Comparing WP_011382583.1 NCBI__GCF_000009985.1:WP_011382583.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6rj3A Crystal structure of phgdh in complex with compound 15 (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 29:285/297 of 6rj3A
6rj2A Crystal structure of phgdh in complex with compound 40 (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 27:283/299 of 6rj2A
6plfA Crystal structure of human phgdh complexed with compound 1 (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 31:287/305 of 6plfA
6plgA Crystal structure of human phgdh complexed with compound 15 (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 30:286/303 of 6plgA
7dkmA Phgdh covalently linked to oridonin (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 31:287/306 of 7dkmA
Sites not aligning to the query:
7ewhA Crystal structure of human phgdh in complex with homoharringtonine (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 30:286/302 of 7ewhA
6rihA Crystal structure of phgdh in complex with compound 9 (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 30:286/302 of 6rihA
6cwaA Crystal structure phgdh in complex with nadh and 3-phosphoglycerate at 1.77 a resolution (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 29:285/299 of 6cwaA
O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 3 papers)
37% identity, 80% coverage: 40:293/318 of query aligns to 35:291/533 of O43175
Sites not aligning to the query:
6rj5A Crystal structure of phgdh in complex with compound 39 (see paper)
37% identity, 80% coverage: 40:293/318 of query aligns to 30:286/301 of 6rj5A
6plfB Crystal structure of human phgdh complexed with compound 1 (see paper)
38% identity, 71% coverage: 67:293/318 of query aligns to 49:277/292 of 6plfB
3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis (see paper)
40% identity, 73% coverage: 63:293/318 of query aligns to 54:286/525 of 3ddnB
Sites not aligning to the query:
3dc2A Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
40% identity, 73% coverage: 63:293/318 of query aligns to 53:285/526 of 3dc2A
Sites not aligning to the query:
5aovA Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
35% identity, 77% coverage: 54:298/318 of query aligns to 47:301/334 of 5aovA
7cvpA The crystal structure of human phgdh from biortus.
37% identity, 65% coverage: 88:293/318 of query aligns to 33:240/254 of 7cvpA
7va1A Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with gdd-04-35
38% identity, 59% coverage: 106:293/318 of query aligns to 1:190/193 of 7va1A
5ofwA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-chloro-4-fluorobenzamide (see paper)
38% identity, 59% coverage: 106:293/318 of query aligns to 3:192/195 of 5ofwA
5ofvA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid (see paper)
38% identity, 59% coverage: 106:293/318 of query aligns to 3:192/195 of 5ofvA
5ofmA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-amino-1-methyl-1h-indole
38% identity, 59% coverage: 106:293/318 of query aligns to 3:192/195 of 5ofmA
5nzqA Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-(1,3-oxazol-5-yl)aniline. (see paper)
38% identity, 59% coverage: 106:293/318 of query aligns to 3:192/195 of 5nzqA
>WP_011382583.1 NCBI__GCF_000009985.1:WP_011382583.1
MTDTTTRVAVASRSFSKHPVLRAELQARYANVTFNDAGLSLSGDDLVAFLLGHDKAVTAL
EKLDEAVLSRLPDLKVVGKYGVGLDMIDLAAMSRLGKRLGWTGGVNRRSVSELVIAFAIA
LLRHIPQGNALIRDGGWRQLMGRQLSERTVGIVGCGHIGKDLSRLLKAFGCRVLAHDIRD
FPEFYAATGVEKMDLEPLLAEADIVTLHLPFDASTRNILSAERLALMRSDAILINAARGG
LVDEAALRVMLATGRLAAAAFDVFATEPPEDRALIELPNFLCTPHVGGSAEEAVLAMGRA
AIAGLDEARDPLDYKGQG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory