L

Y

G

G

C

M

G

F

K

G

A

N

A

V

I

I

R

R

F

I

C

T

P

P

L

L

V

V

I

L

N

T

R

K

E

E

Q

V

I

A

Q

E

T

K

T

A

L

L

D

E

I

I

L

I

A

E

E

R

I

A

L

I

R

K

D251 (≠ E226) mutation to A: Loss of activity.
K308 (= K283) mutation to A: Loss of activity.

2eo5A Crystal structure of 4-aminobutyrate aminotransferase from sulfolobus tokodaii strain7
41% identity, 94% coverage: 25:431/431 of query aligns to 3:410/412 of 2eo5A

query
sites
2eo5A

A

S

K

R

A

K

I

I

V

I

E

E

R

E

D

S

R

D

A

I

V

Y

T

L

S

A

P

T

S

S

Y

-

T
|
T

R

R

D

D

-

P

-

E

-

L

Y

F

P

P

L

L

V

V

V

I

N

D

R

H

G

G

E

E

G

G

C

V

M

W

V

I

E

Y

D

D

V

V

D

D

G

G

N

N

V

K

F

Y

L

L

D

D

M

F

T

T

A

S

G

G

I

I

A

G

V

V

T

N

A

N

T

L

G

G

H

W

-

P

A

S

H

H

P

P

E

E

V

V

V

I

R

K

A

I

I

G

Q

I

E

E

Q

Q

S

M

A

Q

R

K

L

L

I

A

H

H

M

A

S

A

G

A

T

N

D

D

F

F

Y

Y

Y

N

E

I

P

P

M

Q

V

L

E

E

L

L

A

A

E

K

N

K

L

L

A

V

S

T

Q

Y

A

S

P

P

F

G

V

N

H

F

D

Q

T

K

K

K

V

V

F

F

T

S

N

N

S

S

G
|
G

A
x
T

E

E

S

A

N

I

E

E

G

A

A

S

I

I

K

K

L

V

A

V

R

K

Y

N

Y

-

T

T

K

G

R

R

S

K

L

Y

I

I

A

A

F

F

L

L

G

G

A

G

F
|
F

H
|
H

G

G

R

R

T

T

Y

F

G

G

A

S

M

I

S

S

L

L

T

T

G

A

S

S

K

K

T

A

V

V

Q

Q

R

R

A

S

N

I

F

V

G

G

P

P

L

F

V

M

P

P

G

G

V

V

T

I

H

H

I

V

P

P

Y

Y

G

P

T

N

-

P

-

Y

-

R

-

N

-

P

-

W

-

H

-

I

-

N

-

G

-

Y

-

E

-

N

-

P

-

S

-

E

-

L

-

V

H

N

A

R

S

V

L

I

D

E

Y

F

L

I

E

E

N

D

N

Y

L

I

L

F

T

V

T

N

I

L

I

V

P

P

A

P

H

E

E

E

V

V

A

A

A

G

I

I

V

F

E
|
E

P

P

I

I

Q

Q

G

G

E

E

G

G

Y

Y

I

V

V

I

P

P

E

P

D

K

G

N

F

F

L

F

Q

A

R

E

I

L

R

Q

N

K

I

L

C

A

D

K

R

K

Y

Y

G

G

I

I

L

L

M

L

V

V

V

D

D
|
D

E

E

V
|
V

Q
|
Q

S

M

G

G

M

L

G

G

R

R

T

T

G

G

R

K

L

L

F

F

A

A

I

I

E

E

H

N

W

F

N

N

V

T

T

V

P

P

D

D

I

V

I

I

T

T

T

L

A

A

K
|
K

G

A

I

L

A

G

S

G

G

G

-

I

M

M

P

P

L

I

G

G

A

A

I

T

L

I

A

F

R

R

A

K

E

D

L

L

M

-

T

-

W

-

P

-

G

-

S

-

H

D

A

F

T

K

T
|
T

F

F

G

G

N

N

P

A

V

L

A

A

C

C

A

A

A

I

G

G

I

S

V

K

T

V

L

I

K

D

L

I

L

V

E

K

S

D

G

-

L

L

M

L

D

P

N

H

A

V

T

N

Q

E

M

I

G

G

E

K

L

I

L

F

Q

A

T

E

G

E

L

L

T

Q

Q

G

L

L

H

A

Q

D

F

V

P

-

R

-

M

-

S

-

L

-

P

-

R

R

G

G

K

I

G

G

L

L

M

A

V

W

A

G

V

L

D

E

L

Y

L

N

D

E

E

K

D

-

G

-

N

-

F

-

D

-

S

-

K

K

L

V

R

R

D

D

R

R

I

I

Q

G

E

E

A

S

F

F

Y

K

H

R

G

G

L

L

G

P

C

A

G

G

K

R

A

S

A

A

I

I

R
|
R

F

V

C

I

P

P

L

L

V

V

I

I

N

S

R

E

E

E

Q

E

I

A

Q

K

T

Q

T

G

L

L

D

D

I

I

L

L

A

K

E

K

I

V

L

I

R

K

active site: T18 (= T41), F139 (= F159), E219 (= E221), D252 (= D254), Q255 (= Q257), K281 (= K283), T303 (= T311), R386 (= R407)
binding pyridoxal-5'-phosphate: G113 (= G132), T114 (≠ A133), F139 (= F159), H140 (= H160), E219 (= E221), D252 (= D254), V254 (= V256), Q255 (= Q257), K281 (= K283)

P73133 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
41% identity, 91% coverage: 39:430/431 of query aligns to 38:425/429 of P73133

query
sites
P73133

S

T

Y
|
Y

T

G

R

R

D

-

Y

F

P

P

L

I

V

A

V

I

N

A

R

R

G

G

E

Q

G

G

C

S

M

T

V

L

E

W

D

D

V

T

D

E

G

G

N

K

V

S

F

Y

L

L

D

D

M

F

T

V

A

A

G

G

I

I

A

A

V

T

T

C

A

T

T

L

G

G

H

H

A

A

H

H

P

P

E

A

V

L

V

V

R

R

A

A

I

V

Q

S

E

D

Q

Q

S

I

A

Q

R

K

L

L

I

H

H

H

M

V

S

S

G

-

T

-

D

N

F

L

Y

Y

E

I

P

P

-

E

M

Q

V

G

E

E

L

L

A

A

E

K

N

W

L

I

A

V

S

E

Q

H

A

S

P

-

F

-

V

-

H

C

D

A

T

D

K

R

V

V

F

F

T

C

N

N

S
|
S

G
|
G

A
|
A

E

E

S

A

N

N

E

E

G

A

A

A

I

I

K

K

L

L

A

V

R

R

Y

K

Y

Y

T

A

-

H

-

T

-

V

-

L

-

D

-

F

-

L

K

E

R

Q

S

P

L

V

I

I

I

L

A

T

F

A

L

K

G

A

A

S

F

F

H

H

G

G

R
|
R

T

T

Y

L

G

A

A

T

M

I

S

T

L

A

T

T

G

G

S

Q

K

P

T

K

V

Y

Q

Q

R

Q

A

-

N

Y

F

F

G

D

P

P

L

L

V

V

P

P

G

G

V

F

T

D

H

Y

I

V

P

P

Y

Y

G

N

T

D

H

I

A

R

S

S

L

L

D

-

Y

-

L

-

E

E

N

N

N

K

L

V

L

A

T

D

T

L

I

D

I

E

P

G

A

N

H

S

E

R

V

V

A

A

I

I

V

F

V

L

E

E

P

P

I

L

Q

Q

G

G

E
|
E

G

G

Y

V

I

R

V

P

P

G

E

D

D

L

G

A

F

Y

L

F

Q

K

R

R

I

V

R

R

N

E

I

I

C

C

D

D

R

Q

Y

N

G

D

I

I

L

L

M

L

V

V

V

F

D
|
D

E

E

V

V

Q
|
Q

S

V

G

G

M

V

G

G

R

R

T

T

G

G

R

K

L

L

F

W

A

G

I

Y

E

E

H

H

W

L

N

G

V

V

T

E

P

P

D

D

I

I

I

F

T

T

T

S

A

A

K
|
K

G

G

I

L

A

A

S

G

G

G

M

V

P

P

L

I

G

G

A

A

I

M

L

M

A

C

R

K

A

K

E

F

L

C

M

D

T

V

W

F

P

E

P

P

G

G

S

N

H

H

A

A

T

S

T
|
T

F

F

G

G

N

N

P

P

V

L

A

A

C

C

A

A

G

G

I

L

V

A

T

V

L

L

K

K

L

T

L

I

E

E

S

G

G

D

-

R

L

L

M

L

D

D

N

N

A

V

T

Q

Q

A

M

R

G

G

E

E

L

Q

L

L

Q

R

T

S

G

G

L

L

T

A

Q

E

L

I

H

K

Q

N

Q

Q

F

Y

P

P

R

T

M

L

-

F

S

T

L

E

P

V

R

R

G

G

K

W

G

G

L

L

M

I

V

N

A

G

V

L

D

E

L

I

L

S

D

A

E

E

D

-

G

-

N

-

F

-

D

S

S

S

K

L

L

T

R

S

D

V

R

E

I

I

I

V

Q

K

E

A

A

A

F

M

Y

E

H

Q

G

G

L

L

L

A

G

P

C

A

G

G

K

P

A

K

A

V

I

L

R
|
R

F

F

C

V

P

P

L

L

V

V

I

V

N

T

R

E

E

A

Q

E

I

I

Q

A

T

Q

T

A

L

V

D

E

I

I

L

L

A

R

E

Q

I

A

L

I

Y39 (= Y40) mutation to F: Retains 7.4% of N-acetylornithine aminotransferase wild-type activity.
S125 (= S131) mutation to A: Retains 14% of N-acetylornithine aminotransferase wild-type activity.
G126 (= G132) mutation to A: Loss of N-acetylornithine aminotransferase activity.
A127 (= A133) mutation to S: Retains 9.1% of N-acetylornithine aminotransferase wild-type activity.
R163 (= R162) mutation to A: 4100-fold increase in KM for acetylornithine, but does not affect KM for 2-oxoglutarate. Retains 9.5% of N-acetylornithine aminotransferase wild-type activity.
E223 (= E226) mutation to A: 65-fold increase in KM for acetylornithine, but does not affect KM for 2-oxoglutarate. Retains 50% of N-acetylornithine aminotransferase wild-type activity.; mutation to S: 73-fold increase in KM for acetylornithine, but does not affect KM for 2-oxoglutarate. Shows 160% of N-acetylornithine aminotransferase wild-type activity.
D251 (= D254) mutation to A: Loss of N-acetylornithine aminotransferase activity.; mutation to E: Retains 20% of N-acetylornithine aminotransferase wild-type activity.
Q254 (= Q257) mutation to A: Retains 0.9% of N-acetylornithine aminotransferase wild-type activity.
K280 (= K283) mutation to A: Loss of N-acetylornithine aminotransferase activity.
T308 (= T311) mutation to A: Retains 0.3% of N-acetylornithine aminotransferase wild-type activity.
R402 (= R407) mutation to A: 2080-fold increase in KM for acetylornithine, but does not affect KM for 2-oxoglutarate. Retains 18% of N-acetylornithine aminotransferase wild-type activity.

8ht4B Crystal structure of acetylornithine aminotransferase complex with plp from corynebacterium glutamicum (see paper)
43% identity, 90% coverage: 45:430/431 of query aligns to 18:389/390 of 8ht4B

query
sites
8ht4B

P

P

L

V

V

E

V

L

N

V

R

S

G

G

E

K

G

G

C

A

M

T

V

V

E

T

D

D

V

D

D

Q

G

G

N

N

V

V

F

Y

L

I

D

D

M

L

T

L

A

A

G

G

I

I

A

A

V

V

T

N

A

A

T

L

G

G

H

H

A

A

H

H

P

P

E

A

V

I

R

E

A

A

I

V

Q

T

E

N

Q

Q

S

I

A

G

R

Q

L

L

I

G

H

H

M

V

S

S

G

N

T

L

D

-

F

F

Y

A

Y

S

E

R

P

P

M

V

V

V

E

E

L

V

A

A

E

E

N

E

L

L

A

I

S

K

Q

R

-

F

-

S

-

L

-

D

A

A

P

T

F

L

V

A

H

A

D

Q

T

T

K

R

V

V

F

F

T

C

N

N

S
|
S

G
|
G

A
|
A

E

E

S

A

N

N

E

E

G

A

A

A

I

F

K

K

L

I

A

A

R

R

Y

L

Y

-

T

T

K

G

R

R

S

S

L

R

I

I

I

L

A

A

F

A

L

V

G

H

A

G

F
|
F

H
|
H

G

G

R

R

T

T

Y

M

G

G

A

S

M

L

S

A

L

L

T

T

G

G

S

Q

K

P

T

D

V

-

Q

K

R

R

A

E

N

A

F

F

G

L

P

P

L

M

V

P

P

S

G

G

V

V

T

E

H

F

I

Y

P

P

Y

Y

G

G

T

-

H

-

A

-

S

D

L

T

D

D

Y

Y

L

L

E

R

N

K

N

M

L

V

L

E

T

T

T

N

I

-

P

-

A

P

H

T

E

D

V

V

A

A

I

I

V

F

V

L

E
|
E

P

P

I

I

Q

Q

G

G

E

E

G

T

G

G

Y

V

I

V

V

P

P

A

E

P

D

E

G

G

F

F

L

L

Q

K

R

A

I

V

R

R

N

E

I

L

C

C

D

D

R

E

Y

Y

G

G

I

I

L

L

M

M

V

I

V

T

D
|
D

E

E

V
|
V

Q
|
Q

S

T

G

G

M

V

G

G

R

R

T

T

G

G

R

D

L

F

F

F

A

A

I

H

E

Q

H

H

W

D

N

G

V

V

T

V

P

P

D

D

I

V

T

T

T

M

A

A

K
|
K

G

G

I

L

A

G

S

G

G

G

M

L

P

P

L

I

G

G

A

A

I

C

L

L

A

A

R

T

-

G

-

R

-

A

A

A

E

E

L

L

M

M

T

T

W

-

P

-

P

P

G

G

S

K

H

H

A

G

T

T

F

F

G

G

N

N

P

P

V

V

A

A

C

C

A

A

G

A

I

K

V

A

T

V

L

L

K

S

L

V

E

D

S

D

G

A

L

F

M

C

D

A

N

E

A

V

T

A

Q

R

M

K

G

G

E

E

L

L

L

F

Q

K

T

-

G

-

L

-

T

-

Q

E

L

L

H

L

Q

A

Q

K

F

V

P

D

R

G

M

V

S

V

L

D

P

V

R

R

G

G

K

R

G

G

L

L

M

M

V

L

A

G

V

V

D

-

L

V

L

L

D

E

E

R

D

D

G

-

N

-

F

-

D

-

S

-

K

-

L

V

R

A

D

K

R

Q

I

A

I

V

Q

L

E

D

A

G

F

F

Y

K

H

H

G

G

L

V

L

I

L

L

L

N

G

A

C

P

G

A

K

D

A

N

A

I

I

I

R

R

F

L

C

T

P

P

L

L

V

V

I

I

N

T

R

D

E

E

Q

E

I

I

Q

A

T

D

T

A

L

V

D

K

I

A

L

I

A

A

E

E

I

T

L

I

binding pyridoxal-5'-phosphate: S108 (= S131), G109 (= G132), A110 (= A133), F135 (= F159), H136 (= H160), E190 (= E221), D223 (= D254), V225 (= V256), Q226 (= Q257), K252 (= K283)

1sffA Structure of gamma-aminobutyrate aminotransferase complex with aminooxyacetate (see paper)
38% identity, 94% coverage: 26:430/431 of query aligns to 4:420/425 of 1sffA

query
sites
1sffA

K

K

A

E

I

L

V

M

E

Q

R

R

D

R

R

S

A

Q

V

A

T

I

S

P

P

R

S

G

Y
x
V

T

G

R

Q

D

I

Y

H

P

P

L

I

V

F

V

A

N

D

R

R

G

A

E

E

G

N

C

C

M

R

V

V

E

W

D

D

V

V

D

E

G

G

N

R

V

E

F

Y

L

L

D

D

M

F

T

A

A

G

G

G

I

I

A

A

V

V

T

L

A

N

T

T

G

G

H

H

A

L

H

H

P

P

E

K

V

V

R

A

A

A

I

V

Q

E

E

A

Q

Q

S

L

A

K

R

K

L

L

I

S

H

H

M

T

S

C

G

F

T
x
Q

D

V

F

L

Y

A

Y

Y

E

E

P

P

M

Y

V

L

E

E

L

L

A

C

E

E

N

I

L

M

A

N

S

Q

Q

K

A

V

P

P

F

G

V

D

H

F

D

A

T

K

K

K

V

T

F

L

T

V

N

T

S

T

G
|
G

A
x
S

E

E

S

A

N

V

E

E

G

N

A

A

I

V

K

K

L

I

A

A

R

R

Y

A

T

T

K

K

R

R

S

S

L

G

I

T

I

I

A

A

F

F

L

S

G

G

A

A

F
x
Y

H
|
H

G

G

R
|
R

T

T

Y

H

G

Y

A

T

M

L

S

A

L

L

T

T

G

G

S

K

K

V

T
x
N

V

P

Q

Y

R

S

A

A

N

G

F

M

G

G

P

-

L

L

V

M

P

P

G

G

V

H

T

V

H

Y

-

R

-

A

-

L

I

Y

P

P

Y

C

G

P

T

L

H

H

A

G

S

-

L

-

D

-

Y

I

L

S

E

E

N

D

L

A

L

I

T

A

T

S

I

I

-

H

-

R

-

I

-

F

-

K

-

N

-

D

I

A

P

A

A

P

H

E

E

D

V

I

A

A

I

I

V

V

V

I

E
|
E

P

P

I

V

Q

Q

G

G

E

E

G

G

Y

F

I

Y

V

A

P

S

E

S

D

P

G

A

F

F

L

M

Q

Q

R

R

I

L

R

R

N

A

I

L

C

C

D

D

R

E

Y

H

G

G

I

I

L

M

M

L

V

I

V

A

D
|
D

E

E

V
|
V

Q
|
Q

S

S

G

G

M

A

G

G

R

R

T

T

G

G

R

T

L

L

F

F

A

A

I

M

E

E

H

Q

W

M

N

G

V

V

T

A

P

P

D

D

I

L

I

T

T

T

T

F

A

A

K
|
K

G

S

I

I

A

A

S

G

G

G

M

F

P

P

L

L

G

A

A

G

I

V

L

T

A

G

R

R

A

A

E

E

L

V

M

M

-

D

T

A

W

V

P

A

P

P

G

G

S

G

H

L

A

G

T

G

T
|
T

F

Y

G

A

G

G

N

N

P

P

V

I

A

A

C

C

A

V

A

A

G

A

I

L

V

E

T

V

L

L

K

K

L

V

L

F

E

E

-

Q

S

E

G

N

L

L

M

L

D

Q

N

K

A

A

T

N

Q

D

M

L

G

G

E

Q

L

K

L

L

Q

K

T

D

G

G

L

L

T

L

Q

A

L

I

H

A

Q

E

Q

K

F

H

P

P

R

E

M

I

S

G

L

D

P

V

R

R

G

G

K

L

G

G

L

A

M

M

V

I

A

A

V

I

D

E

L

L

L

F

D

-

E

E

D

D

G

G

N

D

F

H

-

N

-

K

-

P

D

D

S

A

K

K

L

L

R

T

D

A

R

E

I

I

I

V

Q

A

E

R

A

A

F

R

Y

D

H

K

G

G

L

L

L

I

L

L

G

S

C

C

G

G

K

P

-

Y

-
x
Y

A

N

A

V

I

L

R
|
R

F

I

C

L

P

V

P

P

L

L

V

T

I

I

N

E

R

D

E

A

Q

Q

I

I

Q

R

T

Q

T

G

L

L

D

E

I

I

L

I

A

S

E

Q

I

C

L

F

active site: V18 (≠ Y40), Y137 (≠ F159), E205 (= E221), D238 (= D254), Q241 (= Q257), K267 (= K283), T296 (= T311), R397 (= R407)
binding 4'-deoxy-4'-acetylyamino-pyridoxal-5'-phosphate: Q78 (≠ T100), G110 (= G132), S111 (≠ A133), Y137 (≠ F159), H138 (= H160), R140 (= R162), E205 (= E221), D238 (= D254), V240 (= V256), Q241 (= Q257), K267 (= K283), T296 (= T311)
binding sulfate ion: N152 (≠ T174), Y393 (vs. gap)

1sf2A Structure of e. Coli gamma-aminobutyrate aminotransferase (see paper)
38% identity, 94% coverage: 26:430/431 of query aligns to 4:420/425 of 1sf2A

query
sites
1sf2A

K

K

A

E

I

L

V

M

E

Q

R

R

D

R

R

S

A

Q

V

A

T

I

S

P

P

R

S

G

Y
x
V

T

G

R

Q

D

I

Y

H

P

P

L

I

V

F

V

A

N

D

R

R

G

A

E

E

G

N

C

C

M

R

V

V

E

W

D

D

V

V

D

E

G

G

N

R

V

E

F

Y

L

L

D

D

M

F

T

A

A

G

G

G

I

I

A

A

V

V

T

L

A

N

T

T

G

G

H

H

A

L

H

H

P

P

E

K

V

V

R

A

A

A

I

V

Q

E

E

A

Q

Q

S

L

A

K

R

K

L

L

I

S

H

H

M

T

S

C

G

F

T

Q

D

V

F

L

Y

A

Y

Y

E

E

P

P

M

Y

V

L

E

E

L

L

A

C

E

E

N

I

L

M

A

N

S

Q

Q

K

A

V

P

P

F

G

V

D

H

F

D

A

T

K

K

K

V

T

F

L

T

V

N

T

S

T

G
|
G

A
x
S

E

E

S

A

N

V

E

E

G

N

A

A

I

V

K

K

L

I

A

A

R

R

Y

A

T

T

K

K

R

R

S

S

L

G

I

T

I

I

A

A

F

F

L

S

G

G

A

A

F
x
Y

H
|
H

G

G

R

R

T

T

Y

H

G

Y

A

T

M

L

S

A

L

L

T

T

G

G

S

K

K

V

T
x
N

V

P

Q

Y

R

S

A

A

N

G

F

M

G

G

P

-

L

L

V

M

P

P

G

G

V

H

T

V

H

Y

-

R

-

A

-

L

I

Y

P

P

Y

C

G

P

T

L

H

H

A

G

S

-

L

-

D

-

Y

I

L

S

E

E

N

D

L

A

L

I

T

A

T

S

I

I

-

H

-

R

-

I

-

F

-

K

-

N

-

D

I

A

P

A

A

P

H

E

E

D

V

I

A

A

I

I

V

V

V

I

E
|
E

P

P

I

V

Q

Q

G

G

E

E

G

G

Y

F

I

Y

V

A

P

S

E

S

D

P

G

A

F

F

L

M

Q

Q

R

R

I

L

R

R

N

A

I

L

C

C

D

D

R

E

Y

H

G

G

I

I

L

M

M

L

V

I

V

A

D
|
D

E

E

V
|
V

Q
|
Q

S

S

G

G

M

A

G

G

R

R

T

T

G

G

R

T

L

L

F

F

A

A

I

M

E

E

H

Q

W

M

N

G

V

V

T

A

P

P

D

D

I

L

I

T

T

T

T

F

A

A

K
|
K

G

S

I

I

A

A

S

G

G

G

M

F

P

P

L

L

G

A

A

G

I

V

L

T

A

G

R

R

A

A

E

E

L

V

M

M

-

D

T

A

W

V

P

A

P

P

G

G

S

G

H

L

A

G

T

G

T
|
T

F

Y

G

A

G

G

N

N

P

P

V

I

A

A

C

C

A

V

A

A

G

A

I

L

V

E

T

V

L

L

K

K

L

V

L

F

E

E

-

Q

S

E

G

N

L

L

M

L

D

Q

N

K

A

A

T

N

Q

D

M

L

G

G

E

Q

L

K

L

L

Q

K

T

D

G

G

L

L

T

L

Q

A

L

I

H

A

Q

E

Q

K

F

H

P

P

R

E

M

I

S

G

L

D

P

V

R

R

G

G

K

L

G

G

L

A

M

M

V

I

A

A

V

I

D

E

L

L

L

F

D

-

E

E

D

D

G

G

N

D

F

H

-

N

-

K

-

P

D

D

S

A

K

K

L

L

R

T

D

A

R

E

I

I

I

V

Q

A

E

R

A

A

F

R

Y

D

H

K

G

G

L

L

L

I

L

L

G

S

C

C

G

G

K

P

-

Y

-
x
Y

A

N

A

V

I

L

R
|
R

F

I

C

L

P

V

P

P

L

L

V

T

I

I

N

E

R

D

E

A

Q

Q

I

I

Q

R

T

Q

T

G

L

L

D

E

I

I

L

I

A

S

E

Q

I

C

L

F

active site: V18 (≠ Y40), Y137 (≠ F159), E205 (= E221), D238 (= D254), Q241 (= Q257), K267 (= K283), T296 (= T311), R397 (= R407)
binding pyridoxal-5'-phosphate: G110 (= G132), S111 (≠ A133), Y137 (≠ F159), H138 (= H160), E205 (= E221), D238 (= D254), V240 (= V256), Q241 (= Q257), K267 (= K283)
binding sulfate ion: N152 (≠ T174), Y393 (vs. gap)

P22256 4-aminobutyrate aminotransferase GabT; 5-aminovalerate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT; EC 2.6.1.19; EC 2.6.1.48 from Escherichia coli (strain K12) (see 2 papers)
38% identity, 94% coverage: 26:430/431 of query aligns to 5:421/426 of P22256

query
sites
P22256

K

K

A

E

I

L

V

M

E

Q

R

R

D

R

R

S

A

Q

V

A

T

I

S

P

P

R

S

G

Y

V

T

G

R

Q

D

I

Y

H

P

P

L

I

V

F

V

A

N

D

R

R

G

A

E

E

G

N

C

C

M

R

V

V

E

W

D

D

V

V

D

E

G

G

N

R

V

E

F

Y

L

L

D

D

M

F

T

A

A

G

G

G

I
|
I

A

A

V

V

T

L

A

N

T

T

G

G

H

H

A

L

H

H

P

P

E

K

V

V

R

A

A

A

I

V

Q

E

E

A

Q

Q

S

L

A

K

R

K

L

L

I

S

H

H

M

T

S

C

G

F

T

Q

D

V

F

L

Y

A

Y

Y

E

E

P

P

M

Y

V

L

E

E

L

L

A

C

E

E

N

I

L

M

A

N

S

Q

Q

K

A

V

P

P

F

G

V

D

H

F

D

A

T

K

K

K

V

T

F

L

T

V

N

T

S

T

G
|
G

A
x
S

E

E

S

A

N

V

E

E

G

N

A

A

I

V

K

K

L

I

A

A

R

R

Y

A

T

T

K

K

R

R

S

S

L

G

I

T

I

I

A

A

F

F

L

S

G

G

A

A

F

Y

H

H

G

G

R

R

T

T

Y

H

G

Y

A

T

M

L

S

A

L

L

T

T

G

G

S

K

K

V

T

N

V

P

Q

Y

R

S

A

A

N

G

F

M

G

G

P

-

L

L

V

M

P

P

G

G

V

H

T

V

H

Y

-

R

-

A

-

L

I

Y

P

P

Y

C

G

P

T

L

H

H

A

G

S

-

L

-

D

-

Y

I

L

S

E

E

N

D

L

A

L

I

T

A

T

S

I

I

-

H

-

R

-

I

-

F

-

K

-

N

-

D

I

A

P

A

A

P

H

E

E

D

V

I

A

A

I

I

V

V

V

I

E

E

P

P

I

V

Q

Q

G

G

E
|
E

G

G

Y

F

I

Y

V

A

P

S

E

S

D

P

G

A

F

F

L

M

Q

Q

R

R

I

L

R

R

N

A

I

L

C

C

D

D

R

E

Y

H

G

G

I

I

L

M

M

L

V

I

V

A

D

D

E

E

V
|
V

Q
|
Q

S

S

G

G

M

A

G

G

R

R

T

T

G

G

R

T

L

L

F

F

A

A

I

M

E

E

H

Q

W

M

N

G

V

V

T

A

P

P

D

D

I

L

I

T

T

T

T

F

A

A

K
|
K

G

S

I

I

A

A

S

G

G

G

M

F

P

P

L

L

G

A

A

G

I

V

L

T

A

G

R

R

A

A

E

E

L

V

M

M

-

D

T

A

W

V

P

A

P

P

G

G

S

G

H

L

A

G

T

G

T
|
T

F

Y

G

A

G

G

N

N

P

P

V

I

A

A

C

C

A

V

A

A

G

A

I

L

V

E

T

V

L

L

K

K

L

V

L

F

E

E

-

Q

S

E

G

N

L

L

M

L

D

Q

N

K

A

A

T

N

Q

D

M

L

G

G

E

Q

L

K

L

L

Q

K

T

D

G

G

L

L

T

L

Q

A

L

I

H

A

Q

E

Q

K

F

H

P

P

R

E

M

I

S

G

L

D

P

V

R

R

G

G

K

L

G

G

L

A

M

M

V

I

A

A

V

I

D

E

L

L

L

F

D

-

E

E

D

D

G

G

N

D

F

H

-

N

-

K

-

P

D

D

S

A

K

K

L

L

R

T

D

A

R

E

I

I

I

V

Q

A

E

R

A

A

F

R

Y

D

H

K

G

G

L

L

L

I

L

L

G

S

C

C

G

G

K

P

-

Y

A

N

A

V

I

L

R

R

F

I

C

L

P

V

P

P

L

L

V

T

I

I

N

E

R

D

E

A

Q

Q

I

I

Q

R

T

Q

T

G

L

L

D

E

I

I

L

I

A

S

E

Q

I

C

L

F

I50 (= I71) mutation to Q: 3-fold decrease in catalytic activity and 12-fold decrease in affinity for GABA.
GS 111:112 (≠ GA 132:133) binding pyridoxal 5'-phosphate
E211 (= E226) mutation to S: 100-fold decrease in catalytic activity and 15-fold decrease in affinity for GABA.
V241 (= V256) mutation to A: 25-fold decrease in catalytic activity and 5-fold decrease in affinity for GABA.
Q242 (= Q257) binding pyridoxal 5'-phosphate
K268 (= K283) modified: N6-(pyridoxal phosphate)lysine
T297 (= T311) binding pyridoxal 5'-phosphate

1szkA The structure of gamma-aminobutyrate aminotransferase mutant: e211s (see paper)
38% identity, 94% coverage: 26:430/431 of query aligns to 4:420/425 of 1szkA

query
sites
1szkA

K

K

A

E

I

L

V

M

E

Q

R

R

D

R

R

S

A

Q

V

A

T

I

S

P

P

R

S

G

Y
x
V

T

G

R

Q

D

I

Y

H

P

P

L

I

V

F

V

A

N

D

R

R

G

A

E

E

G

N

C

C

M

R

V

V

E

W

D

D

V

V

D

E

G

G

N

R

V

E

F

Y

L

L

D

D

M

F

T

A

A

G

G

G

I

I

A

A

V

V

T

L

A

N

T

T

G

G

H

H

A

L

H

H

P

P

E

K

V

V

R

A

A

A

I

V

Q

E

E

A

Q

Q

S

L

A

K

R

K

L

L

I

S

H

H

M

T

S

C

G

F

T

Q

D

V

F

L

Y

A

Y

Y

E

E

P

P

M

Y

V

L

E

E

L

L

A

C

E

E

N

I

L

M

A

N

S

Q

Q

K

A

V

P

P

F

G

V

D

H

F

D

A

T

K

K

K

V

T

F

L

T

V

N

T

S

T

G
|
G

A
x
S

E

E

S

A

N

V

E

E

G

N

A

A

I

V

K

K

L

I

A

A

R

R

Y

A

T

T

K

K

R

R

S

S

L

G

I

T

I

I

A

A

F

F

L

S

G

G

A

A

F
x
Y

H
|
H

G

G

R

R

T

T

Y

H

G

Y

A

T

M

L

S

A

L

L

T

T

G

G

S

K

K

V

T

N

V

P

Q

Y

R

S

A

A

N

G

F

M

G

G

P

-

L

L

V

M

P

P

G

G

V

H

T

V

H

Y

-

R

-

A

-

L

I

Y

P

P

Y

C

G

P

T

L

H

H

A

G

S

-

L

-

D

-

Y

I

L

S

E

E

N

D

L

A

L

I

T

A

T

S

I

I

-

H

-

R

-

I

-

F

-

K

-

N

-

D

I

A

P

A

A

P

H

E

E

D

V

I

A

A

I

I

V

V

V

I

E
|
E

P

P

I

V

Q

Q

G

G

E

S

G

G

Y

F

I

Y

V

A

P

S

E

S

D

P

G

A

F

F

L

M

Q

Q

R

R

I

L

R

R

N

A

I

L

C

C

D

D

R

E

Y

H

G

G

I

I

L

M

M

L

V

I

V

A

D
|
D

E

E

V
|
V

Q
|
Q

S

S

G

G

M

A

G

G

R

R

T

T

G

G

R

T

L

L

F

F

A

A

I

M

E

E

H

Q

W

M

N

G

V

V

T

A

P

P

D

D

I

L

I

T

T

T

T

F

A

A

K
|
K

G

S

I

I

A

A

S

G

G

G

M

F

P

P

L

L

G

A

A

G

I

V

L

T

A

G

R

R

A

A

E

E

L

V

M

M

-

D

T

A

W

V

P

A

P

P

G

G

S

G

H

L

A

G

T

G

T
|
T

F

Y

G

A

G

G

N

N

P

P

V

I

A

A

C

C

A

V

A

A

G

A

I

L

V

E

T

V

L

L

K

K

L

V

L

F

E

E

-

Q

S

E

G

N

L

L

M

L

D

Q

N

K

A

A

T

N

Q

D

M

L

G

G

E

Q

L

K

L

L

Q

K

T

D

G

G

L

L

T

L

Q

A

L

I

H

A

Q

E

Q

K

F

H

P

P

R

E

M

I

S

G

L

D

P

V

R

R

G

G

K

L

G

G

L

A

M

M

V

I

A

A

V

I

D

E

L

L

L

F

D

-

E

E

D

D

G

G

N

D

F

H

-

N

-

K

-

P

D

D

S

A

K

K

L

L

R

T

D

A

R

E

I

I

I

V

Q

A

E

R

A

A

F

R

Y

D

H

K

G

G

L

L

L

I

L

L

G

S

C

C

G

G

K

P

-

Y

A

N

A

V

I

L

R
|
R

F

I

C

L

P

V

P

P

L

L

V

T

I

I

N

E

R

D

E

A

Q

Q

I

I

Q

R

T

Q

T

G

L

L

D

E

I

I

L

I

A

S

E

Q

I

C

L

F

active site: V18 (≠ Y40), Y137 (≠ F159), E205 (= E221), D238 (= D254), Q241 (= Q257), K267 (= K283), T296 (= T311), R397 (= R407)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G110 (= G132), S111 (≠ A133), Y137 (≠ F159), H138 (= H160), E205 (= E221), D238 (= D254), V240 (= V256), Q241 (= Q257), K267 (= K283)

P50457 4-aminobutyrate aminotransferase PuuE; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; EC 2.6.1.19 from Escherichia coli (strain K12) (see paper)
41% identity, 88% coverage: 52:430/431 of query aligns to 30:419/421 of P50457

query
sites
P50457

E

E

G

N

C

A

M

T

V

L

E

K

D

D

V

V

D

E

G

G

N

N

V

E

F

Y

L

I

D

D

M

F

T

A

A

A

G

G

I

I

A

A

V

V

T

L

A

N

T

T

G

G

H

H

A

R

H

H

P

P

E

D

V

L

V

V

R

A

A

A

I

V

Q

E

E

Q

Q

Q

S

L

A

Q

R

Q

L

F

I

T

H

H

M

T

S

A

G

Y

T

Q

D

I

F

V

Y

P

Y

Y

E

E

P

S

M

Y

V

V

E

T

L

L

A

A

E

E

N

K

L

I

A

N

S

A

Q

L

A

A

P

P

F

V

V

S

H

G

D

Q

T

A

K

K

V

T

F

A

F

F

T

F

N

T

S

T

G

G

A

A

E

E

S

A

N

V

E

E

G

N

A

A

I

V

K

K

L

I

A

A

R

R

Y

A

Y

H

T

T

K

G

R

R

S

P

L

G

I

V

I

I

A

A

F

F

L

S

G

G

A

G

F

F

H

H

G

G

R

R

T

T

Y

Y

G

M

A

T

M

M

S

A

L

L

T

T

G

G

S

K

K

V

T

A

V

P

Q

Y

R

K

A

I

N

G

F

F

G

G

P

P

L

F

V

P

P

G

G

S

V

V

T

Y

H

H

I

V

P

P

Y

Y

-

P

-

S

-

D

-

L

-

H

-

G

-

I

G

S

T

T

H

Q

A

D

S

S

L

L

D

D

Y

A

L

I

E

E

N

-

N

R

L

L

L

F

T

K

T

S

I

D

I

I

P

E

A

A

H

K

E

Q

V

V

A

A

I

I

V

I

V

F

E

E

P

P

I

V

Q

Q

G

G

E

E

G

G

Y

F

I

N

V

V

P

A

E

P

D

K

G

E

F

L

L

V

Q

A

R

A

I

I

R

R

N

R

I

L

C

C

D

D

R

E

Y

H

G

G

I

I

L

V

M

M

V

I

V

A

D

D

E

E

V

V

Q

Q

S

S

G

G

M

F

G

A

R

R

T

T

G

G

R

K

L

L

F

F

A

A

I

M

E

D

H

H

W

Y

N

A

V

D

T

K

P

P

D

D

I

L

I

M

T

T

T

M

A

A

K
|
K

G

S

I

L

A

A

S

G

G

G

M

M

P

P

L

L

G

S

A

G

I

V

L

V

A

G

R

N

A

A

E

N

L

I

M

M

T

D

W

A

P

P

-

A

P

P

G

G

S

G

H

L

A

G

T

G

T

T

F

Y

G

A

G

G

N

N

P

P

V

L

A

A

C

V

A

A

G

A

I

H

V

A

T

V

L

L

K

N

L

I

E

D

S

K

-

E

G

S

L

L

M

C

D

E

N

R

A

A

T

N

Q

Q

M

L

G

G

E

Q

L

R

L

L

Q

K

T

N

G

T

L

L

T

I

Q

D

L

A

H

K

Q

E

Q

S

F

V

P

P

R

A

M

I

S

A

L

A

P

V

R

R

G

G

K

L

G

G

L

S

M

M

V

I

A

A

V

V

D

E

L

F

L

N

D

D

-

P

E

Q

D

T

G

G

N

E

F

P

D

S

S

A

K

A

L

I

R

A

D

Q

R

K

I

I

I

Q

Q

Q

E

R

A

A

F

L

Y

A

H

Q

G

G

L

L

G

T

C

C

G

G

K

A

A

Y

A

G

-

N

-

V

I

I

R

R

F

F

C

L

P

Y

P

P

L

L

V

T

I

I

N

P

R

D

E

A

Q

Q

I

F

Q

D

T

A

L

M

D

K

I

I

L

L

A

Q

E

D

I

A

L

L

K267 (= K283) mutation to A: No GABA-AT activity.

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
38% identity, 91% coverage: 39:431/431 of query aligns to 6:383/385 of Q9X2A5

query
sites
Q9X2A5

S

T

Y

Y

T

S

R

R

D

-

Y

F

P

P

L

A

V

T

V

F

N

V

R

Y

G

G

E

K

G

G

C

S

M

W

V

I

E

Y

D

D

V

E

D

K

G

G

N

N

V

A

F

Y

L

L

D

D

M

F

T

T

A

S

G

G

I

I

A

A

V

V

T

N

A

V

T

L

G

G

H

H

A

S

H

H

P

P

E

R

V

L

V

V

R

E

A

A

I

I

Q

K

E

D

Q

Q

S

A

A

E

R

K

L

L

I

I

H

H

M

C

S

S

G

N

T

L

D

-

F

F

Y

W

Y

N

E

R

P

P

M

Q

V

M

E

E

L

L

A

A

E

E

N

-

L

L

A

L

S

S

Q

K

A

N

P

T

F

F

V

-

H

-

D

G

T

G

K

K

V

V

F

F

T

A

N

N

S

T

G
|
G

A
x
T

E

E

S

A

N

N

E

E

G

A

A

A

I

I

K

K

L

I

A

A

R

R

Y

K

Y

Y

T

G

K

K

R

K

S

K

L

S

-

E

-

K

-

Y

-

R

I

I

I

L

A

S

F

A

L

H

G

N

A

S

F

F

H

H

G

G

R

R

T

T

Y

L

G

G

A

S

M

L

S

T

L

A

T

T

G

G

S

Q

K

P

T

K

V

Y

Q

Q

R

K

A

P

N

-

F

F

G

E

P

P

L

L

V

V

P

P

G

G

V

F

T

E

H

Y

I

F

P

E

Y

F

G

N

T

-

H

-

A

-

S

N

L

V

D

E

Y

D

L

L

E

R

N

R

N

K

L

M

L

-

T

-

I

-

P

-

A

S

H

E

E

D

V

V

A

C

A

A

I

V

V

F

V

L

E

E

P

P

I

I

Q

Q

G

G

E

E

G

S

G

G

Y

I

I

V

V

P

P

A

E

T

D

K

G

E

F

F

L

L

Q

E

R

E

I

A

R

R

N

K

I

L

C

C

D

D

R

E

Y

Y

G

D

I

A

L

L

M

L

V

V

V

F

D

D

E

E

V

V

Q

Q

S

C

G

G

M

M

G

G

R

R

T

T

G

G

R

K

L

L

F

F

A

A

I

Y

E

Q

H

K

W

Y

N

G

V

V

T

V

P

P

D

D

I

V

I

L

T

T

A

A

K

K

G

G

I

L

A

G

S

G

G

G

M

V

P

P

L

I

G

G

A

A

I

V

L

I

A

V

R

N

A

E

E

R

L

A

M

N

T

V

W

L

P

E

P

P

G

G

S

D

H

H

A

G

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

A

A

C

C

A

R

A

A

G

G

I

V

V

T

T

V

L

I

K

K

-

E

L

L

L

T

E

K

S

E

G

G

L

F

M

L

D

E

N

E

A

V

T

E

Q

E

M

K

G

G

E

N

L

Y

L

L

Q

M

T

K

G

K

L

L

T

Q

Q

E

L

M

H

K

Q

E

F

Y

P

D

R

V

M

V

S

A

L

D

P

V

R

R

G

G

K

M

G

G

L

L

M

M

V

I

A

G

V

I

D

Q

L

F

L

R

D

E

E

E

D

V

G

S

N

N

F

R

D

E

S

-

K

-

L

-

R

-

D

-

R

-

I

V

I

A

Q

T

E

K

A

C

F

F

Y

E

H

N

G

K

L

L

L

V

G

P

C

A

G

G

K

N

A

N

A

T

I

I

R

R

F

F

C

L

P

P

L

L

V

T

I

V

N

E

R

Y

E

G

Q

E

I

I

Q

D

T

L

T

A

L

V

D

E

I

T

L

L

A

K

E

K

I

V

L

L

R

Q

GT 94:95 (≠ GA 132:133) binding pyridoxal 5'-phosphate
T268 (= T311) binding pyridoxal 5'-phosphate

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
38% identity, 91% coverage: 39:431/431 of query aligns to 14:391/393 of 2ordA

query
sites
2ordA

S

T

Y

Y

T

S

R

R

D

-

Y

F

P

P

L

A

V

T

V

F

N

V

R

Y

G

G

E

K

G

G

C

S

M

W

V

I

E

Y

D

D

V

E

D

K

G

G

N

N

V

A

F

Y

L

L

D

D

M

F

T

T

A

S

G

G

I

I

A

A

V

V

T

N

A

V

T

L

G

G

H

H

A

S

H

H

P

P

E

R

V

L

V

V

R

E

A

A

I

I

Q

K

E

D

Q

Q

S

A

A

E

R

K

L

L

I

I

H

H

M

C

S

S

G

N

T

L

D

-

F

F

Y

W

Y

N

E

R

P

P

M

Q

V

M

E

E

L

L

A

A

E

E

N

-

L

L

A

L

S

S

Q

K

A

N

P

T

F

F

V

-

H

-

D

G

T

G

K

K

V

V

F

F

T

A

N

N

S

T

G
|
G

A
x
T

E

E

S

A

N

N

E

E

G

A

A

A

I

I

K

K

L

I

A

A

R

R

Y

K

Y

Y

T

G

K

K

R

K

S

K

L

S

-

E

-

K

-

Y

-

R

I

I

I

L

A

S

F

A

L

H

G

N

A

S

F
|
F

H
|
H

G

G

R

R

T

T

Y

L

G

G

A

S

M

L

S

T

L

A

T

T

G

G

S

Q

K

P

T

K

V

Y

Q

Q

R

K

A

P

N

-

F

F

G

E

P

P

L

L

V

V

P

P

G

G

V

F

T

E

H

Y

I

F

P

E

Y

F

G

N

T

-

H

-

A

-

S

N

L

V

D

E

Y

D

L

L

E

R

N

R

N

K

L

M

L

-

T

-

I

-

P

-

A

S

H

E

E

D

V

V

A

C

A

A

I

V

V

F

V

L

E
|
E

P

P

I

I

Q

Q

G

G

E

E

G

S

G

G

Y

I

I

V

V

P

P

A

E

T

D

K

G

E

F

F

L

L

Q

E

R

E

I

A

R

R

N

K

I

L

C

C

D

D

R

E

Y

Y

G

D

I

A

L

L

M

L

V

V

V

F

D
|
D

E

E

V
|
V

Q
|
Q

S

C

G

G

M

M

G

G

R

R

T

T

G

G

R

K

L

L

F

F

A

A

I

Y

E

Q

H

K

W

Y

N

G

V

V

T

V

P

P

D

D

I

V

I

L

T

T

A

A

K
|
K

G

G

I

L

A

G

S

G

G

G

M

V

P

P

L

I

G

G

A

A

I

V

L

I

A

V

R

N

A

E

E

R

L

A

M

N

T

V

W

L

P

E

P

P

G

G

S

D

H

H

A

G

T

T

T
|
T

F

F

G

G

N

N

P

P

V

L

A

A

C

C

A

R

A

A

G

G

I

V

V

T

T

V

L

I

K

K

-

E

L

L

L

T

E

K

S

E

G

G

L

F

M

L

D

E

N

E

A

V

T

E

Q

E

M

K

G

G

E

N

L

Y

L

L

Q

M

T

K

G

K

L

L

T

Q

Q

E

L

M

H

K

Q

E

F

Y

P

D

R

V

M

V

S

A

L

D

P

V

R

R

G

G

K

M

G

G

L

L

M

M

V

I

A

G

V

I

D

Q

L

F

L

R

D

E

E

E

D

V

G

S

N

N

F

R

D

E

S

-

K

-

L

-

R

-

D

-

R

-

I

V

I

A

Q

T

E

K

A

C

F

F

Y

E

H

N

G

K

L

L

L

V

G

P

C

A

G

G

K

N

A

N

A

T

I

I

R
|
R

F

F

C

L

P

P

L

L

V

T

I

V

N

E

R

Y

E

G

Q

E

I

I

Q

D

T

L

T

A

L

V

D

E

I

T

L

L

A

K

E

K

I

V

L

L

R

Q

active site: F134 (= F159), E186 (= E221), D219 (= D254), Q222 (= Q257), K248 (= K283), T276 (= T311), R367 (= R407)
binding pyridoxal-5'-phosphate: G102 (= G132), T103 (≠ A133), F134 (= F159), H135 (= H160), E186 (= E221), D219 (= D254), V221 (= V256), Q222 (= Q257), K248 (= K283)

5wyaA Structure of amino acid racemase, 2.65 a (see paper)
34% identity, 94% coverage: 25:428/431 of query aligns to 6:427/439 of 5wyaA

query
sites
5wyaA

A

S

K

K

A

L

I

I

V

D

E

E

R

E

D

N

R

K

A

Y

V

Y

T

A

S

R

P

S

S
x
A

Y

R

T

I

R

N

D

Y

Y

Y

P

N

L

L

V

V

V

I

N

D

R

H

G

A

E

H

G

G

C

A

M

T

V

L

E

V

D

D

V

V

D

D

G

G

N

N

V

K

F

Y

L

I

D

D

M

L

T

L

A

A

G

S

I
x
A

A

S

V

A

T

I

A

N

T

V

G

G

H

H

A

T

H

H

P

E

E

K

V

V

R

K

A

A

I

I

Q

A

E

D

Q

Q

S

A

A

Q

R

K

L

L

I

I

H

H

M

Y

S

T

G

P

T

A

D
x
Y

F

F

Y

H

E

V

P

P

M

G

V

M

E

E

L

L

A

S

E

E

N

K

L

L

A

A

S

K

Q

I

A

A

P

P

F

G

V

N

H

S

D

P

T

K

K

M

V

V

F

S

F

F

T

G

N

N

S
|
S

G
|
G

A
x
S

E

D

S

A

N

N

E

D

G

A

A

I

I

I

K

K

L

F

A

A

R

R

Y

A

Y

Y

T

T

K

G

R

R

S

Q

L

Y

I

I

I

V

A

S

F

Y

L

M

G

G

A

S

F
x
Y

H
|
H

G

G

R

S

T

T

Y

Y

G

G

A

S

M

Q

S

T

L

L

T

S

G

G

S

S

K

S

T

L

V

N

Q

M

R

T

A

R

N

K

F

I

G

G

P

P

L

M

V

L

P

P

G

S

V

V

T

V

H

H

I

V

P

P

Y

Y

G

P

T

D

-

S

-

Y

-

R

-

T

-

Y

-

P

-

G

-

E

-

T

-

E

-

H

H

D

A

V

S

S

L

L

D

R

Y

Y

L

F

E

N

-

E

-

F

N

K

L

P

L

F

T

E

T

S

I

F

I

L

P

P

A

A

H

D

E

E

V

T

A

A

A

C

I

V

V

L

V

I

E
|
E

P

P

I

I

Q

Q

G

G

E

D

G

G

Y

I

I

I

V

K

P

A

E

P

D

E

G

E

F

Y

L

M

Q

Q

R

L

I

V

R

Y

N

K

I

F

C

C

D

H

R

E

Y

H

G

G

I

I

L

L

M

F

V

A

V

I

D
|
D

E

E

V
|
V

Q
x
N

S

Q

G

G

M

L

G

G

R

R

T

T

G

G

R

K

L

M

F

W

A

A

I

I

E

Q

H

Q

W

F

-

K

N

D

V

I

T

E

P

P

D

D

I

L

I

M

T

S

T

V

A

G

K
|
K

G

S

I

L

A

A

S

S

G

G

M

M

P

P

L

L

G

S

A

A

I

V

L

I

A

G

R

K

A

K

E

E

L

V

M

M

-

Q

T

S

W

L

P

D

P

A

G

P

S

A

H

H

A

L

T
x
F

T
|
T

F

T

G

A

G

G

N

N

P

P

V

V

A

C

C

S

A

A

G

S

I

L

V

A

T

T

L

L

K

D

L

V

L

I

E

E

-

Y

S

E

G

G

L

L

M

V

D

E

N

K

A

S

T

A

Q

T

M

D

G

G

E

A

L

Y

L

A

Q

K

T

Q

G

R

L

F

T

L

Q

E

L

M

H

Q

Q

Q

Q

R

F

H

P

P

R

M

M

I

S

G

L

D

P

V

R

R

G

M

K

W

G

G

L

L

M

N

V

G

A

G

V

I

D

E

L

L

L

V

D

K

E

D

D

P

G

K

N

T

F

K

-

E

-

P

D

D

S

S

K

D

L

A

R

A

D

T

R

K

I

V

I

I

Q

Y

E

Y

A

A

F

F

Y

A

H

H

G

G

L

V

L

I

G

T

C

L

G

A

K

G

A

N

A

I

I

L

R
|
R

F

F

C

Q

P

P

L

L

V

V

I

I

N

P

R

R

E

E

Q

Q

I

L

Q

D

T

Q

T

A

L

L

D

Q

I

V

L

L

A

D

E

D

active site: A20 (≠ S39), Y140 (≠ F159), E215 (= E221), D248 (= D254), N251 (≠ Q257), K278 (= K283), T307 (= T311), R406 (= R407)
binding (2S,3S)-3-methyl-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]pentanoic acid: A52 (≠ I71), Y82 (≠ D101), S112 (= S131), G113 (= G132), S114 (≠ A133), Y140 (≠ F159), H141 (= H160), E215 (= E221), D248 (= D254), V250 (= V256), N251 (≠ Q257), K278 (= K283), F306 (≠ T310), T307 (= T311), R406 (= R407)

5wyfA Structure of amino acid racemase, 2.12 a (see paper)
34% identity, 94% coverage: 25:428/431 of query aligns to 8:429/446 of 5wyfA

query
sites
5wyfA

A

S

K

K

A

L

I

I

V

D

E

E

R

E

D

N

R

K

A

Y

V

Y

T

A

S

R

P

S

S
x
A

Y

R

T

I

R

N

D

Y

Y

Y

P

N

L

L

V

V

V

I

N

D

R

H

G

A

E

H

G

G

C

A

M

T

V

L

E

V

D

D

V

V

D

D

G

G

N

N

V

K

F

Y

L

I

D

D

M

L

T

L

A

A

G

S

I
x
A

A

S

V

A

T

I

A

N

T

V

G

G

H

H

A

T

H

H

P

E

E

K

V

V

R

K

A

A

I

I

Q

A

E

D

Q

Q

S

A

A

Q

R

K

L

L

I

I

H

H

M

Y

S

T

G

P

T

A

D
x
Y

F

F

Y

H

E

V

P

P

M

G

V

M

E

E

L

L

A

S

E

E

N

K

L

L

A

A

S

K

Q

I

A

A

P

P

F

G

V

N

H

S

D

P

T

K

K

M

V

V

F

S

F

F

T

G

N

N

S

S

G
|
G

A
x
S

E

D

S

A

N

N

E

D

G

A

A

I

I

I

K

K

L

F

A

A

R

R

Y

A

Y

Y

T

T

K

G

R

R

S

Q

L

Y

I

I

I

V

A

S

F

Y

L

M

G

G

A

S

F
x
Y

H
|
H

G

G

R

S

T

T

Y

Y

G

G

A

S

M

Q

S

T

L

L

T

S

G

G

S

S

K

S

T

L

V

N

Q

M

R

T

A

R

N

K

F

I

G

G

P

P

L

M

V

L

P

P

G

S

V

V

T

V

H

H

I

V

P

P

Y

Y

G

P

T

D

-

S

-

Y

-

R

-

T

-

Y

-

P

-

G

-

E

-

T

-

E

-

H

H

D

A

V

S

S

L

L

D

R

Y

Y

L

F

E

N

-

E

-

F

N

K

L

P

L

F

T

E

T

S

I

F

I

L

P

P

A

A

H

D

E

E

V

T

A

A

A

C

I

V

V

L

V

I

E
|
E

P

P

I

I

Q

Q

G

G

E
x
D

G

G

Y

I

I

I

V

K

P

A

E

P

D

E

G

E

F

Y

L

M

Q

Q

R

L

I

V

R

Y

N

K

I

F

C

C

D

H

R

E

Y

H

G

G

I

I

L

L

M

F

V

A

V

I

D
|
D

E

E

V
|
V

Q
x
N

S

Q

G

G

M

L

G

G

R

R

T

T

G

G

R

K

L

M

F

W

A

A

I

I

E

Q

H

Q

W

F

-

K

N

D

V

I

T

E

P

P

D

D

I

L

I

M

T

S

T

V

A

G

K
|
K

G

S

I

L

A

A

S

S

G

G

M

M

P

P

L

L

G

S

A

A

I

V

L

I

A

G

R

K

A

K

E

E

L

V

M

M

-

Q

T

S

W

L

P

D

P

A

G

P

S

A

H

H

A

L

T
x
F

T
|
T

F

T

G

A

G

G

N

N

P

P

V

V

A

C

C

S

A

A

G

S

I

L

V

A

T

T

L

L

K

D

L

V

L

I

E

E

-

Y

S

E

G

G

L

L

M

V

D

E

N

K

A

S

T

A

Q

T

M

D

G

G

E

A

L

Y

L

A

Q

K

T

Q

G

R

L

F

T

L

Q

E

L

M

H

Q

Q

Q

Q

R

F

H

P

P

R

M

M

I

S

G

L

D

P

V

R

R

G

M

K

W

G

G

L

L

M

N

V

G

A

G

V

I

D

E

L

L

L

V

D

K

E

D

D

P

G

K

N

T

F

K

-

E

-

P

D

D

S

S

K

D

L

A

R

A

D

T

R

K

I

V

I

I

Q

Y

E

Y

A

A

F

F

Y

A

H

H

G

G

L

V

L

I

G

T

C

L

G

A

K

G

A

N

A

I

I

L

R
|
R

F

F

C

Q

P

P

L

L

V

V

I

I

N

P

R

R

E

E

Q

Q

I

L

Q

D

T

Q

T

A

L

L

D

Q

I

V

L

L

A

D

E

D

active site: A22 (≠ S39), Y142 (≠ F159), E217 (= E221), D250 (= D254), N253 (≠ Q257), K280 (= K283), T309 (= T311), R408 (= R407)
binding n-[o-phosphono-pyridoxyl]-isoleucine: A54 (≠ I71), Y84 (≠ D101), G115 (= G132), S116 (≠ A133), Y142 (≠ F159), H143 (= H160), D222 (≠ E226), D250 (= D254), V252 (= V256), N253 (≠ Q257), K280 (= K283), F308 (≠ T310), T309 (= T311), R408 (= R407)

4ysnC Structure of aminoacid racemase in complex with plp (see paper)
34% identity, 94% coverage: 25:428/431 of query aligns to 15:436/448 of 4ysnC

query
sites
4ysnC

A

S

K

K

A

L

I

I

V

D

E

E

R

E

D

N

R

K

A

Y

V

Y

T

A

S

R

P

S

S
x
A

Y

R

T

I

R

N

D

Y

Y

Y

P

N

L

L

V

V

V

I

N

D

R

H

G

A

E

H

G

G

C

A

M

T

V

L

E

V

D

D

V

V

D

D

G

G

N

N

V

K

F

Y

L

I

D

D

M

L

T

L

A

A

G

S

I

A

A

S

V

A

T

I

A

N

T

V

G

G

H

H

A

T

H

H

P

E

E

K

V

V

R

K

A

A

I

I

Q

A

E

D

Q

Q

S

A

A

Q

R

K

L

L

I

I

H

H

M

Y

S

T

G

P

T

A

D

Y

F

F

Y

H

E

V

P

P

M

G

V

M

E

E

L

L

A

S

E

E

N

K

L

L

A

A

S

K

Q

I

A

A

P

P

F

G

V

N

H

S

D

P

T

K

K

M

V

V

F

S

F

F

T

G

N

N

S
|
S

G
|
G

A
x
S

E

D

S

A

N

N

E

D

G

A

A

I

I

I

K

K

L

F

A

A

R

R

Y

A

Y

Y

T

T

K

G

R

R

S

Q

L

Y

I

I

I

V

A

S

F

Y

L

M

G

G

A

S

F
x
Y

H
|
H

G

G

R

S

T

T

Y

Y

G

G

A

S

M

Q

S

T

L

L

T

S

G

G

S

S

K

S

T

L

V

N

Q

M

R

T

A

R

N

K

F

I

G

G

P

P

L

M

V

L

P

P

G

S

V

V

T

V

H

H

I

V

P

P

Y

Y

G

P

T

D

-

S

-

Y

-

R

-

T

-

Y

-

P

-

G

-

E

-

T

-

E

-

H

H

D

A

V

S

S

L

L

D

R

Y

Y

L

F

E

N

-

E

-

F

N

K

L

P

L

F

T

E

T

S

I

F

I

L

P

P

A

A

H

D

E

E

V

T

A

A

A

C

I

V

V

L

V

I

E
|
E

P

P

I

I

Q

Q

G

G

E

D

G

G

Y

I

I

I

V

K

P

A

E

P

D

E

G

E

F

Y

L

M

Q

Q

R

L

I

V

R

Y

N

K

I

F

C

C

D

H

R

E

Y

H

G

G

I

I

L

L

M

F

V

A

V

I

D
|
D

E

E

V
|
V

Q
x
N

S

Q

G

G

M

L

G

G

R

R

T

T

G

G

R

K

L

M

F

W

A

A

I

I

E

Q

H

Q

W

F

-

K

N

D

V

I

T

E

P

P

D

D

I

L

I

M

T

S

T

V

A

G

K
|
K

G

S

I

L

A

A

S

S

G

G

M

M

P

P

L

L

G

S

A

A

I

V

L

I

A

G

R

K

A

K

E

E

L

V

M

M

-

Q

T

S

W

L

P

D

P

A

G

P

S

A

H

H

A

L

T
x
F

T
|
T

F

T

G

A

G

G

N

N

P

P

V

V

A

C

C

S

A

A

G

S

I

L

V

A

T

T

L

L

K

D

L

V

L

I

E

E

-

Y

S

E

G

G

L

L

M

V

D

E

N

K

A

S

T

A

Q

T

M

D

G

G

E

A

L

Y

L

A

Q

K

T

Q

G

R

L

F

T

L

Q

E

L

M

H

Q

Q

Q

Q

R

F

H

P

P

R

M

M

I

S

G

L

D

P

V

R

R

G

M

K

W

G

G

L

L

M

N

V

G

A

G

V

I

D

E

L

L

L

V

D

K

E

D

D

P

G

K

N

T

F

K

-

E

-

P

D

D

S

S

K

D

L

A

R

A

D

T

R

K

I

V

I

I

Q

Y

E

Y

A

A

F

F

Y

A

H

H

G

G

L

V

L

I

G

T

C

L

G

A

K

G

A

N

A

I

I

L

R
|
R

F

F

C

Q

P

P

L

L

V

V

I

I

N

P

R

R

E

E

Q

Q

I

L

Q

D

T

Q

T

A

L

L

D

Q

I

V

L

L

A

D

E

D

active site: A29 (≠ S39), Y149 (≠ F159), E224 (= E221), D257 (= D254), N260 (≠ Q257), K287 (= K283), T316 (= T311), R415 (= R407)
binding pyridoxal-5'-phosphate: S121 (= S131), G122 (= G132), S123 (≠ A133), Y149 (≠ F159), H150 (= H160), E224 (= E221), D257 (= D254), V259 (= V256), K287 (= K283), F315 (≠ T310), T316 (= T311)

3q8nC Crystal structure of 4-aminobutyrate transaminase from mycobacterium smegmatis (see paper)
38% identity, 97% coverage: 15:430/431 of query aligns to 7:435/439 of 3q8nC

query
sites
3q8nC

H

R

L

L

V

V

T

T

S

A

L

I

P

P

G

G

P

P

R

I

A

S

K

Q

A

E

I

L

V

Q

E

A

R

R

D

K

R

Q

A

S

V

A

T

V

S

A

P

A

S

G

Y
x
V

T

G

R

V

D

T

Y

L

P

P

L

V

V

Y

V

V

N

V

R

A

G

A

E

G

G

G

C

G

M

V

V

L

E

A

D

D

V

A

D

D

G

G

N

N

V

Q

F

L

L

I

D

D

M

F

T

G

A

S

G

G

I

I

A

A

V

V

T

T

A

T

T

V

G

G

H

N

A

S

H

A

P

P

E

A

V

V

R

D

A

A

I

V

Q

T

E

Q

Q

Q

S

V

A

A

R

A

L

F

I

T

H

H

M

T

S

C

G

F

T

M

D

V

F

T

Y

P

Y

Y

E

E

P

G

M

Y

V

V

E

K

L

V

A

A

E

E

N

H

L

L

A

N

S

R

Q

L

A

T

P

P

F

G

V

D

H

H

D

E

T

K

K

R

V

T

F

A

F

L

T

F

N

N

S

S

G
|
G

A
|
A

E

E

S

A

N

V

E

E

G

N

A

A

I

V

K

K

L

I

A

A

R

R

Y

A

Y

Y

T

T

K

R

R

R

S

Q

L

A

I

V

A

V

F

F

L

D

G

H

A

A

F
x
Y

H

H

G

G

R

R

T

T

Y

N

G

L

A

T

M

M

S

A

L

M

T

T

G

A

S

K

K

N

T

Q

V

P

Q

Y

R

K

A

H

N

G

F

F

G

G

P

P

L

F

V

A

P

N

G

E

V

V

T

Y

H

R

I

V

P

P

Y

T

-

S

-

Y

-

P

-

F

-

R

-

D

-

G

-

E

-

T

-

D

G

G

T

A

H

A

A

A

S

A

L

A

D

H

Y

A

L

L

E

D

N

-

L

L

L

I

T

N

T

K

I

Q

I

V

P

G

A

A

H

D

E

N

V

V

A

A

I

V

V

V

V

I

E
|
E

P

P

I

V

Q

H

G

G

E

E

G

G

Y

F

I

V

V

V

P

P

E

A

D

P

G

G

F

F

L

L

Q

G

R

A

I

L

R

Q

N

K

I

W

C

C

D

T

R

D

Y

N

G

G

I

A

L

V

M

F

V

V

V

A

D
|
D

E

E

V
|
V

Q
|
Q

S

T

G

G

M

F

G

A

R

R

T

T

G

G

R

A

L

L

F

F

A

A

I

C

E

E

H

H

W

E

N

N

V

V

T

V

P

P

D

D

I

L

I

I

T

V

T

T

A

A

K
|
K

G

G

I

I

A

A

S

G

G

G

M

L

P

P

L

L

G

S

A

A

I

V

L

T

A

G

R

R

A

A

E

E

L

I

M

M

T

D

W

G

P

P

P

Q

G

S

-

G

S

G

H

L

A

G

T

G

T
|
T

F

Y

G

G

N

N

P

P

V

L

A

A

C

C

A

A

G

A

I

L

V

A

T

V

L

I

K

D

L

T

L

I

E

E

-

R

S

E

G

N

L

L

M

V

D

A

N

R

A

A

T

R

Q

A

M

I

G

G

E

E

L

T

L

M

Q

L

T

S

G

R

L

L

T

G

Q

A

L

L

H

A

Q

A

F

D

P

P

R

R

M

I

S

G

L

E

P

V

R

R

G

G

K

R

G

G

L

A

M

M

V

I

A

A

V

V

D

E

L

L

L

V

D

K

E

P

D

G

G

T

N

T

F

E

-

P

D

D

S

A

K

D

L

L

R

T

D

K

R

R

I

V

I

A

Q

A

E

A

A

A

F

H

Y

A

H

Q

G

G

L

L

L

V

L

L

G

T

C

C

G

G

K

T

-

Y

-

G

A

N

A

V

I

L

R
|
R

F

F

C

L

P

P

L

L

V

S

I

M

N

P

R

D

E

H

Q

L

I

L

Q

D

T

E

T

G

L

L

D

D

I

I

L

L

A

A

E

A

I

V

L

F

active site: V32 (≠ Y40), Y151 (≠ F159), E221 (= E221), D254 (= D254), Q257 (= Q257), K283 (= K283), T312 (= T311), R412 (= R407)
binding 4-oxobutanoic acid: G124 (= G132), A125 (= A133), V256 (= V256), K283 (= K283)

2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
38% identity, 91% coverage: 39:430/431 of query aligns to 6:375/375 of 2eh6A

query
sites
2eh6A

S

N

Y

Y

T

A

R

R

D

-

Y

L

P

P

L

V

V

K

V

F

N

V

R

R

G

G

E

K

G

G

C

V

M

Y

V

L

E

Y

D

D

V

E

D

E

G

G

N

K

V

E

F

Y

L

L

D

D

M

F

T

V

A

S

G

G

I

I

A

G

V

V

T

N

A

S

T

L

G

G

H

H

A

A

H

Y

P

P

E

K

V

L

V

T

R

E

A

A

I

L

Q

K

E

E

Q

Q

S

V

A

E

R

K

L

L

I

L

H

H

M

V

S

S

G

-

T

-

D

N

F

L

Y

Y

Y

E

E

N

P

P

M

W

V

Q

E

E

-

E

L

L

A

A

E

H

N

K

L

L

A

V

S

K

Q

H

A

-

P

-

F

F

V

W

H

T

D

E

T

G

K

K

V

V

F

F

T

A

N

N

S

S

G
|
G

A
x
T

E

E

S

S

N

V

E

E

G

A

A

A

I

I

K

K

L

L

A

A

R

R

Y

K

Y

Y

T

W

K

R

-

D

-

K

-

G

-

K

-

N

R

K

S

W

L

K

I

F

I

I

A

S

F

F

L

E

G

N

A

S

F
|
F

H
|
H

G

G

R

R

T

T

Y

Y

G

G

A

S

M

L

S

S

L

A

T

T

G

G

S

Q

K

P

T

K

V

F

Q

H

R

K

A

G

N

-

F

F

G

E

P

P

L

L

V

V

P

P

G

G

V

F

T

S

H

Y

I

-

P

-

Y

-

G

-

T

-

H

-

A

A

S

K

L

L

D

N

Y

D

L

I

E

D

N

S

N

-

L

-

T

V

T

Y

I

K

I

L

P

L

A

D

H

E

E

E

V

T

A

A

A

G

I

I

V

I

E
|
E

P

V

I

I

Q

Q

G

G

E

E

G

G

Y

V

I

N

V

E

P

A

E

S

D

E

G

D

F

F

L

L

Q

S

R

K

I

L

R

Q

N

E

I

I

C

C

D

K

R

E

Y

K

G

D

I

V

L

L

M

L

V

I

D
|
D

E

E

V
|
V

Q
|
Q

S

T

G

G

M

I

G

G

R

R

T

T

G

G

R

E

L

F

F

Y

A

A

I

Y

E

Q

H

H

W

F

N

N

V

L

T

K

P

P

D

D

I

V

I

I

T

A

T

L

A

A

K
|
K

G

G

I

L

A

G

S

G

G

G

M

V

P

P

L

I

G

G

A

A

I

I

L

L

A

A

R

R

A

E

E

E

L

V

-

A

M

Q

T

S

W

F

P

T

P

P

G

G

S

S

H

H

A

G

T

S

T
|
T

F

F

G

G

N

N

P

P

V

L

A

A

C

C

A

R

A

A

G

G

I

T

V

V

T

V

L

V

K

D

L

E

L

V

E

E

S

K

G

-

L

L

M

L

D

P

N

H

A

V

T

R

Q

E

M

V

G

G

E

N

L

Y

L

F

Q

K

T

E

G

K

L

L

T

K

Q

E

L

L

H

G

Q

K

Q

-

F

-

P

-

R

-

M

-

S

G

L

K

P

V

R

K

G

G

K

R

G

G

L

L

M

M

V

L

A

G

V

L

D

E

L

L

L

-

D

-

E

-

D

-

G

-

N

-

F

-

D

E

S

R

K

E

L

C

R

K

D

D

R

Y

I

V

I

L

Q

K

E

-

A

A

F

L

Y

E

H

K

G

G

L

L

L

I

L

N

G

C

C

T

G

A

K

G

A

K

A

V

I

L

R
|
R

F

F

C

L

P

P

L

L

V

I

I

I

N

Q

R

K

E

E

Q

H

I

I

Q

D

T

R

T

A

L

I

D

S

I

V

L

L

A

R

E

E

I

I

L

L

active site: F127 (= F159), E179 (= E221), D212 (= D254), Q215 (= Q257), K241 (= K283), T270 (= T311), R352 (= R407)
binding pyridoxal-5'-phosphate: G95 (= G132), T96 (≠ A133), F127 (= F159), H128 (= H160), E179 (= E221), D212 (= D254), V214 (= V256), K241 (= K283)

Query Sequence

>WP_011317102.1 NCBI__GCF_000204075.1:WP_011317102.1
MLSIPINQHLPHTPHLVTSLPGPRAKAIVERDRAVTSPSYTRDYPLVVNRGEGCMVEDVD
GNVFLDMTAGIAVTATGHAHPEVVRAIQEQSARLIHMSGTDFYYEPMVELAENLASQAPF
VHDTKVFFTNSGAESNEGAIKLARYYTKRSLIIAFLGAFHGRTYGAMSLTGSKTVQRANF
GPLVPGVTHIPYGTHASLDYLENNLLTTIIPAHEVAAIVVEPIQGEGGYIVPEDGFLQRI
RNICDRYGILMVVDEVQSGMGRTGRLFAIEHWNVTPDIITTAKGIASGMPLGAILARAEL
MTWPPGSHATTFGGNPVACAAGIVTLKLLESGLMDNATQMGELLQTGLTQLHQQFPRMSL
PRGKGLMVAVDLLDEDGNFDSKLRDRIIQEAFYHGLLLLGCGKAAIRFCPPLVINREQIQ
TTLDILAEILR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory