SitesBLAST
Comparing WP_011385596.1 NCBI__GCF_000009985.1:WP_011385596.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
70% identity, 99% coverage: 4:391/392 of query aligns to 3:385/385 of 3gqtC
- active site: L135 (= L136), T136 (= T137), A250 (= A250), E365 (= E371), R377 (= R383)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W167), K210 (= K210), L213 (= L213), T218 (= T218), Y364 (= Y370)
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
70% identity, 99% coverage: 4:390/392 of query aligns to 4:380/380 of 3gncA
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
70% identity, 99% coverage: 4:390/392 of query aligns to 3:382/382 of 3eonC
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
66% identity, 99% coverage: 4:392/392 of query aligns to 2:389/390 of 2r0nA
- active site: L133 (= L136), T134 (= T137), A247 (= A250), E368 (= E371), R380 (= R383)
- binding flavin-adenine dinucleotide: F131 (= F134), L133 (= L136), T134 (= T137), G139 (= G142), S140 (= S143), W166 (= W167), I167 (= I168), T168 (= T169), Y367 (= Y370), T370 (≠ A373), D372 (= D375)
- binding 3-thiaglutaryl-CoA: R92 (= R95), S93 (= S96), V97 (= V100), P142 (= P145), G238 (= G241), F241 (= F244), L244 (= L247), N245 (= N248), P318 (= P321), Y367 (= Y370), E368 (= E371), I377 (= I380)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
66% identity, 99% coverage: 4:392/392 of query aligns to 2:389/390 of 1sirA
- active site: L133 (= L136), T134 (= T137), A247 (= A250), E368 (= E371), R380 (= R383)
- binding flavin-adenine dinucleotide: F131 (= F134), L133 (= L136), T134 (= T137), G139 (= G142), S140 (= S143), W166 (= W167), I167 (= I168), T168 (= T169), Y367 (= Y370), T370 (≠ A373)
- binding s-4-nitrobutyryl-coa: S93 (= S96), S140 (= S143), F241 (= F244), G242 (= G245), L244 (= L247), N245 (= N248), R248 (= R251), P318 (= P321), Y367 (= Y370), E368 (= E371), R380 (= R383)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
65% identity, 99% coverage: 4:392/392 of query aligns to 2:389/390 of 2r0mA
- active site: L133 (= L136), T134 (= T137), A247 (= A250), D368 (≠ E371), R380 (= R383)
- binding 4-nitrobutanoic acid: L101 (= L104), Y367 (= Y370), D368 (≠ E371)
- binding flavin-adenine dinucleotide: F131 (= F134), L133 (= L136), T134 (= T137), G139 (= G142), S140 (= S143), W166 (= W167), I167 (= I168), T168 (= T169), L210 (= L213), Y367 (= Y370), T370 (≠ A373)
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
68% identity, 99% coverage: 4:390/392 of query aligns to 3:377/377 of 3d6bC
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
49% identity, 98% coverage: 8:391/392 of query aligns to 3:380/380 of 2ebaA
- active site: L131 (= L136), T132 (= T137), A239 (= A250), E360 (= E371), R372 (= R383)
- binding flavin-adenine dinucleotide: L131 (= L136), T132 (= T137), G136 (≠ A141), G137 (= G142), S138 (= S143), W161 (= W167), T163 (= T169), R265 (= R276), L272 (= L283), K275 (≠ N286), D333 (= D344), I334 (≠ M345), G337 (= G348), T355 (= T366), T358 (= T369), Y359 (= Y370), T362 (≠ A373)
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
48% identity, 98% coverage: 7:391/392 of query aligns to 5:386/387 of 3sf6A
- active site: L134 (= L136), T135 (= T137), A245 (= A250), E366 (= E371), Q378 (≠ R383)
- binding dihydroflavine-adenine dinucleotide: F132 (= F134), L134 (= L136), T135 (= T137), G140 (= G142), S141 (= S143), W165 (= W167), I166 (= I168), T167 (= T169), S361 (≠ T366), T364 (= T369), Y365 (= Y370), T368 (≠ A373), E370 (≠ D375), M371 (≠ V376)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
46% identity, 96% coverage: 16:391/392 of query aligns to 16:387/388 of 3swoA
- active site: L135 (= L136), T136 (= T137), A246 (= A250), E367 (= E371), K379 (≠ R383)
- binding dihydroflavine-adenine dinucleotide: F133 (= F134), L135 (= L136), T136 (= T137), G141 (= G142), S142 (= S143), W166 (= W167), I167 (= I168), T168 (= T169), R272 (= R276), V274 (≠ Q278), F275 (= F279), L279 (= L283), Y282 (≠ N286), T340 (≠ D344), L341 (≠ M345), G344 (= G348), I347 (= I351), T365 (= T369), Y366 (= Y370), T369 (≠ A373), E371 (≠ D375), M372 (≠ V376)
2ix6A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 (see paper)
35% identity, 98% coverage: 7:391/392 of query aligns to 30:412/416 of 2ix6A
- active site: L158 (= L136), T159 (= T137), S271 (≠ A250), E392 (= E371), R404 (= R383)
- binding flavin-adenine dinucleotide: T159 (= T137), G164 (= G142), S165 (= S143), W189 (= W167), N239 (≠ T218), R297 (= R276), F300 (= F279), L304 (= L283), F307 (≠ N286), N310 (≠ P289), E365 (≠ D344), L366 (≠ M345), G369 (= G348), I372 (= I351), Y391 (= Y370), T394 (≠ A373), D396 (= D375)
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
35% identity, 98% coverage: 7:391/392 of query aligns to 30:412/415 of 2ix5A
- active site: L158 (= L136), T159 (= T137), S271 (≠ A250), E392 (= E371), R404 (= R383)
- binding acetoacetyl-coenzyme a: S165 (= S143), A167 (≠ P145), S168 (≠ G146), F261 (≠ L240), L268 (= L247), R272 (= R251), E392 (= E371), G393 (= G372), R404 (= R383)
- binding flavin-adenine dinucleotide: L158 (= L136), T159 (= T137), G164 (= G142), S165 (= S143), W189 (= W167), N239 (≠ T218), R297 (= R276), F300 (= F279), L304 (= L283), F307 (≠ N286), L309 (≠ I288), N310 (≠ P289), E365 (≠ D344), L366 (≠ M345), G368 (= G347), G369 (= G348), Y391 (= Y370), T394 (≠ A373), D396 (= D375), I397 (≠ V376)
Q96329 Acyl-coenzyme A oxidase 4, peroxisomal; AOX 4; G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
35% identity, 98% coverage: 7:391/392 of query aligns to 46:428/436 of Q96329
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
34% identity, 95% coverage: 15:385/392 of query aligns to 4:377/380 of 4l1fA
- active site: L125 (= L136), T126 (= T137), G242 (≠ A250), E363 (= E371), R375 (= R383)
- binding coenzyme a persulfide: T132 (≠ S143), H179 (vs. gap), F232 (≠ L240), M236 (≠ F244), E237 (≠ G245), L239 (= L247), D240 (≠ N248), R243 (= R251), Y362 (= Y370), E363 (= E371), G364 (= G372), R375 (= R383)
- binding flavin-adenine dinucleotide: F123 (= F134), L125 (= L136), T126 (= T137), G131 (= G142), T132 (≠ S143), F156 (≠ W167), I157 (= I168), T158 (= T169), R268 (= R276), Q270 (= Q278), F271 (= F279), I275 (≠ L283), F278 (≠ N286), L281 (≠ P289), Q336 (≠ D344), I337 (≠ M345), G340 (= G348), I358 (≠ T366), Y362 (= Y370), T365 (≠ A373), Q367 (≠ D375)
- binding 1,3-propandiol: L5 (= L16), Q10 (≠ K21)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
36% identity, 94% coverage: 21:387/392 of query aligns to 11:374/374 of 5lnxD
- active site: L122 (= L136), T123 (= T137), G239 (≠ A250), E358 (= E371), K370 (≠ R383)
- binding flavin-adenine dinucleotide: L122 (= L136), T123 (= T137), G128 (= G142), S129 (= S143), F153 (≠ W167), T155 (= T169), R265 (= R276), Q267 (= Q278), F268 (= F279), I272 (≠ L283), N275 (= N286), I278 (≠ P289), Q331 (≠ D344), I332 (≠ M345), G335 (= G348), Y357 (= Y370), T360 (≠ A373), E362 (≠ D375)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
33% identity, 95% coverage: 12:385/392 of query aligns to 2:378/378 of 4n5fA
- active site: L126 (= L136), T127 (= T137), G243 (≠ A250), E364 (= E371), R376 (= R383)
- binding dihydroflavine-adenine dinucleotide: L126 (= L136), T127 (= T137), G132 (= G142), S133 (= S143), F157 (≠ W167), T159 (= T169), T210 (= T218), Y363 (= Y370), T366 (≠ A373), E368 (≠ D375), M372 (≠ L379)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
34% identity, 95% coverage: 13:385/392 of query aligns to 1:376/376 of 4m9aB
- active site: L124 (= L136), T125 (= T137), G241 (≠ A250), E362 (= E371), R374 (= R383)
- binding dihydroflavine-adenine dinucleotide: F122 (= F134), T125 (= T137), G130 (= G142), S131 (= S143), F155 (≠ W167), T157 (= T169), T208 (= T218), Y361 (= Y370), T364 (≠ A373), E366 (≠ D375), M370 (≠ L379)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
32% identity, 94% coverage: 14:381/392 of query aligns to 2:372/378 of 5ol2F
- active site: L124 (= L136), T125 (= T137), G241 (≠ A250)
- binding calcium ion: E29 (≠ K41), E33 (≠ D45), R35 (≠ T47)
- binding coenzyme a persulfide: L238 (= L247), R242 (= R251), E362 (= E371), G363 (= G372)
- binding flavin-adenine dinucleotide: F122 (= F134), L124 (= L136), T125 (= T137), P127 (= P139), T131 (≠ S143), F155 (≠ W167), I156 (= I168), T157 (= T169), E198 (= E208), R267 (= R276), F270 (= F279), L274 (= L283), F277 (≠ N286), Q335 (≠ D344), L336 (≠ M345), G338 (= G347), G339 (= G348), Y361 (= Y370), T364 (≠ A373), E366 (≠ D375)
Sites not aligning to the query:
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
34% identity, 92% coverage: 27:385/392 of query aligns to 16:381/383 of 1bucA
- active site: L128 (= L136), T129 (= T137), G246 (≠ A250), E367 (= E371), G379 (≠ R383)
- binding acetoacetyl-coenzyme a: L96 (= L104), F126 (= F134), G134 (= G142), T135 (≠ S143), T162 (= T169), N182 (≠ K189), H183 (vs. gap), F236 (≠ L240), M240 (≠ F244), M241 (≠ G245), L243 (= L247), D244 (≠ N248), T317 (≠ P321), Y366 (= Y370), E367 (= E371), G368 (= G372)
- binding flavin-adenine dinucleotide: F126 (= F134), L128 (= L136), T129 (= T137), G134 (= G142), T135 (≠ S143), F160 (≠ W167), T162 (= T169), Y366 (= Y370), T369 (≠ A373), E371 (≠ D375), M375 (≠ L379)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
34% identity, 92% coverage: 27:385/392 of query aligns to 16:381/383 of Q06319
- E367 (= E371) active site, Proton acceptor; mutation to Q: Loss of activity.
Query Sequence
>WP_011385596.1 NCBI__GCF_000009985.1:WP_011385596.1
MQHFKWDDPFLLEDQLSEDEKLIRDSAHAYCQEKLQPRVMKAFRDETFDREIMNEMGEMG
LLGPTIPEEYGGPGVNHVAYGLISREVERVDSGYRSAMSVQSSLVMHPIFSYGTEEQKKK
YLPRLATGEIIGCFGLTEPDAGSDPGGMRTRAKKVDGGYLLTGSKMWITNSPISDIAIVW
AKSDAHEGKIKGFIVEKGIKGFTTPKIEGKLSLRASITGEIVLDEAFVPDEALMPNASGL
GGPFGCLNKARYGIAWGVIGAAEFCWHAARQYMLDRKQFGRPLAANQIPQLKLANMMTEI
TLGLQACVRVGRMMDDHTWAPEAVSLIKRNNCGKALDIARMARDMHGGNGISEEFHVIRH
MVNLETVNTYEGAHDVHALILGRAMTGIQAFS
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory