SitesBLAST

Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
35% identity, 87% coverage: 1:185/212 of query aligns to 1:231/234 of Q7WTT9

query
sites
Q7WTT9

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C12 (= C12) binding [4Fe-4S] cluster
C15 (= C15) binding [4Fe-4S] cluster
C18 (= C18) binding [4Fe-4S] cluster
C22 (= C22) binding [4Fe-4S] cluster
C57 (= C57) binding [4Fe-4S] cluster
C60 (= C60) binding [4Fe-4S] cluster
C65 (= C65) binding [4Fe-4S] cluster
C69 (= C69) binding [4Fe-4S] cluster
C89 (= C89) binding [4Fe-4S] cluster
C92 (= C92) binding [4Fe-4S] cluster
C95 (= C95) binding [4Fe-4S] cluster
C99 (= C99) binding [4Fe-4S] cluster
C164 (= C116) binding [4Fe-4S] cluster
C167 (= C119) binding [4Fe-4S] cluster
C179 (= C131) binding [4Fe-4S] cluster
C183 (= C135) binding [4Fe-4S] cluster

P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
38% identity, 69% coverage: 2:147/212 of query aligns to 4:157/205 of P18776

query
sites
P18776

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C102 (= C92) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
40% identity, 65% coverage: 43:179/212 of query aligns to 122:258/337 of 2ivfB

query
sites
2ivfB

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binding fe3-s4 cluster: C148 (= C69), T150 (≠ V71), I153 (≠ L74), C169 (= C89), K170 (≠ I90), G171 (= G91), H172 (≠ C92), R173 (≠ S93), H174 (≠ G94), C175 (= C95), S193 (≠ A113)
binding protoporphyrin ix containing fe: T150 (≠ V71), K170 (≠ I90), H172 (≠ C92)
binding iron/sulfur cluster: M135 (≠ R56), C136 (= C57), N137 (= N58), H138 (= H59), C139 (= C60), P142 (≠ A63), C144 (= C65), V162 (= V82), C179 (= C99), A183 (= A103), I184 (= I104), K195 (= K115), C196 (= C116), I197 (≠ T117), L198 (≠ Y118), C199 (= C119), N209 (≠ P129), C211 (= C131), C215 (= C135), V219 (≠ A139), R220 (≠ N140)

Sites not aligning to the query:

binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41

6f0kB Alternative complex iii (see paper)
30% identity, 74% coverage: 2:157/212 of query aligns to 723:928/961 of 6f0kB

query
sites
6f0kB

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binding fe3-s4 cluster: C803 (= C69), V805 (= V71), M818 (≠ I84), C823 (= C89), I824 (= I90), G825 (= G91), C829 (= C95), M869 (vs. gap)
binding heme c: N821 (≠ E87), R822 (= R88), R884 (vs. gap), N887 (vs. gap)
binding iron/sulfur cluster: C733 (= C12), T734 (≠ M13), G735 (= G14), C736 (= C15), N737 (≠ K16), A738 (≠ G17), C739 (= C18), C743 (= C22), W765 (= W33), I768 (≠ L35), C791 (= C57), M792 (≠ N58), H793 (= H59), C794 (= C60), P798 (= P64), C799 (= C65), N816 (≠ V82), C833 (= C99), C872 (= C116), Y874 (= Y118), C875 (= C119), A901 (= A130), C902 (= C131), C906 (= C135)

Sites not aligning to the query:

binding heme c: 719

8k9fB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 2.9 angstrom (see paper)
27% identity, 72% coverage: 4:155/212 of query aligns to 711:917/951 of 8k9fB

query
sites
8k9fB

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binding fe3-s4 cluster: C787 (= C69), P788 (= P70), M802 (≠ I84), C807 (= C89), G809 (= G91), T810 (≠ C92), K811 (≠ S93), Y812 (≠ G94), C813 (= C95)
binding heme c: N805 (≠ E87), R806 (= R88), R867 (vs. gap), K871 (vs. gap)
binding iron/sulfur cluster: C719 (= C12), G721 (= G14), C722 (= C15), N723 (≠ K16), C725 (= C18), C729 (= C22), N733 (= N26), W751 (= W33), I752 (≠ R34), P772 (= P54), C775 (= C57), M776 (≠ N58), Q777 (≠ H59), C778 (= C60), C783 (= C65), N800 (≠ V82), C817 (= C99), Y819 (= Y101), V821 (≠ A103), C856 (= C116), Y858 (= Y118), C859 (= C119), T891 (≠ P129), C893 (= C131), C897 (= C135), P898 (= P136), T899 (≠ V137)

Sites not aligning to the query:

8k9eB Cryo-em structure of the photosynthetic alternative complex iii from chloroflexus aurantiacus at 3.3 angstrom (see paper)
27% identity, 72% coverage: 4:155/212 of query aligns to 711:917/951 of 8k9eB

query
sites
8k9eB

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T

H

V

Y

H

L

D

E

Y

N

E

G

G

I

L

V
x
N

N

N

I
x
M

D

V

K

Y

E
x
N

R

R

C
|
C

I
x
V

G
|
G

C
x
T

S
x
K

G
x
Y

C
|
C

V

S

M

N

A

N

C
|
C

P

P

Y
|
Y

G

K

A
x
V

-
x
R

-

R

-

F

-

N

-

F

-

L

I

Q

Y

Y

I

S

D

D

P

T

Q

T

T

T

Q

E

T

T

-

F

-

K

-

L

-

A

-

F

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

I

-

R

-

G

-

V

A
x
M

D

E

K

K

C
|
C

T

T

Y
|
Y

C
|
C

A

V

H

Q

R

R

V

I

A

S

-

G

-

A

-
x
R

-

I

-

A

-
x
K

-

R

-

A

-

V

-

Q

-

A

-

G

-

Q

-

S

-

Y

-

V

-

I

-

S

-

D

S

G

S

A

M

I

M

Q

P
x
T

A

A

C
|
C

V

E

V

Q

A

A

C
|
C

P

P

V
x
T

Q

G

A

A

N

I

I

V

F

F

G

G

D

D

L

I

E

N

D

D

P

S

T

N

S

S

N

R

I

V

S

A

K

K

Y

W

binding fe3-s4 cluster: C787 (= C69), M802 (≠ I84), C807 (= C89), V808 (≠ I90), G809 (= G91), T810 (≠ C92), K811 (≠ S93), Y812 (≠ G94), C813 (= C95), M853 (≠ A113)
binding heme c: N805 (≠ E87), R867 (vs. gap), K871 (vs. gap)
binding iron/sulfur cluster: C719 (= C12), I720 (≠ M13), G721 (= G14), C722 (= C15), N723 (≠ K16), C725 (= C18), C729 (= C22), N733 (= N26), I754 (≠ R36), C775 (= C57), M776 (≠ N58), C778 (= C60), P782 (= P64), C783 (= C65), N800 (≠ V82), C817 (= C99), Y819 (= Y101), V821 (≠ A103), R822 (vs. gap), C856 (= C116), Y858 (= Y118), C859 (= C119), T891 (≠ P129), C893 (= C131), C897 (= C135), T899 (≠ V137)

Sites not aligning to the query:

binding heme c: 3

5ch7B Crystal structure of the perchlorate reductase pcrab - phe164 gate switch intermediate - from azospira suillum ps (see paper)
35% identity, 65% coverage: 42:179/212 of query aligns to 118:255/329 of 5ch7B

query
sites
5ch7B

V

A

G

G

T

E

F

Y

P

P

E

N

T

N

K

S

R

F

T

F

F

Y

T

L

P
|
P

L

R

R

M

C
|
C

N
|
N

H

H

C
|
C

E

T

N

K

A
x
P

P

A

C
|
C

E

L

R

E

I

A

C
|
C

P

P

V

N

S

E

A

A

L
x
I

H

Y

Y

K

L

R

E

E

-

Q

N

D

G

G

I

I

V

V

N

V

I

I

D

H

K

Q

E

D

R

K

C
|
C

I
x
K

G
|
G

C
x
A

S
x
Q

G
x
A

C
|
C

V

V

M

Q

A

S

C
|
C

P

P

Y

Y

G

A

A

K

I

P

Y

Y

I

F

D

N

P

P

Q

L

T

T

Q

N

T

K

A
|
A

D

N

K

K

C
|
C

T

I

Y
x
G

C
|
C

A

F

H

P

R

R

V

I

A

E

S

Q

S

G

M

V

M

A

P

P

A

A

C
|
C

V

V

V

A

A

Q

C
|
C

P
x
V

V
x
G

Q

R

A

A

N

M

I

H

F

V

G

G

D

F

L

V

E

D

D

D

P

V

T

N

S

S

N

S

I

V

S

Y

K

K

Y

L

I

I

Q

K

L

Q

H

Y

Q

K

G

V

G

A

V

L

Q

P

V

L

R

H

K

-

P

P

E

E

K

F

G

G

T

T

N

E

P

P

H

N

H

V

Y

F

Y

Y

V

V

binding fe3-s4 cluster: C145 (= C69), I150 (≠ L74), C166 (= C89), K167 (≠ I90), G168 (= G91), A169 (≠ C92), Q170 (≠ S93), A171 (≠ G94), C172 (= C95), A190 (= A113)
binding iron/sulfur cluster: P130 (= P54), C133 (= C57), N134 (= N58), C136 (= C60), P139 (≠ A63), C141 (= C65), C176 (= C99), C193 (= C116), G195 (≠ Y118), C196 (= C119), C208 (= C131), C212 (= C135), V213 (≠ P136), G214 (≠ V137)

Sites not aligning to the query:

binding iron/sulfur cluster: 17, 18, 19, 20, 21, 23, 27, 31, 43, 45

4v4cB Pyrogallol hydroxytransferase small subunit (see paper)
29% identity, 100% coverage: 2:212/212 of query aligns to 3:223/274 of 4v4cB

query
sites
4v4cB

Q

Q

L

Y

G

Y

F

M

L

V

V

I

D

D

L

V

H

A

L

K

C
|
C

M
x
Q

G
x
D

C
|
C

K
x
N

G
x
N

C
|
C

E

F

I

M

A

G

C
|
C

K

M

V

D

E

E

N

H

E

E

V

-

P

-

L

L

S

N

T

E

W

W

-

P

-

G

-

Y

-

T

-

A

-

S

-

M

-

Q

-

R

-

G

-

H

-

R

R

W

L

M

R

N

V

I

K

E

Y

R

V

R

D

E

V

R

G

G

T

T

F

Y

P

P

E

R

T

N

K

D

R
x
I

T
x
N

F

Y

T

R

P

P

L

T

R

P

C
|
C

N
x
M

H
|
H

C
|
C

E

E

N

N

A

A

P

P

C
|
C

E

-

R

V

I

A

C

K

P

G

V

N

S

G

A

A

L

V

H

Y

Y

Q

L

R

E

E

N

D

G

G

I

I

V
|
V

N

L

I

I

D

D

K

P

E

E

R

K

C

A

I

K

G

G

C

K

S

K

G

E

C

L

V

L

M

D

A

T

C
|
C

P

P

Y

Y

G

G

A
x
V

I

M

Y

Y

I

W

D

N

P

E

Q

E

T

E

Q

N

T

V

A

A

D

Q

K

K

C
|
C

T

T

Y
x
M

C
|
C

A

A

H

H

R

L

V

L

A

D

S

D

S

E

-

S

-

W

-

A

-

P

M

K

M

M

P
|
P

A

R

C
|
C

V

A

V

H

A

N

C
|
C

P

-

V

-

Q

G

A
x
S

N

F

I
x
V

F
x
Y

G

E

D

F

L

L

E

K

D

T

P

T

T

P

S

E

N

A

I

M

S

A

K

K

Y

-

I

-

Q

K

L

V

H

E

Q

E

G

E

G

G

V

L

Q

E

V

V

R

I

K

K

P

P

E

E

K

L

G

G

T

T

N

K

P

P

H

R

H

V

Y

Y

V

K

N

N

A

L

G

Y

N

R

V

F

S

E

L

K

N

N

P

Y

L

V

-

T

A

A

S

G

H

I

R

L

V

V

D

Q

G

G

H

D

S

C

L

F

F

E

N

G

K

A

I

K

T

V

L

L

P

K

V

S

G

G

H

K

H

E

binding calcium ion: I61 (≠ R50), N62 (≠ T51)
binding iron/sulfur cluster: C13 (= C12), Q14 (≠ M13), D15 (≠ G14), C16 (= C15), N17 (≠ K16), N18 (≠ G17), C19 (= C18), C23 (= C22), C68 (= C57), M69 (≠ N58), H70 (= H59), C71 (= C60), C76 (= C65), V92 (= V82), C109 (= C99), V113 (≠ A103), C126 (= C116), M128 (≠ Y118), C129 (= C119), P143 (= P129), C145 (= C131), C149 (= C135), S151 (≠ A139), V153 (≠ I141), Y154 (≠ F142)

P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
30% identity, 84% coverage: 2:179/212 of query aligns to 29:227/294 of P0AAJ3

query
sites
P0AAJ3

Q

E

L

V

G

A

F

K

L

L

V

I

D

D

L

V

H

S

L

T

C
|
C

M

I

G

G

C
|
C

K

K

G

A

C
|
C

E

Q

I

V

A

A

C
|
C

K

S

V

E

E

W

N

N

E

D

V

I

P

R

L

D

S

E

T

V

W

G

R

H

-

C

-

V

-

G

-

V

-

Y

-

D

-

N

-

P

-

A

-

D

L

L

R

S

V

A

K

K

Y

S

V

W

D

T

V

V

G

M

T

R

F

F

P

S

E

E

T

T

K

E

R

Q

T

N

-

G

-

K

-

L

-

E

-

W

-

L

F

I

T

R

P

K

L

D

R

G

C
|
C

N

M

H

H

C
|
C

E

E

N

D

A

P

P

G

C
|
C

E

L

R

K

I

A

C
|
C

P

P

-

S

V

A

S

G

A

A

L

I

H

I

Y

Q

L

Y

E

A

N

N

G

G

I

I

V

V

N

D

I

F

D

Q

K

S

E

E

R

N

C
|
C

I

I

G

G

C
|
C

S

G

G

Y

C
|
C

V

I

M

A

A

G

C
|
C

P

P

Y

F

G

N

A

I

I

P

Y

R

I

L

D

N

P

K

Q

E

T

D

Q

N

T

R

A

V

D

Y

K

K

C
|
C

T

T

Y

L

C
|
C

A

V

H

D

R

R

V

V

A

S

S

V

S

G

M

Q

M

E

P

P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P

P

V

T

Q

G

A

A

N

I

I

H

F

F

G

G

D

T

-

K

-

E

-

M

L

L

E

E

D

L

P

A

T

E

S

Q

N

R

I

V

S

A

K

K

Y

L

I

K

Q

A

L

R

H

G

Q

Y

G

E

G

H

V

A

Q

G

V

V

R

Y

K

N

P

P

E

E

K

G

G

V

T

G

N

G

P

T

H

H

H

V

Y

M

Y

Y

V

V

C39 (= C12) binding [4Fe-4S] cluster
C42 (= C15) binding [4Fe-4S] cluster
C45 (= C18) binding [4Fe-4S] cluster
C49 (= C22) binding [4Fe-4S] cluster
C100 (= C57) binding [4Fe-4S] cluster
C103 (= C60) binding [4Fe-4S] cluster
C108 (= C65) binding [4Fe-4S] cluster
C112 (= C69) binding [4Fe-4S] cluster
C133 (= C89) binding [4Fe-4S] cluster
C136 (= C92) binding [4Fe-4S] cluster
C139 (= C95) binding [4Fe-4S] cluster
C143 (= C99) binding [4Fe-4S] cluster
C160 (= C116) binding [4Fe-4S] cluster
C163 (= C119) binding [4Fe-4S] cluster
C175 (= C131) binding [4Fe-4S] cluster
C179 (= C135) binding [4Fe-4S] cluster

1kqfB Formate dehydrogenase n from e. Coli (see paper)
30% identity, 84% coverage: 2:179/212 of query aligns to 28:226/289 of 1kqfB

query
sites
1kqfB

Q

E

L

V

G

A

F
x
K

L

L

V

I

D

D

L

V

H

S

L

T

C
|
C

M
x
I

G
|
G

C
|
C

K
|
K

G

A

C
|
C

E

Q

I

V

A

A

C
|
C

K

S

V

E

E

W

N
|
N

E

D

V

I

P

R

L

D

S

E

T

V

W

G

R

H

-

C

-

V

-

G

-

V

-

Y

-

D

-

N

-

P

-

A

-

D

L

L

R

S

V

A

K

K

Y

S

V

W

D
x
T

V

V

G
x
M

T

R

F

F

P

S

E

E

T

T

K

E

R

Q

T

N

-

G

-

K

-

L

-

E

-

W

-

L

F

I

T

R

P

K

L

D

R

G

C
|
C

N
x
M

H
|
H

C
|
C

E

E

N

D

A
x
P

P

G

C
|
C

E

L

R

K

I

A

C
|
C

P
|
P

-

S

V

A

S

G

A

A

L
x
I

H

I

Y

Q

L

Y

E

A

N

N

G

G

I

I

V
|
V

N

D

I

F

D

Q

K

S

E

E

R

N

C
|
C

I
|
I

G
|
G

C
|
C

S
x
G

G
x
Y

C
|
C

V

I

M

A

A

G

C
|
C

P

P

Y

F

G

N

A
x
I

I
x
P

Y

R

I

L

D

N

P

K

Q

E

T

D

Q

N

T

R

A
x
V

D

Y

K
|
K

C
|
C

T

T

Y
x
L

C
|
C

A

V

H

D

R

R

V

V

A

S

S

V

S

G

M

Q

M

E

P
|
P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P
|
P

V

T

Q

G

A

A

N
x
I

I

H

F

F

G

G

D

T

-

K

-

E

-

M

L

L

E

E

D

L

P

A

T

E

S

Q

N

R

I

V

S

A

K

K

Y

L

I

K

Q

A

L

R

H

G

Q

Y

G

E

G

H

V

A

Q

G

V

V

R

Y

K

N

P

P

E

E

K

G

G

V

T

G

N

G

P

T

H

H

H

V

Y

M

Y

Y

V

V

binding protoporphyrin ix containing fe: Y137 (≠ G94)
binding iron/sulfur cluster: K31 (≠ F5), C38 (= C12), I39 (≠ M13), G40 (= G14), C41 (= C15), K42 (= K16), C44 (= C18), C48 (= C22), N52 (= N26), T77 (≠ D41), M79 (≠ G43), C99 (= C57), M100 (≠ N58), H101 (= H59), C102 (= C60), P105 (≠ A63), C107 (= C65), C111 (= C69), P112 (= P70), I117 (≠ L74), V125 (= V82), C132 (= C89), I133 (= I90), G134 (= G91), C135 (= C92), G136 (≠ S93), Y137 (≠ G94), C138 (= C95), C142 (= C99), I146 (≠ A103), P147 (≠ I104), V156 (≠ A113), K158 (= K115), C159 (= C116), L161 (≠ Y118), C162 (= C119), P172 (= P129), C174 (= C131), C178 (= C135), P179 (= P136), I183 (≠ N140)

Sites not aligning to the query:

binding protoporphyrin ix containing fe: 252

6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
27% identity, 71% coverage: 2:152/212 of query aligns to 682:892/929 of 6lodB

query
sites
6lodB

Q

K

L

W

G

G

F

M

L

S

V

I

D

D

L

L

H

N

L

V

C
|
C

M
x
N

G
x
S

C
|
C

K
x
N

G
x
A

C
|
C

E

V

I

V

A

A

C
|
C

K

Q

V

S

E

E

N
|
N

E

N

V

I

P

P

L

V

-

V

-

G

-

K

-

D

S

E

T

V

W

W

-

L

-

G

-

R

-

E

-

M

-

H

R
x
W

L

I

R

R

V
x
I

K

D

Y

Q

V

Y

D

Y

V

V

G

G

T

D

F

E

P

H

E

T

T

P

K

N

R

V

T

Y

F

N

T

M

P

V

L

M

R
x
L

C
|
C

N
x
Q

H
x
Q

C
|
C

E

E

N

H

A

A

P
|
P

C
|
C

E

E

R

I

I
x
V

C
|
C

P
|
P

V

V

S

A

A

A

L

T

H

V

Y

H

L

D

E

A

N

E

G

G

I

L

V
x
N

N

N

I

M

D

V

K

Y

E
x
N

R
|
R

C
|
C

I
x
V

G
|
G

C
x
T

S

K

G

Y

C
|
C

V

S

M

N

A

N

C
|
C

P

P

Y
|
Y

G

K

A
x
V

I
x
R

Y

R

-

F

-

N

-

F

-

L

-

Q

-

Y

-

Q

-

D

-

V

-

P

-

Y

-

R

-

S

-

P

I

I

D

D

P

A

Q

S

T

T

Q

E

-

N

-

D

-

S

-

I

-

P

-

V

-

L

-

K

-

M

-

R

-

N

-

P

-

D

-

V

-

T

-

V

-

R

-

A

-

R

-

G

T

V

A
x
M

D

E

K
|
K

C
|
C

T

T

Y
x
F

C
|
C

A

V

H

Q

R

R

V

I

A

N

S

E

S

A

-
x
R

-
x
I

-

Q

-

A

-
x
R

-

T

-

E

-

N

-

R

-

I

-

A

-

D

-

G

-

E

M

I

M

M

P
x
T

A

A

C
|
C

V

Q

A

V

C
|
C

P

P

V

T

Q

Q

A

A

N
x
I

I

V

F

F

G

G

D

D

L

L

E

N

D

D

P

P

T

Q

S

A

N

R

I

V

binding fe3-s4 cluster: V758 (≠ I68), C759 (= C69), P760 (= P70), C779 (= C89), V780 (≠ I90), G781 (= G91), T782 (≠ C92), C785 (= C95), M838 (≠ A113)
binding heme c: N777 (≠ E87), R778 (= R88), R852 (vs. gap), I853 (vs. gap), R856 (vs. gap)
binding iron/sulfur cluster: C692 (= C12), N693 (≠ M13), S694 (≠ G14), C695 (= C15), N696 (≠ K16), A697 (≠ G17), C698 (= C18), C702 (= C22), N706 (= N26), W724 (≠ R34), I727 (≠ V37), L746 (≠ R56), C747 (= C57), Q748 (≠ N58), Q749 (≠ H59), C750 (= C60), P754 (= P64), C755 (= C65), N772 (≠ V82), C789 (= C99), Y791 (= Y101), V793 (≠ A103), R794 (≠ I104), K840 (= K115), C841 (= C116), F843 (≠ Y118), C844 (= C119), T869 (≠ P129), C871 (= C131), C875 (= C135), I880 (≠ N140)

7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
34% identity, 60% coverage: 12:139/212 of query aligns to 14:158/183 of 7qv7B

query
sites
7qv7B

C
|
C

M

I

G
|
G

C
|
C

K
|
K

G
x
A

C
|
C

E

E

I

V

A

A

C
|
C

-

F

-

A

-

V

-
x
H

K

N

V

R

E

N

N

N

E

H

V

V

P

G

L

A

S

T

T

V

W

G

R

T

L

V

R

S

V

I

K

P

Y

V

V

I

D

P

V
x
R

G

L

T

H

F

L

P

I

E

K

T

T

K

E

R

H

T

G

F

T

T

M

P

P

L

I

R

Q

C
|
C

N
x
R

H
|
H

C
|
C

E

E

N

D

A
|
A

P

P

C
|
C

E

A

R

N

I

V

C
|
C

P

T

V

V

S

G

A
|
A

L
x
I

H

K

Y

R

L

E

E

G

N

N

G

A

I

I

V

V

N

-

I

V

D

D

K

E

E

K

R

L

C
|
C

I
|
I

G

G

C
|
C

S

K

G

S

C
|
C

V

L

M

L

A

A

C
|
C

P

P

Y

F

G

G

A

A

I
|
I

Y

E

I

L

D

L

P

P

Q

Q

T

Y

Q

E

-

D

-

G

-

R

-

E

-

V

-

F

-

Q

-

I

-

N

-

L

-

K

-

L

-

V

-

Q

-

E

-

P

-

R

-

I

T

I

A

A

D

Y

K

K

C
|
C

T

D

Y
x
L

C
|
C

A

-

H

-

R

-

V

-

A

N

S

D

S

L

M

G

M

E

P
|
P

A

A

C
|
C

V

V

V

K

A

A

C
|
C

P
|
P

V

E

Q

N

A

A

binding iron/sulfur cluster: C14 (= C12), G16 (= G14), C17 (= C15), K18 (= K16), A19 (≠ G17), C20 (= C18), C24 (= C22), H28 (vs. gap), R48 (≠ V42), C63 (= C57), R64 (≠ N58), H65 (= H59), C66 (= C60), A69 (= A63), C71 (= C65), C75 (= C69), A79 (= A73), I80 (≠ L74), C94 (= C89), I95 (= I90), C97 (= C92), C100 (= C95), C104 (= C99), I109 (= I104), C139 (= C116), L141 (≠ Y118), C142 (= C119), P148 (= P129), C150 (= C131), C154 (= C135), P155 (= P136)

Sites not aligning to the query:

binding iron/sulfur cluster: 159

7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
35% identity, 63% coverage: 6:139/212 of query aligns to 6:145/174 of 7qv7A

query
sites
7qv7A

L

I

V

A

D

D

L

P

H

K

L

R

C
|
C

M
x
L

G
|
G

C
|
C

K
x
Y

G

T

C
|
C

E

I

I

A

A

A

C
|
C

K

A

-

F

V

V

E
x
H

N

E

E

E

V

Q

P

G

L

L

S

Q

T

P

W

F

-

P

R

R

L
|
L

R

Y

V

L

K

T

Y

Y

V

T

D

S

V

E

G

G

T

I

F

M

P

P

E

-

T

-

K

-

R

-

T

-

F

-

T

-

P

-

L

I

R

Q

C
|
C

N
x
R

H

H

C
|
C

E

E

N

D

A

A

P

P

C
|
C

E

A

R

E

I

V

C
|
C

P

P

V

V

S

E

A

A

L

I

H

K

Y

K

L

E

E

G

N

N

G

A

I

I

V

I

N

-

I

I

D

D

K

E

E

K

R

A

C
|
C

I
|
I

G
|
G

C
|
C

S

K

G

T

C
|
C

V

L

M

L

A

A

C
|
C

P

S

Y

F

G

G

A

A

I
|
I

Y

D

I
x
F

D

S

P

V

Q

Q

T

D

Q

S

-

L

-

E

-

Q

-

S

-

I

-

F

-

K

-

D

-

I

-

K

-

E

-

N

-

L

-

M

-

R

-

I

T

V

A

A

D

V

K

K

C
|
C

T

D

Y
x
L

C
|
C

A

N

H

F

R

R

V

E

A

E

S

G

S

-

M

-

P

P

A
|
A

C
|
C

V

V

V

Q

A

F

C
|
C

P

P

V

T

Q

K

A

A

binding iron/sulfur cluster: C12 (= C12), L13 (≠ M13), G14 (= G14), C15 (= C15), Y16 (≠ K16), C18 (= C18), C22 (= C22), H26 (≠ E25), L37 (= L35), C51 (= C57), R52 (≠ N58), C54 (= C60), C59 (= C65), C63 (= C69), C82 (= C89), I83 (= I90), G84 (= G91), C85 (= C92), C88 (= C95), C92 (= C99), I97 (= I104), F99 (≠ I106), C125 (= C116), L127 (≠ Y118), C128 (= C119), A136 (= A130), C137 (= C131), C141 (= C135)

8cm6D W-formate dehydrogenase c872a from desulfovibrio vulgaris - with formamide (see paper)
31% identity, 67% coverage: 5:147/212 of query aligns to 4:168/214 of 8cm6D

query
sites
8cm6D

F
|
F

L

F

V

V

D

D

L

L

H

S

L

R

C
|
C

M
x
T

G
x
A

C
|
C

K
x
R

G

G

C
|
C

E

Q

I

I

A

A

C
|
C

K

K

V

Q

E

W

N
x
K

E

N

V

L

P

P

L

A

S

E

T

E

W

T

R

R

-

N

-

T

-

G

-

S

-

H

-

Q

-

N

-

P

L

P

R

D

V

L

K

S

Y

Y

V

V

D

T

V

L

G
x
K

T

T

-

V

-

R

F

F

P

T

E

E

T

K

K

S

R
|
R

T

K

-

G

-
x
P

-

G

-

I

-

D

-

W

-

L

F

F

T

F

P

P

L

E

R

Q

C
|
C

N
x
R

H

H

C
|
C

E

V

N

E

A
x
P

P
|
P

C
|
C

E

K

R

G

I

Q

C

A

P

D

V

V

S

D

A

-

L

-

H

-

Y

-

L

L

E

E

N

G

G

A

I

V

V

V

N

K

I

D

D

E

K

T

E

T

R

G

C

A

I
x
V

G

L

C

F

S

T

G

E

C

L

V

T

M

A

-

K

-

V

-

D

-

G

-

E

-

S

-

V

-

R

-

S

A

A

C
|
C

P

P

Y

Y

G

D

A
x
I

I
x
P

Y

R

I

I

D

D

P

P

Q

V

T

T

Q

K

T

R

A

L

D

S

K
|
K

C
|
C

T
x
D

Y
x
M

C
|
C

A

N

H

D

R

R

V

V

A

Q

S

N

S

G

M

L

P

P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P
|
P

V
x
T

Q

G

A
x
T

N
x
M

I

N

F

F

G

G

D

D

L

E

E

Q

D

E

binding formamide: R59 (= R50), P62 (vs. gap)
binding iron/sulfur cluster: F4 (= F5), C11 (= C12), T12 (≠ M13), A13 (≠ G14), C14 (= C15), R15 (≠ K16), C17 (= C18), C21 (= C22), K25 (≠ N26), K50 (≠ G43), C73 (= C57), R74 (≠ N58), C76 (= C60), P79 (≠ A63), P80 (= P64), C81 (= C65), V102 (≠ I90), C120 (= C99), I124 (≠ A103), P125 (≠ I104), K136 (= K115), C137 (= C116), D138 (≠ T117), M139 (≠ Y118), C140 (= C119), C152 (= C131), C156 (= C135), P157 (= P136), T158 (≠ V137), T160 (≠ A139), M161 (≠ N140)

8bqgB W-formate dehydrogenase from desulfovibrio vulgaris - soaking with formate 1 min (see paper)
31% identity, 67% coverage: 5:147/212 of query aligns to 4:168/214 of 8bqgB

query
sites
8bqgB

F
|
F

L

F

V

V

D

D

L

L

H

S

L

R

C
|
C

M
x
T

G
x
A

C
|
C

K
x
R

G

G

C
|
C

E

Q

I

I

A

A

C
|
C

K

K

V

Q

E

W

N
x
K

E

N

V

L

P

P

L

A

S

E

T

E

W

T

R

R

-

N

-

T

-

G

-

S

-

H

-

Q

-

N

-

P

L

P

R

D

V

L

K

S

Y

Y

V

V

D

T

V

L

G
x
K

T

T

-

V

-

R

F

F

P

T

E

E

T

K

K

S

R

R

T

K

-

G

-

P

-

G

-

I

-

D

-

W

-

L

F

F

T

F

P

P

L

E

R

Q

C
|
C

N
x
R

H

H

C
|
C

E

V

N

E

A

P

P
|
P

C
|
C

E

K

R

G

I

Q

C

A

P

D

V

V

S

D

A

-

L

-

H

-

Y

-

L

L

E

E

N

G

G

A

I

V

V

V

N

K

I

D

D

E

K

T

E

T

R

G

C

A

I
x
V

G

L

C

F

S

T

G

E

C

L

V

T

M

A

-

K

-

V

-

D

-

G

-

E

-

S

-

V

-

R

-

S

A

A

C
|
C

P

P

Y

Y

G

D

A
x
I

I
x
P

Y

R

I

I

D

D

P

P

Q

V

T

T

Q

K

T

R

A

L

D

S

K
|
K

C
|
C

T

D

Y
x
M

C
|
C

A

N

H

D

R

R

V

V

A

Q

S

N

S

G

M

L

P

P

A

A

C
|
C

V

V

V

K

A

T

C
|
C

P
|
P

V
x
T

Q

G

A
x
T

N
x
M

I

N

F

F

G

G

D

D

L

E

E

Q

D

E

binding iron/sulfur cluster: F4 (= F5), C11 (= C12), T12 (≠ M13), A13 (≠ G14), C14 (= C15), R15 (≠ K16), C17 (= C18), C21 (= C22), K25 (≠ N26), K50 (≠ G43), C73 (= C57), R74 (≠ N58), C76 (= C60), P80 (= P64), C81 (= C65), V102 (≠ I90), C120 (= C99), I124 (≠ A103), P125 (≠ I104), K136 (= K115), C137 (= C116), M139 (≠ Y118), C140 (= C119), C152 (= C131), C156 (= C135), P157 (= P136), T158 (≠ V137), T160 (≠ A139), M161 (≠ N140)

7b04A of Nitrite oxidoreductase (Nxr) from the anammox bacterium Kuenenia stuttgartiensis.
33% identity, 66% coverage: 41:179/212 of query aligns to 156:305/409 of 7b04A

query
sites
7b04A

D

E

V

Y

G

S

T

T

F

L

P

P

E

E

T

H

K

S

R

R

T

W

F

F

T

F

P

Y

L

L

R
x
Q

-

R

-
x
I

C
|
C

N
|
N

H
|
H

C
|
C

E

T

N

Y

A
x
P

P

G

C
|
C

E

L

R

A

I

A

C
|
C

P

P

V
x
R

S

K

A

A

L
x
I

H

Y

Y

K

L

R

-

K

E

E

N

D

G

G

I

I

V

V

N

L

I

I

D

D

K

Q

E

K

R

R

C
|
C

I
x
R

G
|
G

C
x
Y

S
x
R

G
x
K

C
|
C

V

V

M

E

A

Q

C
|
C

P

P

Y

Y

G

K

A

K

I
x
P

Y

M

I

Y

D

R

P

G

Q

L

T

T

Q

R

T

V

A
x
S

D

E

K
|
K

C
|
C

T

I

Y
x
A

C
|
C

A

Y

H

P

R

R

V

I

A

E

S

G

S

R

-

D

-

S

-

L

-

T

-

D

-

G

-

R

-

P

M

M

M

E

P
x
T

A
x
R

C
|
C

V

M

V

S

A

A

C
|
C

P
x
V

V

G

Q

Q

A
x
I

N
x
R

I

L

F

Q

G

G

D

F

L

L

E

D

D

D

P

N

T

P

S

K

N

N

I

P

S

I

K

T

Y

W

I

L

Q

I

L

R

H

H

Q

Q

G

K

G

I

V

A

Q

L

V

P

R

L

K

Y

P

P

E

Q

K

F

G

G

T

T

N

E

P

P

H

N

H

I

Y

Y

V

I

binding fe3-s4 cluster: C186 (= C69), I191 (≠ L74), C207 (= C89), R208 (≠ I90), G209 (= G91), Y210 (≠ C92), R211 (≠ S93), K212 (≠ G94), C213 (= C95), S231 (≠ A113)
binding protoporphyrin ix containing fe: R188 (≠ V71), R208 (≠ I90), Y210 (≠ C92)
binding iron/sulfur cluster: Q171 (≠ R56), I173 (vs. gap), C174 (= C57), N175 (= N58), H176 (= H59), C177 (= C60), P180 (≠ A63), C182 (= C65), C217 (= C99), P222 (≠ I104), K233 (= K115), C234 (= C116), A236 (≠ Y118), C237 (= C119), T255 (≠ P129), R256 (≠ A130), C257 (= C131), C261 (= C135), V262 (≠ P136), I265 (≠ A139), R266 (≠ N140)

Sites not aligning to the query:

binding iron/sulfur cluster: 34, 35, 36, 37, 38, 40, 44, 48, 59, 60, 62

8c0zC Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
32% identity, 69% coverage: 1:146/212 of query aligns to 1:137/158 of 8c0zC

query
sites
8c0zC

M

M

Q

W

L

K

G

S

F

L

L

H

V

I

D

D

L

P

H

A

L

K

C
|
C

M
x
T

G

G

C
|
C

K

L

G

Q

C
|
C

E

E

I

M

A

A

C
|
C

K

S

V

Y

E

E

N

H

E

T

V

G

P

V

L

I

S

N

T

P

W

S

R

K

L

S

R

R

V

I

K

K

Y

-

V

-

D

-

V

V

G

F

T

S

F

F

P

E

E

H

T

E

K

G

R

R

T

K

F

V

T

-

P

P

L

Y

R

T

C
|
C

N

T

H

Q

C
|
C

E

T

N

E

A

A

P

W

C
|
C

E

L

R

H

I

S

C
|
C

P

P

V

V

S

D

A

A

L
x
I

H

R

Y

L

-

D

L

L

E

T

N

T

G

G

I

A

V

K

N

M

I

V

D

F

K

E

E

D

R

T

C
|
C

I

V

G

G

C
|
C

S

K

G

V

C
|
C

V

T

M

I

A

A

C
|
C

P

P

Y

F

G

G

A
x
T

I

I

Y

N

I

Y

D

N

P

Q

Q

D

T

T

Q

G

T

K

A

V

D

Q

K
|
K

C
|
C

T

D

Y

L

C
|
C

A

E

H

G

R

D

V

-

A

-

S

-

M

-

P

P

A

A

C
|
C

V

A

V

K

A

A

C
|
C

P

P

V
x
T

Q

A

A

A

N

I

I

T

F

Y

G

I

D

D

L

A

E

D

binding iron/sulfur cluster: C12 (= C12), T13 (≠ M13), C15 (= C15), C18 (= C18), C22 (= C22), C53 (= C57), C56 (= C60), C61 (= C65), C65 (= C69), I70 (≠ L74), C86 (= C89), C89 (= C92), C92 (= C95), C96 (= C99), T100 (≠ A103), K112 (= K115), C113 (= C116), C116 (= C119), C122 (= C131), C126 (= C135), T128 (≠ V137)

Query Sequence

>WP_011372132.1 NCBI__GCF_000012965.1:WP_011372132.1
MQLGFLVDLHLCMGCKGCEIACKVENEVPLSTWRLRVKYVDVGTFPETKRTFTPLRCNHC
ENAPCERICPVSALHYLENGIVNIDKERCIGCSGCVMACPYGAIYIDPQTQTADKCTYCA
HRVASSMMPACVVACPVQANIFGDLEDPTSNISKYIQLHQGGVQVRKPEKGTNPHHYYVN
AGNVSLNPLASHRVDGHSLFNKITTLPVGGHH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory