SitesBLAST
Comparing WP_011373513.1 NCBI__GCF_000012965.1:WP_011373513.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5kf0A Crystal structure of an aldedhyde dehydrogenase from burkholderia vietnamiensis
38% identity, 95% coverage: 22:470/471 of query aligns to 28:477/480 of 5kf0A
- active site: N157 (= N151), K180 (= K174), E252 (= E247), C288 (= C281), E382 (= E375), E460 (= E453)
- binding magnesium ion: E88 (≠ K82)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I153 (= I147), S154 (≠ T148), P155 (= P149), F156 (= F150), N157 (= N151), L162 (= L156), K180 (= K174), S183 (≠ P177), R184 (≠ E178), R213 (≠ A208), T231 (= T226), G232 (= G227), S233 (= S228), V236 (= V231), E252 (= E247), L253 (= L248), C288 (= C281), E382 (= E375), F384 (= F377)
Sites not aligning to the query:
3rhdA Crystal structure of glyceraldehyde-3-phosphate dehydrogenase gapn from methanocaldococcus jannaschii dsm 2661 complexed with NADP
39% identity, 96% coverage: 21:471/471 of query aligns to 9:455/456 of 3rhdA
- active site: N133 (= N151), H156 (≠ K174), E233 (= E247), C267 (= C281), E360 (= E375), E437 (= E453)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I129 (= I147), T130 (= T148), F132 (= F150), H156 (≠ K174), S158 (≠ T176), S159 (≠ P177), K160 (≠ E178), G193 (≠ A208), E194 (≠ D209), G197 (= G211), D198 (≠ G212), F211 (= F225), S214 (= S228), V217 (= V231)
5j6bA Crystal structure of aldehyde dehydrogenase from burkholderia thailandensis in covelent complex with NADPH
38% identity, 95% coverage: 22:470/471 of query aligns to 29:478/481 of 5j6bA
- active site: N158 (= N151), K181 (= K174), E253 (= E247), C289 (= C281), E383 (= E375), E461 (= E453)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I154 (= I147), S155 (≠ T148), P156 (= P149), F157 (= F150), N158 (= N151), L163 (= L156), K181 (= K174), A183 (≠ T176), S184 (≠ P177), R214 (≠ A208), T232 (= T226), G233 (= G227), S234 (= S228), V237 (= V231), L241 (≠ I235), E253 (= E247), L254 (= L248), C289 (= C281), E383 (= E375), F385 (= F377), Y450 (= Y442)
5n5sB Crystal structure of aldehyde dehydrogenase 21 (aldh21) from physcomitrella patens in complex with NADP+ (see paper)
38% identity, 87% coverage: 61:470/471 of query aligns to 65:475/481 of 5n5sB
- active site: N155 (= N151), K178 (= K174), E251 (= E247), C286 (= C281), E380 (= E375), E458 (= E453)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V151 (≠ I147), S152 (≠ T148), P153 (= P149), W154 (≠ F150), N155 (= N151), L160 (= L156), K178 (= K174), A180 (≠ T176), S181 (≠ P177), R212 (≠ A208), A215 (≠ G211), T230 (= T226), G231 (= G227), S232 (= S228), I235 (≠ V231), E251 (= E247), L252 (= L248), C286 (= C281), E380 (= E375), F382 (= F377), Y447 (= Y442)
8hapB Crystal structure of thermostable acetaldehyde dehydrogenase from hyperthermophilic archaeon sulfolobus tokodaii (see paper)
34% identity, 96% coverage: 22:471/471 of query aligns to 7:464/466 of 8hapB
- binding 2'-monophosphoadenosine-5'-diphosphate: I136 (= I147), L137 (≠ T148), F139 (= F150), K163 (= K174), S165 (≠ T176), I166 (≠ P177), S196 (≠ D207), G200 (= G211), G216 (= G227), S217 (= S228), T220 (≠ V231), I224 (= I234)
8hapA Crystal structure of thermostable acetaldehyde dehydrogenase from hyperthermophilic archaeon sulfolobus tokodaii (see paper)
34% identity, 96% coverage: 22:471/471 of query aligns to 7:464/466 of 8hapA
- binding [(2r,3r,4r,5r)-5-(6-amino-9h-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]methyl [(2r,3s,4s)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate: I136 (= I147), L137 (≠ T148), F139 (= F150), K163 (= K174), S165 (≠ T176), I166 (≠ P177), S196 (≠ D207), G200 (= G211), G216 (= G227), S217 (= S228), T220 (≠ V231), I224 (= I234), L239 (= L248), C272 (= C281), E368 (= E375), F370 (= F377)
Q59931 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]; Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase; Triosephosphate dehydrogenase; EC 1.2.1.9 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see 3 papers)
35% identity, 87% coverage: 61:469/471 of query aligns to 63:471/475 of Q59931
- R103 (= R101) binding substrate
- S151 (≠ T148) binding NADP(+)
- K177 (= K174) binding NADP(+)
- T180 (≠ P177) binding NADP(+)
- D215 (≠ G212) binding NADP(+)
- 230:251 (vs. 227:248, 55% identical) binding NADP(+)
- E377 (= E375) binding NADP(+)
- R437 (≠ L435) binding substrate
2esdA Crystal structure of thioacylenzyme intermediate of an NADP dependent aldehyde dehydrogenase (see paper)
35% identity, 87% coverage: 61:469/471 of query aligns to 62:470/474 of 2esdA
- active site: N153 (= N151), K176 (= K174), A249 (≠ E247), C283 (= C281), E376 (= E375), Q454 (≠ E453)
- binding glyceraldehyde-3-phosphate: R102 (= R101), Y154 (≠ F152), R282 (≠ V280), C283 (= C281), T284 (≠ I282), Q435 (≠ T434), R436 (≠ L435)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: F152 (= F150), K176 (= K174), P178 (≠ T176), T179 (≠ P177), G209 (≠ D207), G213 (= G211), D214 (≠ G212), F227 (= F225), S230 (= S228), I233 (≠ V231), K328 (≠ E327), S329 (≠ A328), Y332 (≠ R331)
1qi1B Ternary complex of an NADP dependent aldehyde dehydrogenase (see paper)
35% identity, 87% coverage: 61:469/471 of query aligns to 62:470/474 of 1qi1B
- active site: N153 (= N151), K176 (= K174), E249 (= E247), S283 (≠ C281), E376 (= E375), Q454 (≠ E453)
- binding sn-glycerol-3-phosphate: Y154 (≠ F152), R282 (≠ V280), S283 (≠ C281), T284 (≠ I282), R436 (≠ L435)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P151 (= P149), F152 (= F150), N153 (= N151), L158 (= L156), K176 (= K174), P178 (≠ T176), T179 (≠ P177), G209 (≠ D207), G213 (= G211), G229 (= G227), S230 (= S228), I233 (≠ V231), E249 (= E247), L250 (= L248), S283 (≠ C281)
O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 98% coverage: 10:470/471 of query aligns to 28:495/503 of O14293