SitesBLAST
Comparing WP_011384423.1 NCBI__GCF_000009985.1:WP_011384423.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
92% identity, 100% coverage: 1:768/769 of query aligns to 1:768/769 of O33819
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
93% identity, 99% coverage: 9:768/769 of query aligns to 1:760/761 of 1rm6A
- active site: Q206 (= Q214), T241 (= T249), Y318 (= Y326), L322 (= L330), R350 (= R358), E718 (= E726), G719 (= G727)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G243), G236 (= G244), F237 (= F245), G238 (= G246), R350 (= R358), I473 (= I481), G474 (= G482), Q475 (= Q483), G476 (= G484), Y513 (= Y521), S514 (= S522), S515 (= S523), V517 (= V525), T518 (= T526), L646 (= L654), N647 (= N655), V651 (= V659), Q654 (= Q662), K714 (= K722), E715 (= E723), A716 (= A724), S717 (= S725), E718 (= E726)
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
31% identity, 94% coverage: 7:729/769 of query aligns to 10:746/786 of 1t3qB
- active site: Q224 (= Q214), A259 (≠ T249), E336 (≠ Y326), V343 (≠ L330), R371 (= R358), E743 (= E726), S744 (≠ G727)
- binding pterin cytosine dinucleotide: G254 (= G244), F255 (= F245), R371 (= R358), S506 (≠ I481), G507 (= G482), Q508 (= Q483), H510 (≠ S485), T513 (≠ M488), Y545 (= Y521), S547 (= S523), G549 (≠ V525), A550 (≠ T526), C666 (≠ V650), I670 (≠ L654), I674 (≠ A658), V675 (= V659), Q678 (= Q662), K739 (= K722), G740 (≠ E723), M741 (≠ A724), G742 (≠ S725)
7dqxD Crystal structure of xanthine dehydrogenase family protein
29% identity, 96% coverage: 24:758/769 of query aligns to 19:762/770 of 7dqxD
- binding pterin cytosine dinucleotide: G247 (= G243), S248 (≠ G244), F249 (= F245), R363 (= R358), V491 (≠ I481), G492 (= G482), Q493 (= Q483), G494 (= G484), V498 (≠ M488), S530 (= S520), W531 (≠ Y521), S532 (= S522), S533 (= S523), R534 (= R524), S535 (≠ V525), T536 (= T526), T658 (≠ A658), T659 (≠ V659), Q662 (= Q662), G725 (≠ E723), L726 (≠ A724), G727 (≠ S725), E728 (= E726)
4zohA Crystal structure of glyceraldehyde oxidoreductase (see paper)
28% identity, 97% coverage: 11:758/769 of query aligns to 3:700/701 of 4zohA
- active site: Q186 (= Q214), I219 (≠ T249), V298 (≠ I324), S300 (≠ Y326), M304 (≠ L330), R332 (= R358), E668 (= E726), A669 (≠ G727)
- binding pterin cytosine dinucleotide: G213 (= G243), A214 (≠ G244), F215 (= F245), R332 (= R358), H442 (≠ I481), G443 (= G482), Q444 (= Q483), D446 (≠ S485), W482 (≠ Y521), S484 (= S523), T486 (≠ V525), V487 (≠ T526), I594 (≠ L654), N595 (= N655), L598 (≠ A658), Q602 (= Q662), K664 (= K722), G665 (≠ E723), I666 (≠ A724), G667 (≠ S725), E668 (= E726)
Q0QLF2 Nicotinate dehydrogenase large molybdopterin subunit; NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
36% identity, 50% coverage: 11:391/769 of query aligns to 8:384/425 of Q0QLF2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2:425 modified: mature protein, Nicotinate dehydrogenase large molybdopterin subunit
3hrdE Crystal structure of nicotinate dehydrogenase (see paper)
36% identity, 50% coverage: 11:391/769 of query aligns to 7:383/420 of 3hrdE
- active site: Q207 (= Q214), L242 (≠ T249), R318 (≠ Y326), H322 (≠ L330), R350 (= R358)
- binding calcium ion: T206 (= T213), N208 (≠ V215), D212 (≠ V219), K241 (≠ R248), L242 (≠ T249), D243 (≠ E250)
- binding pterin cytosine dinucleotide: G237 (= G244), F238 (= F245), R350 (= R358)
- binding selenium atom: F238 (= F245), A348 (= A356), F349 (≠ M357), R350 (= R358)
3hrdA Crystal structure of nicotinate dehydrogenase (see paper)
36% identity, 50% coverage: 11:391/769 of query aligns to 7:383/420 of 3hrdA
- active site: Q207 (= Q214), L242 (≠ T249), R318 (≠ Y326), H322 (≠ L330), R350 (= R358)
- binding pterin cytosine dinucleotide: G236 (= G243), G237 (= G244), F238 (= F245), R350 (= R358)
- binding magnesium ion: T206 (= T213), N208 (≠ V215), D212 (≠ V219), K241 (≠ R248), L242 (≠ T249), D243 (≠ E250), T305 (≠ G313), Y308 (= Y316), A309 (= A317), S346 (≠ C354)
- binding nicotinic acid: A314 (≠ I322), R318 (≠ Y326), F352 (≠ H360)
- binding selenium atom: F238 (= F245), G239 (= G246), A348 (= A356), F349 (≠ M357), R350 (= R358)
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
27% identity, 95% coverage: 11:743/769 of query aligns to 15:774/803 of 1n60B
- active site: Q234 (= Q214), V269 (≠ T249), P346 (≠ Y326), I352 (≠ L330), R381 (≠ G359), C382 (≠ H360), E757 (= E726), S758 (≠ G727)
- binding pterin cytosine dinucleotide: G264 (= G244), F265 (= F245), R381 (≠ G359), Q522 (≠ I481), G523 (= G482), Q524 (= Q483), H526 (≠ S485), T529 (≠ M488), T561 (≠ S520), Y562 (= Y521), G563 (≠ S522), S564 (= S523), S566 (≠ V525), T567 (= T526), C680 (≠ V650), I684 (≠ L654), I688 (≠ A658), I689 (≠ V659), Q692 (= Q662), K753 (= K722), G754 (≠ E723), V755 (≠ A724), E757 (= E726)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F245), G266 (= G246), Y562 (= Y521), G563 (≠ S522), E757 (= E726)
1n63B Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state (see paper)
27% identity, 95% coverage: 11:743/769 of query aligns to 17:776/805 of 1n63B
- active site: Q236 (= Q214), V271 (≠ T249), P348 (≠ Y326), I354 (≠ L330), R383 (≠ G359), C384 (≠ H360), E759 (= E726), S760 (≠ G727)
- binding cu(i)-s-mo(iv)(=o)oh cluster: G268 (= G246), A381 (≠ M357), R383 (≠ G359), C384 (≠ H360), Y564 (= Y521), G565 (≠ S522), E759 (= E726)
- binding pterin cytosine dinucleotide: G266 (= G244), F267 (= F245), R383 (≠ G359), Q524 (≠ I481), G525 (= G482), Q526 (= Q483), H528 (≠ S485), T531 (≠ M488), T563 (≠ S520), Y564 (= Y521), S566 (= S523), S568 (≠ V525), T569 (= T526), C682 (≠ V650), I686 (≠ L654), I690 (≠ A658), I691 (≠ V659), Q694 (= Q662), K755 (= K722), G756 (≠ E723), V757 (≠ A724), E759 (= E726)
1n62B Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state (see paper)
27% identity, 95% coverage: 11:743/769 of query aligns to 16:775/804 of 1n62B
- active site: Q235 (= Q214), V270 (≠ T249), P347 (≠ Y326), I353 (≠ L330), R382 (≠ G359), C383 (≠ H360), E758 (= E726), S759 (≠ G727)
- binding cu(i)-s-mo(iv)(=o)o-nbic cluster: G267 (= G246), V379 (≠ A356), A380 (≠ M357), R382 (≠ G359), C383 (≠ H360), F385 (≠ T362), Y563 (= Y521), G564 (≠ S522), E758 (= E726)
- binding pterin cytosine dinucleotide: G265 (= G244), F266 (= F245), R382 (≠ G359), Q523 (≠ I481), G524 (= G482), Q525 (= Q483), H527 (≠ S485), T530 (≠ M488), T562 (≠ S520), Y563 (= Y521), G564 (≠ S522), S565 (= S523), S567 (≠ V525), T568 (= T526), C681 (≠ V650), I685 (≠ L654), I689 (≠ A658), I690 (≠ V659), Q693 (= Q662), K754 (= K722), G755 (≠ E723), V756 (≠ A724), G757 (≠ S725), E758 (= E726)
1n5wB Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
27% identity, 95% coverage: 11:743/769 of query aligns to 16:775/804 of 1n5wB
- active site: Q235 (= Q214), V270 (≠ T249), P347 (≠ Y326), I353 (≠ L330), R382 (≠ G359), C383 (≠ H360), E758 (= E726), S759 (≠ G727)
- binding cu(i)-s-mo(vi)(=o)oh cluster: G267 (= G246), A380 (≠ M357), R382 (≠ G359), C383 (≠ H360), Y563 (= Y521), G564 (≠ S522), E758 (= E726)
- binding pterin cytosine dinucleotide: G265 (= G244), F266 (= F245), R382 (≠ G359), Q523 (≠ I481), G524 (= G482), Q525 (= Q483), H527 (≠ S485), T530 (≠ M488), T562 (≠ S520), Y563 (= Y521), S565 (= S523), S567 (≠ V525), T568 (= T526), C681 (≠ V650), I685 (≠ L654), I689 (≠ A658), I690 (≠ V659), Q693 (= Q662), K754 (= K722), G755 (≠ E723), V756 (≠ A724), E758 (= E726)
P19919 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
27% identity, 95% coverage: 11:743/769 of query aligns to 21:780/809 of P19919
- C388 (≠ H360) binding
- E763 (= E726) binding
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
27% identity, 95% coverage: 11:743/769 of query aligns to 16:775/804 of 1zxiB
- active site: Q235 (= Q214), V270 (≠ T249), P347 (≠ Y326), I353 (≠ L330), R382 (≠ G359), C383 (≠ H360), E758 (= E726), S759 (≠ G727)
- binding copper (ii) ion: C383 (≠ H360), S384 (≠ G361), E758 (= E726)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F245), G267 (= G246), A380 (≠ M357), Y381 (≠ R358), R382 (≠ G359), C383 (≠ H360), Y563 (= Y521), G564 (≠ S522), E758 (= E726)
- binding pterin cytosine dinucleotide: G265 (= G244), F266 (= F245), R382 (≠ G359), Q523 (≠ I481), G524 (= G482), Q525 (= Q483), H527 (≠ S485), T530 (≠ M488), T562 (≠ S520), Y563 (= Y521), S565 (= S523), S567 (≠ V525), T568 (= T526), C681 (≠ V650), I685 (≠ L654), I689 (≠ A658), I690 (≠ V659), Q693 (= Q662), K754 (= K722), G755 (≠ E723), V756 (≠ A724), E758 (= E726)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
27% identity, 95% coverage: 24:752/769 of query aligns to 31:786/803 of P19913
- R384 (≠ G359) modified: 4-hydroxyarginine
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
27% identity, 95% coverage: 24:752/769 of query aligns to 25:780/797 of 1ffvB
- active site: Q231 (= Q214), V266 (≠ T249), P343 (≠ Y326), I349 (vs. gap), R378 (≠ G359), C379 (≠ H360), E751 (= E726), S752 (≠ G727)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G243), G261 (= G244), F262 (= F245), G263 (= G246), A376 (≠ M357), R378 (≠ G359), C379 (≠ H360), Q516 (≠ I481), G517 (= G482), Q518 (= Q483), H520 (≠ S485), T523 (≠ M488), Y556 (= Y521), G557 (≠ S522), S558 (= S523), S560 (≠ V525), T561 (= T526), C674 (≠ V650), I678 (≠ L654), I683 (≠ V659), Q686 (= Q662), K747 (= K722), G748 (≠ E723), V749 (≠ A724), A750 (≠ S725), E751 (= E726)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
27% identity, 95% coverage: 24:752/769 of query aligns to 25:780/797 of 1ffuB
- active site: Q231 (= Q214), V266 (≠ T249), P343 (≠ Y326), I349 (vs. gap), R378 (≠ G359), C379 (≠ H360), E751 (= E726), S752 (≠ G727)
- binding cytidine-5'-diphosphate: Q518 (= Q483), H520 (≠ S485), T523 (≠ M488), S558 (= S523), S560 (≠ V525), T561 (= T526), C674 (≠ V650), T676 (≠ K652), I678 (≠ L654), I683 (≠ V659), K747 (= K722), G748 (≠ E723), V749 (≠ A724), A750 (≠ S725)
1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
26% identity, 99% coverage: 1:762/769 of query aligns to 165:905/906 of 1dgjA
- active site: V391 (≠ Q214), F427 (vs. gap), R503 (≠ Y326), Y507 (≠ L330), R535 (= R358), E869 (= E726), M870 (≠ G727)
- binding molybdenum (iv)oxide: G424 (= G246), R535 (= R358), G698 (≠ Y521), E869 (= E726)
- binding pterin cytosine dinucleotide: F423 (= F245), G424 (= G246), R535 (= R358), W652 (≠ A478), H655 (≠ I481), G656 (= G482), Q657 (= Q483), G658 (= G484), A697 (≠ S520), G698 (≠ Y521), S700 (= S523), S702 (≠ V525), Q703 (≠ T526), C799 (≠ L654), N800 (= N655), V803 (≠ A658), V804 (= V659), Q807 (= Q662), S865 (≠ K722), G866 (≠ E723), V867 (≠ A724), G868 (≠ S725), E869 (= E726)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 39, 40, 41, 43, 44, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding pterin cytosine dinucleotide: 99, 139
5y6qC Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
28% identity, 97% coverage: 11:758/769 of query aligns to 7:747/748 of 5y6qC
- active site: Q204 (= Q214), P239 (≠ T249), A310 (≠ Y326), V316 (vs. gap), R344 (= R358), E715 (= E726), L716 (≠ G727)
- binding pterin cytosine dinucleotide: G233 (= G243), G234 (= G244), F235 (= F245), I461 (= I481), G462 (= G482), T463 (≠ Q483), G464 (= G484), I468 (≠ M488), G500 (≠ Y521), S502 (= S523), Q503 (≠ R524), L504 (≠ V525), A505 (≠ T526), R638 (≠ K652), Y640 (≠ L654), N641 (= N655), Q648 (= Q662), K711 (= K722), V713 (≠ A724), G714 (≠ S725), E715 (= E726)
7orcB Human aldehyde oxidase in complex with raloxifene (see paper)
26% identity, 98% coverage: 2:758/769 of query aligns to 534:1274/1299 of 7orcB
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 43, 44, 228, 229, 230, 231, 232, 233, 234, 235, 236, 309, 310, 318, 319, 322, 323, 326, 328, 331, 332, 376, 403
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 111, 112, 114, 146, 148
- binding raloxifene: 417, 418, 419, 449, 451, 506, 507
Query Sequence
>WP_011384423.1 NCBI__GCF_000009985.1:WP_011384423.1
MSPKFPKNGTVGARTPLVDGVEKVTGKAKYTADIAAPGALVGRILRSPVAHARIISIDTS
AAEALDGVYAVCTGAETPVPYGVLPIAENEYPLARDKVRYRGDPVAAVAAVDELTAEQAL
NLIKVEYEVLPAYMTPKAAMKEGAIALHDDKPNNVLREVHAEFGDVEAAFGEAELIREKV
YTFAEVNHVHMELNATLAEYDPVRDMLTLNTTTQVPYYVHLKVAACLQMDSARIRVIKPF
LGGGFGARTECLHFEIIAGLLARKAKGTVKLVQTREETFIAHRGRPWTEVKMKIGLMRDG
KIAALALEATQAGGAYAGYGIITILYTGALMHGLYHIPAIKHDAWRVYTNTPPCGAMRGH
GTVDTRAAFEALLTEMGEELGIDSLDIRQRNMLPQIPYTTMYAQKVMSYGVPECLEKVKA
ASGWAERKGKMPKGRGLGIALSHFVSGTSTPKHWTGEPHATVNLKLDFDGGITLLTGAAD
IGQGSNTMATQVAAEVLGVRMSRIRVISADSALTPKDNGSYSSRVTFMVGNASISAAEEL
KAILVKAAAKKLDAREEDIEVIDEVFMVAGSQDPGLTFQEVVKAALIDTGTITVKGTFTC
PTEFQGDKKIRGSAIGATMGFCYAAQVVEASVDEITGRVTAHKVWVAVDVGKALNPLAVE
GQTQGGVWMGMGQALSEETRWDDGKMMHGNILDYRVPTMAESPDIEVMIVESLDPNGPFG
AKEASEGMLAGFLPAVHEAVYEAVGVRSTKFPLSPETITELLDAKEAAE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory