Comparing WP_011386419.1 NCBI__GCF_000009985.1:WP_011386419.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 14 hits to proteins with known functional sites (download)
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
65% identity, 99% coverage: 3:201/201 of query aligns to 539:734/758 of O14289
Sites not aligning to the query:
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
42% identity, 95% coverage: 1:191/201 of query aligns to 1:184/198 of P9WK95
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
40% identity, 51% coverage: 18:119/201 of query aligns to 13:103/170 of Q58667
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
40% identity, 51% coverage: 18:119/201 of query aligns to 13:103/167 of 2pkpA
P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 2 papers)
32% identity, 47% coverage: 36:129/201 of query aligns to 760:841/909 of P09339
Sites not aligning to the query:
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
37% identity, 35% coverage: 49:119/201 of query aligns to 637:707/780 of P20004
Sites not aligning to the query:
5acnA Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
35% identity, 35% coverage: 49:119/201 of query aligns to 610:680/754 of 5acnA
Sites not aligning to the query:
P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 3 papers)
35% identity, 35% coverage: 49:119/201 of query aligns to 637:707/781 of P16276
Sites not aligning to the query:
P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
39% identity, 37% coverage: 48:121/201 of query aligns to 633:706/778 of P19414
Sites not aligning to the query:
8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound (see paper)
35% identity, 35% coverage: 49:119/201 of query aligns to 609:679/753 of 8acnA
Sites not aligning to the query:
1fghA Complex with 4-hydroxy-trans-aconitate (see paper)
35% identity, 35% coverage: 49:119/201 of query aligns to 609:679/753 of 1fghA
Sites not aligning to the query:
1amjA Steric and conformational features of the aconitase mechanism (see paper)
35% identity, 35% coverage: 49:119/201 of query aligns to 609:679/753 of 1amjA
Sites not aligning to the query:
1amiA Steric and conformational features of the aconitase mechanism (see paper)
35% identity, 35% coverage: 49:119/201 of query aligns to 609:679/753 of 1amiA
Sites not aligning to the query:
1acoA Crystal structure of aconitase with transaconitate bound (see paper)
35% identity, 35% coverage: 49:119/201 of query aligns to 609:679/753 of 1acoA
Sites not aligning to the query:
>WP_011386419.1 NCBI__GCF_000009985.1:WP_011386419.1
MEKFTTLTGVAAPLPMINVDTDMIIPKQFLKTIKRTGLGKNLFDEMRYTQDGKEVPDFVL
NKPAYRSAKILVAGANFGCGSSREHAPWAIGDFGIRCVIAPSFADIFFNNCFKNGILPIK
LPQEQVDKLLDDANRGSNAIVTVDLARQVITGPDGGSISFEVDPFRKHCLLNGLDDIGLT
LQREDKIAAFEESRKTSSPWL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory