SitesBLAST
Comparing WP_011365992.1 NCBI__GCF_000012925.1:WP_011365992.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 9 hits to proteins with known functional sites (download)
3oa4A Crystal structure of hypothetical protein bh1468 from bacillus halodurans c-125
32% identity, 54% coverage: 46:132/162 of query aligns to 33:118/138 of 3oa4A
Sites not aligning to the query:
6xbqA Streptomyces coelicolor methylmalonyl-coa epimerase in complex with carboxy-carba(dethia)-coa
27% identity, 86% coverage: 7:145/162 of query aligns to 2:135/144 of 6xbqA
- active site: H7 (≠ Q12), E43 (= E57), Q60 (≠ E73), H84 (= H96), E134 (= E144)
- binding carboxymethyldethia coenzyme *a: Q39 (≠ H47), Q60 (≠ E73), A70 (≠ I82), K73 (≠ D85), W74 (≠ F86), H83 (= H95), H84 (= H96), L107 (= L119), F122 (≠ Y132), P125 (≠ T135), K126 (≠ T136), L132 (≠ I142)
- binding cobalt (ii) ion: H7 (≠ Q12), Q60 (≠ E73), H84 (= H96), E134 (= E144)
6wfiA Methylmalonyl-coa epimerase in complex with 2-nitronate-propionyl-coa (see paper)
27% identity, 86% coverage: 7:145/162 of query aligns to 2:135/144 of 6wfiA
- active site: H7 (≠ Q12), E43 (= E57), Q60 (≠ E73), H84 (= H96), E134 (= E144)
- binding cobalt (ii) ion: H7 (≠ Q12), Q60 (≠ E73), H84 (= H96), E134 (= E144)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: H7 (≠ Q12), Q39 (≠ H47), Q60 (≠ E73), A70 (≠ I82), K73 (≠ D85), W74 (≠ F86), H83 (= H95), H84 (= H96), L107 (= L119), G114 (≠ A126), S115 (≠ G127), I120 (≠ Y130), F122 (≠ Y132), P125 (≠ T135), L132 (≠ I142), E134 (= E144)
6wf7A Methylmalonyl-coa epimerase in complex with methylmalonyl-coa and nh4+ (see paper)
27% identity, 86% coverage: 7:145/162 of query aligns to 2:135/144 of 6wf7A
- active site: H7 (≠ Q12), E43 (= E57), Q60 (≠ E73), H84 (= H96), E134 (= E144)
- binding (S)-Methylmalonyl-Coenzyme A: Q39 (≠ H47), E43 (= E57), Q60 (≠ E73), A70 (≠ I82), W74 (≠ F86), H83 (= H95), H84 (= H96), L107 (= L119), G114 (≠ A126), S115 (≠ G127), F122 (≠ Y132), P125 (≠ T135), K126 (≠ T136), L132 (≠ I142), E134 (= E144)
- binding methylmalonyl-coenzyme a: Q39 (≠ H47), Q60 (≠ E73), A70 (≠ I82), W74 (≠ F86), H83 (= H95), H84 (= H96), L107 (= L119), G114 (≠ A126), S115 (≠ G127), I120 (≠ Y130), F122 (≠ Y132), P125 (≠ T135), K126 (≠ T136), L132 (≠ I142), E134 (= E144)
6wf6A Streptomyces coelicolor methylmalonyl-coa epimerase (see paper)
27% identity, 86% coverage: 7:145/162 of query aligns to 2:135/141 of 6wf6A
6wfhA Streptomyces coelicolor methylmalonyl-coa epimerase substrate complex (see paper)
27% identity, 86% coverage: 7:145/162 of query aligns to 2:135/139 of 6wfhA
- active site: H7 (≠ Q12), E43 (= E57), Q60 (≠ E73), H84 (= H96), E134 (= E144)
- binding cobalt (ii) ion: H7 (≠ Q12), Q60 (≠ E73), H84 (= H96), E134 (= E144)
- binding (3S,5R,9R,19E)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,19-tetrahydroxy-8,8,20-trimethyl-10,14-dioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicos-19-en-21-oic acid 3,5-dioxide (non-preferred name): H7 (≠ Q12), Q39 (≠ H47), Q60 (≠ E73), A70 (≠ I82), K73 (≠ D85), W74 (≠ F86), H83 (= H95), H84 (= H96), L107 (= L119), G114 (≠ A126), S115 (≠ G127), F122 (≠ Y132), P125 (≠ T135), K126 (≠ T136), L132 (≠ I142), E134 (= E144)
6xbtA Streptomyces coelicolor methylmalonyl-coa epimerase (q60a) in complex with 2-nitronate-propionyl-coa
27% identity, 86% coverage: 7:145/162 of query aligns to 2:135/140 of 6xbtA
- active site: H7 (≠ Q12), E43 (= E57), A60 (≠ E73), H84 (= H96), E134 (= E144)
- binding cobalt (ii) ion: H7 (≠ Q12), H84 (= H96), E134 (= E144)
- binding coenzyme a: Q39 (≠ H47), A70 (≠ I82), K73 (≠ D85), W74 (≠ F86), K77 (≠ E89), H83 (= H95), L107 (= L119), F122 (≠ Y132), P125 (≠ T135), K126 (≠ T136), L132 (≠ I142)
- binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: H7 (≠ Q12), Q39 (≠ H47), A70 (≠ I82), K73 (≠ D85), W74 (≠ F86), H83 (= H95), H84 (= H96), L107 (= L119), G114 (≠ A126), S115 (≠ G127), P125 (≠ T135), K126 (≠ T136), L132 (≠ I142), E134 (= E144)
6qh4C Crystal structure of human methylmalonyl-coa epimerase (mcee) p.Arg143cys variant
26% identity, 88% coverage: 4:145/162 of query aligns to 6:135/138 of 6qh4C
Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Homo sapiens (Human) (see paper)
27% identity, 83% coverage: 12:145/162 of query aligns to 50:173/176 of Q96PE7
- H50 (≠ Q12) binding Co(2+)
- R104 (vs. gap) to L: in dbSNP:rs6748672
- H122 (= H96) binding Co(2+)
- E172 (= E144) binding Co(2+)
Query Sequence
>WP_011365992.1 NCBI__GCF_000012925.1:WP_011365992.1
MAKQPVFKKVLQVGIVVHDLEKAVRTYADDFGIGPWQFYNLDKSNMHDMKMRGEKAEFSM
KVAFTDLGGVQLELIEPLDESIYSDFLREHGEGIHHIACGVRNFEETMASMQKKDIKVLL
EGTTSAGMGYVYLDTTDALSCITEIYRIPENLQYIPPDKTYP
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory