SitesBLAST
Comparing WP_011317547.1 NCBI__GCF_000204075.1:WP_011317547.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8y1jA Structure of the pyridoxal 5'-phosphate-dependent (plp) threonine deaminase ilva1 from pseudomonas aeruginosa pao1 (see paper)
61% identity, 100% coverage: 2:502/503 of query aligns to 1:502/502 of 8y1jA
- binding 2-ketobutyric acid: K50 (= K51), S74 (= S75), H78 (= H79), E336 (= E337), R337 (≠ T338), P338 (= P339), S340 (= S341), F341 (≠ L342), Y358 (= Y359), N448 (= N448), I449 (= I449)
P04968 L-threonine dehydratase biosynthetic IlvA; Threonine deaminase; EC 4.3.1.19 from Escherichia coli (strain K12) (see paper)
51% identity, 99% coverage: 4:502/503 of query aligns to 15:512/514 of P04968
- K62 (= K51) modified: N6-(pyridoxal phosphate)lysine
- N89 (= N78) binding pyridoxal 5'-phosphate
- GGGGL 188:192 (= GGGGL 178:182) binding pyridoxal 5'-phosphate
- S315 (≠ C305) binding pyridoxal 5'-phosphate
1tdjA Threonine deaminase (biosynthetic) from e. Coli (see paper)
50% identity, 99% coverage: 4:502/503 of query aligns to 11:492/494 of 1tdjA
- active site: K58 (= K51), A83 (= A76), E209 (= E203), S213 (≠ A207), C215 (≠ A209), G237 (= G231), L310 (≠ A304), S311 (≠ C305)
- binding pyridoxal-5'-phosphate: F57 (= F50), K58 (= K51), N85 (= N78), G184 (= G178), G185 (= G179), G186 (= G180), G187 (= G181), G237 (= G231), E282 (= E276), S311 (≠ C305), G312 (= G306)
2gn2A Crystal structure of tetrameric biodegradative threonine deaminase (tdcb) from salmonella typhimurium in complex with cmp at 2.5a resolution (hexagonal form) (see paper)
40% identity, 57% coverage: 29:314/503 of query aligns to 34:318/326 of 2gn2A
- active site: K56 (= K51), A81 (= A76), Q207 (≠ E203), V211 (≠ A207), G213 (≠ A209), G235 (= G231), I308 (≠ A304), S309 (≠ C305)
- binding cytidine-5'-monophosphate: R51 (≠ S46), T52 (≠ V47), G53 (≠ F48), A114 (= A109), D117 (≠ A112), Y118 (≠ R113), N312 (= N308)
Q7XSN8 Serine racemase; D-serine dehydratase; D-serine ammonia-lyase; L-serine dehydratase; L-serine ammonia-lyase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Oryza sativa subsp. japonica (Rice) (see paper)
36% identity, 55% coverage: 12:286/503 of query aligns to 29:301/339 of Q7XSN8
- E219 (= E203) mutation to A: Reduces catalytic activity and abolishes the regulatory effect of Mg(2+) addition; when associated with A-225.
- D225 (≠ A209) mutation to A: Reduces catalytic activity and abolishes the regulatory effect of Mg(2+) addition; when associated with A-219.
O59791 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
33% identity, 60% coverage: 11:313/503 of query aligns to 17:316/323 of O59791
- K57 (= K51) active site, Proton acceptor; modified: Lysino-D-alanine (Lys); alternate; modified: N6-(pyridoxal phosphate)lysine; alternate
- S82 (≠ A76) active site, Proton acceptor; mutation to A: Loss of racemase activity. Reduces D-serine dehydratase activity by 99%. Slightly reduced L-serine dehydratase activity.
- N84 (= N78) binding pyridoxal 5'-phosphate
- G183 (= G178) binding pyridoxal 5'-phosphate
- G184 (= G179) binding pyridoxal 5'-phosphate
- G185 (= G180) binding pyridoxal 5'-phosphate
- G186 (= G181) binding pyridoxal 5'-phosphate
- L187 (= L182) binding pyridoxal 5'-phosphate
- E208 (= E203) binding Mg(2+)
- G212 (≠ A207) binding Mg(2+)
- D214 (≠ A209) binding Mg(2+)
- S308 (≠ C305) binding pyridoxal 5'-phosphate
1wtcA Crystal structure of s.Pombe serine racemase complex with amppcp (see paper)
33% identity, 60% coverage: 11:313/503 of query aligns to 12:311/318 of 1wtcA
- active site: K52 (= K51), S77 (≠ A76), E203 (= E203), G207 (≠ A207), D209 (≠ A209), G231 (= G231), I302 (≠ A304), S303 (≠ C305)
- binding phosphomethylphosphonic acid adenylate ester: N20 (≠ Q19), K47 (≠ S46), M48 (≠ V47), A109 (≠ D108), A110 (= A109), Y114 (≠ R113)
- binding magnesium ion: E203 (= E203), G207 (≠ A207), D209 (≠ A209)
- binding pyridoxal-5'-phosphate: F51 (= F50), K52 (= K51), N79 (= N78), G178 (= G178), G179 (= G179), G180 (= G180), G181 (= G181), G231 (= G231), E276 (= E276), T278 (≠ A278), S303 (≠ C305)
1v71A Crystal structure of s.Pombe serine racemase
33% identity, 60% coverage: 11:313/503 of query aligns to 12:311/318 of 1v71A
- active site: K52 (= K51), S77 (≠ A76), E203 (= E203), G207 (≠ A207), D209 (≠ A209), G231 (= G231), I302 (≠ A304), S303 (≠ C305)
- binding magnesium ion: E203 (= E203), G207 (≠ A207), D209 (≠ A209)
- binding pyridoxal-5'-phosphate: F51 (= F50), K52 (= K51), N79 (= N78), G178 (= G178), G179 (= G179), G180 (= G180), G181 (= G181), G231 (= G231), E276 (= E276), T278 (≠ A278), S303 (≠ C305), G304 (= G306)
2zr8A Crystal structure of modified serine racemase complexed with serine (see paper)
33% identity, 60% coverage: 11:313/503 of query aligns to 13:312/319 of 2zr8A
- active site: K53 (= K51), S78 (≠ A76), E204 (= E203), G208 (≠ A207), D210 (≠ A209), G232 (= G231), I303 (≠ A304), S304 (≠ C305)
- binding magnesium ion: E204 (= E203), G208 (≠ A207), D210 (≠ A209)
- binding n-(5'-phosphopyridoxyl)-d-alanine: F52 (= F50), K53 (= K51), S77 (= S75), S78 (≠ A76), N80 (= N78), H81 (= H79), P147 (= P145), G179 (= G178), G180 (= G179), G181 (= G180), G182 (= G181), G232 (= G231), E277 (= E276), T279 (≠ A278), S304 (≠ C305)
- binding serine: S78 (≠ A76), R129 (≠ A127), D231 (= D230), G232 (= G231), A233 (≠ V232), Q234 (≠ A233), T235 (≠ V234)
2zpuA Crystal structure of modified serine racemase from s.Pombe. (see paper)
33% identity, 60% coverage: 11:313/503 of query aligns to 13:312/319 of 2zpuA
- active site: K53 (= K51), S78 (≠ A76), E204 (= E203), G208 (≠ A207), D210 (≠ A209), G232 (= G231), I303 (≠ A304), S304 (≠ C305)
- binding magnesium ion: E204 (= E203), G208 (≠ A207), D210 (≠ A209)
- binding n-(5'-phosphopyridoxyl)-d-alanine: F52 (= F50), K53 (= K51), S77 (= S75), S78 (≠ A76), N80 (= N78), H81 (= H79), P147 (= P145), G179 (= G178), G180 (= G179), G181 (= G180), G182 (= G181), G232 (= G231), E277 (= E276), T279 (≠ A278), S304 (≠ C305)
A4F2N8 L-threo-3-hydroxyaspartate ammonia-lyase; L-threo-3-hydroxyaspartate dehydratase; L-THA DH; EC 4.3.1.16 from Pseudomonas sp. (see paper)
33% identity, 60% coverage: 13:313/503 of query aligns to 15:312/319 of A4F2N8
- K53 (= K51) mutation to A: Loss of enzymatic activity.
1ve5A Crystal structure of t.Th. Hb8 threonine deaminase
42% identity, 54% coverage: 42:312/503 of query aligns to 41:307/308 of 1ve5A
- active site: K50 (= K51), S56 (≠ N57), S72 (≠ A76), E200 (= E203), A204 (= A207), D206 (≠ A209), G229 (= G231), L299 (≠ A304), S300 (≠ C305)
- binding calcium ion: E200 (= E203), A204 (= A207), D206 (≠ A209)
- binding pyridoxal-5'-phosphate: F49 (= F50), K50 (= K51), N74 (= N78), G175 (= G178), G176 (= G179), G177 (= G180), G178 (= G181), E274 (= E276), T276 (≠ A278), S300 (≠ C305), G301 (= G306)
7nbgAAA structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen (see paper)
34% identity, 54% coverage: 13:285/503 of query aligns to 15:289/322 of 7nbgAAA
- active site: K53 (= K51), S81 (≠ A76), E207 (= E203), A211 (= A207), D213 (≠ A209), G236 (= G231)
- binding calcium ion: E207 (= E203), A211 (= A207), D213 (≠ A209)
- binding pyridoxal-5'-phosphate: F52 (= F50), K53 (= K51), N83 (= N78), G182 (= G178), G183 (= G179), G184 (= G180), G185 (= G181), M186 (≠ L182), G236 (= G231), V237 (= V232), T282 (≠ A278)
- binding ~{N}-[2-(2-methylphenyl)ethyl]ethanamide: S81 (≠ A76), G85 (≠ A80), Q86 (= Q81), I101 (= I96), K111 (= K106), I115 (≠ V110), Y118 (≠ R113)
Sites not aligning to the query:
Q9GZT4 Serine racemase; D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; EC 5.1.1.18; EC 4.3.1.18; EC 4.3.1.17 from Homo sapiens (Human) (see 4 papers)
34% identity, 54% coverage: 13:285/503 of query aligns to 18:292/340 of Q9GZT4
- S31 (≠ A26) binding ATP
- S32 (≠ P27) binding ATP
- I33 (≠ N28) binding ATP
- K51 (≠ S46) binding ATP
- T52 (≠ V47) binding ATP
- K56 (= K51) modified: N6-(pyridoxal phosphate)lysine
- P69 (= P64) binding Ca(2+)
- T81 (≠ A73) binding Ca(2+)
- N86 (= N78) binding pyridoxal 5'-phosphate
- Q89 (= Q81) binding ATP
- Y121 (≠ R113) binding ATP
- D178 (≠ H171) binding Mg(2+)
- G185 (= G178) binding pyridoxal 5'-phosphate
- G186 (= G179) binding pyridoxal 5'-phosphate
- G187 (= G180) binding pyridoxal 5'-phosphate
- G188 (= G181) binding pyridoxal 5'-phosphate
- M189 (≠ L182) binding pyridoxal 5'-phosphate
- E210 (= E203) binding Ca(2+); binding Mg(2+); binding Mn(2+)
- A214 (= A207) binding Ca(2+); binding Mg(2+); binding Mn(2+)
- D216 (≠ A209) binding Ca(2+); binding Mg(2+); binding Mn(2+)
- N247 (≠ E240) binding Ca(2+); binding Mg(2+)
- K279 (≠ R272) binding ATP
Sites not aligning to the query:
- 13 binding Mg(2+)
- 313 binding pyridoxal 5'-phosphate
- 316 binding ATP
7nbhAAA structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen (see paper)
34% identity, 54% coverage: 13:285/503 of query aligns to 15:289/320 of 7nbhAAA
- active site: K53 (= K51), S81 (≠ A76), E207 (= E203), A211 (= A207), D213 (≠ A209), G236 (= G231)
- binding calcium ion: E207 (= E203), A211 (= A207), D213 (≠ A209)
- binding N-[(1H-benzimidazol-2-yl)methyl]furan-2-carboxamide: S81 (≠ A76), G85 (≠ A80), Q86 (= Q81), K111 (= K106), I115 (≠ V110), Y118 (≠ R113), D235 (= D230), P281 (= P277)
Sites not aligning to the query:
7nbfAAA structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen (see paper)
34% identity, 54% coverage: 13:285/503 of query aligns to 15:289/323 of 7nbfAAA
- active site: K53 (= K51), S81 (≠ A76), E207 (= E203), A211 (= A207), D213 (≠ A209), G236 (= G231)
- binding calcium ion: E207 (= E203), A211 (= A207), D213 (≠ A209)
- binding magnesium ion: N244 (≠ E240)
- binding pyridoxal-5'-phosphate: F52 (= F50), K53 (= K51), N83 (= N78), G182 (= G178), G183 (= G179), G184 (= G180), G185 (= G181), M186 (≠ L182), G236 (= G231), V237 (= V232), T282 (≠ A278)
- binding 2-[(methylsulfonyl)methyl]-1H-benzimidazole: H21 (≠ Q19), L22 (≠ E20), T23 (≠ S21), P24 (= P22), L26 (≠ E24), T27 (≠ Y25), F46 (≠ M44)
Sites not aligning to the query:
7nbdAAA structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen (see paper)
34% identity, 54% coverage: 13:285/503 of query aligns to 15:289/323 of 7nbdAAA
- active site: K53 (= K51), S81 (≠ A76), E207 (= E203), A211 (= A207), D213 (≠ A209), G236 (= G231)
- binding calcium ion: E207 (= E203), A211 (= A207), D213 (≠ A209)
- binding [4-(1H-benzimidazol-1-yl)phenyl]methanol: W272 (≠ F268), L278 (≠ I274)
- binding magnesium ion: N244 (≠ E240)
- binding pyridoxal-5'-phosphate: F52 (= F50), K53 (= K51), N83 (= N78), G182 (= G178), G183 (= G179), G184 (= G180), G185 (= G181), M186 (≠ L182), G236 (= G231), V237 (= V232), E280 (= E276), T282 (≠ A278)
Sites not aligning to the query:
7nbcCCC structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
34% identity, 54% coverage: 13:285/503 of query aligns to 15:289/323 of 7nbcCCC
- active site: K53 (= K51), S81 (≠ A76), E207 (= E203), A211 (= A207), D213 (≠ A209), G236 (= G231)
- binding biphenyl-4-ylacetic acid: T78 (≠ A73), H79 (≠ A74), H84 (= H79), V148 (≠ I143), H149 (= H144), P150 (= P145)
- binding calcium ion: E207 (= E203), A211 (= A207), D213 (≠ A209)
- binding pyridoxal-5'-phosphate: F52 (= F50), K53 (= K51), N83 (= N78), G182 (= G178), G183 (= G179), G184 (= G180), G185 (= G181), M186 (≠ L182), G236 (= G231), V237 (= V232), T282 (≠ A278)
Sites not aligning to the query:
7nbcAAA structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen (see paper)
34% identity, 54% coverage: 13:285/503 of query aligns to 15:289/323 of 7nbcAAA
- active site: K53 (= K51), S81 (≠ A76), E207 (= E203), A211 (= A207), D213 (≠ A209), G236 (= G231)
- binding calcium ion: E207 (= E203), A211 (= A207), D213 (≠ A209)
- binding magnesium ion: N244 (≠ E240)
- binding pyridoxal-5'-phosphate: F52 (= F50), K53 (= K51), N83 (= N78), G182 (= G178), G183 (= G179), G184 (= G180), G185 (= G181), M186 (≠ L182), G236 (= G231), V237 (= V232), T282 (≠ A278)
Sites not aligning to the query:
5cvcA Structure of maize serine racemase (see paper)
36% identity, 55% coverage: 12:286/503 of query aligns to 13:285/329 of 5cvcA
- active site: K52 (= K51), S77 (≠ A76), E203 (= E203), A207 (= A207), D209 (≠ A209), G231 (= G231)
- binding magnesium ion: E203 (= E203), A207 (= A207), D209 (≠ A209)
- binding pyridoxal-5'-phosphate: F51 (= F50), K52 (= K51), N79 (= N78), S178 (≠ G178), G179 (= G179), G180 (= G180), G181 (= G181), L232 (≠ V232), E275 (= E276)
Sites not aligning to the query:
Query Sequence
>WP_011317547.1 NCBI__GCF_000204075.1:WP_011317547.1
MLCDYLVQILTARVYDVAQESPLEYAPNLSARLNNKLLLKREDMQSVFSFKLRGAYNKMV
NLTPDLLAQGVIAASAGNHAQGVALGAKQLGTRAIIVMPVTTPQVKVDAVKARGGEVVLH
GDTYDDAYAYARQLEAEKGLTFIHPFDDPHVIAGQGTIGMEILRQYQQPIHAIFVAIGGG
GLISGIAAYVKRLRPEIKIIGVEPVDADAMNQSLQAGKRVRLSQVGLFADGVAVREVGEE
TFRLCQEYVDEIILVDTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQGQTL
VAVACGANMNFDRLRFVAERAEFGERREAIFAVTIPETPGSLRKFCECIGRRNLTEFNYR
IADEKIAHIFIGMQIQNRADKIHMVETFAECGFEILDLTDDELTKLHLRHMVGGHSPLAH
NELLYRFEFPERPGALMKFVASMSPNWNISMFHYRNNGSDYGRIVVGMQVPPQEMEEWQA
FLDSLGYQYWDESQNPAYKLFLG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory