SitesBLAST
Comparing WP_011385867.1 NCBI__GCF_000009985.1:WP_011385867.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (= A32), I34 (≠ V33), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R226 (≠ Q226), M262 (= M262), V289 (= V289), V405 (= V398), L430 (= L423), G431 (= G424), M433 (= M426), D458 (≠ E451), N485 (= N478), E487 (≠ Y480), Q488 (≠ L481), M490 (= M483), V491 (= V484), W494 (= W487), L516 (= L510), G521 (= G515), L522 (≠ A516), K555 (≠ A549)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V106), P108 (= P107), D287 (= D287), R288 (= R288), M490 (= M483), W494 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R156), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (= N219), T242 (= T242), L243 (= L243), Q244 (≠ M244), M259 (= M259), L260 (= L260), M262 (= M262), H263 (= H263), G282 (= G282), A283 (= A283), R284 (= R284), D286 (= D286), R288 (= R288), V289 (= V289), E315 (≠ D306), V316 (≠ I307), N320 (≠ S311), G333 (= G324), D334 (= D325), A335 (≠ C326), Q409 (= Q402), M410 (= M403), G428 (= G421), G429 (= G422)
- binding magnesium ion: D458 (≠ E451), N485 (= N478), E487 (≠ Y480)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (= Y28), G33 (= G30), G34 (= G31), A35 (= A32), I36 (≠ V33), E57 (= E54), T80 (= T77), F119 (= F116), Q120 (= Q117), E121 (= E118), K169 (= K166), R230 (≠ Q226), M266 (= M262), V293 (= V289), V409 (= V398), L434 (= L423), G435 (= G424), M437 (= M426), D462 (≠ E451), N489 (= N478), E491 (≠ Y480), Q492 (≠ L481), M494 (= M483), V495 (= V484), W498 (= W487), L520 (= L510), G525 (= G515), L526 (≠ A516), K559 (≠ A549)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V398), G410 (= G399), Q411 (= Q400), H412 (= H401), G435 (= G424), M437 (= M426), G461 (= G450), D462 (≠ E451), A463 (= A452), S464 (= S453), M467 (= M456), N489 (= N478), E491 (≠ Y480), Q492 (≠ L481), G493 (= G482), V495 (= V484)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G31), A35 (= A32), V109 (= V106), P110 (= P107), F119 (= F116), K169 (= K166), M266 (= M262), D291 (= D287), R292 (= R288), V495 (= V484), W498 (= W487)
- binding flavin-adenine dinucleotide: R159 (= R156), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (= N219), T246 (= T242), L247 (= L243), Q248 (≠ M244), L264 (= L260), G265 (= G261), M266 (= M262), H267 (= H263), G286 (= G282), A287 (= A283), R288 (= R284), D290 (= D286), R292 (= R288), V293 (= V289), E319 (≠ D306), V320 (≠ I307), N324 (≠ S311), G337 (= G324), D338 (= D325), A339 (≠ C326), M414 (= M403), G432 (= G421), G433 (= G422)
- binding magnesium ion: D462 (≠ E451), N489 (= N478), E491 (≠ Y480)
- binding thiamine diphosphate: Y31 (= Y28), E57 (= E54), P83 (= P80)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (= A32), I34 (≠ V33), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R227 (≠ Q226), M263 (= M262), V290 (= V289), V406 (= V398), L431 (= L423), G432 (= G424), M434 (= M426), D459 (≠ E451), N486 (= N478), E488 (≠ Y480), Q489 (≠ L481), M491 (= M483), V492 (= V484), W495 (= W487), L517 (= L510), G522 (= G515), L523 (≠ A516), K556 (≠ A549)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G31), V107 (= V106), P108 (= P107), F117 (= F116), K167 (= K166), D288 (= D287), R289 (= R288), W495 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R156), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (= N219), T243 (= T242), L244 (= L243), Q245 (≠ M244), L261 (= L260), M263 (= M262), H264 (= H263), G283 (= G282), A284 (= A283), R285 (= R284), D287 (= D286), R289 (= R288), V290 (= V289), E316 (≠ D306), V317 (≠ I307), N321 (≠ S311), G334 (= G324), D335 (= D325), A336 (≠ C326), M411 (= M403), G429 (= G421), G430 (= G422)
- binding magnesium ion: D459 (≠ E451), N486 (= N478), E488 (≠ Y480)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (= A32), I34 (≠ V33), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R227 (≠ Q226), M263 (= M262), V290 (= V289), V406 (= V398), L431 (= L423), G432 (= G424), M434 (= M426), D459 (≠ E451), N486 (= N478), E488 (≠ Y480), Q489 (≠ L481), M491 (= M483), V492 (= V484), W495 (= W487), L517 (= L510), G522 (= G515), L523 (≠ A516), K556 (≠ A549)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G31), A33 (= A32), V107 (= V106), P108 (= P107), F117 (= F116), K167 (= K166), M263 (= M262), D288 (= D287), R289 (= R288), W495 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R156), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (= N219), T243 (= T242), L244 (= L243), Q245 (≠ M244), M260 (= M259), L261 (= L260), H264 (= H263), G283 (= G282), A284 (= A283), R285 (= R284), D287 (= D286), R289 (= R288), V290 (= V289), E316 (≠ D306), V317 (≠ I307), N321 (≠ S311), G334 (= G324), D335 (= D325), A336 (≠ C326), Q410 (= Q402), M411 (= M403), G429 (= G421), G430 (= G422)
- binding magnesium ion: D459 (≠ E451), N486 (= N478), E488 (≠ Y480)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E54), P81 (= P80), Q118 (= Q117), G432 (= G424), M434 (= M426), M464 (= M456)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 8:569/591 of 5wkcA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (= A32), I34 (≠ V33), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R222 (≠ Q226), M258 (= M262), V285 (= V289), V401 (= V398), L426 (= L423), G427 (= G424), M429 (= M426), D454 (≠ E451), N481 (= N478), E483 (≠ Y480), Q484 (≠ L481), M486 (= M483), V487 (= V484), W490 (= W487), L512 (= L510), G517 (= G515), L518 (≠ A516), K551 (≠ A549)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V398), G402 (= G399), Q403 (= Q400), H404 (= H401), G427 (= G424), M429 (= M426), G453 (= G450), D454 (≠ E451), A455 (= A452), S456 (= S453), M459 (= M456), N481 (= N478), E483 (≠ Y480), Q484 (≠ L481), G485 (= G482), M486 (= M483), V487 (= V484)
- binding ethaneperoxoic acid: G32 (= G31), Q118 (= Q117)
- binding flavin-adenine dinucleotide: R157 (= R156), G211 (= G214), A212 (≠ G215), G213 (= G216), N216 (= N219), T238 (= T242), L239 (= L243), Q240 (≠ M244), L256 (= L260), M258 (= M262), G278 (= G282), A279 (= A283), R280 (= R284), R284 (= R288), V285 (= V289), E311 (≠ D306), V312 (≠ I307), N316 (≠ S311), D330 (= D325), A331 (≠ C326), M406 (= M403), G424 (= G421)
- binding magnesium ion: D454 (≠ E451), N481 (= N478), E483 (≠ Y480)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G31), A33 (= A32), V107 (= V106), F117 (= F116), K167 (= K166), M258 (= M262), R284 (= R288), M486 (= M483), W490 (= W487)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P29), E55 (= E54)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (= Y28), G32 (= G30), G33 (= G31), A34 (= A32), I35 (≠ V33), E56 (= E54), T79 (= T77), F118 (= F116), Q119 (= Q117), E120 (= E118), K168 (= K166), R228 (≠ Q226), M264 (= M262), V291 (= V289), V407 (= V398), L432 (= L423), G433 (= G424), M435 (= M426), D460 (≠ E451), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), M492 (= M483), V493 (= V484), W496 (= W487), L518 (= L510), G523 (= G515), L524 (≠ A516), K557 (≠ A549)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G31), V108 (= V106), P109 (= P107), F118 (= F116), K168 (= K166), M264 (= M262), D289 (= D287), R290 (= R288), M492 (= M483), V493 (= V484), W496 (= W487)
- binding flavin-adenine dinucleotide: R158 (= R156), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (= N219), T244 (= T242), L245 (= L243), Q246 (≠ M244), L262 (= L260), M264 (= M262), H265 (= H263), G284 (= G282), A285 (= A283), R286 (= R284), D288 (= D286), R290 (= R288), V291 (= V289), E317 (≠ D306), V318 (≠ I307), N322 (≠ S311), G335 (= G324), D336 (= D325), A337 (≠ C326), Q411 (= Q402), M412 (= M403), G430 (= G421), G431 (= G422)
- binding magnesium ion: D460 (≠ E451), N487 (= N478), E489 (≠ Y480)
- binding propyl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), G491 (= G482), M492 (= M483)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G424), M435 (= M426), M465 (= M456)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 92:665/687 of P07342
- R241 (= R156) binding
- 355:376 (vs. 263:284, 50% identical) binding
- 407:426 (vs. 306:325, 35% identical) binding
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (= A32), I38 (≠ V33), E59 (= E54), T82 (= T77), F121 (= F116), Q122 (= Q117), E123 (= E118), K171 (= K166), M274 (= M262), V301 (= V289), V417 (= V398), G443 (= G424), M445 (= M426), D470 (≠ E451), N497 (= N478), E499 (≠ Y480), Q500 (≠ L481), M502 (= M483), V503 (= V484), W506 (= W487)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G31), V111 (= V106), P112 (= P107), F121 (= F116), K171 (= K166), D299 (= D287), R300 (= R288), M502 (= M483), W506 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R156), A228 (≠ G215), G229 (= G216), N232 (= N219), T254 (= T242), L255 (= L243), Q256 (≠ M244), L272 (= L260), M274 (= M262), G294 (= G282), R296 (= R284), D298 (= D286), R300 (= R288), V301 (= V289), E327 (≠ D306), V328 (≠ I307), N332 (≠ S311), D346 (= D325), A347 (≠ C326), M422 (= M403), G440 (= G421), G441 (= G422)
- binding magnesium ion: D470 (≠ E451), N497 (= N478)
- binding thiamine diphosphate: E59 (= E54), P85 (= P80), V417 (= V398), G418 (= G399), Q419 (= Q400), H420 (= H401), G443 (= G424), M445 (= M426), A471 (= A452), S472 (= S453), N497 (= N478), E499 (≠ Y480), Q500 (≠ L481), G501 (= G482), M502 (= M483), V503 (= V484)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 8:561/583 of 1t9bA
- active site: Y29 (= Y28), G31 (= G30), G32 (= G31), A33 (= A32), I34 (≠ V33), E55 (= E54), T78 (= T77), F117 (= F116), Q118 (= Q117), E119 (= E118), K167 (= K166), R214 (≠ Q226), M250 (= M262), V277 (= V289), V393 (= V398), L418 (= L423), G419 (= G424), M421 (= M426), D446 (≠ E451), N473 (= N478), E475 (≠ Y480), Q476 (≠ L481), M478 (= M483), V479 (= V484), W482 (= W487), L504 (= L510), G509 (= G515), L510 (≠ A516), K543 (≠ A549)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V106), P108 (= P107), F117 (= F116), D275 (= D287), R276 (= R288), M478 (= M483), W482 (= W487)
- binding flavin-adenine dinucleotide: R157 (= R156), G203 (= G214), A204 (≠ G215), G205 (= G216), N208 (= N219), T230 (= T242), L231 (= L243), Q232 (≠ M244), M247 (= M259), L248 (= L260), M250 (= M262), H251 (= H263), G270 (= G282), A271 (= A283), R272 (= R284), D274 (= D286), R276 (= R288), V277 (= V289), E303 (≠ D306), V304 (≠ I307), N308 (≠ S311), D322 (= D325), A323 (≠ C326), Q397 (= Q402), M398 (= M403), G416 (= G421), G417 (= G422)
- binding magnesium ion: D446 (≠ E451), N473 (= N478), E475 (≠ Y480)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 95% coverage: 7:567/588 of query aligns to 7:560/582 of 1t9dB
- active site: Y28 (= Y28), G30 (= G30), G31 (= G31), A32 (= A32), I33 (≠ V33), E54 (= E54), T77 (= T77), F116 (= F116), Q117 (= Q117), E118 (= E118), K166 (= K166), R213 (≠ Q226), M249 (= M262), V276 (= V289), V392 (= V398), L417 (= L423), G418 (= G424), M420 (= M426), D445 (≠ E451), N472 (= N478), E474 (≠ Y480), Q475 (≠ L481), M477 (= M483), V478 (= V484), W481 (= W487), L503 (= L510), G508 (= G515), L509 (≠ A516), K542 (≠ A549)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G31), A32 (= A32), V106 (= V106), P107 (= P107), F116 (= F116), K166 (= K166), M249 (= M262), D274 (= D287), R275 (= R288), W481 (= W487)
- binding flavin-adenine dinucleotide: R156 (= R156), G202 (= G214), A203 (≠ G215), G204 (= G216), N207 (= N219), T229 (= T242), L230 (= L243), Q231 (≠ M244), L247 (= L260), M249 (= M262), H250 (= H263), G269 (= G282), A270 (= A283), R271 (= R284), D273 (= D286), R275 (= R288), V276 (= V289), E302 (≠ D306), V303 (≠ I307), N307 (≠ S311), G320 (= G324), D321 (= D325), A322 (≠ C326), Q396 (= Q402), M397 (= M403), G415 (= G421), G416 (= G422)
- binding magnesium ion: D445 (≠ E451), N472 (= N478), E474 (≠ Y480)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E54), P80 (= P80), G418 (= G424), M420 (= M426), M450 (= M456)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
45% identity, 96% coverage: 7:568/588 of query aligns to 10:572/593 of 6deoA
- active site: Y31 (= Y28), G33 (= G30), G34 (= G31), A35 (= A32), I36 (≠ V33), E57 (= E54), T80 (= T77), F119 (= F116), Q120 (= Q117), E121 (= E118), K169 (= K166), K224 (≠ Q226), M260 (= M262), V287 (= V289), V403 (= V398), L428 (= L423), G429 (= G424), M431 (= M426), D456 (≠ E451), N483 (= N478), E485 (≠ Y480), Q486 (≠ L481), M488 (= M483), V489 (= V484), W492 (= W487), L514 (= L510), N519 (≠ G515), V520 (≠ A516)
- binding flavin-adenine dinucleotide: R159 (= R156), G213 (= G214), A214 (≠ G215), G215 (= G216), N218 (= N219), T240 (= T242), L241 (= L243), Q242 (≠ M244), L258 (= L260), G280 (= G282), A281 (= A283), R282 (= R284), D284 (= D286), R286 (= R288), V287 (= V289), E313 (≠ D306), I314 (= I307), N318 (≠ S311), D332 (= D325), V333 (≠ C326), M408 (= M403), G426 (= G421)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M262), D285 (= D287), R286 (= R288), M488 (= M483), W492 (= W487)
- binding magnesium ion: D456 (≠ E451), N483 (= N478), E485 (≠ Y480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V398), G404 (= G399), Q405 (= Q400), H406 (= H401), G429 (= G424), M431 (= M426), G455 (= G450), D456 (≠ E451), A457 (= A452), S458 (= S453), M461 (= M456), N483 (= N478), E485 (≠ Y480), Q486 (≠ L481), G487 (= G482), M488 (= M483), V489 (= V484)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 96% coverage: 7:568/588 of query aligns to 14:580/601 of 6deqA
- active site: Y35 (= Y28), G37 (= G30), G38 (= G31), A39 (= A32), I40 (≠ V33), E61 (= E54), T84 (= T77), F123 (= F116), Q124 (= Q117), E125 (= E118), K173 (= K166), K232 (≠ Q226), M268 (= M262), V295 (= V289), V411 (= V398), L436 (= L423), G437 (= G424), M439 (= M426), D464 (≠ E451), N491 (= N478), E493 (≠ Y480), Q494 (≠ L481), M496 (= M483), V497 (= V484), W500 (= W487), L522 (= L510), N527 (≠ G515), V528 (≠ A516)
- binding flavin-adenine dinucleotide: R163 (= R156), G221 (= G214), A222 (≠ G215), G223 (= G216), N226 (= N219), T248 (= T242), L249 (= L243), Q250 (≠ M244), L266 (= L260), G288 (= G282), A289 (= A283), R290 (= R284), D292 (= D286), R294 (= R288), V295 (= V289), E321 (≠ D306), I322 (= I307), D340 (= D325), V341 (≠ C326), M416 (= M403), G434 (= G421)
- binding magnesium ion: D464 (≠ E451), N491 (= N478), E493 (≠ Y480)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M262), R294 (= R288), M496 (= M483), V497 (= V484), W500 (= W487), A571 (≠ P559)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V398), G412 (= G399), Q413 (= Q400), H414 (= H401), M439 (= M426), G463 (= G450), D464 (≠ E451), A465 (= A452), S466 (= S453), N491 (= N478), E493 (≠ Y480), Q494 (≠ L481), G495 (= G482), M496 (= M483), V497 (= V484)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
44% identity, 96% coverage: 7:568/588 of query aligns to 14:578/599 of 6denA
- active site: Y35 (= Y28), G37 (= G30), G38 (= G31), A39 (= A32), I40 (≠ V33), E61 (= E54), T84 (= T77), F123 (= F116), Q124 (= Q117), E125 (= E118), K173 (= K166), K230 (≠ Q226), M266 (= M262), V293 (= V289), V409 (= V398), L434 (= L423), G435 (= G424), M437 (= M426), D462 (≠ E451), N489 (= N478), E491 (≠ Y480), Q492 (≠ L481), M494 (= M483), V495 (= V484), W498 (= W487), L520 (= L510), N525 (≠ G515), V526 (≠ A516)
- binding flavin-adenine dinucleotide: R163 (= R156), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (= N219), T246 (= T242), L247 (= L243), Q248 (≠ M244), L264 (= L260), G286 (= G282), A287 (= A283), R288 (= R284), D290 (= D286), R292 (= R288), V293 (= V289), E319 (≠ D306), I320 (= I307), N324 (≠ S311), D338 (= D325), V339 (≠ C326), M414 (= M403), G432 (= G421)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M262), D291 (= D287), R292 (= R288), W498 (= W487)
- binding magnesium ion: D462 (≠ E451), N489 (= N478), E491 (≠ Y480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V398), G410 (= G399), Q411 (= Q400), H412 (= H401), G435 (= G424), M437 (= M426), G461 (= G450), D462 (≠ E451), A463 (= A452), S464 (= S453), N489 (= N478), E491 (≠ Y480), Q492 (≠ L481), G493 (= G482), M494 (= M483), V495 (= V484)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
44% identity, 96% coverage: 7:568/588 of query aligns to 12:576/597 of 6demA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (= A32), I38 (≠ V33), E59 (= E54), T82 (= T77), F121 (= F116), Q122 (= Q117), E123 (= E118), K171 (= K166), K228 (≠ Q226), M264 (= M262), V291 (= V289), V407 (= V398), L432 (= L423), G433 (= G424), M435 (= M426), D460 (≠ E451), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), M492 (= M483), V493 (= V484), W496 (= W487), L518 (= L510), N523 (≠ G515), V524 (≠ A516)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M262), D289 (= D287), R290 (= R288), M492 (= M483), W496 (= W487), A567 (≠ P559)
- binding flavin-adenine dinucleotide: R161 (= R156), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (= N219), T244 (= T242), L245 (= L243), Q246 (≠ M244), L262 (= L260), G284 (= G282), A285 (= A283), R286 (= R284), D288 (= D286), R290 (= R288), V291 (= V289), E317 (≠ D306), I318 (= I307), N322 (≠ S311), D336 (= D325), V337 (≠ C326), M412 (= M403), G430 (= G421)
- binding magnesium ion: D460 (≠ E451), N487 (= N478), E489 (≠ Y480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), G491 (= G482), M492 (= M483), V493 (= V484)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
44% identity, 96% coverage: 7:568/588 of query aligns to 12:576/597 of 6delA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (= A32), I38 (≠ V33), E59 (= E54), T82 (= T77), F121 (= F116), Q122 (= Q117), E123 (= E118), K171 (= K166), K228 (≠ Q226), M264 (= M262), V291 (= V289), V407 (= V398), L432 (= L423), G433 (= G424), M435 (= M426), D460 (≠ E451), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), M492 (= M483), V493 (= V484), W496 (= W487), L518 (= L510), N523 (≠ G515), V524 (≠ A516)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D287), R290 (= R288), W496 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R156), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (= N219), T244 (= T242), L245 (= L243), Q246 (≠ M244), L262 (= L260), G284 (= G282), A285 (= A283), R286 (= R284), D288 (= D286), R290 (= R288), V291 (= V289), E317 (≠ D306), I318 (= I307), N322 (≠ S311), D336 (= D325), V337 (≠ C326), M412 (= M403), G430 (= G421)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), G433 (= G424), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), G491 (= G482), M492 (= M483), V493 (= V484)
- binding magnesium ion: D460 (≠ E451), N487 (= N478), E489 (≠ Y480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V398), G408 (= G399), Q409 (= Q400), H410 (= H401), G433 (= G424), M435 (= M426), G459 (= G450), D460 (≠ E451), A461 (= A452), S462 (= S453), M465 (= M456), N487 (= N478), E489 (≠ Y480), Q490 (≠ L481), G491 (= G482), M492 (= M483), V493 (= V484)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
45% identity, 96% coverage: 7:568/588 of query aligns to 14:579/600 of 6derA
- active site: Y35 (= Y28), G37 (= G30), G38 (= G31), A39 (= A32), I40 (≠ V33), E61 (= E54), T84 (= T77), F123 (= F116), Q124 (= Q117), E125 (= E118), K173 (= K166), K231 (≠ Q226), M267 (= M262), V294 (= V289), V410 (= V398), L435 (= L423), G436 (= G424), M438 (= M426), D463 (≠ E451), N490 (= N478), E492 (≠ Y480), Q493 (≠ L481), M495 (= M483), V496 (= V484), W499 (= W487), L521 (= L510), N526 (≠ G515), V527 (≠ A516)
- binding flavin-adenine dinucleotide: R163 (= R156), G220 (= G214), A221 (≠ G215), G222 (= G216), N225 (= N219), T247 (= T242), L248 (= L243), Q249 (≠ M244), L265 (= L260), H268 (= H263), G287 (= G282), A288 (= A283), R289 (= R284), D291 (= D286), R293 (= R288), V294 (= V289), E320 (≠ D306), I321 (= I307), N325 (≠ S311), G338 (= G324), D339 (= D325), V340 (≠ C326), Q414 (= Q402), M415 (= M403), G433 (= G421)
- binding Metosulam: R293 (= R288), M495 (= M483), W499 (= W487), A570 (≠ P559)
- binding magnesium ion: D463 (≠ E451), N490 (= N478), E492 (≠ Y480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V398), G411 (= G399), Q412 (= Q400), H413 (= H401), G436 (= G424), M438 (= M426), G462 (= G450), D463 (≠ E451), A464 (= A452), S465 (= S453), N490 (= N478), E492 (≠ Y480), Q493 (≠ L481), G494 (= G482), M495 (= M483), V496 (= V484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V398), G411 (= G399), Q412 (= Q400), H413 (= H401), G436 (= G424), M438 (= M426), G462 (= G450), D463 (≠ E451), A464 (= A452), S465 (= S453), M468 (= M456), N490 (= N478), E492 (≠ Y480), Q493 (≠ L481), G494 (= G482), V496 (= V484)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
45% identity, 96% coverage: 7:568/588 of query aligns to 12:577/598 of 6desA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (= A32), I38 (≠ V33), E59 (= E54), T82 (= T77), F121 (= F116), Q122 (= Q117), E123 (= E118), K171 (= K166), K229 (≠ Q226), M265 (= M262), V292 (= V289), V408 (= V398), L433 (= L423), G434 (= G424), M436 (= M426), D461 (≠ E451), N488 (= N478), E490 (≠ Y480), Q491 (≠ L481), M493 (= M483), V494 (= V484), W497 (= W487), L519 (= L510), N524 (≠ G515), V525 (≠ A516)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M262), D290 (= D287), R291 (= R288), W497 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R156), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (= N219), T245 (= T242), L246 (= L243), Q247 (≠ M244), L263 (= L260), G285 (= G282), A286 (= A283), R287 (= R284), D289 (= D286), R291 (= R288), V292 (= V289), E318 (≠ D306), I319 (= I307), N323 (≠ S311), D337 (= D325), V338 (≠ C326), Q412 (= Q402), M413 (= M403), G431 (= G421)
- binding magnesium ion: D461 (≠ E451), N488 (= N478), E490 (≠ Y480)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V398), G409 (= G399), Q410 (= Q400), H411 (= H401), G434 (= G424), M436 (= M426), G460 (= G450), D461 (≠ E451), A462 (= A452), S463 (= S453), N488 (= N478), E490 (≠ Y480), Q491 (≠ L481), G492 (= G482), M493 (= M483), V494 (= V484)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
45% identity, 96% coverage: 7:568/588 of query aligns to 12:577/598 of 6depA
- active site: Y33 (= Y28), G35 (= G30), G36 (= G31), A37 (= A32), I38 (≠ V33), E59 (= E54), T82 (= T77), F121 (= F116), Q122 (= Q117), E123 (= E118), K171 (= K166), K229 (≠ Q226), M265 (= M262), V292 (= V289), V408 (= V398), L433 (= L423), G434 (= G424), M436 (= M426), D461 (≠ E451), N488 (= N478), E490 (≠ Y480), Q491 (≠ L481), M493 (= M483), V494 (= V484), W497 (= W487), L519 (= L510), N524 (≠ G515), V525 (≠ A516)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D287), R291 (= R288), M493 (= M483), W497 (= W487)
- binding flavin-adenine dinucleotide: R161 (= R156), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (= N219), T245 (= T242), L246 (= L243), Q247 (≠ M244), L263 (= L260), G264 (= G261), G285 (= G282), A286 (= A283), R287 (= R284), D289 (= D286), R291 (= R288), V292 (= V289), E318 (≠ D306), I319 (= I307), N323 (≠ S311), D337 (= D325), V338 (≠ C326), M413 (= M403), G431 (= G421)
- binding magnesium ion: D461 (≠ E451), N488 (= N478), E490 (≠ Y480)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V398), G409 (= G399), Q410 (= Q400), H411 (= H401), G434 (= G424), M436 (= M426), G460 (= G450), D461 (≠ E451), A462 (= A452), S463 (= S453), M466 (= M456), N488 (= N478), E490 (≠ Y480), Q491 (≠ L481), G492 (= G482), M493 (= M483), V494 (= V484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V398), G409 (= G399), Q410 (= Q400), H411 (= H401), G434 (= G424), M436 (= M426), G460 (= G450), D461 (≠ E451), A462 (= A452), S463 (= S453), M466 (= M456), N488 (= N478), E490 (≠ Y480), Q491 (≠ L481), G492 (= G482), M493 (= M483), V494 (= V484)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
44% identity, 96% coverage: 9:575/588 of query aligns to 96:664/667 of P09342
- C161 (≠ V74) modified: Disulfide link with 307
- P194 (= P107) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V217) modified: Disulfide link with 161
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
45% identity, 97% coverage: 9:577/588 of query aligns to 99:669/670 of P17597
- A122 (= A32) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L34) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E54) binding
- S186 (= S96) binding
- P197 (= P107) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ H109) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q117) binding
- K220 (= K130) binding
- R246 (= R156) binding ; binding
- K256 (= K166) binding
- G308 (= G215) binding
- TL 331:332 (= TL 242:243) binding
- C340 (≠ G251) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 260:263) binding
- GVRFD 371:375 (≠ GARFD 282:286) binding
- DR 376:377 (= DR 287:288) binding
- DI 395:396 (= DI 306:307) binding
- DV 414:415 (≠ DC 325:326) binding
- QH 487:488 (= QH 400:401) binding
- GG 508:509 (= GG 421:422) binding
- GAM 511:513 (≠ GTM 424:426) binding
- D538 (≠ E451) binding
- DGS 538:540 (≠ EAS 451:453) binding
- N565 (= N478) binding
- NQHLGM 565:570 (≠ NQYLGM 478:483) binding
- H567 (≠ Y480) binding
- W574 (= W487) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ P559) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
Query Sequence
>WP_011385867.1 NCBI__GCF_000009985.1:WP_011385867.1
MVHHDTLTGAEILLKALVDQGVEVIFGYPGGAVLPIYDELFKQNRLRHVLVRHEQAAVHA
AEGYARSTGKVGCVLVTSGPGATNAVTGLADAQCDSVPLVCLTGQVPTHLIGNDAFQEAD
ITGITRPCTKHNYLVKDVADLARTVHEAFHVARSGRPGPVLVDLPKDVVQAKGEYQPPSK
LKSKYKPQVKGDLKAIEKAIEMIAHAKKPIFYVGGGVVNSGPAACQLLTQFVRMTGYPCT
LTLMGLGAFPGSDPLFLGMLGMHGTVEANMAMHDCDLMINIGARFDDRVTGKLDGFSPKS
KKIHVDIDPSSINKNVAVDLPIVGDCAHVLEDMIKVWKAKQSRVDDKALKAWWAKIDQWR
GADCLSFENSNKIIKPQYAIQRLYEMTRHRNPYFCTEVGQHQMWAAQHLKFDLPLHWLTS
GGLGTMGYGLPSAMGVQMAHPEALVINIAGEASIQMNIQEMATLVQHRLPVKIVILNNQY
LGMVRQWQELIHGGRYSESHMIHHPDFVKLAEAFGAVGLRADKPGEVDGAIKEMIAVDRP
VILELRTDASENVFPMIMPGMAHNEMVLGPEDKGRDKPGSEQDGMVLV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory