SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_011365913.1 NCBI__GCF_000012925.1:WP_011365913.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

5odcD Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus at 2.3 a resolution (see paper)
48% identity, 50% coverage: 8:135/255 of query aligns to 3:129/138 of 5odcD

query
sites
5odcD
K
 
E
P
 
P
S
 
K
V
 
I
V
 
I
G
 
G
F
 
F
L
 
C
C
|
C
T
 
N
W
 
W
U
 
C
A
 
T
Y
 
Y
G
 
G
A
 
G
A
 
A
D
 
D
L
 
T
A
 
A
G
 
G
V
 
V
S
 
G
R
 
R
L
 
M
Q
 
Q
Y
 
Y
T
 
P
T
 
P
E
 
S
T
 
I
K
 
R
I
 
I
I
 
I
R
 
R
V
 
V
M
 
M
C
|
C
T
x
S
G
 
G
R
 
R
V
 
I
D
 
E
L
 
P
A
 
S
F
 
L
V
 
I
L
 
L
R
 
K
A
 
A
F
 
F
S
 
K
K
 
E
G
 
G
A
 
A
D
 
D
G
 
G
V
 
V
F
 
F
I
 
V
G
 
G
G
 
G
C
|
C
W
 
H
P
 
L
G
 
G
E
 
D
C
|
C
H
|
H
Y
 
Y
V
 
D
T
 
S
E
 
-
G
 
G
N
 
N
Y
 
Y
D
 
K
V
 
W
L
 
Q
K
 
R
N
 
R
V
 
V
H
 
M
I
 
M
A
 
L
K
 
Y
K
 
E
I
 
L
L
 
L
E
 
E
R
 
E
I
 
L
G
 
G
I
 
I
N
 
E
P
 
K
D
 
E
R
 
R
L
 
L
R
 
N
L
 
H
E
 
E
W
 
W
I
 
I
A
 
S
A
 
A
S
 
S
E
 
E
G
 
G
M
 
E
R
 
K
Y
 
F
A
 
Q
E
 
N
V
 
T
M
 
M
N
 
K
D
 
D
F
 
F
G
 
Y
K
 
N
R
 
K
L
 
I
K
 
E
E
 
A
L
 
L
G
 
G
P
 
P

7bkbF Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
48% identity, 51% coverage: 6:135/255 of query aligns to 1:129/137 of 7bkbF

query
sites
7bkbF
D
 
D
H
 
W
K
 
K
P
 
P
S
 
Q
V
 
I
V
 
L
G
 
A
F
 
I
L
 
I
C
|
C
T
 
N
W
|
W
U
 
C
A
 
S
Y
 
Y
G
 
A
A
 
G
A
 
A
D
 
D
L
 
L
A
 
A
G
 
G
V
 
G
S
 
A
R
 
R
L
 
I
Q
 
Q
Y
 
Y
T
 
P
T
 
P
E
 
T
T
 
V
K
 
R
I
 
A
I
 
I
R
 
R
V
 
V
M
 
M
C
|
C
T
|
T
G
 
G
R
 
R
V
 
V
D
 
D
L
 
M
A
 
L
F
 
F
V
 
I
L
 
L
R
 
K
A
 
A
F
 
F
S
 
V
K
 
E
G
 
G
A
 
A
D
 
D
G
 
G
V
 
V
F
 
L
I
 
V
G
 
S
G
 
G
C
|
C
W
 
H
P
 
F
G
 
G
E
 
D
C
|
C
H
|
H
Y
 
Y
V
 
L
T
 
-
E
 
E
G
 
G
N
 
N
Y
 
Y
D
 
K
V
 
A
L
 
A
K
 
K
N
 
R
V
 
M
H
 
F
I
 
M
A
 
I
K
 
K
K
 
N
I
 
L
L
 
L
E
 
R
R
 
N
I
 
I
G
 
G
I
 
L
N
 
D
P
 
D
D
 
R
R
 
R
L
 
F
R
 
R
L
 
M
E
 
T
W
 
F
I
 
V
A
 
S
A
 
A
S
 
S
E
 
E
G
 
G
M
 
A
R
 
K
Y
 
W
A
 
G
E
 
M
V
 
V
M
 
M
N
 
E
D
 
D
F
 
V
G
 
T
K
 
N
R
 
T
L
 
I
K
 
K
E
 
E
L
 
L
G
 
G
P
 
P

Query Sequence

>WP_011365913.1 NCBI__GCF_000012925.1:WP_011365913.1
MSTGRDHKPSVVGFLCTWUAYGAADLAGVSRLQYTTETKIIRVMCTGRVDLAFVLRAFSK
GADGVFIGGCWPGECHYVTEGNYDVLKNVHIAKKILERIGINPDRLRLEWIAASEGMRYA
EVMNDFGKRLKELGPLGKGEGIEPGALKLRLEAANKLVPYVKLVERERLRQRFKTEQEYT
DFFASDELKKLFDELVANKLAVSQITLLLQDKPLNTGEIVTTLGMNASEVSRHLKSATMH
GLVRFDEELKRYALA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory