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Comparing WP_011319687.1 NCBI__GCF_000204075.1:WP_011319687.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5ur2B Crystal structure of proline utilization a (puta) from bdellovibrio bacteriovorus inactivated by n-propargylglycine (see paper)
46% identity, 96% coverage: 33:990/993 of query aligns to 27:959/959 of 5ur2B
- active site: N618 (= N649), K641 (= K672), E722 (= E753), C756 (= C787), E851 (= E882), T931 (≠ A962)
- binding N-propargylglycine-modified flavin adenine dinucleotide: K174 (= K207), D215 (= D248), M216 (= M249), Q249 (= Q282), V278 (= V311), K279 (= K312), G280 (= G313), A281 (= A314), W283 (= W316), Y300 (≠ F333), T301 (≠ N334), N302 (≠ D335), K303 (= K336), S306 (≠ T339), A329 (≠ G362), S330 (= S363), H331 (= H364), N332 (= N365), Q356 (= Q389), M357 (≠ V390), L358 (= L391), Y379 (= Y412), E398 (= E431), E403 (≠ S436), W405 (≠ F438)
4nmdA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca reduced with dithionite (see paper)
45% identity, 97% coverage: 29:990/993 of query aligns to 16:973/979 of 4nmdA
- active site: N631 (= N649), K654 (= K672), E735 (= E753), C769 (= C787), E865 (= E882), A945 (= A962)
- binding dihydroflavine-adenine dinucleotide: D226 (= D248), M227 (= M249), V256 (≠ T280), Q258 (= Q282), R285 (= R309), V287 (= V311), K288 (= K312), G289 (= G313), A290 (= A314), W292 (= W316), W309 (≠ F333), T310 (≠ N334), I311 (≠ D335), K312 (= K336), S315 (≠ T339), A338 (≠ G362), S339 (= S363), H340 (= H364), N341 (= N365), Q365 (= Q389), V366 (= V390), L367 (= L391), Y388 (= Y412), F414 (= F438)
4nmaA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca in complex with l-tetrahydro-2-furoic acid (see paper)
45% identity, 96% coverage: 34:990/993 of query aligns to 27:971/977 of 4nmaA
- active site: N629 (= N649), K652 (= K672), E733 (= E753), C767 (= C787), E863 (= E882), A943 (= A962)
- binding flavin-adenine dinucleotide: D226 (= D248), M227 (= M249), Q258 (= Q282), R285 (= R309), V287 (= V311), K288 (= K312), G289 (= G313), A290 (= A314), Y291 (= Y315), W292 (= W316), W309 (≠ F333), T310 (≠ N334), I311 (≠ D335), K312 (= K336), S315 (≠ T339), A338 (≠ G362), S339 (= S363), H340 (= H364), N341 (= N365), Q365 (= Q389), L367 (= L391), E407 (= E431), S413 (= S437), F414 (= F438)
- binding tetrahydrofuran-2-carboxylic acid: K185 (= K207), Y388 (= Y412), Y400 (= Y424), R403 (= R427), R404 (= R428)
4nmfB Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine and complexed with menadione bisulfite (see paper)
45% identity, 96% coverage: 34:990/993 of query aligns to 23:973/979 of 4nmfB
- active site: N631 (= N649), K654 (= K672), E735 (= E753), C769 (= C787), E865 (= E882), A945 (= A962)
- binding (2R)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K184 (= K207), Y290 (= Y315), Y387 (= Y412), Y399 (= Y424), R402 (= R427), R403 (= R428)
- binding (2S)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K184 (= K207), L366 (= L391), Y399 (= Y424), R402 (= R427)
- binding N-propargylglycine-modified flavin adenine dinucleotide: K184 (= K207), D225 (= D248), M226 (= M249), V255 (≠ T280), Q257 (= Q282), R284 (= R309), V286 (= V311), K287 (= K312), G288 (= G313), A289 (= A314), W291 (= W316), W308 (≠ F333), T309 (≠ N334), I310 (≠ D335), K311 (= K336), S314 (≠ T339), A337 (≠ G362), S338 (= S363), H339 (= H364), N340 (= N365), Q364 (= Q389), L366 (= L391), Y387 (= Y412), E406 (= E431), E411 (≠ S436), S412 (= S437), F413 (= F438)
4nmfA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine and complexed with menadione bisulfite (see paper)
45% identity, 97% coverage: 29:990/993 of query aligns to 13:967/973 of 4nmfA
- active site: N625 (= N649), K648 (= K672), E729 (= E753), C763 (= C787), E859 (= E882), A939 (= A962)
- binding (2R)-2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid: K181 (= K207), Y287 (= Y315), Y384 (= Y412), Y396 (= Y424), R399 (= R427), R400 (= R428)
- binding N-propargylglycine-modified flavin adenine dinucleotide: K181 (= K207), D222 (= D248), M223 (= M249), V252 (≠ T280), Q254 (= Q282), R281 (= R309), V283 (= V311), K284 (= K312), G285 (= G313), A286 (= A314), W288 (= W316), W305 (≠ F333), T306 (≠ N334), I307 (≠ D335), K308 (= K336), S311 (≠ T339), A334 (≠ G362), S335 (= S363), H336 (= H364), N337 (= N365), Q361 (= Q389), V362 (= V390), L363 (= L391), Y384 (= Y412), E403 (= E431), E408 (≠ S436), F410 (= F438)
4nmeA Crystal structure of proline utilization a (puta) from geobacter sulfurreducens pca inactivated by n-propargylglycine (see paper)
45% identity, 97% coverage: 29:990/993 of query aligns to 16:966/972 of 4nmeA
- active site: N624 (= N649), K647 (= K672), E728 (= E753), C762 (= C787), E858 (= E882), A938 (= A962)
- binding N-propargylglycine-modified flavin adenine dinucleotide: K183 (= K207), D224 (= D248), M225 (= M249), V254 (≠ T280), Q256 (= Q282), R283 (= R309), V285 (= V311), K286 (= K312), G287 (= G313), A288 (= A314), W290 (= W316), W307 (≠ F333), T308 (≠ N334), I309 (≠ D335), K310 (= K336), S313 (≠ T339), A336 (≠ G362), S337 (= S363), H338 (= H364), N339 (= N365), Q363 (= Q389), L365 (= L391), Y383 (= Y412), E402 (= E431), F409 (= F438)
7na0A Structure of geobacter sulfurreducens proline utilization a (puta) variant a206w (see paper)
45% identity, 96% coverage: 34:990/993 of query aligns to 26:974/981 of 7na0A
- binding flavin-adenine dinucleotide: D226 (= D248), M227 (= M249), V256 (≠ T280), Q258 (= Q282), R285 (= R309), V287 (= V311), K288 (= K312), G289 (= G313), A290 (= A314), Y291 (= Y315), W292 (= W316), W309 (≠ F333), T310 (≠ N334), I311 (≠ D335), K312 (= K336), S315 (≠ T339), A338 (≠ G362), S339 (= S363), H340 (= H364), N341 (= N365), L367 (= L391), Y388 (= Y412), E407 (= E431), S413 (= S437), F414 (= F438)
4nmcA Crystal structure of oxidized proline utilization a (puta) from geobacter sulfurreducens pca complexed with zwittergent 3-12 (see paper)
44% identity, 94% coverage: 55:990/993 of query aligns to 19:936/941 of 4nmcA
- active site: N594 (= N649), K617 (= K672), E698 (= E753), C732 (= C787), E828 (= E882), A908 (= A962)
- binding flavin-adenine dinucleotide: D215 (= D248), M216 (= M249), V245 (≠ T280), Q247 (= Q282), R274 (= R309), V276 (= V311), K277 (= K312), G278 (= G313), A279 (= A314), W281 (= W316), W298 (≠ F333), T299 (≠ N334), I300 (≠ D335), K301 (= K336), S304 (≠ T339), A327 (≠ G362), S328 (= S363), H329 (= H364), N330 (= N365), L356 (= L391), Y377 (= Y412)
2eiwA Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from thermus thermophilus with bound l-proline
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2eiwA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding proline: E137 (= E604), F185 (= F650), S323 (= S788), G477 (= G942), A478 (= A943), F485 (= F950)
2j5nA 1-pyrroline-5-carboxylate dehydrogenase from thermus thermophirus with bound inhibitor glycine and NAD.
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2j5nA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding glycine: S323 (= S788), G477 (= G942), A478 (= A943), F485 (= F950)
- binding nicotinamide-adenine-dinucleotide: I180 (= I645), A181 (≠ S646), P182 (= P647), W183 (= W648), N184 (= N649), I189 (= I654), K207 (= K672), E210 (= E675), G240 (= G705), F258 (= F723), T259 (= T724), G260 (= G725), S261 (= S726), V264 (= V729), E288 (= E753), T289 (≠ M754), C322 (= C787), E417 (= E882), F419 (= F884)
2ej6A Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from thermus thermophilus with bound d-proline
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2ej6A
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding d-proline: E137 (= E604), F185 (= F650), S323 (= S788), G477 (= G942), A478 (= A943), F485 (= F950)
2eitA Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from thermus thermophilus with bound l-alanine and NAD
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2eitA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding alanine: S323 (= S788), G477 (= G942), A478 (= A943), F485 (= F950)
- binding nicotinamide-adenine-dinucleotide: I180 (= I645), A181 (≠ S646), W183 (= W648), N184 (= N649), I189 (= I654), K207 (= K672), E210 (= E675), G240 (= G705), E241 (≠ S706), G244 (= G709), F258 (= F723), T259 (= T724), G260 (= G725), S261 (= S726), V264 (= V729), E288 (= E753), G290 (= G755), C322 (= C787), E417 (= E882), F419 (= F884)
2eiiA Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from thermus thermophilus with bound l-valine and NAD.
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2eiiA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding nicotinamide-adenine-dinucleotide: I180 (= I645), A181 (≠ S646), P182 (= P647), W183 (= W648), N184 (= N649), I189 (= I654), K207 (= K672), E210 (= E675), G240 (= G705), E241 (≠ S706), G244 (= G709), F258 (= F723), T259 (= T724), G260 (= G725), S261 (= S726), V264 (= V729), E288 (= E753), T289 (≠ M754), C322 (= C787), E417 (= E882), F419 (= F884)
- binding valine: E137 (= E604), F185 (= F650), S323 (= S788), G477 (= G942), A478 (= A943), F485 (= F950)
2ehuA Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NAD and inhibitor l-serine
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2ehuA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding nicotinamide-adenine-dinucleotide: I180 (= I645), A181 (≠ S646), P182 (= P647), W183 (= W648), N184 (= N649), I189 (= I654), K207 (= K672), E210 (= E675), G240 (= G705), F258 (= F723), T259 (= T724), G260 (= G725), S261 (= S726), V264 (= V729), E288 (= E753), T289 (≠ M754), C322 (= C787), E417 (= E882), F419 (= F884)
- binding serine: F185 (= F650), C322 (= C787), S323 (= S788), G477 (= G942), A478 (= A943), F485 (= F950)
2ehqA Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NADP (see paper)
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2ehqA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I180 (= I645), A181 (≠ S646), P182 (= P647), W183 (= W648), N184 (= N649), I189 (= I654), K207 (= K672), A209 (= A674), E210 (= E675), V239 (≠ K704), G240 (= G705), E241 (≠ S706), F258 (= F723), T259 (= T724), G260 (= G725), S261 (= S726), V264 (= V729), E288 (= E753), T289 (≠ M754), C322 (= C787), E417 (= E882), F419 (= F884)
2bhqA Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound product glutamate. (see paper)
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2bhqA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding glutamic acid: F185 (= F650), I189 (= I654), K321 (= K786), C322 (= C787), S323 (= S788), T476 (= T941), G477 (= G942), A478 (= A943), F485 (= F950)
2bhpA Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NAD. (see paper)
48% identity, 50% coverage: 481:981/993 of query aligns to 14:516/516 of 2bhpA
- active site: N184 (= N649), K207 (= K672), E288 (= E753), C322 (= C787), E417 (= E882), T497 (≠ A962)
- binding nicotinamide-adenine-dinucleotide: I180 (= I645), A181 (≠ S646), P182 (= P647), W183 (= W648), N184 (= N649), I189 (= I654), K207 (= K672), E210 (= E675), G240 (= G705), E241 (≠ S706), F258 (= F723), T259 (= T724), G260 (= G725), S261 (= S726), V264 (= V729), E288 (= E753), T289 (≠ M754), C322 (= C787), E417 (= E882), F419 (= F884)
3hazA Crystal structure of bifunctional proline utilization a (puta) protein (see paper)
35% identity, 88% coverage: 113:985/993 of query aligns to 148:983/983 of 3hazA
- active site: N652 (= N649), K675 (= K672), E752 (= E753), C786 (= C787), E878 (= E882), A960 (= A962)
- binding flavin-adenine dinucleotide: D272 (= D248), A273 (≠ M249), Q306 (= Q282), R333 (= R309), V335 (= V311), K336 (= K312), G337 (= G313), A338 (= A314), Y339 (= Y315), W340 (= W316), F358 (= F333), T359 (≠ N334), R360 (≠ D335), K361 (= K336), T364 (= T339), A387 (≠ G362), T388 (≠ S363), H389 (= H364), N390 (= N365), Y435 (= Y412), S460 (= S437), F461 (= F438)
- binding nicotinamide-adenine-dinucleotide: I648 (= I645), S649 (= S646), P650 (= P647), W651 (= W648), N652 (= N649), I657 (= I654), K675 (= K672), P676 (= P673), A677 (= A674), G708 (= G705), G711 (= G709), A712 (= A710), T726 (= T724), G727 (= G725), S728 (= S726), V731 (= V729), I735 (= I733), E752 (= E753), T753 (≠ M754), C786 (= C787), E878 (= E882), F880 (= F884), F948 (= F950)
6bsnA Structure of proline utilization a (puta) with proline bound in remote sites (see paper)
35% identity, 87% coverage: 113:980/993 of query aligns to 145:969/973 of 6bsnA
- active site: N643 (= N649), E743 (= E753), A777 (≠ C787), A951 (= A962)
- binding dihydroflavine-adenine dinucleotide: D269 (= D248), A270 (≠ M249), Q303 (= Q282), R330 (= R309), V332 (= V311), K333 (= K312), G334 (= G313), A335 (= A314), Y336 (= Y315), W337 (= W316), F355 (= F333), T356 (≠ N334), R357 (≠ D335), K358 (= K336), T361 (= T339), A384 (≠ G362), T385 (≠ S363), H386 (= H364), N387 (= N365), Y432 (= Y412), S457 (= S437), F458 (= F438)
- binding proline: M630 (≠ Y636), W642 (= W648), F644 (= F650), G718 (= G725), R776 (≠ K786), S778 (= S788), F871 (= F884), I930 (≠ T941), G931 (= G942), A932 (= A943), F939 (= F950), A958 (≠ L969), R959 (≠ Q970), A961 (≠ L972)
6x9cA Structure of proline utilization a with l-proline bound in the l- glutamate-gamma-semialdehyde dehydrogenase active site (see paper)
37% identity, 86% coverage: 115:968/993 of query aligns to 164:1008/1209 of 6x9cA
- active site: N687 (= N649), K710 (= K672), E790 (= E753), C824 (= C787), E920 (= E882), A1002 (= A962)
- binding dihydroflavine-adenine dinucleotide: D286 (= D248), A287 (≠ M249), V318 (≠ T280), Q320 (= Q282), R347 (= R309), V349 (= V311), K350 (= K312), G351 (= G313), A352 (= A314), Y353 (= Y315), W354 (= W316), F372 (= F333), T373 (≠ N334), R374 (≠ D335), K375 (= K336), T378 (= T339), A401 (≠ G362), T402 (≠ S363), H403 (= H364), N404 (= N365), Q427 (= Q389), C428 (≠ V390), E472 (= E431), S478 (= S437), F479 (= F438)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I683 (= I645), S684 (= S646), P685 (= P647), W686 (= W648), N687 (= N649), K710 (= K672), E713 (= E675), G743 (= G705), G746 (= G709), A747 (= A710), F760 (= F723), G762 (= G725), S763 (= S726), V766 (= V729), E920 (= E882), F922 (= F884)
- binding proline: R823 (≠ K786), C824 (= C787), S825 (= S788), G982 (= G942), A983 (= A943), F990 (= F950)
Query Sequence
>WP_011319687.1 NCBI__GCF_000204075.1:WP_011319687.1
MVLQVQTSTYEAKTQEIARQLLGATQENRSFFASLRDQMRWDDKLLAWAMSNPGLRVQLF
RFIDTLPALHSKAEIAAHLQEYLGDESVELPAALKGMLNFANPDSVPGQVAATTVSTAVE
TLAHKYISGENIKQVIKTVERLRKEKMAFTIDLLGEAVITETEAQSYLERYLELISQLTE
ASKNWGTVGAIDEADGEQLAKVQVSVKLTAFYSQFDPLDAKGSEEKVSDRIRILLRRAKE
LGAAIHFDMEQYAYKNLTLNILQKILLEDEFRQRTDIGITIQAYLRDSEQDARNAIAWLK
QRGYPLTIRLVKGAYWDQETIKAAQKHWPQPVFNDKAATDANFEAITQLLLENNQYVYSA
IGSHNVRSQALAIAIAETLQVPRRRFEMQVLYGMGDKLAKALVDRGYRVRVYCPYGDLLP
GMAYLIRRLLENTANSSFLRQNLENRPVEELLAAPDINLAHAKAQRSKEEKGSFGATDTD
FAVEEERKEAARAFAEVRGALGRSYLPLINGEYVQTAEVIDSVNPSNFGEVIGKVGLISV
EQAEQAMQAAKAAFPGWRRTPVKERAAILRRAGDLLEERRAELSAWIVLEVGKPVKEADA
EVSEAIDFCRYYADEMERLYQGINYDVAGETNRYIYQPRGIVVVISPWNFPLAIACGMTV
AALVTGNCTLLKPAETSSVITAKLTEILLEAGIPKGVFQYVPGKGSQVGAYLVSHPDTHL
IAFTGSQEVGCRIYAEAATLKPQQRHMKRVIAEMGGKNAIIVDESADLDQAVIGVVQSAF
GYSGQKCSACSRVIVVEAIYDAFIHRLVEATKSLNIGEAELPSTQVGPVIDANARDRIRE
YIEKGKAESQVALELSAPNHGYFVGPVIFGEVPPHGTIAQQEIFGPVLAVIKAKDFAQAL
AIANDTDYALTGGLYSRTPSHIQQAQEEFEVGNLYINRNITGAIVARQPFGGFKLSGVGS
KAGGPDYLLQFLEPRTITENIQRQGFAPIEGAE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory