SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011386786.1 NCBI__GCF_000009985.1:WP_011386786.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

8tzjA Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
47% identity, 91% coverage: 10:228/240 of query aligns to 2:220/220 of 8tzjA

query
sites
8tzjA

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binding adenosine-5'-diphosphate: Y12 (= Y20), R16 (≠ P24), A18 (≠ V26), G39 (= G47), G41 (= G49), K42 (= K50), S43 (= S51)

8i6rB Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
47% identity, 85% coverage: 10:214/240 of query aligns to 1:205/222 of 8i6rB

query
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8i6rB

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binding adenosine-5'-triphosphate: Y11 (= Y20), H15 (≠ P24), S37 (= S46), A39 (= A48), G40 (= G49), K41 (= K50), S42 (= S51), T43 (≠ S52), D137 (≠ T146), S139 (= S148), T140 (≠ G149), G141 (= G150), Q142 (= Q151)
binding magnesium ion: K41 (= K50), S42 (= S51)

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
48% identity, 84% coverage: 10:211/240 of query aligns to 1:202/222 of P0A9R7

query
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P0A9R7

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K41 (= K50) mutation to R: Does not bind ATP.
C49 (≠ Y58) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
48% identity, 84% coverage: 10:211/240 of query aligns to 1:202/219 of 8w6iD

query
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8w6iD

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binding phosphothiophosphoric acid-adenylate ester: Y11 (= Y20), S37 (= S46), G38 (= G47), A39 (= A48), G40 (= G49), K41 (= K50), S42 (= S51), T43 (≠ S52), Q86 (= Q95), K130 (≠ H139), Q137 (≠ T146), S139 (= S148), G140 (= G149), G141 (= G150), E142 (≠ Q151), H195 (= H204)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
47% identity, 85% coverage: 10:214/240 of query aligns to 1:205/218 of 8hd0A

query
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8hd0A

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binding adenosine-5'-triphosphate: Y11 (= Y20), R15 (≠ P24), A17 (≠ V26), G40 (= G49), K41 (= K50), S42 (= S51), T43 (≠ S52), S139 (= S148), G141 (= G150)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
40% identity, 90% coverage: 9:225/240 of query aligns to 2:217/229 of 6z67B

query
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6z67B

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Q

Q

R

R

V

I

A

A

I

I

A

A

R

R

A

A

V

I

I

V

G

N

R

N

P

P

D

K

L

V

L

L

L

I

A

A

D

D

E

E

P

P

T

T

G

G

N

N

V

L

D

D

D

P

H

D

I

N

A

S

M

W

R

E

L

I

M

M

Y

N

L

L

F

L

E

E

E

R

L

I

N

N

K

L

L

Q

G

G

T

T

T

T

I

I

V

L

V

M

A

A

T

T

H

H

N

N

E

S

L

Q

L

I

V

V

R

N

R

T

F

L

A

R

H

H

L

R

P

V

R

-

L

I

H

A

I

I

E

E

H

N

G

G

M

R

V

V

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y20), G16 (= G23), A19 (≠ V26), S39 (= S46), G40 (= G47), G42 (= G49), K43 (= K50), S44 (= S51), T45 (≠ S52)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
40% identity, 90% coverage: 9:225/240 of query aligns to 2:217/230 of 6z4wA

query
sites
6z4wA

N

S

I

I

I

I

R

E

F

M

D

R

S

D

V

V

G

V

L

K

R

K

Y
|
Y

G

D

L

N

G

G

P
x
T

E

T

V
x
A

L

L

Q

R

D

G

V

V

T

S

F

V

K

S

L

V

P

Q

A

P

G

G

S

E

F

F

H

A

F

Y

L

I

T

V

G

G

P

P

S

S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

S
x
T

L

F

L

I

R

R

L

S

M

L

Y

Y

L

R

G

E

L

V

R

K

P

I

T

D

R

K

G

G

R

S

V

L

V

S

L

V

F

A

D

G

R

F

D

N

I

L

A

V

A

K

T

I

K

K

R

K

Y

K

E

D

L

V

P

P

A

L

L

L

R

R

R

R

R

S

I

V

G

G

V

V

V

V

F

F

Q

Q

D

D

F

Y

R

K

L

L

L

L

D

P

H

K

M

K

T

T

A

V

L

Y

D

E

N

N

V

I

A

A

L

Y

P

A

L

M

R

E

V

V

R

I

G

G

V

E

K

N

E

R

S

R

E

N

I

I

R

K

R

R

H

R

V

V

P

M

E

E

L

V

L

L

S

D

W

L

V

V

G

G

L

L

A

K

D

H

H

K

L

V

G

R

A

S

K

F

P

P

S

N

T

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

I

A

A

I

I

A

A

R

R

A

A

V

I

I

V

G

N

R

N

P

P

D

K

L

V

L

L

L

I

A

A

D

D

E

E

P

P

T

T

G

G

N

N

V

L

D

D

D

P

H

D

I

N

A

S

M

W

R

E

L

I

M

M

Y

N

L

L

F

L

E

E

E

R

L

I

N

N

K

L

L

Q

G

G

T

T

T

T

I

I

V

L

V

M

A

A

T

T

H

H

N

N

E

S

L

Q

L

I

V

V

R

N

R

T

F

L

A

R

H

H

L

R

P

V

R

-

L

I

H

A

I

I

E

E

H

N

G

G

M

R

V

V

binding adenosine-5'-diphosphate: Y13 (= Y20), T17 (≠ P24), A19 (≠ V26), G40 (= G47), G42 (= G49), K43 (= K50), S44 (= S51), T45 (≠ S52)

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc (see paper)
45% identity, 83% coverage: 10:209/240 of query aligns to 2:202/225 of 8iddA

query
sites
8iddA

I

M

I

I

R

T

F

L

D

D

S

H

V

V

G

T

L

K

R

Q

Y
|
Y

G

K

L

S

G

S

P

A

E

R

-

P

V

A

L

L

Q

D

D

D

V

I

T

N

F

V

K

K

L

I

P

D

A

K

G

G

S

E

F

F

H

V

F

F

L

L

T

I

G

G

P

P

S
|
S

G

G

A

S

G
|
G

K
|
K

S
|
S

S

T

L

F

L

M

R

R

L

L

M

L

Y

L

L

A

G

A

L

E

R

T

P

P

T

T

R

S

G

G

R

D

V

V

V

R

L

V

F

S

D

K

R

F

D

H

I

V

A

N

A

K

T

L

K

R

R

G

Y

R

E

H

L

V

P

P

A

K

L

L

R

R

R

Q

R

V

I

I

G

G

V

C

V

V

F

F

Q

Q

D

D

F

F

R

R

L

L

L

L

D

Q

H

Q

M

K

T

T

A

V

L

Y

D

D

N

N

V

V

A

A

L

F

P

A

L

L

R

E

V

V

R

I

G

G

V

K

K

R

E

T

S

D

E

A

I

I

R

N

R

R

H

V

V

V

P

P

E

E

L

V

L

L

S

E

W

T

V

V

G

G

L

L

A

S

D

G

H

K

L

A

G

N

A

R

K

L

P

P

S

D

T

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

F

I

V

G

N

R

R

P

P

D

L

L

V

L

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

V

L

D

D

D

P

H

E

I

T

A

S

M

R

R

D

L

I

M

M

Y

D

L

L

F

L

E

E

E

R

L

I

N

N

K

R

L

T

G

G

T

T

T

T

I

V

V

L

V

M

A

A

T

T

H

H

N

D

E

H

L

H

L

I

V

V

binding adenosine-5'-triphosphate: Y12 (= Y20), S39 (= S46), G42 (= G49), K43 (= K50), S44 (= S51)

A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
45% identity, 83% coverage: 10:209/240 of query aligns to 1:201/229 of A5U7B7

query
sites
A5U7B7

I

M

I

I

R

T

F

L

D

D

S

H

V

V

G

T

L

K

R

Q

Y

Y

G

K

L

S

G

S

P

A

E

R

-

P

V

A

L

L

Q

D

D

D

V

I

T

N

F

V

K

K

L

I

P

D

A

K

G

G

S

E

F

F

H

V

F

F

L

L

T

I

G

G

P

P

S

S

G

G

A

S

G

G

K
|
K

S

S

S

T

L

F

L

M

R

R

L

L

M

L

Y

L

L

A

G

A

L

E

R

T

P

P

T

T

R

S

G

G

R

D

V

V

V

R

L

V

F

S

D

K

R

F

D

H

I

V

A

N

A

K

T

L

K

R

R

G

Y

R

E

H

L

V

P

P

A

K

L

L

R

R

R

Q

R

V

I

I

G

G

V
x
C

V

V

F

F

Q

Q

D

D

F

F

R

R

L

L

L

L

D

Q

H

Q

M

K

T

T

A

V

L

Y

D

D

N

N

V

V

A

A

L

F

P

A

L

L

R

E

V

V

R

I

G

G

V

K

K

R

E

T

S

D

E

A

I

I

R

N

R

R

H

V

V

V

P

P

E

E

L

V

L

L

S

E

W

T

V

V

G

G

L

L

A

S

D

G

H

K

L

A

G

N

A

R

K

L

P

P

S

D

T

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

F

I

V

G

N

R

R

P

P

D

L

L

V

L

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

V

L

D

D

D

P

H

E

I

T

A

S

M

R

R

D

L

I

M

M

Y

D

L

L

F

L

E

E

E

R

L

I

N

N

K

R

L

T

G

G

T

T

T

T

I

V

V

L

V

M

A

A

T

T

H

H

N

D

E

H

L

H

L

I

V

V

K42 (= K50) mutation to R: Does not bind ATP. Does not affect dimerization.
C84 (≠ V92) mutation to A: Does not affect ATPase activity.

8igqA Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
45% identity, 83% coverage: 10:209/240 of query aligns to 2:202/227 of 8igqA

query
sites
8igqA

I

M

I

I

R

T

F

L

D

D

S

H

V

V

G

T

L

K

R

Q

Y
|
Y

G

K

L

S

G

S

P

A

E

R

-

P

V

A

L

L

Q

D

D

D

V

I

T

N

F

V

K

K

L

I

P

D

A

K

G

G

S

E

F

F

H

V

F

F

L

L

T

I

G

G

P

P

S

S

G
|
G

A
x
S

G

G

K
|
K

S
|
S

S

T

L

F

L

M

R

R

L

L

M

L

Y

L

L

A

G

A

L

E

R

T

P

P

T

T

R

S

G

G

R

D

V

V

V

R

L

V

F

S

D

K

R

F

D

H

I

V

A

N

A

K

T

L

K

R

R

G

Y

R

E

H

L

V

P

P

A

K

L

L

R

R

R

Q

R

V

I

I

G

G

V

C

V

V

F

F

Q

Q

D

D

F

F

R

R

L

L

L

L

D

Q

H

Q

M

K

T

T

A

V

L

Y

D

D

N

N

V

V

A

A

L

F

P

A

L

L

R

E

V

V

R

I

G

G

V

K

K

R

E

T

S

D

E

A

I

I

R

N

R

R

H

V

V

V

P

P

E

E

L

V

L

L

S

E

W

T

V

V

G

G

L

L

A

S

D

G

H

K

L

A

G

N

A

R

K

L

P

P

S

D

T

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

F

I

V

G

N

R

R

P

P

D

L

L

V

L

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

V

L

D

D

D

P

H

E

I

T

A

S

M

R

R

D

L

I

M

M

Y

D

L

L

F

L

E

E

E

R

L

I

N

N

K

R

L

T

G

G

T

T

T

T

I

V

V

L

V

M

A

A

T

T

H

H

N

D

E

H

L

H

L

I

V

V

binding adenosine-5'-diphosphate: Y12 (= Y20), G40 (= G47), S41 (≠ A48), K43 (= K50), S44 (= S51)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
43% identity, 79% coverage: 25:213/240 of query aligns to 19:208/343 of P30750

query
sites
P30750

E

Q

V

A

L

L

Q

N

D

N

V

V

T

S

F

L

K

H

L

V

P

P

A

A

G

G

S

Q

F

I

H

Y

F

G

L

V

T

I

G

G

P

A

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

L

I

R

R

L

C

M

V

Y

N

L

L

G

L

L

E

R

R

P

P

T

T

R

E

G

G

R

S

V

V

V

L

L

V

F

D

D

G

R

Q

D

E

I

L

A

T

A

T

T

L

K

S

R

E

Y

S

E

E

L

L

P

T

A

K

L

A

R

R

R

R

R

Q

I

I

G

G

V

M

V

I

F

F

Q

Q

D

H

F

F

R

N

L

L

L

L

D

S

H

S

M

R

T

T

A

V

L

F

D

G

N

N

V

V

A

A

L

L

P

P

L

L

R

E

V

L

R

D

G

N

V

T

K

P

E

K

S

D

E

E

I

V

R

K

R

R

H

R

V

V

P

T

E

E

L

L

L

L

S

S

W

L

V

V

G

G

L

L

A

G

D

D

H

K

L

H

G

D

A

S

K

Y

P

P

S

S

T

N

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

S

R

N

P

P

D

K

L

V

L

L

L

L

A

C

D

D

E
|
E

P

A

T

T

G

S

N

A

V

L

D

D

D

P

H

A

I

T

A

T

M

R

R

S

L

I

M

L

Y

E

L

L

F

L

E

K

E

D

L

I

N

N

-

R

K

R

L

L

G

G

T

L

T

T

I

I

V

L

V

L

A

I

T

T

H

H

N

E

E

M

L

D

L

V

V

V

R

K

R

R

F

I

A

C

40:46 (vs. 46:52, 86% identical) binding
E166 (= E172) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
43% identity, 79% coverage: 25:213/240 of query aligns to 20:209/344 of 3tuzC

query
sites
3tuzC

E

Q

V

A

L

L

Q

N

D

N

V

V

T

S

F

L

K

H

L

V

P

P

A

A

G

G

S

Q

F

I

H

Y

F

G

L

V

T

I

G

G

P

A

S

S

G
|
G

A

A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

L

I

R

R

L

C

M

V

Y

N

L

L

G

L

L

E

R

R

P

P

T

T

R

E

G

G

R

S

V

V

V

L

L

V

F

D

D

G

R

Q

D

E

I

L

A

T

A

T

T

L

K

S

R

E

Y

S

E

E

L

L

P

T

A

K

L

A

R

R

R

R

R

Q

I

I

G

G

V

M

V

I

F

F

Q

Q

D

H

F

F

R

N

L

L

L

L

D

S

H

S

M

R

T

T

A

V

L

F

D

G

N

N

V

V

A

A

L

L

P

P

L

L

R

E

V

L

R

D

G

N

V

T

K

P

E

K

S

D

E

E

I

V

R

K

R

R

H

R

V

V

P

T

E

E

L

L

L

L

S

S

W

L

V

V

G

G

L

L

A

G

D

D

H

K

L

H

G

D

A

S

K

Y

P

P

S

S

T

N

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

S

R

N

P

P

D

K

L

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

V

L

D

D

D

P

H

A

I

T

A

T

M

R

R

S

L

I

M

L

Y

E

L

L

F

L

E

K

E

D

L

I

N

N

-

R

K

R

L

L

G

G

T

L

T

T

I

I

V

L

V

L

A

I

T

T

H

H

N

E

E

M

L

D

L

V

V

V

R

K

R

R

F

I

A

C

binding adenosine-5'-diphosphate: G42 (= G47), G44 (= G49), K45 (= K50), S46 (= S51), T47 (≠ S52)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 14
binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
43% identity, 79% coverage: 25:213/240 of query aligns to 20:209/344 of 3tuiC

query
sites
3tuiC

E

Q

V

A

L

L

Q

N

D

N

V

V

T

S

F

L

K

H

L

V

P

P

A

A

G

G

S

Q

F

I

H

Y

F

G

L

V

T

I

G

G

P

A

S

S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

L

I

R

R

L

C

M

V

Y

N

L

L

G

L

L

E

R

R

P

P

T

T

R

E

G

G

R

S

V

V

V

L

L

V

F

D

D

G

R

Q

D

E

I

L

A

T

A

T

T

L

K

S

R

E

Y

S

E

E

L

L

P

T

A

K

L

A

R

R

R

R

R

Q

I

I

G

G

V

M

V

I

F

F

Q

Q

D

H

F

F

R

N

L

L

L

L

D

S

H

S

M

R

T

T

A

V

L

F

D

G

N

N

V

V

A

A

L

L

P

P

L

L

R

E

V

L

R

D

G

N

V

T

K

P

E

K

S

D

E

E

I

V

R

K

R

R

H

R

V

V

P

T

E

E

L

L

L

L

S

S

W

L

V

V

G

G

L

L

A

G

D

D

H

K

L

H

G

D

A

S

K

Y

P

P

S

S

T

N

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

S

R

N

P

P

D

K

L

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

V

L

D

D

D

P

H

A

I

T

A

T

M

R

R

S

L

I

M

L

Y

E

L

L

F

L

E

K

E

D

L

I

N

N

-

R

K

R

L

L

G

G

T

L

T

T

I

I

V

L

V

L

A

I

T

T

H

H

N

E

E

M

L

D

L

V

V

V

R

K

R

R

F

I

A

C

binding adenosine-5'-diphosphate: G42 (= G47), A43 (= A48), G44 (= G49), K45 (= K50), S46 (= S51), T47 (≠ S52)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
43% identity, 79% coverage: 25:213/240 of query aligns to 20:209/344 of 6cvlD

query
sites
6cvlD

E

Q

V

A

L

L

Q

N

D

N

V

V

T

S

F

L

K

H

L

V

P

P

A

A

G

G

S

Q

F

I

H

Y

F

G

L

V

T

I

G

G

P

A

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

S
x
T

L

L

L

I

R

R

L

C

M

V

Y

N

L

L

G

L

L

E

R

R

P

P

T

T

R

E

G

G

R

S

V

V

V

L

L

V

F

D

D

G

R

Q

D

E

I

L

A

T

A

T

T

L

K

S

R

E

Y

S

E

E

L

L

P

T

A

K

L

A

R

R

R

R

R

Q

I

I

G

G

V

M

V

I

F

F

Q

Q

D

H

F

F

R

N

L

L

L

L

D

S

H

S

M

R

T

T

A

V

L

F

D

G

N

N

V

V

A

A

L

L

P

P

L

L

R

E

V

L

R

D

G

N

V

T

K

P

E

K

S

D

E

E

I

V

R

K

R

R

H

R

V

V

P

T

E

E

L

L

L

L

S

S

W

L

V

V

G

G

L

L

A

G

D

D

H

K

L

H

G

D

A

S

K

Y

P

P

S

S

T
x
N

L

L

S
|
S

G

G

G

G

Q
|
Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

S

R

N

P

P

D

K

L

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

G

S

N

A

V

L

D

D

D

P

H

A

I

T

A

T

M

R

R

S

L

I

M

L

Y

E

L

L

F

L

E

K

E

D

L

I

N

N

-

R

K

R

L

L

G

G

T

L

T

T

I

I

V

L

V

L

A

I

T

T

H
|
H

N

E

E

M

L

D

L

V

V

V

R

K

R

R

F

I

A

C

binding phosphothiophosphoric acid-adenylate ester: S41 (= S46), G42 (= G47), A43 (= A48), G44 (= G49), K45 (= K50), S46 (= S51), T47 (≠ S52), N141 (≠ T146), S143 (= S148), Q146 (= Q151), H200 (= H204)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 12, 14, 19

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
44% identity, 76% coverage: 23:204/240 of query aligns to 15:197/223 of 2pclA

query
sites
2pclA

G

G

P

Y

E

E

V

I

L

L

Q

K

D

G

V

I

T

S

F

L

K

S

L

V

P

K

A

K

G

G

S

E

F

F

H

V

F

S

L

I

T

I

G

G

P

A

S

S

G

G

A

S

G

G

K

K

S

S

S

T

L

L

L

L

R

Y

L

I

M

L

Y

G

L

L

G

L

L

D

R

A

P

P

T

T

R

E

G

G

R

K

V

V

V

F

L

L

F

E

D

G

R

K

D

E

I

V

A

D

A

Y

T

T

K

N

R

E

Y

K

E

E

L

L

P

S

A

L

L

L

R

R

-

N

R

R

R

K

I

L

G

G

V

F

V

V

F

F

Q

Q

D

F

F

H

R

Y

L

L

L

I

D

P

H

E

M

L

T

T

A

A

L

L

D

E

N

N

V

V

A

I

L

V

P

P

L

M

R

L

V

K

R

M

G

G

V

K

K

P

E

K

S

K

E

E

I

A

R

K

R

E

H

R

V

G

P

E

E

Y

L

L

L

L

S

S

W

E

V

L

G

G

L

L

A

G

D

D

H

K

L

L

G

S

A

R

K

K

P

P

S

Y

T

E

L

L

S

S

G

G

G

G

Q

E

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

N

R

E

P

P

D

I

L

L

L

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

N

N

V

L

D

D

D

S

H

A

I

N

A

T

M

K

R

R

L

V

M

M

Y

D

L

I

F

F

E

L

E

K

L

I

N

N

K

E

L

G

G

G

T

T

T

S

I

I

V

V

V

M

A

V

T
|
T

H

H

binding magnesium ion: E165 (= E172), P166 (= P173), T167 (= T174), T196 (= T203)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
43% identity, 75% coverage: 25:204/240 of query aligns to 21:201/226 of 5xu1B

query
sites
5xu1B

E

Q

V

V

L

L

Q

K

D

N

V

I

T

N

F

L

K

E

L

V

P

N

A

E

G

G

S

E

F

F

H

V

F

A

L

I

T

M

G

G

P

P

S

S

G

G

A

S

G
|
G

K
|
K

S
|
S

S

T

L

L

L

M

R

N

L

T

M

I

Y

G

L

M

G

L

L

D

R

T

P

P

T

T

R

S

G

G

R

E

V

Y

V

Y

L

L

F

E

D

G

R

Q

D

E

I

V

A

A

A

G

T

L

K

G

R

E

Y

K

E

Q

L

L

P

A

A

K

L

V

R

R

-

N

R

Q

R

Q

I

I

G

G

V

F

V

V

F

F

Q

Q

D

Q

F

F

R

F

L

L

L

L

D

S

H

K

M

L

T

N

A

A

L

L

D

Q

N

N

V

V

A

E

L

L

P

P

L

L

R

I

V

Y

R

A

G

G

V

V

K

S

E

S

S

S

E

K

I

R

R

R

R

K

H

L

V

A

P

E

E

E

L

Y

L

L

S

D

W

K

V

V

G

E

L

L

A

T

D

E

H

R

L

S

G

H

A

H

K

L

P

P

S

S

T

E

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

V

G

N

R

N

P

P

D

S

L

I

L

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

V

L

D

D

D

T

H

K

I

T

A

G

M

N

R

Q

L

I

M

M

Y

Q

L

L

F

L

E

V

E

D

L

L

N

N

K

K

L

E

G

G

T

K

T

T

I

I

V

I

V

M

A

V

T

T

H

H

binding magnesium ion: G45 (= G49), K46 (= K50), S47 (= S51)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
40% identity, 85% coverage: 10:214/240 of query aligns to 1:213/232 of 1f3oA

query
sites
1f3oA

I

M

I

I

R

K

F

L

D

K

S

N

V

V

G

T

L

K

R

T

Y
|
Y

G

K

L

M

G

G

P

E

E

E

V

I

-

I

-

Y

-

A

L

L

Q

K

D

N

V

V

T

N

F

L

K

N

L

I

P

K

A

E

G

G

S

E

F

F

H

V

F

S

L

I

T

M

G

G

P

P

S

S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

S
x
T

L

M

L

L

R

N

L

I

M

I

Y

G

L

C

G

L

L

D

R

K

P

P

T

T

R

E

G

G

R

E

V

V

V

Y

L

I

F

D

D

N

R

I

D

K

I

T

A

N

A

D

T

L

K

D

R

D

Y

D

E

E

L

L

P

T

A

K

L

I

R

R

R

R

-

D

R

K

I

I

G

G

V

F

V

V

F

F

Q

Q

D

Q

F

F

R

N

L

L

L

I

D

P

H

L

M

L

T

T

A

A

L

L

D

E

N

N

V

V

A

E

L

L

P

P

L

L

-

I

-

F

R

K

V

Y

R

R

G

G

V

A

K

M

E

S

S

G

E

E

I

E

R

R

R

R

H

K

-

R

V

A

P

L

E

E

L

C

L

L

S

K

W

M

V

A

G

E

L

L

A

E

D

E

H

R

L

F

G

A

A

N

-

H

K

K

P

P

S

N

T

Q

L

L

S

S

G

G

G

G

Q

Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

N

R

N

P

P

D

P

L

I

L

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

V

L

D

D

D

S

H

K

I

T

A

G

M

E

R

K

L

I

M

M

Y

Q

L

L

F

L

E

K

E

K

L

L

N

N

K

E

L

E

-

D

G

G

T

K

T

T

I

V

V

V

V

V

A

V

T

T

H

H

N

-

E

D

L

I

L

N

V

V

R

A

R

R

F

F

A

G

H

E

binding adenosine-5'-diphosphate: Y11 (= Y20), G41 (= G47), G43 (= G49), K44 (= K50), S45 (= S51), T46 (≠ S52)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
39% identity, 85% coverage: 10:214/240 of query aligns to 1:213/230 of 1l2tA

query
sites
1l2tA

I

M

I

I

R

K

F

L

D

K

S

N

V

V

G

T

L

K

R

T

Y
|
Y

G

K

L

M

G

G

P

E

E

E

V

I

-

I

-

Y

-

A

L

L

Q

K

D

N

V

V

T

N

F

L

K

N

L

I

P

K

A

E

G

G

S

E

F

F

H

V

F

S

L

I

T

M

G

G

P

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

M

L

L

R

N

L

I

M

I

Y

G

L

C

G

L

L

D

R

K

P

P

T

T

R

E

G

G

R

E

V

V

V

Y

L

I

F

D

D

N

R

I

D

K

I

T

A

N

A

D

T

L

K

D

R

D

Y

D

E

E

L

L

P

T

A

K

L

I

R

R

R

R

-

D

R

K

I

I

G

G

V

F

V

V

F

F

Q

Q

D

Q

F

F

R

N

L

L

L

I

D

P

H

L

M

L

T

T

A

A

L

L

D

E

N

N

V

V

A

E

L

L

P

P

L

L

-

I

-

F

R

K

V

Y

R

R

G

G

V

A

K

M

E

S

S

G

E

E

I

E

R

R

R

R

H

K

-

R

V

A

P

L

E

E

L

C

L

L

S

K

W

M

V

A

G

E

L

L

A

E

D

E

H

R

L
x
F

G

A

A

N

-

H

K

K

P

P

S

N

T
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

K

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

N

R

N

P

P

D

P

L

I

L

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

V

L

D

D

D

S

H

K

I

T

A

G

M

E

R

K

L

I

M

M

Y

Q

L

L

F

L

E

K

E

K

L

L

N

N

K

E

L

E

-

D

G

G

T

K

T

T

I

V

V

V

V

V

A

V

T

T

H
|
H

N

-

E

D

L

I

L

N

V

V

R

A

R

R

F

F

A

G

H

E

binding adenosine-5'-triphosphate: Y11 (= Y20), S40 (= S46), G41 (= G47), S42 (≠ A48), G43 (= G49), K44 (= K50), S45 (= S51), T46 (≠ S52), F138 (≠ L140), Q145 (≠ T146), S147 (= S148), G149 (= G150), Q150 (= Q151), H204 (= H204)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
40% identity, 75% coverage: 25:204/240 of query aligns to 15:194/240 of 4ymuJ

query
sites
4ymuJ

E

E

V
|
V

L

L

Q

K

D

G

V

V

T

T

F

L

K

K

L

V

P

N

A

K

G

G

S

E

F

V

H

V

F

V

L

I

T

I

G

G

P

P

S
|
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

L

L

L

R

R

L

C

M

I

Y

N

L

L

G

L

L

E

R

E

P

P

T

T

R

K

G

G

R

E

V

V

V

F

L

I

F

D

D

G

R

V

D

K

I

I

A

N

A

N

T

G

K

K

R

-

Y

V

E

N

L

I

P

N

A

K

L

V

R

R

R

Q

R

K

I

V

G

G

V

M

V

V

F

F

Q

Q

D

H

F

F

R

N

L

L

L

F

D

P

H

H

M

L

T

T

A

A

L

I

D

E

N

N

V

I

A

T

L

L

-

A

P

P

L

V

R

K

V

V

R

K

G

K

V

M

K

N

E

K

S

K

E

E

I

A

R

E

R

E

H

L

V

A

P

V

E

D

L

L

L

L

S

A

W

K

V

V

G

G

L

L

A

L

D

D

H

K

L

K

G

D

A

Q

K

Y

P

P

S

I

T

K

L

L

S

S

G

G

G

G

Q

Q

K

K

Q

Q

R

R

V

L

A

A

I

I

A

A

R

R

A

A

V

L

I

A

G

M

R

Q

P

P

D

E

L

V

L

M

L

L

A

F

D

D

E
|
E

P

P

T

T

G

S

N

A

V

L

D

D

D

P

H

E

I

M

A

V

M

K

R

E

L

V

M

L

Y

N

L

V

F

M

E

K

E

Q

L

L

N

A

K

N

L

E

G

G

T

M

T

T

I

M

V

V

V

V

A

V

T

T

H
|
H

binding adenosine-5'-triphosphate: V16 (= V26), S36 (= S46), G37 (= G47), S38 (≠ A48), G39 (= G49), K40 (= K50), S41 (= S51), T42 (≠ S52), E162 (= E172), H194 (= H204)
binding magnesium ion: S41 (= S51), E162 (= E172)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
39% identity, 85% coverage: 10:213/240 of query aligns to 5:213/233 of P75957

query
sites
P75957

I

L

I

L

R

Q

F

C

D

D

S

N

V

L

G

C

L

K

R

R

Y

Y

G

Q

L

E

G

G

P

S

-

V

-

Q

-

T

E

D

V

V

L

L

Q

H

D

N

V

V

T

S

F

F

K

S

L

V

P

G

A

E

G

G

S

E

F

M

H

M

F

A

L

I

T

V

G
|
G

P

S

S

S

G

G

A

S

G

G

K

K

S

S

S

T

L

L

L

L

R

H

L

L

M

L

Y

G

L

G

G

L

L

D

R

T

P

P

T

T

R

S

G

G

R

D

V

V

V

I

L

F

F

N

D

G

R

Q

D

P

I

M

A

S

A

K

T

L

K

S

R

S

Y

A

E

A

L

K

P

A

A

E

L

L

R

R

-

N

R

Q

R

K

I

L

G

G

V

F

V

I

F

Y

Q

Q

D

F

F

H

R

H

L

L

L

L

D

P

H

D

M

F

T

T

A

A

L

L

D

E

N

N

V

V

A

A

L

M

P

P

L

L

R

L

V

I

R

G

G

K

V

K

K

K

E

P

S

A

E

E

I

I

R

N

R

S

H

R

V

A

P

L

E

E

L

M

L

L

S

K

W

A

V

V

G

G

L

L

A

D

D

H

H

R

L

A

G

N

A

H

K

R

P

P

S

S

T

E

L

L

S

S

G

G

G

G

Q

E

K

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

V

L

I

V

G

N

R

N

P

P

D

R

L

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

V

L

D

D

D

A

H

R

I

N

A

A

M

D

R

S

L

I

M

F

Y

Q

L

L

F

L

E

G

E

E

L

L

N

N

K

R

L

L

-

Q

G

G

T

T

T

A

I

F

V

L

V

V

A

V

T

T

H

H

N

D

E

L

L

Q

L

L

V

A

R

K

R

R

F

M

A

S

G42 (= G44) mutation to D: Loss of lipoprotein release when overexpressed.

Query Sequence

>WP_011386786.1 NCBI__GCF_000009985.1:WP_011386786.1
MRHRPRGENIIRFDSVGLRYGLGPEVLQDVTFKLPAGSFHFLTGPSGAGKSSLLRLMYLG
LRPTRGRVVLFDRDIAATKRYELPALRRRIGVVFQDFRLLDHMTALDNVALPLRVRGVKE
SEIRRHVPELLSWVGLADHLGAKPSTLSGGQKQRVAIARAVIGRPDLLLADEPTGNVDDH
IAMRLMYLFEELNKLGTTIVVATHNELLVRRFAHLPRLHIEHGMVTTLHNEPVVDDLEAE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory