Comparing WP_011384539.1 NCBI__GCF_000009985.1:WP_011384539.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 4 hits to proteins with known functional sites (download)
3o3oA (R)-2-hydroxyisocaproyl-coa dehydratase in complex with (r)-2- hydroxyisocaproate (see paper)
25% identity, 94% coverage: 18:423/432 of query aligns to 9:397/399 of 3o3oA
3o3nA (R)-2-hydroxyisocaproyl-coa dehydratase in complex with its substrate (r)-2-hydroxyisocaproyl-coa (see paper)
25% identity, 94% coverage: 18:423/432 of query aligns to 10:398/399 of 3o3nA
Sites not aligning to the query:
3o3mC (R)-2-hydroxyisocaproyl-coa dehydratase (see paper)
25% identity, 94% coverage: 18:423/432 of query aligns to 11:399/401 of 3o3mC
Q5U924 (R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit; EC 4.2.1.157 from Clostridioides difficile (Peptoclostridium difficile) (see 2 papers)
25% identity, 94% coverage: 18:423/432 of query aligns to 14:402/408 of Q5U924
Sites not aligning to the query:
>WP_011384539.1 NCBI__GCF_000009985.1:WP_011384539.1
MSKPEAVKEPSMEMQKAMIARNYDAITSKHETGRKVSSTFVPGNLNELLMCFDIVNNLPE
INAIQAGMRKASGGYIMEAEKSGHSEDVCTYVKADIGQMSKGNIAPNGKPYPNPDVLMLS
YTGCYTFMKWFELLREEYKCPTLMLHVPYEGDGHSTKNMRDYIVKQLKEVVIPGLEQVSG
VKFDIDRLRQYLRNSAKAEDNLVWCLEQGKVKPSPIDAYFGGVYYIGPIFTAFRGTEDAV
SYYEMLRKEVQGRIENHQGPLTPEGTYFNDQKYRLIVEGPPNWTNFREFWKMFYDEGAIV
VASSYTKVGGLYDQGFRHDPDNPLESLADYCLGCYTNLNLPTRVDLLAKYVEEYEADGLL
INSIKSCNSFSAGQLMIMKEVERRTGRPGAFIETDLVDPRYFSAANVKNRLESYFQMIEQ
KRRGGGSKTVAA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory